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The map label for this gene is folE [H]

Identifier: 124026602

GI number: 124026602

Start: 1561192

End: 1561938

Strand: Direct

Name: folE [H]

Synonym: NATL1_18971

Alternate gene names: 124026602

Gene position: 1561192-1561938 (Clockwise)

Preceding gene: 124026600

Following gene: 124026604

Centisome position: 83.72

GC content: 37.35

Gene sequence:

>747_bases
ATGACTTCTACTGCTCCTAATGAGAATGTTAAGGATAATTTAAAAGATCAAATTTCTTGCAAATTAGTCTCAGAAATAAT
TCGCGAACGTATACAAGCAAATGGAGCTAGATTCCATGCAAATGATAATATTTCCGATTTCATTCAGCCTAGAGAACTAG
AAACTCTTGAGAGAGAAGTTGCCACCAGAGTTAGAGATTTGCTGAAGACTTTATTGATTGATGTTGATAATGACCACAAC
ACTCAAGAAACTGCAGAACGCGTTTCCAGAATGTATCTAAATGAAGTTTTTAAAGGCAGATATCATCCCCAACCTAAAGT
TACTAATTTTCCTAACGATAGGAATTTAGATGAGATCTATACACTCGGGCCAATAACCGTTCGCTCTGCATGTTCTCATC
ACTTTGTTCCAATTCTTGGAGATTGTTGGATAGGAATAAAACCTGGAGAAAAAGTTATTGGAATCTCGAAGTTTGCCAGA
GTAGCTGATTGGGTTTTTTCTAGACCACATATTCAAGAAGAAGCTGTCATGATTCTTGCTGATGAAATAGAGCGATTATG
TGAACCCAAAGGTCTAGCGATACTTGTTAAAGCTCAACATTATTGTATGAAATGGCGAGGAGTCAAAGAGCCTGAAACCA
GCATGATCAACTCAATCGTTAGGGGTGATTTTCGCCATGATGCAAGCTTGAAGCAGGAGTTCTTCGAACTTGTTAAGCAA
CAGTCTAATTTCGGTAAAAATTATTAG

Upstream 100 bases:

>100_bases
GCGTCTAGGTATTCTGTTCATAACGAAAGTGATCTTGATATGTTAGGGTCTTAGCGCTCTAAATGTATGTCATCGGTTTT
TACCCTTACAAACAAAGGTT

Downstream 100 bases:

>100_bases
GAAATTTTAGAAAACTATCAACTGATCTAAAAGCGAACTCACAATACTCACTAGATTTTAAAACTAGAAATTAAAAGTAG
TTTTCACCAAGGCTCCATTA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MTSTAPNENVKDNLKDQISCKLVSEIIRERIQANGARFHANDNISDFIQPRELETLEREVATRVRDLLKTLLIDVDNDHN
TQETAERVSRMYLNEVFKGRYHPQPKVTNFPNDRNLDEIYTLGPITVRSACSHHFVPILGDCWIGIKPGEKVIGISKFAR
VADWVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAQHYCMKWRGVKEPETSMINSIVRGDFRHDASLKQEFFELVKQ
QSNFGKNY

Sequences:

>Translated_248_residues
MTSTAPNENVKDNLKDQISCKLVSEIIRERIQANGARFHANDNISDFIQPRELETLEREVATRVRDLLKTLLIDVDNDHN
TQETAERVSRMYLNEVFKGRYHPQPKVTNFPNDRNLDEIYTLGPITVRSACSHHFVPILGDCWIGIKPGEKVIGISKFAR
VADWVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAQHYCMKWRGVKEPETSMINSIVRGDFRHDASLKQEFFELVKQ
QSNFGKNY
>Mature_247_residues
TSTAPNENVKDNLKDQISCKLVSEIIRERIQANGARFHANDNISDFIQPRELETLEREVATRVRDLLKTLLIDVDNDHNT
QETAERVSRMYLNEVFKGRYHPQPKVTNFPNDRNLDEIYTLGPITVRSACSHHFVPILGDCWIGIKPGEKVIGISKFARV
ADWVFSRPHIQEEAVMILADEIERLCEPKGLAILVKAQHYCMKWRGVKEPETSMINSIVRGDFRHDASLKQEFFELVKQQ
SNFGKNY

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=127, Percent_Identity=33.8582677165354, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4503949, Length=127, Percent_Identity=33.8582677165354, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1788476, Length=190, Percent_Identity=30, Blast_Score=110, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17560486, Length=129, Percent_Identity=34.1085271317829, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321706, Length=191, Percent_Identity=29.8429319371728, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24656791, Length=129, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656796, Length=129, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656782, Length=126, Percent_Identity=34.1269841269841, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 28593; Mature: 28462

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSTAPNENVKDNLKDQISCKLVSEIIRERIQANGARFHANDNISDFIQPRELETLEREV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCHHHHHHHHHH
ATRVRDLLKTLLIDVDNDHNTQETAERVSRMYLNEVFKGRYHPQPKVTNFPNDRNLDEIY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
TLGPITVRSACSHHFVPILGDCWIGIKPGEKVIGISKFARVADWVFSRPHIQEEAVMILA
CCCCHHHHHHHCCCCCHHHCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DEIERLCEPKGLAILVKAQHYCMKWRGVKEPETSMINSIVRGDFRHDASLKQEFFELVKQ
HHHHHHCCCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QSNFGKNY
HHHCCCCC
>Mature Secondary Structure 
TSTAPNENVKDNLKDQISCKLVSEIIRERIQANGARFHANDNISDFIQPRELETLEREV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHCCCHHHHHHHHHH
ATRVRDLLKTLLIDVDNDHNTQETAERVSRMYLNEVFKGRYHPQPKVTNFPNDRNLDEIY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
TLGPITVRSACSHHFVPILGDCWIGIKPGEKVIGISKFARVADWVFSRPHIQEEAVMILA
CCCCHHHHHHHCCCCCHHHCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DEIERLCEPKGLAILVKAQHYCMKWRGVKEPETSMINSIVRGDFRHDASLKQEFFELVKQ
HHHHHHCCCCCCEEEEEHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
QSNFGKNY
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA