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The map label for this gene is hisD [H]

Identifier: 124026594

GI number: 124026594

Start: 1551192

End: 1552541

Strand: Direct

Name: hisD [H]

Synonym: NATL1_18891

Alternate gene names: 124026594

Gene position: 1551192-1552541 (Clockwise)

Preceding gene: 124026579

Following gene: 124026597

Centisome position: 83.19

GC content: 37.19

Gene sequence:

>1350_bases
ATGACGCAAATAATTAATAAAGACGAGGTTCAAGAAACCTCTTCAAAAAAATTGACCATAAAAACAGCTAATAGCATTGA
TCAGGCACAGTTTGAGCTAAGGAGAATTACTGAGAGAACATCTGGAACCGTTCAAGATGAAGCTATAAAGGTAGTTGACG
ATATTCTTAAAAACGTAAGGGAAAGAGGGGATGAAGCACTTACAGAATACACTTCTCGCTTTGATGGATTTCTAACGGAA
AAATTTCAAGTTTCATCAGATTTAATACTGAAAGCTTGGGAAGAGACTCCTAGGGAACTTCAAGATTCGCTTTTATTGGC
AAAAAAAAGAATTGAAAAATTTCATAGTCTTCAGGTACCAAAAAATATTACTTATACAGGACCCAATGGTGAAACACTTG
GAAGAAGATGGAGCCCTGTTGAAAAAGCAGGCATTTATGTTCCTGGCGGAAGAGCCGCCTATCCCAGCACTGTGTTAATG
AATGCTATTCCTGCTTATGTTGCAGGAGTCAATCAAATTATTATGGTTTCTCCTGCTAACTCTCAAGGAGAGATAAACCA
AACCGTTTTAGCTGCAGCACATATTACAGGTATCAACAAAATCTTTCGTCTTGGAGGCGCTCAAGCTATTTGCGCACTTG
CTAGTGGAACTGAATCAATTCCAAAAGTAGATGTAATTACTGGACCAGGAAATATTTATGTAACGTTGGCAAAGAAAAAA
GTTTATGGAAAGGTAGGAATTGATTCTTTGGCTGGTCCAAGCGAGATCCTAATAATCGCTGATCAATCAGCAAAATTAGA
ACATGTTGCATCTGATATGTTAGCTCAGTCAGAACATGATCCTTTAGCCTCAGCGATACTAATCACTACAAATACAAAAT
TAGCTGAAAAGTTACCCGCAGAAATTAACCGTCAATTAATTAATCATCCAAGATTAAAAATATGTCAAGAATCAATTTCC
AACTGGGGTTTAATAGTCCTTTGTGATGATTTAGAAACTTGTGCGCAATTGAGCGATACTTTTGCCCCAGAACATCTTGA
ATTACTTGTAGAGGACCCAAAAAAATTATCAGAAAGCATAAACAATGCTGGGGCAATATTTATGGGCCCATGGAGCCCAG
AGGCTATTGGAGATTATCTTGGCGGGCCTAATCACACTCTTCCCACTTCTGGAACTGCAAGATTTGCTGGCGCTCTTGGA
GTTGAAACTTTTATGAAAAATACCTCACTTATAGATTTTTCAAAAGAAGCATTTAATGAAAATAAAAATGCAGTTGTACA
ATTAGCCAATAGCGAGGGACTACATAGTCATGCAGAATCAATAAGAATTAGAGACTCTAAATCTTTTTAA

Upstream 100 bases:

>100_bases
GTCTTATGTTAATCCACACTACCTCAAGACCATGAAGAAGATCTACATAAATCAAAATTAAGGCATAAGATAATCAAATT
GAACCAATAGCCAAAAGTTC

Downstream 100 bases:

>100_bases
GTGATTCAACACCCACAACATCACTTTCTACTTTCCCAACCAATACTTCATCAGTCAGGTTTACAAAAAGTCCATTTTCA
AGGACACCTGGAATATTATT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MTQIINKDEVQETSSKKLTIKTANSIDQAQFELRRITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGFLTE
KFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVPKNITYTGPNGETLGRRWSPVEKAGIYVPGGRAAYPSTVLM
NAIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITGINKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKK
VYGKVGIDSLAGPSEILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKICQESIS
NWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPEAIGDYLGGPNHTLPTSGTARFAGALG
VETFMKNTSLIDFSKEAFNENKNAVVQLANSEGLHSHAESIRIRDSKSF

Sequences:

>Translated_449_residues
MTQIINKDEVQETSSKKLTIKTANSIDQAQFELRRITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGFLTE
KFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVPKNITYTGPNGETLGRRWSPVEKAGIYVPGGRAAYPSTVLM
NAIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITGINKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKK
VYGKVGIDSLAGPSEILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKICQESIS
NWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPEAIGDYLGGPNHTLPTSGTARFAGALG
VETFMKNTSLIDFSKEAFNENKNAVVQLANSEGLHSHAESIRIRDSKSF
>Mature_448_residues
TQIINKDEVQETSSKKLTIKTANSIDQAQFELRRITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGFLTEK
FQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVPKNITYTGPNGETLGRRWSPVEKAGIYVPGGRAAYPSTVLMN
AIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITGINKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKKV
YGKVGIDSLAGPSEILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKICQESISN
WGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPEAIGDYLGGPNHTLPTSGTARFAGALGV
ETFMKNTSLIDFSKEAFNENKNAVVQLANSEGLHSHAESIRIRDSKSF

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=39.2771084337349, Blast_Score=305, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=428, Percent_Identity=38.785046728972, Blast_Score=281, Evalue=1e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 48890; Mature: 48759

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIINKDEVQETSSKKLTIKTANSIDQAQFELRRITERTSGTVQDEAIKVVDDILKNVR
CCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERGDEALTEYTSRFDGFLTEKFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVP
HHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCC
KNITYTGPNGETLGRRWSPVEKAGIYVPGGRAAYPSTVLMNAIPAYVAGVNQIIMVSPAN
CCEEEECCCCCCCCCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
SQGEINQTVLAAAHITGINKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKK
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEE
VYGKVGIDSLAGPSEILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPA
HCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCCH
EINRQLINHPRLKICQESISNWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESI
HHHHHHHCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHH
NNAGAIFMGPWSPEAIGDYLGGPNHTLPTSGTARFAGALGVETFMKNTSLIDFSKEAFNE
CCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCHHHHCC
NKNAVVQLANSEGLHSHAESIRIRDSKSF
CCCEEEEEECCCCCHHHHHHEEECCCCCC
>Mature Secondary Structure 
TQIINKDEVQETSSKKLTIKTANSIDQAQFELRRITERTSGTVQDEAIKVVDDILKNVR
CCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ERGDEALTEYTSRFDGFLTEKFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVP
HHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCC
KNITYTGPNGETLGRRWSPVEKAGIYVPGGRAAYPSTVLMNAIPAYVAGVNQIIMVSPAN
CCEEEECCCCCCCCCCCCCHHHCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
SQGEINQTVLAAAHITGINKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKK
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEEEEEE
VYGKVGIDSLAGPSEILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPA
HCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCCH
EINRQLINHPRLKICQESISNWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESI
HHHHHHHCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHH
NNAGAIFMGPWSPEAIGDYLGGPNHTLPTSGTARFAGALGVETFMKNTSLIDFSKEAFNE
CCCCEEEECCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCHHHHCC
NKNAVVQLANSEGLHSHAESIRIRDSKSF
CCCEEEEEECCCCCHHHHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA