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The map label for this gene is thrA [H]

Identifier: 124026242

GI number: 124026242

Start: 1249605

End: 1250927

Strand: Direct

Name: thrA [H]

Synonym: NATL1_15361

Alternate gene names: 124026242

Gene position: 1249605-1250927 (Clockwise)

Preceding gene: 124026241

Following gene: 124026243

Centisome position: 67.01

GC content: 38.7

Gene sequence:

>1323_bases
ATGAACATGAAAAAAGTTGGTATCGGTTTACTTGGACTAGGAACTGTTGGCCAGGGTGTCGCAAATATAATAAGCCAACC
AAAAGATAGGCATCCTTTGGTTGGAGAACTTGAACTTTTAAGTGTCGCGGTAAGAAATCTCAAAAAGAAAAGAGATATAT
CCATCCCAGATTCAATACTTACAACAAACCCAACTGAAATAATAAATAATCCCAATATTCAAATAGTTGTTGAAGTAATG
GGCGGTATAGAACCAGCCAAATCATTAATTATCCAAGCGATAAGAGCAGGTAAATCTGTTGTTACTGCTAATAAAGCAGT
AATTGCAAGACATGGTGAAGAAATCTCAAATGAAGCAAAAGCCGCTGGGGTTTATGTCCTCATTGAAGCAGCAGTTGGAG
GGGGAATCCCAATAATTGAGCCTTTAAAACAATCTTTAGGAGGGAATCAGATAACAAAAGTAAGCGGAATAATAAATGGA
ACAACTAATTACATACTCTCCAGAATGGATAAAGAAGGAGTTAATTATGCTGAAGTTTTAAAAGATGCCCAAGTCCTTGG
ATATGCAGAAAGTGATCCTGCCGCTGATGTAGAGGGATCAGACGCAGCTGACAAAATTGCAATTCTTAGTGGCCTTGCTT
TTGGTGGAGCAATTAATAGAGCTCACATACCGACAACTGGAATAAACCTACTAGAGGCTATAGATGTTAATTACGCTAGG
AAGCTAGGGTATGGAATCAAGCTTTTAGCAATATCTGAGAAAGGAGCAACTCAACCAAGCAAAGAAGACAGTCAACCACT
CTCCATTTGGGTTGAGCCAACATTAGTACCTGAAGACAATCCATTAGCGGGAGTAAATGGAGTTAACAATGCAATCCTTG
TAGAAGGAAATCCCATTGGCCAAGTAATGTTTTTGGGTCCAGGTGCAGGTTCCGGCCCAACTGCATCAGCTGTTGTTGCA
GACATACTTAACATTGCAGGTATTCAGTCTATGAGTGAAGACAAAATCTTTAACTTAGATCCTCTTCTATCAGCGAAAGG
TTGGAGAAGTTGTCACGTAGCAGAAAAGGAACAAATAACTAAAAAGAATTACATACGGCTTATTGCAGAAGATAGCCCAG
GGGTAATTGGAGAAATCGGGACTATCTTTGGAAAGAAGAAAATATCTATTGAATCAATTGTGCAATTTGATGCAAAGGAT
AAAAAAGCAGAGATAGTAGTTATTACCCACAAAATCAATCAAGGTCAACTTGAAGAGGCTCTTTTAGATATCAAAAACTT
GCCACAAGTCAAAAGAATTGCAGCAAAGATGGGTTGCCTTTAG

Upstream 100 bases:

>100_bases
TTCTCAACATATTCCTAAAGATGAAAGCTCAAGCCAAAAACCTATCAATACCTAGCTCTGACAATGAATAAATAAGATTC
AAACAAAATTATCGCTCTAT

Downstream 100 bases:

>100_bases
CTAACGAAAGCTAGTCAAATCGAAATTAAGTTGCTAATTATATAAATAGAACAAAGGAAATTTTATCTTAAATTTCTTTT
CGGAACTAAACCATGAAAAC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MNMKKVGIGLLGLGTVGQGVANIISQPKDRHPLVGELELLSVAVRNLKKKRDISIPDSILTTNPTEIINNPNIQIVVEVM
GGIEPAKSLIIQAIRAGKSVVTANKAVIARHGEEISNEAKAAGVYVLIEAAVGGGIPIIEPLKQSLGGNQITKVSGIING
TTNYILSRMDKEGVNYAEVLKDAQVLGYAESDPAADVEGSDAADKIAILSGLAFGGAINRAHIPTTGINLLEAIDVNYAR
KLGYGIKLLAISEKGATQPSKEDSQPLSIWVEPTLVPEDNPLAGVNGVNNAILVEGNPIGQVMFLGPGAGSGPTASAVVA
DILNIAGIQSMSEDKIFNLDPLLSAKGWRSCHVAEKEQITKKNYIRLIAEDSPGVIGEIGTIFGKKKISIESIVQFDAKD
KKAEIVVITHKINQGQLEEALLDIKNLPQVKRIAAKMGCL

Sequences:

>Translated_440_residues
MNMKKVGIGLLGLGTVGQGVANIISQPKDRHPLVGELELLSVAVRNLKKKRDISIPDSILTTNPTEIINNPNIQIVVEVM
GGIEPAKSLIIQAIRAGKSVVTANKAVIARHGEEISNEAKAAGVYVLIEAAVGGGIPIIEPLKQSLGGNQITKVSGIING
TTNYILSRMDKEGVNYAEVLKDAQVLGYAESDPAADVEGSDAADKIAILSGLAFGGAINRAHIPTTGINLLEAIDVNYAR
KLGYGIKLLAISEKGATQPSKEDSQPLSIWVEPTLVPEDNPLAGVNGVNNAILVEGNPIGQVMFLGPGAGSGPTASAVVA
DILNIAGIQSMSEDKIFNLDPLLSAKGWRSCHVAEKEQITKKNYIRLIAEDSPGVIGEIGTIFGKKKISIESIVQFDAKD
KKAEIVVITHKINQGQLEEALLDIKNLPQVKRIAAKMGCL
>Mature_440_residues
MNMKKVGIGLLGLGTVGQGVANIISQPKDRHPLVGELELLSVAVRNLKKKRDISIPDSILTTNPTEIINNPNIQIVVEVM
GGIEPAKSLIIQAIRAGKSVVTANKAVIARHGEEISNEAKAAGVYVLIEAAVGGGIPIIEPLKQSLGGNQITKVSGIING
TTNYILSRMDKEGVNYAEVLKDAQVLGYAESDPAADVEGSDAADKIAILSGLAFGGAINRAHIPTTGINLLEAIDVNYAR
KLGYGIKLLAISEKGATQPSKEDSQPLSIWVEPTLVPEDNPLAGVNGVNNAILVEGNPIGQVMFLGPGAGSGPTASAVVA
DILNIAGIQSMSEDKIFNLDPLLSAKGWRSCHVAEKEQITKKNYIRLIAEDSPGVIGEIGTIFGKKKISIESIVQFDAKD
KKAEIVVITHKINQGQLEEALLDIKNLPQVKRIAAKMGCL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=121, Percent_Identity=34.7107438016529, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=129, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46415; Mature: 46415

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00175 PG_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMKKVGIGLLGLGTVGQGVANIISQPKDRHPLVGELELLSVAVRNLKKKRDISIPDSIL
CCCCHHCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
TTNPTEIINNPNIQIVVEVMGGIEPAKSLIIQAIRAGKSVVTANKAVIARHGEEISNEAK
CCCCHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHHEECCCHHHHHHHH
AAGVYVLIEAAVGGGIPIIEPLKQSLGGNQITKVSGIINGTTNYILSRMDKEGVNYAEVL
HCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEHEEECCHHHHHHHHHHHCCCCHHHHH
KDAQVLGYAESDPAADVEGSDAADKIAILSGLAFGGAINRAHIPTTGINLLEAIDVNYAR
HHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHH
KLGYGIKLLAISEKGATQPSKEDSQPLSIWVEPTLVPEDNPLAGVNGVNNAILVEGNPIG
HCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCC
QVMFLGPGAGSGPTASAVVADILNIAGIQSMSEDKIFNLDPLLSAKGWRSCHVAEKEQIT
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KKNYIRLIAEDSPGVIGEIGTIFGKKKISIESIVQFDAKDKKAEIVVITHKINQGQLEEA
HCCEEEEEECCCCCCEEHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEEECCCCHHHHH
LLDIKNLPQVKRIAAKMGCL
HHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNMKKVGIGLLGLGTVGQGVANIISQPKDRHPLVGELELLSVAVRNLKKKRDISIPDSIL
CCCCHHCEEEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHH
TTNPTEIINNPNIQIVVEVMGGIEPAKSLIIQAIRAGKSVVTANKAVIARHGEEISNEAK
CCCCHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEECCHHHEECCCHHHHHHHH
AAGVYVLIEAAVGGGIPIIEPLKQSLGGNQITKVSGIINGTTNYILSRMDKEGVNYAEVL
HCCEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEHEEECCHHHHHHHHHHHCCCCHHHHH
KDAQVLGYAESDPAADVEGSDAADKIAILSGLAFGGAINRAHIPTTGINLLEAIDVNYAR
HHHHHEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHH
KLGYGIKLLAISEKGATQPSKEDSQPLSIWVEPTLVPEDNPLAGVNGVNNAILVEGNPIG
HCCCCEEEEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCC
QVMFLGPGAGSGPTASAVVADILNIAGIQSMSEDKIFNLDPLLSAKGWRSCHVAEKEQIT
EEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
KKNYIRLIAEDSPGVIGEIGTIFGKKKISIESIVQFDAKDKKAEIVVITHKINQGQLEEA
HCCEEEEEECCCCCCEEHHHHHHCCCCCCHHHHHHHCCCCCCEEEEEEEEECCCCHHHHH
LLDIKNLPQVKRIAAKMGCL
HHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]