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The map label for this gene is lon2 [H]

Identifier: 124026652

GI number: 124026652

Start: 1599694

End: 1600356

Strand: Reverse

Name: lon2 [H]

Synonym: NATL1_19471

Alternate gene names: 124026652

Gene position: 1600356-1599694 (Counterclockwise)

Preceding gene: 124026653

Following gene: 124026651

Centisome position: 85.82

GC content: 37.86

Gene sequence:

>663_bases
TTGAGCGAACTTTCAGTTAGGGAGCTACCACTTTTCCCATTGCCTGAGGTTGTGCTTTTTCCTCAGGAGTATTTGCCACT
TCATATTTTCGAGACTCGTTACAGAGTTATGCTTCAATCTGTGTTGAAATCGGATAGCCGTTTTGGAGTCGTTAGATGGG
ATCCAATTGCAAAAAAAATGGCAGATGTAGGTTGTTGCGCTGAGATTATTAAGCATCAAACTTCACAAGATGGTAGAAGT
AATATTGTGACTATTGGACAGCAAAGATTTCGAATTCTTGAAATTATTAGTGAAACTCCTTTTATTAACGCACTAGTTAG
TTGGGTCGATGATGAACAAATCTCAGATCAAACCCAATTATTGGAACTAAAGGATTCAGTATCAATTGCTCTAAAGGATG
TAGTTTCACTTACCTCAAAATTAACTGAATCTGAGAAAGAACTTCCTGATTCTTTGCCTGATATTCCAAGAGAATTGTCT
TTTTGGATAGCTGCTCATCTTGGCGGTCCAGTAGCAAGCGAGCAGCAAAATCTATTAGAAATAACAAATACGTTTCACCG
TTTGGAAAGAGAATATGAACTGCTTGATCACACAAGAAAGCAATTAGCTGCCAGAACTGCTCTAAAAGATACTTTTTCAA
ACGCCGATCAAGCCAACAATTAA

Upstream 100 bases:

>100_bases
GGATCTTCCTAGTGGAGTTGATATAGAAGTTAAGCTCTAGATCTTTTTCTCTCAAACCAGAGATTGATTATCTAGGATAT
GTTTAATTAGGAATACCCAT

Downstream 100 bases:

>100_bases
TTATGCAATGGATATTGATTTTAATATTTAGTATTTTCTGTCTCTTCACTTTAACTAATCAGTGGGTTAGGAAAAGTCGT
AAATATGAGTCTGTTAATAG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MSELSVRELPLFPLPEVVLFPQEYLPLHIFETRYRVMLQSVLKSDSRFGVVRWDPIAKKMADVGCCAEIIKHQTSQDGRS
NIVTIGQQRFRILEIISETPFINALVSWVDDEQISDQTQLLELKDSVSIALKDVVSLTSKLTESEKELPDSLPDIPRELS
FWIAAHLGGPVASEQQNLLEITNTFHRLEREYELLDHTRKQLAARTALKDTFSNADQANN

Sequences:

>Translated_220_residues
MSELSVRELPLFPLPEVVLFPQEYLPLHIFETRYRVMLQSVLKSDSRFGVVRWDPIAKKMADVGCCAEIIKHQTSQDGRS
NIVTIGQQRFRILEIISETPFINALVSWVDDEQISDQTQLLELKDSVSIALKDVVSLTSKLTESEKELPDSLPDIPRELS
FWIAAHLGGPVASEQQNLLEITNTFHRLEREYELLDHTRKQLAARTALKDTFSNADQANN
>Mature_219_residues
SELSVRELPLFPLPEVVLFPQEYLPLHIFETRYRVMLQSVLKSDSRFGVVRWDPIAKKMADVGCCAEIIKHQTSQDGRSN
IVTIGQQRFRILEIISETPFINALVSWVDDEQISDQTQLLELKDSVSIALKDVVSLTSKLTESEKELPDSLPDIPRELSF
WIAAHLGGPVASEQQNLLEITNTFHRLEREYELLDHTRKQLAARTALKDTFSNADQANN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG2802

COG function: function code R; Uncharacterized protein, similar to the N-terminal domain of Lon protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI73747840, Length=132, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI37622896, Length=132, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI148528975, Length=238, Percent_Identity=30.2521008403361, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 25073; Mature: 24942

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELSVRELPLFPLPEVVLFPQEYLPLHIFETRYRVMLQSVLKSDSRFGVVRWDPIAKKM
CCCCCCCCCCCCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHH
ADVGCCAEIIKHQTSQDGRSNIVTIGQQRFRILEIISETPFINALVSWVDDEQISDQTQL
HHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
LELKDSVSIALKDVVSLTSKLTESEKELPDSLPDIPRELSFWIAAHLGGPVASEQQNLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
ITNTFHRLEREYELLDHTRKQLAARTALKDTFSNADQANN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SELSVRELPLFPLPEVVLFPQEYLPLHIFETRYRVMLQSVLKSDSRFGVVRWDPIAKKM
CCCCCCCCCCCCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHH
ADVGCCAEIIKHQTSQDGRSNIVTIGQQRFRILEIISETPFINALVSWVDDEQISDQTQL
HHHHHHHHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHH
LELKDSVSIALKDVVSLTSKLTESEKELPDSLPDIPRELSFWIAAHLGGPVASEQQNLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHH
ITNTFHRLEREYELLDHTRKQLAARTALKDTFSNADQANN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8331083; 8331082 [H]