Click here to switch to the map view.

The map label for this gene is serA [H]

Identifier: 124026487

GI number: 124026487

Start: 1461528

End: 1463114

Strand: Reverse

Name: serA [H]

Synonym: NATL1_17821

Alternate gene names: 124026487

Gene position: 1463114-1461528 (Counterclockwise)

Preceding gene: 124026490

Following gene: 124026486

Centisome position: 78.46

GC content: 40.58

Gene sequence:

>1587_bases
ATGACGAAAGTTCTTGTTTCTGATCCCATTGATCAAGCAGGTATAGATATTCTTACTCAGGTTGCCCAGGTTGACCAAAA
AGTAGGTCTTTCACCAGATCAGTTGAAGAATATTATTGGTGAGTATGACGGATTAATGATCCGTTCAGGAACCCAAGTCA
CATCAGATGTTATATCTGAGGCTAAGAAATTGAGAATCATTGGTAGAGCTGGAGTTGGAGTGGATAATGTTGATGTGCCA
ACTGCTACTAGAAAGGGTGTCTTAGTCGTTAATTCTCCAGGTGGGAACACGATTGCTGCAGCTGAGCATGCTTTAGCAAT
GATGCTTGCATTATCTAGAAATATTCCCCCAGCAAACGCAAGTATGTTTGCTGGAGGTTGGGACCGAAAGAAATATGTAG
GAAATGAGCTTTATAAGAAAACCTTGGGTGTCGTTGGACTTGGCAAGATTGGATCTCATGTCGCAAAGGTTGCAAATGCA
ATGGGTATGGAAGTCATTGGATTTGATCCTTTTGTTTCTAATGAAAGAGCTCAGCAAATGCAGGTTCGATTAAGCGATAT
TGAGGAGTTATTTAAAGAATCTGATTATGTCACCCTTCATCTTCCAAGGACACCTGAAACAGAGAATTTAGTTGATATTG
ATCTTCTAAGAAAAATGAAACCAACTGCCAGATTGGTTAACTGTGCAAGGGGTGGCATTATTAATGAAAATGATTTAGCT
AATGCCTTAGCAGAAAATGTTATTCAAGGTGCTGCAATCGATGTATATGCAAAAGAACCTCTAGCTGAAAACTCGCCTTT
ACGCGCTGTAAAAAAAGGCTTGGTACTTACGCCTCATCTAGGCGCTTCAACTGTTGAGGCACAACAAAATGTAGCAATTG
ATGTTGCAGAACAAATTAGAGATGTCCTCTTAGGCTTGCCAGCACGCAGCGCTGTAAATATTCCTGGTCTTAGCGCAGAG
ATAATGGATAGTCTTAAACCACATTTAAAACTTGCGGAGACATTAGGATTATTAGTTAGTCAAATTTCAGGGGGACAGAT
TCAAAAACTAGAGGTACGTTTGCAAGGGGAATTCGCTCAACATCCATCTCAACCTCTAGTTATTGCAACTTTGAAGGGAT
TACTCACCAGTGCATTGGGCGATAAAATTAACTATGTAAACGCTTCATTGGAAGCTAAAGGACGTGGTATTGATGTCGTA
GAAATTAAGGATGAGTTGTGCCCAGAGTTTGCTCGAGGCTCTTTGCAGTTGGATAGTTTTAGTGACAAAGGCGGTCACAG
TGTCTCTGGAACTGTTTTTGGTGATGGCGATCTTGGTATTACAAGTATTGATGAGTACCCGATAAATTTTGTGCCAAGTA
GACATATGCTTTTTACAAGGCATAGGGATATGCCGGGAATCATTGGTCAAATAGGTTCACTTCTCGGGAAATACAATGTG
AATATTGCATCAATGCAAGTAGGAAGAAGGATTGTAAGAGGTGAGGCAGTAATGGTTTTAAGTATCGATGACCCCATCCC
TTCTGAGTTGTTGGGCTCAATTCTTTCAATGCAAGGAATTAACGAAGCTCATTCAGTGACTCTGTAA

Upstream 100 bases:

>100_bases
TAGCTCCTTGAAATGTTTGGATATTCAATCCTGCTCAACATAATTCTGTTCAGCGGCAAATAGATCACTAAAGTTCAGAT
CGGCACGTTTATCGCCTTTA

Downstream 100 bases:

>100_bases
TTTGTTGGTTGAAAAAACTGTAAATTTGCAAAACTCCCAACTGTCGTGGTTGAGATTGGAGCAGGAATTTTCATTTGAGC
TAGAAGATTCTTTTTATTGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MTKVLVSDPIDQAGIDILTQVAQVDQKVGLSPDQLKNIIGEYDGLMIRSGTQVTSDVISEAKKLRIIGRAGVGVDNVDVP
TATRKGVLVVNSPGGNTIAAAEHALAMMLALSRNIPPANASMFAGGWDRKKYVGNELYKKTLGVVGLGKIGSHVAKVANA
MGMEVIGFDPFVSNERAQQMQVRLSDIEELFKESDYVTLHLPRTPETENLVDIDLLRKMKPTARLVNCARGGIINENDLA
NALAENVIQGAAIDVYAKEPLAENSPLRAVKKGLVLTPHLGASTVEAQQNVAIDVAEQIRDVLLGLPARSAVNIPGLSAE
IMDSLKPHLKLAETLGLLVSQISGGQIQKLEVRLQGEFAQHPSQPLVIATLKGLLTSALGDKINYVNASLEAKGRGIDVV
EIKDELCPEFARGSLQLDSFSDKGGHSVSGTVFGDGDLGITSIDEYPINFVPSRHMLFTRHRDMPGIIGQIGSLLGKYNV
NIASMQVGRRIVRGEAVMVLSIDDPIPSELLGSILSMQGINEAHSVTL

Sequences:

>Translated_528_residues
MTKVLVSDPIDQAGIDILTQVAQVDQKVGLSPDQLKNIIGEYDGLMIRSGTQVTSDVISEAKKLRIIGRAGVGVDNVDVP
TATRKGVLVVNSPGGNTIAAAEHALAMMLALSRNIPPANASMFAGGWDRKKYVGNELYKKTLGVVGLGKIGSHVAKVANA
MGMEVIGFDPFVSNERAQQMQVRLSDIEELFKESDYVTLHLPRTPETENLVDIDLLRKMKPTARLVNCARGGIINENDLA
NALAENVIQGAAIDVYAKEPLAENSPLRAVKKGLVLTPHLGASTVEAQQNVAIDVAEQIRDVLLGLPARSAVNIPGLSAE
IMDSLKPHLKLAETLGLLVSQISGGQIQKLEVRLQGEFAQHPSQPLVIATLKGLLTSALGDKINYVNASLEAKGRGIDVV
EIKDELCPEFARGSLQLDSFSDKGGHSVSGTVFGDGDLGITSIDEYPINFVPSRHMLFTRHRDMPGIIGQIGSLLGKYNV
NIASMQVGRRIVRGEAVMVLSIDDPIPSELLGSILSMQGINEAHSVTL
>Mature_527_residues
TKVLVSDPIDQAGIDILTQVAQVDQKVGLSPDQLKNIIGEYDGLMIRSGTQVTSDVISEAKKLRIIGRAGVGVDNVDVPT
ATRKGVLVVNSPGGNTIAAAEHALAMMLALSRNIPPANASMFAGGWDRKKYVGNELYKKTLGVVGLGKIGSHVAKVANAM
GMEVIGFDPFVSNERAQQMQVRLSDIEELFKESDYVTLHLPRTPETENLVDIDLLRKMKPTARLVNCARGGIINENDLAN
ALAENVIQGAAIDVYAKEPLAENSPLRAVKKGLVLTPHLGASTVEAQQNVAIDVAEQIRDVLLGLPARSAVNIPGLSAEI
MDSLKPHLKLAETLGLLVSQISGGQIQKLEVRLQGEFAQHPSQPLVIATLKGLLTSALGDKINYVNASLEAKGRGIDVVE
IKDELCPEFARGSLQLDSFSDKGGHSVSGTVFGDGDLGITSIDEYPINFVPSRHMLFTRHRDMPGIIGQIGSLLGKYNVN
IASMQVGRRIVRGEAVMVLSIDDPIPSELLGSILSMQGINEAHSVTL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=404, Percent_Identity=40.3465346534653, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI61743967, Length=280, Percent_Identity=32.1428571428571, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI4557497, Length=280, Percent_Identity=32.1428571428571, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI6912396, Length=303, Percent_Identity=29.3729372937294, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI145580578, Length=295, Percent_Identity=30.5084745762712, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4557499, Length=295, Percent_Identity=30.5084745762712, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI145580575, Length=284, Percent_Identity=30.2816901408451, Blast_Score=122, Evalue=9e-28,
Organism=Escherichia coli, GI1789279, Length=322, Percent_Identity=32.9192546583851, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI87082289, Length=303, Percent_Identity=32.013201320132, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787645, Length=205, Percent_Identity=34.6341463414634, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1788660, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081824, Length=187, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=324, Percent_Identity=42.5925925925926, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI25147481, Length=281, Percent_Identity=29.1814946619217, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=326, Percent_Identity=34.6625766871166, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6322116, Length=333, Percent_Identity=33.033033033033, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324964, Length=262, Percent_Identity=28.6259541984733, Blast_Score=107, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=248, Percent_Identity=27.8225806451613, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321253, Length=155, Percent_Identity=32.258064516129, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324980, Length=187, Percent_Identity=26.2032085561497, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19921140, Length=305, Percent_Identity=42.9508196721311, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24646446, Length=302, Percent_Identity=32.4503311258278, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646448, Length=302, Percent_Identity=32.4503311258278, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646452, Length=302, Percent_Identity=32.4503311258278, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24646450, Length=302, Percent_Identity=32.4503311258278, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI28574286, Length=304, Percent_Identity=30.5921052631579, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI62472511, Length=300, Percent_Identity=31.6666666666667, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=29.2452830188679, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=29.2452830188679, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=29.2452830188679, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45551003, Length=315, Percent_Identity=29.2063492063492, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=29.2452830188679, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=28.8461538461538, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=26.1980830670927, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56435; Mature: 56304

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVLVSDPIDQAGIDILTQVAQVDQKVGLSPDQLKNIIGEYDGLMIRSGTQVTSDVISE
CCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHH
AKKLRIIGRAGVGVDNVDVPTATRKGVLVVNSPGGNTIAAAEHALAMMLALSRNIPPANA
HHHEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC
SMFAGGWDRKKYVGNELYKKTLGVVGLGKIGSHVAKVANAMGMEVIGFDPFVSNERAQQM
CEECCCCCHHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHH
QVRLSDIEELFKESDYVTLHLPRTPETENLVDIDLLRKMKPTARLVNCARGGIINENDLA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHCCHHHHHHHHHCCCCCCCHHHH
NALAENVIQGAAIDVYAKEPLAENSPLRAVKKGLVLTPHLGASTVEAQQNVAIDVAEQIR
HHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCCCEECCCCCCCHHHHHHCHHHHHHHHHH
DVLLGLPARSAVNIPGLSAEIMDSLKPHLKLAETLGLLVSQISGGQIQKLEVRLQGEFAQ
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLVIATLKGLLTSALGDKINYVNASLEAKGRGIDVVEIKDELCPEFARGSLQLDSF
CCCCCCHHHHHHHHHHHHHCCCEEEEECEEECCCCCEEEEECCHHHCHHHHCCCEEECCC
SDKGGHSVSGTVFGDGDLGITSIDEYPINFVPSRHMLFTRHRDMPGIIGQIGSLLGKYNV
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
NIASMQVGRRIVRGEAVMVLSIDDPIPSELLGSILSMQGINEAHSVTL
EEHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCC
>Mature Secondary Structure 
TKVLVSDPIDQAGIDILTQVAQVDQKVGLSPDQLKNIIGEYDGLMIRSGTQVTSDVISE
CEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCHHHHHHHHH
AKKLRIIGRAGVGVDNVDVPTATRKGVLVVNSPGGNTIAAAEHALAMMLALSRNIPPANA
HHHEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCC
SMFAGGWDRKKYVGNELYKKTLGVVGLGKIGSHVAKVANAMGMEVIGFDPFVSNERAQQM
CEECCCCCHHHHHHHHHHHHHHCCEECHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHH
QVRLSDIEELFKESDYVTLHLPRTPETENLVDIDLLRKMKPTARLVNCARGGIINENDLA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHCCHHHHHHHHHCCCCCCCHHHH
NALAENVIQGAAIDVYAKEPLAENSPLRAVKKGLVLTPHLGASTVEAQQNVAIDVAEQIR
HHHHHHHHCCCEEEEEECCCCCCCCCHHHHHCCCEECCCCCCCHHHHHHCHHHHHHHHHH
DVLLGLPARSAVNIPGLSAEIMDSLKPHLKLAETLGLLVSQISGGQIQKLEVRLQGEFAQ
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHC
HPSQPLVIATLKGLLTSALGDKINYVNASLEAKGRGIDVVEIKDELCPEFARGSLQLDSF
CCCCCCHHHHHHHHHHHHHCCCEEEEECEEECCCCCEEEEECCHHHCHHHHCCCEEECCC
SDKGGHSVSGTVFGDGDLGITSIDEYPINFVPSRHMLFTRHRDMPGIIGQIGSLLGKYNV
CCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
NIASMQVGRRIVRGEAVMVLSIDDPIPSELLGSILSMQGINEAHSVTL
EEHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]