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The map label for this gene is lysA [H]

Identifier: 124026196

GI number: 124026196

Start: 1200167

End: 1201531

Strand: Reverse

Name: lysA [H]

Synonym: NATL1_14901

Alternate gene names: 124026196

Gene position: 1201531-1200167 (Counterclockwise)

Preceding gene: 124026202

Following gene: 124026195

Centisome position: 64.43

GC content: 36.19

Gene sequence:

>1365_bases
ATGCACGGATCAAAGGCTTATGAACCTAATGTGGATATTGATAGTCCAAATCGAAATATAGCTCCGATCACTTCAGAAAT
TAATGAGAGTAAAAAATTAGTTGTTGGAGGATGTCAACTCAGTGAACTAGCGAAAAAATATGGCACACCTCTTTATGTTT
TAGATGAGTTTTCACTTAGGACTGCATGCAAAACTTATATTTCTTCTTTAAATAAACATTACCCAGGGAAGTCACTTCCT
CTATTTGCTTCAAAAGCAAATAGCTCCCTAGCTATTTGTGCAGTTATTGCTTCTGAAGGTTTTGGGCTTGATGCAGTATC
AGAGGGTGAATTACTTACTGCAATAAATGGAGGTGTAAAAGAGAAAGATATTGTTTTTCATGGAAATAACAAATCTCAGG
ATGAATTGAATTTTGCCTACAGTAATAATGTGACGATTGTTTTAGATAATTATCATGATATTGAGTTACTAAAAAATATT
GCCTCCGATAACAAGCCAGCAAAGTTAATGTTGAGGTTTACTCCTGGAATTGAATGTCATACTCATGAATATATAAGGAC
TGGGCATTTAGATAGTAAATTTGGTTTTGATCCTGATGATCTTAAGTCAATTTTAGAAGAATTAAAAACGTATAAGTGGG
CTAATTTAACTGGTTTACATGCACATATAGGGTCTCAAATTTTTGAAGTTCAACCCCATATCGATCTTGCTGGCGTTATG
GCTGATGCTTTAAAGCTTGCTAAGGAAATTGGTCATCCAGTTGTTGATCTAAATTTAGGAGGCGGTTTAGGGATTAAATA
TGTTCAAGAAGATAATCCTCCCTCTATTGAAAAATGGGTTGAAATTATTTCTAAGGCTGTTGTTAAGGCTTGTAGGGAAA
GAAATCTTGATTTACCAAGATTAATGTGTGAACCGGGAAGATCTCTTGTCGCTAATTCGGGGCTCACTATTTACAAGATT
GGAGCTAAAAAAGTTGTCCCTGGTGTCAGAACTTATTTATCTGTTGATGGAGGGATGAGTGATAATCCTCGTCCAATAAC
CTATCAGTCTCTTTACAGTGCATGTTTAGTCGATAAACCAATGAATACAAATTTTGAAAAAGTCACAATAGCCGGGAAGC
ATTGTGAGTCTGGAGATGTTTTATTGAAAGATTTTCTACTTCCTTCTTGTGAAAGTGGCGATTTTCTTGCTGTGTTTGGA
ACGGGTGCATACAACTATTCAATGAGTTCCAATTACAACAGAATACCTAGACCTGCGACAATTATGGTTGGGAAAGGTTC
GGCCGAGTTGACTCAAAGGAGAGAACTTCCTGAAGATCTATTGCAATTAGATGTATTGCCCGATCGCTTTATTCCCAAGA
ATTAG

Upstream 100 bases:

>100_bases
GATTCATATCCAAATATTAATGAATGGTTCTTTCTTGAAAAAGAATACTAATTTGTTGATTGATCTCTAGATTAACCAGA
TATCGTTGTAAAAAATTTCT

Downstream 100 bases:

>100_bases
GTAAGTTGAAATAACGTTGGGGTGTAGGAGTGAATTTCTGGTGGTTTATAAATTTGCGTGTTTTCCTTGATGTGTTGTTT
GCTTCTTCTCTTGGAGTGCT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MHGSKAYEPNVDIDSPNRNIAPITSEINESKKLVVGGCQLSELAKKYGTPLYVLDEFSLRTACKTYISSLNKHYPGKSLP
LFASKANSSLAICAVIASEGFGLDAVSEGELLTAINGGVKEKDIVFHGNNKSQDELNFAYSNNVTIVLDNYHDIELLKNI
ASDNKPAKLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDDLKSILEELKTYKWANLTGLHAHIGSQIFEVQPHIDLAGVM
ADALKLAKEIGHPVVDLNLGGGLGIKYVQEDNPPSIEKWVEIISKAVVKACRERNLDLPRLMCEPGRSLVANSGLTIYKI
GAKKVVPGVRTYLSVDGGMSDNPRPITYQSLYSACLVDKPMNTNFEKVTIAGKHCESGDVLLKDFLLPSCESGDFLAVFG
TGAYNYSMSSNYNRIPRPATIMVGKGSAELTQRRELPEDLLQLDVLPDRFIPKN

Sequences:

>Translated_454_residues
MHGSKAYEPNVDIDSPNRNIAPITSEINESKKLVVGGCQLSELAKKYGTPLYVLDEFSLRTACKTYISSLNKHYPGKSLP
LFASKANSSLAICAVIASEGFGLDAVSEGELLTAINGGVKEKDIVFHGNNKSQDELNFAYSNNVTIVLDNYHDIELLKNI
ASDNKPAKLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDDLKSILEELKTYKWANLTGLHAHIGSQIFEVQPHIDLAGVM
ADALKLAKEIGHPVVDLNLGGGLGIKYVQEDNPPSIEKWVEIISKAVVKACRERNLDLPRLMCEPGRSLVANSGLTIYKI
GAKKVVPGVRTYLSVDGGMSDNPRPITYQSLYSACLVDKPMNTNFEKVTIAGKHCESGDVLLKDFLLPSCESGDFLAVFG
TGAYNYSMSSNYNRIPRPATIMVGKGSAELTQRRELPEDLLQLDVLPDRFIPKN
>Mature_454_residues
MHGSKAYEPNVDIDSPNRNIAPITSEINESKKLVVGGCQLSELAKKYGTPLYVLDEFSLRTACKTYISSLNKHYPGKSLP
LFASKANSSLAICAVIASEGFGLDAVSEGELLTAINGGVKEKDIVFHGNNKSQDELNFAYSNNVTIVLDNYHDIELLKNI
ASDNKPAKLMLRFTPGIECHTHEYIRTGHLDSKFGFDPDDLKSILEELKTYKWANLTGLHAHIGSQIFEVQPHIDLAGVM
ADALKLAKEIGHPVVDLNLGGGLGIKYVQEDNPPSIEKWVEIISKAVVKACRERNLDLPRLMCEPGRSLVANSGLTIYKI
GAKKVVPGVRTYLSVDGGMSDNPRPITYQSLYSACLVDKPMNTNFEKVTIAGKHCESGDVLLKDFLLPSCESGDFLAVFG
TGAYNYSMSSNYNRIPRPATIMVGKGSAELTQRRELPEDLLQLDVLPDRFIPKN

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=375, Percent_Identity=24.8, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI22538418, Length=362, Percent_Identity=24.0331491712707, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21361583, Length=362, Percent_Identity=24.0331491712707, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=412, Percent_Identity=29.3689320388349, Blast_Score=141, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562780, Length=364, Percent_Identity=23.3516483516484, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24586474, Length=355, Percent_Identity=25.9154929577465, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586472, Length=351, Percent_Identity=24.2165242165242, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49832; Mature: 49832

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGSKAYEPNVDIDSPNRNIAPITSEINESKKLVVGGCQLSELAKKYGTPLYVLDEFSLR
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHCCCEEEEECHHHH
TACKTYISSLNKHYPGKSLPLFASKANSSLAICAVIASEGFGLDAVSEGELLTAINGGVK
HHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCC
EKDIVFHGNNKSQDELNFAYSNNVTIVLDNYHDIELLKNIASDNKPAKLMLRFTPGIECH
CCEEEEECCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCC
THEYIRTGHLDSKFGFDPDDLKSILEELKTYKWANLTGLHAHIGSQIFEVQPHIDLAGVM
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCCHHHHHH
ADALKLAKEIGHPVVDLNLGGGLGIKYVQEDNPPSIEKWVEIISKAVVKACRERNLDLPR
HHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
LMCEPGRSLVANSGLTIYKIGAKKVVPGVRTYLSVDGGMSDNPRPITYQSLYSACLVDKP
HHHCCCCHHHHCCCEEEEEECCHHHCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHCCCC
MNTNFEKVTIAGKHCESGDVLLKDFLLPSCESGDFLAVFGTGAYNYSMSSNYNRIPRPAT
CCCCCEEEEEECCCCCCCCEEHHHHCCCCCCCCCEEEEEECCEEEECCCCCCCCCCCCEE
IMVGKGSAELTQRRELPEDLLQLDVLPDRFIPKN
EEEECCCHHHHHHHCCHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHGSKAYEPNVDIDSPNRNIAPITSEINESKKLVVGGCQLSELAKKYGTPLYVLDEFSLR
CCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCHHHHHHHHCCCEEEEECHHHH
TACKTYISSLNKHYPGKSLPLFASKANSSLAICAVIASEGFGLDAVSEGELLTAINGGVK
HHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEEEEECCCCCCCCCCCCCEEEEECCCCC
EKDIVFHGNNKSQDELNFAYSNNVTIVLDNYHDIELLKNIASDNKPAKLMLRFTPGIECH
CCEEEEECCCCCCCCEEEEECCCEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCC
THEYIRTGHLDSKFGFDPDDLKSILEELKTYKWANLTGLHAHIGSQIFEVQPHIDLAGVM
CHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCEEEEECCCCHHHHHH
ADALKLAKEIGHPVVDLNLGGGLGIKYVQEDNPPSIEKWVEIISKAVVKACRERNLDLPR
HHHHHHHHHHCCCEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCH
LMCEPGRSLVANSGLTIYKIGAKKVVPGVRTYLSVDGGMSDNPRPITYQSLYSACLVDKP
HHHCCCCHHHHCCCEEEEEECCHHHCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHCCCC
MNTNFEKVTIAGKHCESGDVLLKDFLLPSCESGDFLAVFGTGAYNYSMSSNYNRIPRPAT
CCCCCEEEEEECCCCCCCCEEHHHHCCCCCCCCCEEEEEECCEEEECCCCCCCCCCCCEE
IMVGKGSAELTQRRELPEDLLQLDVLPDRFIPKN
EEEECCCHHHHHHHCCHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]