Click here to switch to the map view.

The map label for this gene is trpC

Identifier: 124026421

GI number: 124026421

Start: 1401246

End: 1402133

Strand: Reverse

Name: trpC

Synonym: NATL1_17161

Alternate gene names: 124026421

Gene position: 1402133-1401246 (Counterclockwise)

Preceding gene: 124026422

Following gene: 124026417

Centisome position: 75.19

GC content: 32.88

Gene sequence:

>888_bases
ATGGAAATCAGAAGAAGACCTCCTAACCCAAGTATAAAAGTAGCTAATTTAGAGTATGCAATTCCTCACCCAGATTCAAA
ACCTAAAAATATTTTGGAGGAAATTGTTTGGGAAAAACATCTAGAAGTTGAGATTGCAAGAAAAAAAGTTTCGCTTGAAG
ATTTAAAGAAAAAGATCAAGGATTTACCAAAAACAAAAAATTTCATAGATGCATTAAGAAATAGTAATTCGAAACCAGCA
CTAATCTCAGAAATAAAAAAGGCTAGTCCAAGTAGAGGGATAATTAGAGAAGACTTTGATGCGAAAATGATAGGTAAAAT
GTATCAAGAGGGGGGTGCTAACTGCATATCGGTCTTAACAGATAAAAAATTTTTTCAAGGTGGTTTTGATGTCTTAGTGG
AAGTTAGAAAGGAAATAATAATCCCAATCCTATGTAAGGACTTCATCCTTTACCCATATCAGCTTTACCAAGCAAGAGCT
GCTGGTGCTGATGCTGCACTTTTGATAGCGGCAATTCTGACTGATTCTGATTTAAAGTACTTATCTAAAGTCGCTGAACA
TTTGGGACTTACAATATTAGTAGAGGTTCATGACTCAGAAGAACTTGAACGAGTACTAAATATTAATGTATTTAATTTAA
TAGGTATTAATAATAGAAATTTAAAGAGTTTTAAAACTGATCTTGAGGTTACAAAGAAATTGGCTAAGAATTATGCTAAC
CAAATCAAGGAAAATTCTATTACTTTGGTAAGCGAGTCAGGTTTATTTAATCGTGAGGATTTGGATTTAGTGAAGAGTTA
TGGGGCTGATGCTGTTTTAGTTGGTGAATCTCTTATGTCACAGGAAGATATATTAGGTGGAGTTAAAAAGTTAGTTGGTA
ACTTATAA

Upstream 100 bases:

>100_bases
ATTAAGCGAAGTTGTAGAGGTTGCTTATAAGCAGGCATCTTTACAAATAAAGAAGTAGTAAATCAAATTTTATCTTTATA
GATCATTAATTATTTAAATT

Downstream 100 bases:

>100_bases
ATTAGGGAAAAATATCTTAGCCAATCTCATAAGCCTAGTTAGAGAAGATTTTGTCTACTTTCCCAATGATTAAATCTAAT
TCAAATAAACCTAATTCACG

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MEIRRRPPNPSIKVANLEYAIPHPDSKPKNILEEIVWEKHLEVEIARKKVSLEDLKKKIKDLPKTKNFIDALRNSNSKPA
LISEIKKASPSRGIIREDFDAKMIGKMYQEGGANCISVLTDKKFFQGGFDVLVEVRKEIIIPILCKDFILYPYQLYQARA
AGADAALLIAAILTDSDLKYLSKVAEHLGLTILVEVHDSEELERVLNINVFNLIGINNRNLKSFKTDLEVTKKLAKNYAN
QIKENSITLVSESGLFNREDLDLVKSYGADAVLVGESLMSQEDILGGVKKLVGNL

Sequences:

>Translated_295_residues
MEIRRRPPNPSIKVANLEYAIPHPDSKPKNILEEIVWEKHLEVEIARKKVSLEDLKKKIKDLPKTKNFIDALRNSNSKPA
LISEIKKASPSRGIIREDFDAKMIGKMYQEGGANCISVLTDKKFFQGGFDVLVEVRKEIIIPILCKDFILYPYQLYQARA
AGADAALLIAAILTDSDLKYLSKVAEHLGLTILVEVHDSEELERVLNINVFNLIGINNRNLKSFKTDLEVTKKLAKNYAN
QIKENSITLVSESGLFNREDLDLVKSYGADAVLVGESLMSQEDILGGVKKLVGNL
>Mature_295_residues
MEIRRRPPNPSIKVANLEYAIPHPDSKPKNILEEIVWEKHLEVEIARKKVSLEDLKKKIKDLPKTKNFIDALRNSNSKPA
LISEIKKASPSRGIIREDFDAKMIGKMYQEGGANCISVLTDKKFFQGGFDVLVEVRKEIIIPILCKDFILYPYQLYQARA
AGADAALLIAAILTDSDLKYLSKVAEHLGLTILVEVHDSEELERVLNINVFNLIGINNRNLKSFKTDLEVTKKLAKNYAN
QIKENSITLVSESGLFNREDLDLVKSYGADAVLVGESLMSQEDILGGVKKLVGNL

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=264, Percent_Identity=37.8787878787879, Blast_Score=175, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6322638, Length=284, Percent_Identity=35.5633802816901, Blast_Score=136, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_PROM1 (A2C462)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015536.1
- ProteinModelPortal:   A2C462
- SMR:   A2C462
- STRING:   A2C462
- GeneID:   4780266
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_17161
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   PMAR167555:NATL1_17161-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 33087; Mature: 33087

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRRRPPNPSIKVANLEYAIPHPDSKPKNILEEIVWEKHLEVEIARKKVSLEDLKKKIK
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DLPKTKNFIDALRNSNSKPALISEIKKASPSRGIIREDFDAKMIGKMYQEGGANCISVLT
HCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHCCCHHHHHHH
DKKFFQGGFDVLVEVRKEIIIPILCKDFILYPYQLYQARAAGADAALLIAAILTDSDLKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
LSKVAEHLGLTILVEVHDSEELERVLNINVFNLIGINNRNLKSFKTDLEVTKKLAKNYAN
HHHHHHHCCEEEEEEECCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
QIKENSITLVSESGLFNREDLDLVKSYGADAVLVGESLMSQEDILGGVKKLVGNL
HHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEIRRRPPNPSIKVANLEYAIPHPDSKPKNILEEIVWEKHLEVEIARKKVSLEDLKKKIK
CCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DLPKTKNFIDALRNSNSKPALISEIKKASPSRGIIREDFDAKMIGKMYQEGGANCISVLT
HCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHCCCHHHHHHH
DKKFFQGGFDVLVEVRKEIIIPILCKDFILYPYQLYQARAAGADAALLIAAILTDSDLKY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHH
LSKVAEHLGLTILVEVHDSEELERVLNINVFNLIGINNRNLKSFKTDLEVTKKLAKNYAN
HHHHHHHCCEEEEEEECCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
QIKENSITLVSESGLFNREDLDLVKSYGADAVLVGESLMSQEDILGGVKKLVGNL
HHHCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA