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The map label for this gene is elaC

Identifier: 124026481

GI number: 124026481

Start: 1457775

End: 1458719

Strand: Direct

Name: elaC

Synonym: NATL1_17761

Alternate gene names: 124026481

Gene position: 1457775-1458719 (Clockwise)

Preceding gene: 124026479

Following gene: 124026482

Centisome position: 78.18

GC content: 39.05

Gene sequence:

>945_bases
TTGCAAGTCACTTTTCTAGGAACAAGTTCAGGGGTCCCAACTCTTAATAGGAACGTATCAGCGATGGTACTAAAGCCTCC
ACAAAGGTCAGAATTGTGGTTGTTCGATTGTGGTGAAGGTACACAGCATCAGTTCATTAGAAGCAATCTTAAGTTATCTC
AAATCAAAAAAATATTTATTACCCATATGCATGGGGATCATATTTATGGTCTACCAGGACTTCTAGCAAGTATTGGATTA
GCAGGCAGCAGCTCTGGAATTGAGTTGTACGGGCCAGCTCCGCTTAAGAACTTTATTGATTCTTGTCTATACAACAGCTC
AAGCCGATTGGCTTATTCACTCAAATTCCATAGGGTCGAAAATGCTGCTAATAATAAAGAAATTTTGTTTGAAGATTCAG
AGTTAGAAGTCAAAACTGCTCCACTCAAGCATCGAATCCCATCTTTTGCTTACAGAGTGAATCAAAAAACTAGGCCAGGC
AGATTCGATATAGAGAAAGCAAAATTAAAAGGAATACCTCCTGGTCCAGTTTATGCAGACCTTCAGAGAGGGGAGGAAGT
GAGATTAGAAGATGGTCGCATTTTTTCTGGGAAAGAATTCTGCGGTCCACCTAGACCTGGGGTAAGCATGGTTTATTGCA
CAGATACTGTTTATACAGAATCAGCAATTGAGATTTCTAGAAAAGCCGATCTACTAATCCATGAATCAACTTATTCTTAT
AAAGAAACTGAAATGGCATATGAACGCGGACATTCAACTGCAACAATGGCCGCTCAGATTGCTGCAAAAGCGAATGTTGA
TCAACTAATTCTTACTCATTTGAGTCCGAGATATACCCCTGGCAATCAAACATGTCCTAATGATTTGCTTAATGAAGCAA
AAGCAATTTTTCCAAATACCCAGTTAGCAAAAGACTTTCTGCAAATTGACTTAAATAAAAGCTGA

Upstream 100 bases:

>100_bases
CACAATAAAAATTGGATTTAGGTACTAATTTTGCCTATAAGAAAGAAGATCCACCAGTGGTCAAAGCTATGAATGTCACC
ATGTCTTAAAAGGGGGAAAC

Downstream 100 bases:

>100_bases
AACTGCAACAGTTCGTGATCCCTTTACCTATGAAATGCCTCTACATGAAACAATAGTCGAGTTTGGTGCTTCTTTAATCG
CTGGCGTTATTAATGAATTC

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MQVTFLGTSSGVPTLNRNVSAMVLKPPQRSELWLFDCGEGTQHQFIRSNLKLSQIKKIFITHMHGDHIYGLPGLLASIGL
AGSSSGIELYGPAPLKNFIDSCLYNSSSRLAYSLKFHRVENAANNKEILFEDSELEVKTAPLKHRIPSFAYRVNQKTRPG
RFDIEKAKLKGIPPGPVYADLQRGEEVRLEDGRIFSGKEFCGPPRPGVSMVYCTDTVYTESAIEISRKADLLIHESTYSY
KETEMAYERGHSTATMAAQIAAKANVDQLILTHLSPRYTPGNQTCPNDLLNEAKAIFPNTQLAKDFLQIDLNKS

Sequences:

>Translated_314_residues
MQVTFLGTSSGVPTLNRNVSAMVLKPPQRSELWLFDCGEGTQHQFIRSNLKLSQIKKIFITHMHGDHIYGLPGLLASIGL
AGSSSGIELYGPAPLKNFIDSCLYNSSSRLAYSLKFHRVENAANNKEILFEDSELEVKTAPLKHRIPSFAYRVNQKTRPG
RFDIEKAKLKGIPPGPVYADLQRGEEVRLEDGRIFSGKEFCGPPRPGVSMVYCTDTVYTESAIEISRKADLLIHESTYSY
KETEMAYERGHSTATMAAQIAAKANVDQLILTHLSPRYTPGNQTCPNDLLNEAKAIFPNTQLAKDFLQIDLNKS
>Mature_314_residues
MQVTFLGTSSGVPTLNRNVSAMVLKPPQRSELWLFDCGEGTQHQFIRSNLKLSQIKKIFITHMHGDHIYGLPGLLASIGL
AGSSSGIELYGPAPLKNFIDSCLYNSSSRLAYSLKFHRVENAANNKEILFEDSELEVKTAPLKHRIPSFAYRVNQKTRPG
RFDIEKAKLKGIPPGPVYADLQRGEEVRLEDGRIFSGKEFCGPPRPGVSMVYCTDTVYTESAIEISRKADLLIHESTYSY
KETEMAYERGHSTATMAAQIAAKANVDQLILTHLSPRYTPGNQTCPNDLLNEAKAIFPNTQLAKDFLQIDLNKS

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=359, Percent_Identity=36.4902506963788, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI87082078, Length=308, Percent_Identity=40.2597402597403, Blast_Score=245, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24652403, Length=184, Percent_Identity=30.9782608695652, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_PROM1 (A2C4C2)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015596.1
- ProteinModelPortal:   A2C4C2
- SMR:   A2C4C2
- STRING:   A2C4C2
- GeneID:   4781274
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_17761
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK919698
- BioCyc:   PMAR167555:NATL1_17761-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34938; Mature: 34938

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTFLGTSSGVPTLNRNVSAMVLKPPQRSELWLFDCGEGTQHQFIRSNLKLSQIKKIFI
CEEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHEEHE
THMHGDHIYGLPGLLASIGLAGSSSGIELYGPAPLKNFIDSCLYNSSSRLAYSLKFHRVE
EEECCCEEECHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEEEEEEHH
NAANNKEILFEDSELEVKTAPLKHRIPSFAYRVNQKTRPGRFDIEKAKLKGIPPGPVYAD
CCCCCCEEEEECCCCEEEECCHHHCCCHHHEEECCCCCCCCCCCHHHHCCCCCCCCCCHH
LQRGEEVRLEDGRIFSGKEFCGPPRPGVSMVYCTDTVYTESAIEISRKADLLIHESTYSY
HHCCCEEEECCCEEECCCCCCCCCCCCCEEEEEECCEECCHHHHHHCCCEEEEECCCCCC
KETEMAYERGHSTATMAAQIAAKANVDQLILTHLSPRYTPGNQTCPNDLLNEAKAIFPNT
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCH
QLAKDFLQIDLNKS
HHHHHHHHEECCCC
>Mature Secondary Structure
MQVTFLGTSSGVPTLNRNVSAMVLKPPQRSELWLFDCGEGTQHQFIRSNLKLSQIKKIFI
CEEEEEECCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCHHHHHEEHE
THMHGDHIYGLPGLLASIGLAGSSSGIELYGPAPLKNFIDSCLYNSSSRLAYSLKFHRVE
EEECCCEEECHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHCCCCCCEEEEEEEEEHH
NAANNKEILFEDSELEVKTAPLKHRIPSFAYRVNQKTRPGRFDIEKAKLKGIPPGPVYAD
CCCCCCEEEEECCCCEEEECCHHHCCCHHHEEECCCCCCCCCCCHHHHCCCCCCCCCCHH
LQRGEEVRLEDGRIFSGKEFCGPPRPGVSMVYCTDTVYTESAIEISRKADLLIHESTYSY
HHCCCEEEECCCEEECCCCCCCCCCCCCEEEEEECCEECCHHHHHHCCCEEEEECCCCCC
KETEMAYERGHSTATMAAQIAAKANVDQLILTHLSPRYTPGNQTCPNDLLNEAKAIFPNT
HHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCH
QLAKDFLQIDLNKS
HHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA