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The map label for this gene is pheS [H]

Identifier: 124026394

GI number: 124026394

Start: 1376972

End: 1377979

Strand: Reverse

Name: pheS [H]

Synonym: NATL1_16891

Alternate gene names: 124026394

Gene position: 1377979-1376972 (Counterclockwise)

Preceding gene: 124026396

Following gene: 124026393

Centisome position: 73.9

GC content: 38.79

Gene sequence:

>1008_bases
TTGAGTTCAACATTATCCCTAAAACAGCTCATCGGTGAGCTTGAGATTCTAGAAAGCGAGGCGGCAAAAGAAATTGCTTC
TGCTGAAAATTCTGAATCAATAGAGAAATTAAGGTTGAGTTTCCTTGGGAAGAAAGGAAAACTCTCACTTCTATTGGGAG
GGATGAAAAATCTTTCTAATGAAGAAAGACCTTTAATTGGTCAAAGAGCGAACGTTTTAAAAACTCAATTGCAAGAATTA
ATCAAGGAAAAGCTTGAAATTTTAAAAACTCAAGCTTTAAGTCAGATATTAATAAAGGAAACTATAGATGTTACAGCGCC
TCCAACAGGTATTCCTCAAGGACATCGCCACCCCTTAATAACGACTACTGAGCAAATAATTGATCTTTTCTTGGGTCTTG
GATACCAAGTTTCTGAAGGTCCTGAGATAGAGAATGATTACTACAATTTCGAGGCACTGAATATTCCACCTGATCATCCT
GCAAGAGATATGCAAGATACTTTTTATCTGGGAGGTGAATACCTTTTGAGAACTCATACATCGCCTGTTCAGATTCGTTG
CCTTGAAAGCAAAAAGCCACCTGTAAGAATTGTTTCACCCGGTCGGGTTTATCGAAGAGATGCAGTTGATGCAACTCATT
CGCCTGTGTTCCACCAGGTTGAGGTCTTAGCAATTGATGAAAAGCTTGACTTTAGTCATTTAAGAGGAACAGTAATGGCC
TTTTTAAAAGCATTTTTTGGAGATCTTCCTATTCGATTCAGGGCTAGCTATTTCCCATTTACGGAGCCATCAGCAGAAGT
TGATGTCCAATGGAGAGGTAAGTGGTTAGAAGTTATGGGTTGCGGGATGGTCGATCCTGCTGTCTTAGAGGAATTAGGGA
TTGATCCAGAAAAATATAGTGGATTTGCTGCTGGACTAGGGGTTGAAAGATTTTGCATGGTTCGTCATGGCCTAGATGAT
ATTAGAAAGTTATATACAAGTGATCTCAGATTTTTAGAACAATTTTAA

Upstream 100 bases:

>100_bases
TCATTACTAATTAAAATTTTCAATGGTTTCATTTTTTTGCTAATAGTTTTTAGAACTGGGACAGGTTGCCGATTAAACTA
GTACTCGAGATGGCAATTCA

Downstream 100 bases:

>100_bases
AGTTGGATTTTTTGAATTAAATTTTAATTTATTAAATAAATAATATTGACATTTAATTGCTAATATTGTGCAATAGTTTG
TGAAGTATGATCGGTGCCCC

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MSSTLSLKQLIGELEILESEAAKEIASAENSESIEKLRLSFLGKKGKLSLLLGGMKNLSNEERPLIGQRANVLKTQLQEL
IKEKLEILKTQALSQILIKETIDVTAPPTGIPQGHRHPLITTTEQIIDLFLGLGYQVSEGPEIENDYYNFEALNIPPDHP
ARDMQDTFYLGGEYLLRTHTSPVQIRCLESKKPPVRIVSPGRVYRRDAVDATHSPVFHQVEVLAIDEKLDFSHLRGTVMA
FLKAFFGDLPIRFRASYFPFTEPSAEVDVQWRGKWLEVMGCGMVDPAVLEELGIDPEKYSGFAAGLGVERFCMVRHGLDD
IRKLYTSDLRFLEQF

Sequences:

>Translated_335_residues
MSSTLSLKQLIGELEILESEAAKEIASAENSESIEKLRLSFLGKKGKLSLLLGGMKNLSNEERPLIGQRANVLKTQLQEL
IKEKLEILKTQALSQILIKETIDVTAPPTGIPQGHRHPLITTTEQIIDLFLGLGYQVSEGPEIENDYYNFEALNIPPDHP
ARDMQDTFYLGGEYLLRTHTSPVQIRCLESKKPPVRIVSPGRVYRRDAVDATHSPVFHQVEVLAIDEKLDFSHLRGTVMA
FLKAFFGDLPIRFRASYFPFTEPSAEVDVQWRGKWLEVMGCGMVDPAVLEELGIDPEKYSGFAAGLGVERFCMVRHGLDD
IRKLYTSDLRFLEQF
>Mature_334_residues
SSTLSLKQLIGELEILESEAAKEIASAENSESIEKLRLSFLGKKGKLSLLLGGMKNLSNEERPLIGQRANVLKTQLQELI
KEKLEILKTQALSQILIKETIDVTAPPTGIPQGHRHPLITTTEQIIDLFLGLGYQVSEGPEIENDYYNFEALNIPPDHPA
RDMQDTFYLGGEYLLRTHTSPVQIRCLESKKPPVRIVSPGRVYRRDAVDATHSPVFHQVEVLAIDEKLDFSHLRGTVMAF
LKAFFGDLPIRFRASYFPFTEPSAEVDVQWRGKWLEVMGCGMVDPAVLEELGIDPEKYSGFAAGLGVERFCMVRHGLDDI
RKLYTSDLRFLEQF

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI4758340, Length=263, Percent_Identity=36.5019011406844, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI5729820, Length=225, Percent_Identity=34.2222222222222, Blast_Score=135, Evalue=8e-32,
Organism=Escherichia coli, GI1788007, Length=327, Percent_Identity=49.8470948012232, Blast_Score=328, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI32566635, Length=264, Percent_Identity=34.8484848484849, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32563657, Length=262, Percent_Identity=30.9160305343511, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508957, Length=262, Percent_Identity=30.9160305343511, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321087, Length=383, Percent_Identity=28.7206266318538, Blast_Score=135, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6325304, Length=88, Percent_Identity=43.1818181818182, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18858079, Length=281, Percent_Identity=32.0284697508897, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI17137424, Length=278, Percent_Identity=28.7769784172662, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d [H]

EC number: =6.1.1.20 [H]

Molecular weight: Translated: 37744; Mature: 37613

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTLSLKQLIGELEILESEAAKEIASAENSESIEKLRLSFLGKKGKLSLLLGGMKNLSN
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCC
EERPLIGQRANVLKTQLQELIKEKLEILKTQALSQILIKETIDVTAPPTGIPQGHRHPLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
TTTEQIIDLFLGLGYQVSEGPEIENDYYNFEALNIPPDHPARDMQDTFYLGGEYLLRTHT
ECHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHEEECCCEEEEECC
SPVQIRCLESKKPPVRIVSPGRVYRRDAVDATHSPVFHQVEVLAIDEKLDFSHLRGTVMA
CCEEEEEECCCCCCEEEECCCHHHHHHCCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHH
FLKAFFGDLPIRFRASYFPFTEPSAEVDVQWRGKWLEVMGCGMVDPAVLEELGIDPEKYS
HHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHHHCCCHHHHC
GFAAGLGVERFCMVRHGLDDIRKLYTSDLRFLEQF
CHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSTLSLKQLIGELEILESEAAKEIASAENSESIEKLRLSFLGKKGKLSLLLGGMKNLSN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHCCC
EERPLIGQRANVLKTQLQELIKEKLEILKTQALSQILIKETIDVTAPPTGIPQGHRHPLI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
TTTEQIIDLFLGLGYQVSEGPEIENDYYNFEALNIPPDHPARDMQDTFYLGGEYLLRTHT
ECHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHEEECCCEEEEECC
SPVQIRCLESKKPPVRIVSPGRVYRRDAVDATHSPVFHQVEVLAIDEKLDFSHLRGTVMA
CCEEEEEECCCCCCEEEECCCHHHHHHCCCCCCCCHHHEEEEEEECCCCCHHHHHHHHHH
FLKAFFGDLPIRFRASYFPFTEPSAEVDVQWRGKWLEVMGCGMVDPAVLEELGIDPEKYS
HHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCEEEECCCCCCCHHHHHHHCCCHHHHC
GFAAGLGVERFCMVRHGLDDIRKLYTSDLRFLEQF
CHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA