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The map label for this gene is groEL [H]

Identifier: 124026541

GI number: 124026541

Start: 1497893

End: 1499524

Strand: Reverse

Name: groEL [H]

Synonym: NATL1_18361

Alternate gene names: 124026541

Gene position: 1499524-1497893 (Counterclockwise)

Preceding gene: 124026542

Following gene: 124026538

Centisome position: 80.42

GC content: 41.54

Gene sequence:

>1632_bases
ATGGCTAAGCGCATCATTTACAACGAGCAAGCCCGCCGAGCACTCGAGCGTGGTATTGACATTTTGGCTGAATCAGTCGC
AGTCACTTTAGGGCCGAAAGGTCGTAATGTTGTTCTCGAGAAAAAGTTCGGTGCACCTCAAATAATCAATGATGGTGTAA
CCATTGCTAAGGAGATCGAACTCGAAGATCACATTGAAAACACTGGAGTTGCTCTAATTCGTCAAGCCGCATCAAAAACA
AATGATGCAGCTGGAGATGGCACGACCACTGCAACTGTTCTTGCTCATGCAATGGTCAAAGCCGGTTTGAAAAATGTTGC
AGCAGGAGCAAATGCAATCACTTTGAAAAAAGGAATTGATAAGGCAACTGACTTTTTGGTTGAAAAAATAAAAGATCATT
CCAAGCCAATTAGTGACAGTAATGCAATTGCTCAATGTGGCACGATTGCTGCTGGTAATGATGAAGAAGTTGGCAAAATG
ATTGCTGATGCTATGGATAAAGTTGGAAAAGAAGGTGTTATCTCTTTAGAAGAAGGCAAGTCAATGACCACTGAGCTAGA
GGTTACTGAAGGAATGCGTTTTGATAAAGGATATATTTCTCCTTATTTCGCAACTGATACTGAGAGAATGGAAGCAGTAT
TGGACGAGCCTTATATACTTCTTACTGACAAGAAAATTGGTCTAGTTCAAGATCTTGTTCCTGTCTTAGAACAAGTTGCT
AAAACTGGTAAACCTCTTCTAATAATTGCTGAAGATATAGAAAAAGAAGCTTTGGCGACATTAGTTGTCAATCGCTTAAG
AGGTGTTCTTAACGTTGCCGCAGTTAAGGCTCCTGGTTTTGGTGATCGTAGAAAGGCGATGCTTGAAGATATGGCTGTTT
TAACTAATGGCCAACTCATTACTGAGGATGCAGGCTTAAAACTTGAGAATGCAACTCTTGATATGCTTGGAACTTCAAGG
AGAGTGACCATTAATAAGGACACATCAACAATTGTTGCTGAAGGCAATGAAGTCGCTGTAAATGCAAGATGTGAACAAAT
CAAGAAGCAGATGGATGAGACCGACTCAACCTATGACAAAGAAAAACTTCAGGAAAGATTAGCTAAGCTATCTGGTGGCG
TAGCTGTAGTGAAAGTGGGAGCTGCGACTGAGACTGAGATGAAAGATAAGAAGCTTCGATTAGAGGATGCAATTAACGCA
ACTAAAGCTGCAGTTGAAGAAGGCATTGTTCCTGGTGGTGGAACTACTCTCGCTCATTTAGCTCCTGCATTGGAAGATTG
GTCCTCCACCAATCTTTCTGGTGAGGAATTAATCGGTGCAAATATCGTTGAAGCTGCTCTTACTTCTCCACTAATGCGCA
TAGCTGAAAATGCTGGTGCTAATGGAGCAGTTGTTGCAGAGAATGTTAAATCTAAGCCAGTTAATGATGGCTATAACGCT
GCAACTGGTGAATATGTAGATATGCTTTCTGCTGGAATCGTTGATCCTGCGAAGGTAACAAGATCAGGGTTGCAAAATGC
TGCATCAATAGCAGGAATGGTTCTTACAACTGAATGCATAGTTGCTGATCTACCAGAGAAGAAAGACTCTTCTCCAGCAG
GTGGTGGAATGGGTGGTGATTTTGATTATTAA

Upstream 100 bases:

>100_bases
TTCTCTCTGAGAAAGACATTCTTGCTGTCGTCAACTAATACTCAGCTTTTGCTGAAGTCCAAACCAAAAAACTTTTCGAA
ATTAAAGGAAATCGCCTCTT

Downstream 100 bases:

>100_bases
ATAATCATTTTCTTTCAATTAAAGAGAAAGAGAGAGATTGTTTTTAACAATCTCTCTCTTTCTCTTTAATTAGGCATGAA
TAATCTGGCTTTTAAATAAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLKNVAAGANAITLKKGIDKATDFLVEKIKDHSKPISDSNAIAQCGTIAAGNDEEVGKM
IADAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQVA
KTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTSR
RVTINKDTSTIVAEGNEVAVNARCEQIKKQMDETDSTYDKEKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLAPALEDWSSTNLSGEELIGANIVEAALTSPLMRIAENAGANGAVVAENVKSKPVNDGYNA
ATGEYVDMLSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSSPAGGGMGGDFDY

Sequences:

>Translated_543_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLKNVAAGANAITLKKGIDKATDFLVEKIKDHSKPISDSNAIAQCGTIAAGNDEEVGKM
IADAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQVA
KTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTSR
RVTINKDTSTIVAEGNEVAVNARCEQIKKQMDETDSTYDKEKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLAPALEDWSSTNLSGEELIGANIVEAALTSPLMRIAENAGANGAVVAENVKSKPVNDGYNA
ATGEYVDMLSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSSPAGGGMGGDFDY
>Mature_542_residues
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKTN
DAAGDGTTTATVLAHAMVKAGLKNVAAGANAITLKKGIDKATDFLVEKIKDHSKPISDSNAIAQCGTIAAGNDEEVGKMI
ADAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQVAK
TGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLDMLGTSRR
VTINKDTSTIVAEGNEVAVNARCEQIKKQMDETDSTYDKEKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINAT
KAAVEEGIVPGGGTTLAHLAPALEDWSSTNLSGEELIGANIVEAALTSPLMRIAENAGANGAVVAENVKSKPVNDGYNAA
TGEYVDMLSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSSPAGGGMGGDFDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=45.1977401129944, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=45.1977401129944, Blast_Score=466, Evalue=1e-131,
Organism=Escherichia coli, GI1790586, Length=526, Percent_Identity=58.5551330798479, Blast_Score=600, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=45.4716981132076, Blast_Score=467, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI193210679, Length=212, Percent_Identity=43.8679245283019, Blast_Score=179, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=49.0494296577947, Blast_Score=494, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6322524, Length=147, Percent_Identity=31.2925170068027, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=46.5909090909091, Blast_Score=477, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=46.5909090909091, Blast_Score=477, Evalue=1e-134,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=43.7262357414449, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=43.7262357414449, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=43.7262357414449, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI17864606, Length=550, Percent_Identity=38.5454545454545, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=34.9056603773585, Blast_Score=301, Evalue=6e-82,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=34.9056603773585, Blast_Score=301, Evalue=6e-82,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57314; Mature: 57183

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCCEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLKNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCH
KATDFLVEKIKDHSKPISDSNAIAQCGTIAAGNDEEVGKMIADAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQVA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
KTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLDMLGTSRRVTINKDTSTIVAEGNEVAVNARCEQIKKQMDETDSTYDK
ECCCCCEEECCCHHHCCCCEEEEEECCCCEEEECCCEEEECHHHHHHHHHHHHCCCCCCH
EKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
APALEDWSSTNLSGEELIGANIVEAALTSPLMRIAENAGANGAVVAENVKSKPVNDGYNA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMLSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSSPAGGGMGGD
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
FDY
CCC
>Mature Secondary Structure 
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLKNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCH
KATDFLVEKIKDHSKPISDSNAIAQCGTIAAGNDEEVGKMIADAMDKVGKEGVISLEEGK
HHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIGLVQDLVPVLEQVA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
KTGKPLLIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLDMLGTSRRVTINKDTSTIVAEGNEVAVNARCEQIKKQMDETDSTYDK
ECCCCCEEECCCHHHCCCCEEEEEECCCCEEEECCCEEEECHHHHHHHHHHHHCCCCCCH
EKLQERLAKLSGGVAVVKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
APALEDWSSTNLSGEELIGANIVEAALTSPLMRIAENAGANGAVVAENVKSKPVNDGYNA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMLSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADLPEKKDSSPAGGGMGGD
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
FDY
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA