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The map label for this gene is cobQ [H]

Identifier: 124026318

GI number: 124026318

Start: 1317516

End: 1319000

Strand: Direct

Name: cobQ [H]

Synonym: NATL1_16121

Alternate gene names: 124026318

Gene position: 1317516-1319000 (Clockwise)

Preceding gene: 124026316

Following gene: 124026319

Centisome position: 70.65

GC content: 33.87

Gene sequence:

>1485_bases
ATGGTTTTAGGAACCTCAAGTGGCGCAGGTAAAACACTCATAGCTACTGCTATTTGTCGATGCTTAAGAAGGAAAGGGGA
ACAGCCAATACCTTTTAAGGGCCAAAACATGAGCAATAACGCTTGGGTTGATACCCAGGGAAGAGAAATGGCATATTCTC
AAGCCCTTCAATCTTGGTCTGCAGGCTTAGAGCCAAGTGCTGAAATGAATCCTGTACTTCTAAAGCCAAAAGGGGATTGC
ACAAGTGAAGTAATTCATCTAGGCAAAAGTGTCGGCACTAGCAAAGCGATCAATTATTACGAAGACTGGTTTGATTCAGG
GTGGGAAGCTATTAAAAAAGGCCTAGCAATATTATTAAAGAGTAAAATCGACGGAAGACTGATTCTTGAAGGGGCCGGAA
GCCCAGTAGAAGTGAATTTGCAACATAAAGATCTTACAAATTTGAAATTAGCAAAATTTCTAAATGCAAATTGTATTTTA
GTAGCAGATATTGAAAGGGGAGGAGTTTTTGCTCAAATCATTGGAACAATTGCATTGATGAAACCTGATGAAAAAAAATT
AATTAAAGGAATAATTATTAATAGATTCAGAGGCGATAAAGCCTTATTCGAATCAGGAGTCACATGGATAGAAAAAGAAA
CAGGAATCCCAGTTTTAGGAATATTACCGTGGCTAAAAGAGATTTTTCCACCTGAAGATTCCCTTGACTTACTTGAAAGG
AAACAAGTAAATAAAAGTGCAGAAATAGAAATAGCAATAATAAAATTACCTAGGATTAGCAATTTTTCTGATTTAGATCC
TTTCTTTAGCGATTCAAGTATTCAAATGCGATGGATAGAACCCGGACAAGACCTAGGTAATCCAGATGTATTAATAATTC
CTGGAAGCAAACAAACAATTAAAGATTTAGAAAGTCTAAATAAAACTGGTTTGAGCAATCAAATAAAAAATTATGCAAAA
AAAGGGGGAAATATTTTTGGCATATGTGGAGGGTTACAAATGCTAGGAAAAACATTGGAAGACCCTCACAAGCAAGAAAG
TATCAAGGAGCAAAATACATTTTCAAATATGGGGATGAATCTTCTTCCAATCAAAACAACTTTTGGAGAAATCAAGCACA
CCTCACAAAGAGAAGAAAAAGTTTCATGGCCAGTTTCTCAGAGTCTAAAGGGGTTTGAAATGCATTATGGGGAAAGTGAT
TTGATCAATAATACAGATTCCGAAATTATTTCTCTATTTAAAAACAGTTCTTTAGGGTGGGTAATAGAAAAAAAAGATAA
AAGCTTTGTTGGGGGAACTTATTTACATGGAATTTTTGAAAATGATGAATGGCGAAGGCAATGGATCAATAAAATAAGAC
AGAAAAAGGGATTAAATCATTTAAAAATTGATAAAGAAAACAATAATGATAAAAGAGAAAGATTATTAGATTTATTAACT
GATGCCTTCGAAAAAAATATAAATATAGATATTTTAATCAAATAA

Upstream 100 bases:

>100_bases
ATTTATTTACTAAAAGAATATCGCTTATAAAAAAATTAATTACATGCCTAAAGTATCAATTATCACCAAGATGAGCATAG
ATCTCAAAAGGACTCCACTA

Downstream 100 bases:

>100_bases
CTTAAATAATGAATACTGTAAAAATAAACTGGCCTAATAAGAAACCAAGCAATTGCTCTCCTGGAATTGATTGGTTAAAA
GCTGCTTATGATGCTGATAT

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MVLGTSSGAGKTLIATAICRCLRRKGEQPIPFKGQNMSNNAWVDTQGREMAYSQALQSWSAGLEPSAEMNPVLLKPKGDC
TSEVIHLGKSVGTSKAINYYEDWFDSGWEAIKKGLAILLKSKIDGRLILEGAGSPVEVNLQHKDLTNLKLAKFLNANCIL
VADIERGGVFAQIIGTIALMKPDEKKLIKGIIINRFRGDKALFESGVTWIEKETGIPVLGILPWLKEIFPPEDSLDLLER
KQVNKSAEIEIAIIKLPRISNFSDLDPFFSDSSIQMRWIEPGQDLGNPDVLIIPGSKQTIKDLESLNKTGLSNQIKNYAK
KGGNIFGICGGLQMLGKTLEDPHKQESIKEQNTFSNMGMNLLPIKTTFGEIKHTSQREEKVSWPVSQSLKGFEMHYGESD
LINNTDSEIISLFKNSSLGWVIEKKDKSFVGGTYLHGIFENDEWRRQWINKIRQKKGLNHLKIDKENNNDKRERLLDLLT
DAFEKNINIDILIK

Sequences:

>Translated_494_residues
MVLGTSSGAGKTLIATAICRCLRRKGEQPIPFKGQNMSNNAWVDTQGREMAYSQALQSWSAGLEPSAEMNPVLLKPKGDC
TSEVIHLGKSVGTSKAINYYEDWFDSGWEAIKKGLAILLKSKIDGRLILEGAGSPVEVNLQHKDLTNLKLAKFLNANCIL
VADIERGGVFAQIIGTIALMKPDEKKLIKGIIINRFRGDKALFESGVTWIEKETGIPVLGILPWLKEIFPPEDSLDLLER
KQVNKSAEIEIAIIKLPRISNFSDLDPFFSDSSIQMRWIEPGQDLGNPDVLIIPGSKQTIKDLESLNKTGLSNQIKNYAK
KGGNIFGICGGLQMLGKTLEDPHKQESIKEQNTFSNMGMNLLPIKTTFGEIKHTSQREEKVSWPVSQSLKGFEMHYGESD
LINNTDSEIISLFKNSSLGWVIEKKDKSFVGGTYLHGIFENDEWRRQWINKIRQKKGLNHLKIDKENNNDKRERLLDLLT
DAFEKNINIDILIK
>Mature_494_residues
MVLGTSSGAGKTLIATAICRCLRRKGEQPIPFKGQNMSNNAWVDTQGREMAYSQALQSWSAGLEPSAEMNPVLLKPKGDC
TSEVIHLGKSVGTSKAINYYEDWFDSGWEAIKKGLAILLKSKIDGRLILEGAGSPVEVNLQHKDLTNLKLAKFLNANCIL
VADIERGGVFAQIIGTIALMKPDEKKLIKGIIINRFRGDKALFESGVTWIEKETGIPVLGILPWLKEIFPPEDSLDLLER
KQVNKSAEIEIAIIKLPRISNFSDLDPFFSDSSIQMRWIEPGQDLGNPDVLIIPGSKQTIKDLESLNKTGLSNQIKNYAK
KGGNIFGICGGLQMLGKTLEDPHKQESIKEQNTFSNMGMNLLPIKTTFGEIKHTSQREEKVSWPVSQSLKGFEMHYGESD
LINNTDSEIISLFKNSSLGWVIEKKDKSFVGGTYLHGIFENDEWRRQWINKIRQKKGLNHLKIDKENNNDKRERLLDLLT
DAFEKNINIDILIK

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 55335; Mature: 55335

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLGTSSGAGKTLIATAICRCLRRKGEQPIPFKGQNMSNNAWVDTQGREMAYSQALQSWS
CEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHH
AGLEPSAEMNPVLLKPKGDCTSEVIHLGKSVGTSKAINYYEDWFDSGWEAIKKGLAILLK
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKIDGRLILEGAGSPVEVNLQHKDLTNLKLAKFLNANCILVADIERGGVFAQIIGTIALM
CCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHC
KPDEKKLIKGIIINRFRGDKALFESGVTWIEKETGIPVLGILPWLKEIFPPEDSLDLLER
CCCHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHH
KQVNKSAEIEIAIIKLPRISNFSDLDPFFSDSSIQMRWIEPGQDLGNPDVLIIPGSKQTI
HHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCHHHH
KDLESLNKTGLSNQIKNYAKKGGNIFGICGGLQMLGKTLEDPHKQESIKEQNTFSNMGMN
HHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCE
LLPIKTTFGEIKHTSQREEKVSWPVSQSLKGFEMHYGESDLINNTDSEIISLFKNSSLGW
EEEEEHHHHHHHCCHHHHHHCCCCHHHCCCCCEEECCCCHHCCCCHHHHHHHHHCCCCCE
VIEKKDKSFVGGTYLHGIFENDEWRRQWINKIRQKKGLNHLKIDKENNNDKRERLLDLLT
EEEECCCCCCCCHHEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHH
DAFEKNINIDILIK
HHHHCCCCEEEEEC
>Mature Secondary Structure
MVLGTSSGAGKTLIATAICRCLRRKGEQPIPFKGQNMSNNAWVDTQGREMAYSQALQSWS
CEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHH
AGLEPSAEMNPVLLKPKGDCTSEVIHLGKSVGTSKAINYYEDWFDSGWEAIKKGLAILLK
CCCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKIDGRLILEGAGSPVEVNLQHKDLTNLKLAKFLNANCILVADIERGGVFAQIIGTIALM
CCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHC
KPDEKKLIKGIIINRFRGDKALFESGVTWIEKETGIPVLGILPWLKEIFPPEDSLDLLER
CCCHHHHHHHHHHHHCCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHH
KQVNKSAEIEIAIIKLPRISNFSDLDPFFSDSSIQMRWIEPGQDLGNPDVLIIPGSKQTI
HHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEECCCHHHH
KDLESLNKTGLSNQIKNYAKKGGNIFGICGGLQMLGKTLEDPHKQESIKEQNTFSNMGMN
HHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCE
LLPIKTTFGEIKHTSQREEKVSWPVSQSLKGFEMHYGESDLINNTDSEIISLFKNSSLGW
EEEEEHHHHHHHCCHHHHHHCCCCHHHCCCCCEEECCCCHHCCCCHHHHHHHHHCCCCCE
VIEKKDKSFVGGTYLHGIFENDEWRRQWINKIRQKKGLNHLKIDKENNNDKRERLLDLLT
EEEECCCCCCCCHHEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHH
DAFEKNINIDILIK
HHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA