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The map label for this gene is murA

Identifier: 124026425

GI number: 124026425

Start: 1404691

End: 1406067

Strand: Direct

Name: murA

Synonym: NATL1_17201

Alternate gene names: 124026425

Gene position: 1404691-1406067 (Clockwise)

Preceding gene: 124026420

Following gene: 124026426

Centisome position: 75.33

GC content: 37.84

Gene sequence:

>1377_bases
ATGAGTAGTGTGGCGACGATTAAAAGGAATATTATTCCGCCACATCTGGAGGTAAAAGGAGGGCGTCCGCTTAGTGGGAT
CTTAAAAGTTAGTGGGGCAAAAAATTCTTCGCTAGCTTTAATGGCTGCGGCGCTTCTTACGAAAGAGAAACTCCTCATTC
AAAATGTCCCAGAACTTACGGACATTGAAGTCATGTCAGAGATTCTCCGTAATTTGGGCGCAAAGTTAACTAAAACAAAT
AATTCTATCGAAATTAATTCAGAGTCCATTCATAATGTTGAATTACCGTATGAATTAGTTCATAGCTTGAGAGCAAGCTT
TTTCTGTGTTGGCCCCTTACTTACAAGACTTGGAGAAGCAAAAATTCCTTTACCTGGTGGTTGCAATATTGGAGCAAGAC
CTGTCGATGAACATATCAATGGTCTAAAAGCTTTAGGAGCGGAAGTTGAAGTTATAAATGATGTTGTAAAAGCTAAAGTT
TCTACCAAAGACAAAAGATTACTTGGAGCGAATATTACTCTTAAATATCCCAGCGTTGGAGCCACGGAAACCATCTTGAT
GGCTTCTTGCTTAGCTTCAGGCAAAACAACAATATCGAATCCAGCCAGAGAGCCAGAGATCCAGGATCTCGCAAAAATGC
TTAATTCAATGGGAGCAAAAGTTTTTGGAGCAGGAACGAAAAGAATCACAATCCTTGGAGTTGAATCTTTAAGCGGGACT
TCTCATTGTGTTATTCCAGACAGGATAGAAGCAGGAACTTTTCTTATTGCTGCAGCAATAACACGATCGCCTCTCATTAT
TGGTCCAGTAATCCCAAATCATTTGAGCGCTGTTATTTCAAAATTAAAAGAATGTGGCTGTTCAATATCTCAACATGGGA
ATCATCATTTAAAAATCATTCCAATAGAGATTTCAGGAGTTGATATAACAACAAGTCCATTCCCTGGCTTCCCAACTGAT
CTTCAGGCTCCATTTATGTCACTAATGGCCACCGCTAAGGGTTCAAGCAAAATCAAAGAAAGAGTTTTTGAGAATAGAAT
GCAACACGTTTTGGAACTAAATAAAATGGGCGCCTGTATTTATCTAGAAAACAATACTGCTTATATAAAAGGAGTAAAAG
AACTTGTAGGTTCAAATGTAGAGGGAGGAGATTTACGTTCTTCTGCTGCCATTATCCTTGCATGTCTCTCTGCCAAAGGA
AATAGTATTTTCACGGGCCTCGAACACTTAGATAGAGGCTATGAAAAATTAGAAGAAAAATTAACGAATGCAGGTTCTAT
TATTTCTAGAAAATTTGATCAAATAACATCTCATAGTTCTTTCTCTAACAAAATAATTAGTGAAGACAATATTGATACTC
AAAAAAATGCAGCTTAG

Upstream 100 bases:

>100_bases
ATTATCAATATTTAATTTGAACCCATCAATTTTCAATAAGGTTGACTGGACTATTTGAAATCCACTTGGCATTATGGCTG
GGTAAGCAGTTCGCTCCAAT

Downstream 100 bases:

>100_bases
TTTCATATATTTGCTAGTTTTGACATAAAATAAACACATGGGAGCGTGGTGGAATTGGTAGACGCACCGCACTCAAAATG
CGGCACCTTCGGGTTTGTCG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase; UDP-N-acetylglucosamine enolpyruvyl transferase; EPT

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSSVATIKRNIIPPHLEVKGGRPLSGILKVSGAKNSSLALMAAALLTKEKLLIQNVPELTDIEVMSEILRNLGAKLTKTN
NSIEINSESIHNVELPYELVHSLRASFFCVGPLLTRLGEAKIPLPGGCNIGARPVDEHINGLKALGAEVEVINDVVKAKV
STKDKRLLGANITLKYPSVGATETILMASCLASGKTTISNPAREPEIQDLAKMLNSMGAKVFGAGTKRITILGVESLSGT
SHCVIPDRIEAGTFLIAAAITRSPLIIGPVIPNHLSAVISKLKECGCSISQHGNHHLKIIPIEISGVDITTSPFPGFPTD
LQAPFMSLMATAKGSSKIKERVFENRMQHVLELNKMGACIYLENNTAYIKGVKELVGSNVEGGDLRSSAAIILACLSAKG
NSIFTGLEHLDRGYEKLEEKLTNAGSIISRKFDQITSHSSFSNKIISEDNIDTQKNAA

Sequences:

>Translated_458_residues
MSSVATIKRNIIPPHLEVKGGRPLSGILKVSGAKNSSLALMAAALLTKEKLLIQNVPELTDIEVMSEILRNLGAKLTKTN
NSIEINSESIHNVELPYELVHSLRASFFCVGPLLTRLGEAKIPLPGGCNIGARPVDEHINGLKALGAEVEVINDVVKAKV
STKDKRLLGANITLKYPSVGATETILMASCLASGKTTISNPAREPEIQDLAKMLNSMGAKVFGAGTKRITILGVESLSGT
SHCVIPDRIEAGTFLIAAAITRSPLIIGPVIPNHLSAVISKLKECGCSISQHGNHHLKIIPIEISGVDITTSPFPGFPTD
LQAPFMSLMATAKGSSKIKERVFENRMQHVLELNKMGACIYLENNTAYIKGVKELVGSNVEGGDLRSSAAIILACLSAKG
NSIFTGLEHLDRGYEKLEEKLTNAGSIISRKFDQITSHSSFSNKIISEDNIDTQKNAA
>Mature_457_residues
SSVATIKRNIIPPHLEVKGGRPLSGILKVSGAKNSSLALMAAALLTKEKLLIQNVPELTDIEVMSEILRNLGAKLTKTNN
SIEINSESIHNVELPYELVHSLRASFFCVGPLLTRLGEAKIPLPGGCNIGARPVDEHINGLKALGAEVEVINDVVKAKVS
TKDKRLLGANITLKYPSVGATETILMASCLASGKTTISNPAREPEIQDLAKMLNSMGAKVFGAGTKRITILGVESLSGTS
HCVIPDRIEAGTFLIAAAITRSPLIIGPVIPNHLSAVISKLKECGCSISQHGNHHLKIIPIEISGVDITTSPFPGFPTDL
QAPFMSLMATAKGSSKIKERVFENRMQHVLELNKMGACIYLENNTAYIKGVKELVGSNVEGGDLRSSAAIILACLSAKGN
SIFTGLEHLDRGYEKLEEKLTNAGSIISRKFDQITSHSSFSNKIISEDNIDTQKNAA

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=420, Percent_Identity=45.4761904761905, Blast_Score=352, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA_PROM1 (A2C466)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015540.1
- ProteinModelPortal:   A2C466
- SMR:   A2C466
- STRING:   A2C466
- GeneID:   4779437
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_17201
- eggNOG:   COG0766
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   PMAR167555:NATL1_17201-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 48950; Mature: 48819

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVATIKRNIIPPHLEVKGGRPLSGILKVSGAKNSSLALMAAALLTKEKLLIQNVPELT
CCCHHHHHHCCCCCCEEECCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
DIEVMSEILRNLGAKLTKTNNSIEINSESIHNVELPYELVHSLRASFFCVGPLLTRLGEA
HHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
KIPLPGGCNIGARPVDEHINGLKALGAEVEVINDVVKAKVSTKDKRLLGANITLKYPSVG
CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECEEEEECCCCC
ATETILMASCLASGKTTISNPAREPEIQDLAKMLNSMGAKVFGAGTKRITILGVESLSGT
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCCC
SHCVIPDRIEAGTFLIAAAITRSPLIIGPVIPNHLSAVISKLKECGCSISQHGNHHLKII
CEEECCCCCCCCCEEEEHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
PIEISGVDITTSPFPGFPTDLQAPFMSLMATAKGSSKIKERVFENRMQHVLELNKMGACI
EEEEECEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEE
YLENNTAYIKGVKELVGSNVEGGDLRSSAAIILACLSAKGNSIFTGLEHLDRGYEKLEEK
EEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LTNAGSIISRKFDQITSHSSFSNKIISEDNIDTQKNAA
HHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSVATIKRNIIPPHLEVKGGRPLSGILKVSGAKNSSLALMAAALLTKEKLLIQNVPELT
CCHHHHHHCCCCCCEEECCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
DIEVMSEILRNLGAKLTKTNNSIEINSESIHNVELPYELVHSLRASFFCVGPLLTRLGEA
HHHHHHHHHHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
KIPLPGGCNIGARPVDEHINGLKALGAEVEVINDVVKAKVSTKDKRLLGANITLKYPSVG
CCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEECEEEEECCCCC
ATETILMASCLASGKTTISNPAREPEIQDLAKMLNSMGAKVFGAGTKRITILGVESLSGT
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCEEEEEEEECCCCC
SHCVIPDRIEAGTFLIAAAITRSPLIIGPVIPNHLSAVISKLKECGCSISQHGNHHLKII
CEEECCCCCCCCCEEEEHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
PIEISGVDITTSPFPGFPTDLQAPFMSLMATAKGSSKIKERVFENRMQHVLELNKMGACI
EEEEECEEEECCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCEEE
YLENNTAYIKGVKELVGSNVEGGDLRSSAAIILACLSAKGNSIFTGLEHLDRGYEKLEEK
EEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LTNAGSIISRKFDQITSHSSFSNKIISEDNIDTQKNAA
HHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA