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The map label for this gene is pntA [H]

Identifier: 124026301

GI number: 124026301

Start: 1305240

End: 1306385

Strand: Reverse

Name: pntA [H]

Synonym: NATL1_15951

Alternate gene names: 124026301

Gene position: 1306385-1305240 (Counterclockwise)

Preceding gene: 124026305

Following gene: 124026300

Centisome position: 70.06

GC content: 38.92

Gene sequence:

>1146_bases
TTGGTCAGTTTCTTAATTCCCTTTGAATCAGCTTTAGGAGAAACACGTGTTTCAGCTACTCCAGAGACCGTTAAAAAGTT
TTTGGACTTGGGATGTAAAGTGTTTTTCGAAAAAGGTGCTGGAAAGGCTGCAGGCTTTTTAGATGATACTTACATGGACG
CTGGGGCTGAATTAGTTGAAAGAGAGAACGATGAAGTAAAAAAAATTGTTGACATTGTTCTATGTGTCCAACCTCCTAAC
GAAAAATTTCTTTCGCATTTAAAACCAGGATCTTTTCTTGTTGGCCTTTTGAACCCTTACGGAAATAAGTTATTAGCTGA
AACATTAAAATCTAAAAATATTTCTGCAATAGCATTGGAGTTACTCCCTCGAATTAGCAGAGCTCAATCATCTGATGCAT
TGTCTTCCCAGGCAAATATTGCTGGTTATAAATCTGTACTTTTAGCGGCAAGCGCTCTTGATCGATATTTTCCAATGTTG
ATGACTGCTGCTGGTACTATTCAGCCTTCGAAAATTGTTGTTTTAGGTGCTGGGGTCGCAGGGCTTCAAGCTATTGCAAC
AGCCAAAAGACTAGGCGCTGTTGTTTATGTGAGTGATATTCGTGAGGCTGTAAAGGAGCAAGTTGAATCACTAGGTGCAA
GATTTATTGAACTTCCAAAGATTGACGAAACCCCATCAGAGTCAGGTGGATATGCAAAACAAGTCTCTGATGACTTTATA
GTTGCTCAAAGAAAAGAATTGGCAAAACAATTATCTGAAGCTGATGTAGCAATTTGCACTGCTCAGGTGCCGGGGAAAAA
AGCCCCCAAACTCATTGATGAAAAAATGTTGGATGACATGCGTCCTGGTTCTGTAGTAATTGATCTTGCTGTGCTAAGTG
GTGGAAATTGTGCATGCTCAAAACCAGGAGAAACTATTGTTAGAGAAGGGGTGAAGATTATTGGTGCTTCTAATCTCCCC
TGTTCAATTCCAAATCATGCTAGTTCTCTTTATTCGAGGAATTTATTGTCTCTTCTCCAACCAATGTTTAAAGAAGGTAA
GTTTTTGATTGATAACGATGATGAGCTTATTGCTGGTTCTTTGATTAGTAAGGATGGGGTAATACTTAAATCTGAAATTA
TTGAGAATGGAGGAACAAGGTCATGA

Upstream 100 bases:

>100_bases
CTATTAAGAAAACCTTTCTTAACTAAAAATGCTGGTATTCAAACGTTTACTCCTCTAATCGTTTACTCCCCTAATCTTTA
AGAGGATAAATTTTTTTACT

Downstream 100 bases:

>100_bases
GTTTTTTTAGTGAAGCTCTTTGGGTGCTGCTACTCGGAAGCTTATTGGGTTTGGAGCTAATAGGTAAGGTCCCTCCAACT
TTGCATACTCCATTAATGAG

Product: putative nicotinamide nucleotide transhydrogenase, subunit alpha 1 (A1)

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MVSFLIPFESALGETRVSATPETVKKFLDLGCKVFFEKGAGKAAGFLDDTYMDAGAELVERENDEVKKIVDIVLCVQPPN
EKFLSHLKPGSFLVGLLNPYGNKLLAETLKSKNISAIALELLPRISRAQSSDALSSQANIAGYKSVLLAASALDRYFPML
MTAAGTIQPSKIVVLGAGVAGLQAIATAKRLGAVVYVSDIREAVKEQVESLGARFIELPKIDETPSESGGYAKQVSDDFI
VAQRKELAKQLSEADVAICTAQVPGKKAPKLIDEKMLDDMRPGSVVIDLAVLSGGNCACSKPGETIVREGVKIIGASNLP
CSIPNHASSLYSRNLLSLLQPMFKEGKFLIDNDDELIAGSLISKDGVILKSEIIENGGTRS

Sequences:

>Translated_381_residues
MVSFLIPFESALGETRVSATPETVKKFLDLGCKVFFEKGAGKAAGFLDDTYMDAGAELVERENDEVKKIVDIVLCVQPPN
EKFLSHLKPGSFLVGLLNPYGNKLLAETLKSKNISAIALELLPRISRAQSSDALSSQANIAGYKSVLLAASALDRYFPML
MTAAGTIQPSKIVVLGAGVAGLQAIATAKRLGAVVYVSDIREAVKEQVESLGARFIELPKIDETPSESGGYAKQVSDDFI
VAQRKELAKQLSEADVAICTAQVPGKKAPKLIDEKMLDDMRPGSVVIDLAVLSGGNCACSKPGETIVREGVKIIGASNLP
CSIPNHASSLYSRNLLSLLQPMFKEGKFLIDNDDELIAGSLISKDGVILKSEIIENGGTRS
>Mature_381_residues
MVSFLIPFESALGETRVSATPETVKKFLDLGCKVFFEKGAGKAAGFLDDTYMDAGAELVERENDEVKKIVDIVLCVQPPN
EKFLSHLKPGSFLVGLLNPYGNKLLAETLKSKNISAIALELLPRISRAQSSDALSSQANIAGYKSVLLAASALDRYFPML
MTAAGTIQPSKIVVLGAGVAGLQAIATAKRLGAVVYVSDIREAVKEQVESLGARFIELPKIDETPSESGGYAKQVSDDFI
VAQRKELAKQLSEADVAICTAQVPGKKAPKLIDEKMLDDMRPGSVVIDLAVLSGGNCACSKPGETIVREGVKIIGASNLP
CSIPNHASSLYSRNLLSLLQPMFKEGKFLIDNDDELIAGSLISKDGVILKSEIIENGGTRS

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=381, Percent_Identity=38.8451443569554, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI122939153, Length=381, Percent_Identity=38.8451443569554, Blast_Score=245, Evalue=5e-65,
Organism=Escherichia coli, GI1787887, Length=366, Percent_Identity=45.9016393442623, Blast_Score=301, Evalue=6e-83,
Organism=Caenorhabditis elegans, GI17550456, Length=361, Percent_Identity=44.3213296398892, Blast_Score=296, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40628; Mature: 40628

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSFLIPFESALGETRVSATPETVKKFLDLGCKVFFEKGAGKAAGFLDDTYMDAGAELVE
CCEEEECHHHHCCCCCCCCCHHHHHHHHHCCHHEEHCCCCCCCCCCCHHHHHHHHHHHHH
RENDEVKKIVDIVLCVQPPNEKFLSHLKPGSFLVGLLNPYGNKLLAETLKSKNISAIALE
CCCHHHHHHHHHHEECCCCCHHHHHHCCCCHHEEEHHCCCCHHHHHHHHHCCCHHHHHHH
LLPRISRAQSSDALSSQANIAGYKSVLLAASALDRYFPMLMTAAGTIQPSKIVVLGAGVA
HHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHH
GLQAIATAKRLGAVVYVSDIREAVKEQVESLGARFIELPKIDETPSESGGYAKQVSDDFI
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHCCCHHH
VAQRKELAKQLSEADVAICTAQVPGKKAPKLIDEKMLDDMRPGSVVIDLAVLSGGNCACS
HHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
KPGETIVREGVKIIGASNLPCSIPNHASSLYSRNLLSLLQPMFKEGKFLIDNDDELIAGS
CCCHHHHHCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEHH
LISKDGVILKSEIIENGGTRS
HHCCCCCEEHHHHHCCCCCCC
>Mature Secondary Structure
MVSFLIPFESALGETRVSATPETVKKFLDLGCKVFFEKGAGKAAGFLDDTYMDAGAELVE
CCEEEECHHHHCCCCCCCCCHHHHHHHHHCCHHEEHCCCCCCCCCCCHHHHHHHHHHHHH
RENDEVKKIVDIVLCVQPPNEKFLSHLKPGSFLVGLLNPYGNKLLAETLKSKNISAIALE
CCCHHHHHHHHHHEECCCCCHHHHHHCCCCHHEEEHHCCCCHHHHHHHHHCCCHHHHHHH
LLPRISRAQSSDALSSQANIAGYKSVLLAASALDRYFPMLMTAAGTIQPSKIVVLGAGVA
HHHHHHHHCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHH
GLQAIATAKRLGAVVYVSDIREAVKEQVESLGARFIELPKIDETPSESGGYAKQVSDDFI
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHCCCHHH
VAQRKELAKQLSEADVAICTAQVPGKKAPKLIDEKMLDDMRPGSVVIDLAVLSGGNCACS
HHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCC
KPGETIVREGVKIIGASNLPCSIPNHASSLYSRNLLSLLQPMFKEGKFLIDNDDELIAGS
CCCHHHHHCCHHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEHH
LISKDGVILKSEIIENGGTRS
HHCCCCCEEHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]