Click here to switch to the map view.

The map label for this gene is pepP [H]

Identifier: 124026546

GI number: 124026546

Start: 1502777

End: 1504096

Strand: Reverse

Name: pepP [H]

Synonym: NATL1_18411

Alternate gene names: 124026546

Gene position: 1504096-1502777 (Counterclockwise)

Preceding gene: 124026551

Following gene: 124026545

Centisome position: 80.66

GC content: 40.3

Gene sequence:

>1320_bases
GTGGCTGATTCAAGTGTTTTTCATCGCCGAAGAGACTCGTTTCTGTCAGGTTTAGGTTCGTATGCGGCTATTGTTCCAGC
TGGAGAGTTAGTTACTCATCACGCAGATTGCGAATATCCTTTCAGACAAAATAGCGACTTTTGGTATTTAACTGGTTTTG
ATGAGCCAAATGCAGTGGCTTTATTTTTGCCTCATAAACCCAAAGGAGAACAATACGTATTATTTGTCTTACCTAAAGAG
TCTGCGGCAGAGGTTTGGACAGGCTTTAGATGGGGAACAAAAGGAGTTTTAGATAATTTTGATGTTGATATAGCCCACTC
TTTGAATGAATTGCCAAGCCTTTTAGCTCATTATTTAGAGGGGGCAGAGGGAATTGCTTTTCGAATTGGGAAGCATCCGA
ACATAGAGCCTTTGGTTTTAAAAACTTGGTCGGAGCATTTACAAAAACTTCCAAGAAGTGGTTTGGCCCCATTATCCATG
ATTGCGCCTTGTCCAATACTTCACGATATGAGACTTCGTAAGGACGATTTTGAAATAGAAAGGATGCGTATTGCATCACA
AATTTCTGCAGAGGCTCATGAATTAGTTAGAGAATTTGCTCGTCCAGGAATGAATGAGAGGGATTTACAAGCGCAGATAG
AAAAATACTTTCTTGAGAAGGGGACTAGAGGACCTGCTTATGGCTCAATAGTTGCATCAGGTGATAATGCATGCGTGCTT
CATTACACGGAGAACAATTCACTCATAAAGAATGGGGACCTTGTTTTGATAGATGCAGGTTGCTCTCTAGATGACTATTA
CAATGGTGACATAACAAGAACCTTTCCAGTTAATGGAAGGTTTTCTGGAGAGCAAAAAGCCTTATATGAAATTGTTCTAA
GTTCTCAAAAAGCTGCAATTAATTGTGTTCGACCAGGTGATAATGCTGAGAACGTACATATGACTGCCTTAAAACATCTC
GTTGGGGGGTTAGTCGATATTGGCTTACTTGTTGGCGATGTTGATTCTATTATTGAACAACAAGCTTACTCGCATTTGTA
CATGCATCGAACAGGGCATTGGTTAGGACTTGATGTCCATGATGTAGGTGCATATAGGCTTGGTGACTATCATTTGAATC
TTGAACCTGGGATGGTTTTAACGGTTGAACCTGGCATTTATATAAGTGATCGGTTAGCGGTTCCCCAAGGGCAACCTGAG
ATAGACAAAAGATGGAAAGGTATTGGAATTCGTATCGAGGATGATGTTTTGGTTACACAAGATTCTGTAGAAGTATTGAG
TTGTAAAGCAGCTAAGGATTTGATAGATATGGAATGTTAG

Upstream 100 bases:

>100_bases
TCATCCTCTAAAGATTTTTTAAAGAGTAAGGATCTTTTGCTTTTATTTTTCCACTAAGTTAGATCTCTTGCCATCCTAAA
GTATAAATAGGAGTATTTTT

Downstream 100 bases:

>100_bases
TTGAAACTCTTTTAATTATTTTTTGGATGAATCTAACCATATATTTTTCTACTATTTAATAATTCCATTATTATCAAATA
GTAGAAAAGCTTTTGGATTA

Product: putative aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MADSSVFHRRRDSFLSGLGSYAAIVPAGELVTHHADCEYPFRQNSDFWYLTGFDEPNAVALFLPHKPKGEQYVLFVLPKE
SAAEVWTGFRWGTKGVLDNFDVDIAHSLNELPSLLAHYLEGAEGIAFRIGKHPNIEPLVLKTWSEHLQKLPRSGLAPLSM
IAPCPILHDMRLRKDDFEIERMRIASQISAEAHELVREFARPGMNERDLQAQIEKYFLEKGTRGPAYGSIVASGDNACVL
HYTENNSLIKNGDLVLIDAGCSLDDYYNGDITRTFPVNGRFSGEQKALYEIVLSSQKAAINCVRPGDNAENVHMTALKHL
VGGLVDIGLLVGDVDSIIEQQAYSHLYMHRTGHWLGLDVHDVGAYRLGDYHLNLEPGMVLTVEPGIYISDRLAVPQGQPE
IDKRWKGIGIRIEDDVLVTQDSVEVLSCKAAKDLIDMEC

Sequences:

>Translated_439_residues
MADSSVFHRRRDSFLSGLGSYAAIVPAGELVTHHADCEYPFRQNSDFWYLTGFDEPNAVALFLPHKPKGEQYVLFVLPKE
SAAEVWTGFRWGTKGVLDNFDVDIAHSLNELPSLLAHYLEGAEGIAFRIGKHPNIEPLVLKTWSEHLQKLPRSGLAPLSM
IAPCPILHDMRLRKDDFEIERMRIASQISAEAHELVREFARPGMNERDLQAQIEKYFLEKGTRGPAYGSIVASGDNACVL
HYTENNSLIKNGDLVLIDAGCSLDDYYNGDITRTFPVNGRFSGEQKALYEIVLSSQKAAINCVRPGDNAENVHMTALKHL
VGGLVDIGLLVGDVDSIIEQQAYSHLYMHRTGHWLGLDVHDVGAYRLGDYHLNLEPGMVLTVEPGIYISDRLAVPQGQPE
IDKRWKGIGIRIEDDVLVTQDSVEVLSCKAAKDLIDMEC
>Mature_438_residues
ADSSVFHRRRDSFLSGLGSYAAIVPAGELVTHHADCEYPFRQNSDFWYLTGFDEPNAVALFLPHKPKGEQYVLFVLPKES
AAEVWTGFRWGTKGVLDNFDVDIAHSLNELPSLLAHYLEGAEGIAFRIGKHPNIEPLVLKTWSEHLQKLPRSGLAPLSMI
APCPILHDMRLRKDDFEIERMRIASQISAEAHELVREFARPGMNERDLQAQIEKYFLEKGTRGPAYGSIVASGDNACVLH
YTENNSLIKNGDLVLIDAGCSLDDYYNGDITRTFPVNGRFSGEQKALYEIVLSSQKAAINCVRPGDNAENVHMTALKHLV
GGLVDIGLLVGDVDSIIEQQAYSHLYMHRTGHWLGLDVHDVGAYRLGDYHLNLEPGMVLTVEPGIYISDRLAVPQGQPEI
DKRWKGIGIRIEDDVLVTQDSVEVLSCKAAKDLIDMEC

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=410, Percent_Identity=34.390243902439, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI149589008, Length=445, Percent_Identity=31.2359550561798, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI260593665, Length=293, Percent_Identity=37.8839590443686, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI260593663, Length=249, Percent_Identity=37.7510040160643, Blast_Score=148, Evalue=1e-35,
Organism=Escherichia coli, GI1789275, Length=436, Percent_Identity=43.1192660550459, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI1788728, Length=261, Percent_Identity=33.7164750957854, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790282, Length=354, Percent_Identity=28.2485875706215, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786364, Length=271, Percent_Identity=24.7232472324723, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17508215, Length=461, Percent_Identity=28.8503253796095, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71989583, Length=274, Percent_Identity=29.5620437956204, Blast_Score=110, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320922, Length=449, Percent_Identity=29.8440979955457, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6321118, Length=446, Percent_Identity=30.2690582959641, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19920384, Length=445, Percent_Identity=33.2584269662921, Blast_Score=197, Evalue=9e-51,
Organism=Drosophila melanogaster, GI21357079, Length=426, Percent_Identity=31.924882629108, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 48921; Mature: 48790

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSSVFHRRRDSFLSGLGSYAAIVPAGELVTHHADCEYPFRQNSDFWYLTGFDEPNAVA
CCCCHHHHHHHHHHHHHHCCCEEEECCCHHHEECCCCCCCCCCCCCEEEEECCCCCCEEE
LFLPHKPKGEQYVLFVLPKESAAEVWTGFRWGTKGVLDNFDVDIAHSLNELPSLLAHYLE
EEECCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GAEGIAFRIGKHPNIEPLVLKTWSEHLQKLPRSGLAPLSMIAPCPILHDMRLRKDDFEIE
CCCCEEEEECCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHCCCCCCHHH
RMRIASQISAEAHELVREFARPGMNERDLQAQIEKYFLEKGTRGPAYGSIVASGDNACVL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEE
HYTENNSLIKNGDLVLIDAGCSLDDYYNGDITRTFPVNGRFSGEQKALYEIVLSSQKAAI
EEECCCCEEECCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEE
NCVRPGDNAENVHMTALKHLVGGLVDIGLLVGDVDSIIEQQAYSHLYMHRTGHWLGLDVH
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEE
DVGAYRLGDYHLNLEPGMVLTVEPGIYISDRLAVPQGQPEIDKRWKGIGIRIEDDVLVTQ
CCCCEEECCEEEECCCCEEEEECCCEEEECEEECCCCCCCHHHHHCCCCEEEECCEEEEC
DSVEVLSCKAAKDLIDMEC
CCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADSSVFHRRRDSFLSGLGSYAAIVPAGELVTHHADCEYPFRQNSDFWYLTGFDEPNAVA
CCCHHHHHHHHHHHHHHCCCEEEECCCHHHEECCCCCCCCCCCCCEEEEECCCCCCEEE
LFLPHKPKGEQYVLFVLPKESAAEVWTGFRWGTKGVLDNFDVDIAHSLNELPSLLAHYLE
EEECCCCCCCEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHC
GAEGIAFRIGKHPNIEPLVLKTWSEHLQKLPRSGLAPLSMIAPCPILHDMRLRKDDFEIE
CCCCEEEEECCCCCCCEEEEHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHCCCCCCHHH
RMRIASQISAEAHELVREFARPGMNERDLQAQIEKYFLEKGTRGPAYGSIVASGDNACVL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCEEEE
HYTENNSLIKNGDLVLIDAGCSLDDYYNGDITRTFPVNGRFSGEQKALYEIVLSSQKAAI
EEECCCCEEECCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCEE
NCVRPGDNAENVHMTALKHLVGGLVDIGLLVGDVDSIIEQQAYSHLYMHRTGHWLGLDVH
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEEEE
DVGAYRLGDYHLNLEPGMVLTVEPGIYISDRLAVPQGQPEIDKRWKGIGIRIEDDVLVTQ
CCCCEEECCEEEECCCCEEEEECCCEEEECEEECCCCCCCHHHHHCCCCEEEECCEEEEC
DSVEVLSCKAAKDLIDMEC
CCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659585; 1339425; 9278503; 9520390 [H]