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The map label for this gene is pdxJ

Identifier: 124026180

GI number: 124026180

Start: 1179406

End: 1180143

Strand: Direct

Name: pdxJ

Synonym: NATL1_14741

Alternate gene names: 124026180

Gene position: 1179406-1180143 (Clockwise)

Preceding gene: 124026176

Following gene: 124026181

Centisome position: 63.25

GC content: 37.13

Gene sequence:

>738_bases
ATGGCAAGTCTTGGCGTAAACATTGATCACATAGCAAATGTCCGAGAAGCTCGTAAGACATTTGAACCTGACCCAGTAAA
AATGGTTCTTTTAGCGGAATTAGGTGGAGCTGACGGCATAACAGTTCATCTAAGAGAAGATAGAAGGCATATTCAAGATA
GAGATCTAAATCTTCTAAAAGAGACTGTACATACTCGACTAAATCTTGAAATGGCTGCAACTGAAGAAATGACTTCAATA
GCACTTAATCTCAAGCCAGATATGGTTACATTGGTTCCTGAGAAAAGGGAAGAGGTCACGACAGAAGGAGGACTCGATGT
CATTAAAAACAAAAACAAATTAAAGGAAATAATTCAACGTCTTTCAGGTGAGGACATTCCAGTTAGTCTTTTTGTTGATC
CAGTCCAAGCTCAATTAGAAAATTGCGCTGAAGTAAAGGCCGCTTGGATTGAACTGCACACAGGTAAATATGCAATTACA
AAAAACAAGGCAAGAGATTTAGAATTATCTATTCTTAAAGAGAACACAGCTAAAGCAAAGTCTTATGGTTTGAGAGTAAA
CGCAGGGCATGGATTGACATATCAAAACGTTGAACCGATTGCAGCTATTGAAGGGATTGAAGAATTAAATATTGGCCATA
CAATTATTTCTAGAGCCCTTTCAGTAGGTCTATCTCAGGCAGTAAAAGAAATGAAAAGCCTAATTATCAATCCAAGAAAA
GACAACTTCTTACTTTAA

Upstream 100 bases:

>100_bases
CCGAAAGCTTTATTATTAACGCTCGGACTGGGCAGTTACTCCAGCGGCTAAACCTTATTTTGCTTTTGATGAATACAATC
AAAGTATATTTTAAATACTT

Downstream 100 bases:

>100_bases
AGATTTTTAAATCGCATTTTGACTCTTGCTAACAATTTATCGAAGTAATAAAGCTGAATGGTTGGCAGAGATACTTGGAC
AGGAACTCCGATTAAACCCT

Product: pyridoxine 5'-phosphate synthase

Products: NA

Alternate protein names: PNP synthase

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MASLGVNIDHIANVREARKTFEPDPVKMVLLAELGGADGITVHLREDRRHIQDRDLNLLKETVHTRLNLEMAATEEMTSI
ALNLKPDMVTLVPEKREEVTTEGGLDVIKNKNKLKEIIQRLSGEDIPVSLFVDPVQAQLENCAEVKAAWIELHTGKYAIT
KNKARDLELSILKENTAKAKSYGLRVNAGHGLTYQNVEPIAAIEGIEELNIGHTIISRALSVGLSQAVKEMKSLIINPRK
DNFLL

Sequences:

>Translated_245_residues
MASLGVNIDHIANVREARKTFEPDPVKMVLLAELGGADGITVHLREDRRHIQDRDLNLLKETVHTRLNLEMAATEEMTSI
ALNLKPDMVTLVPEKREEVTTEGGLDVIKNKNKLKEIIQRLSGEDIPVSLFVDPVQAQLENCAEVKAAWIELHTGKYAIT
KNKARDLELSILKENTAKAKSYGLRVNAGHGLTYQNVEPIAAIEGIEELNIGHTIISRALSVGLSQAVKEMKSLIINPRK
DNFLL
>Mature_244_residues
ASLGVNIDHIANVREARKTFEPDPVKMVLLAELGGADGITVHLREDRRHIQDRDLNLLKETVHTRLNLEMAATEEMTSIA
LNLKPDMVTLVPEKREEVTTEGGLDVIKNKNKLKEIIQRLSGEDIPVSLFVDPVQAQLENCAEVKAAWIELHTGKYAITK
NKARDLELSILKENTAKAKSYGLRVNAGHGLTYQNVEPIAAIEGIEELNIGHTIISRALSVGLSQAVKEMKSLIINPRKD
NFLL

Specific function: Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate

COG id: COG0854

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP synthase family

Homologues:

Organism=Escherichia coli, GI1788917, Length=237, Percent_Identity=56.5400843881857, Blast_Score=265, Evalue=1e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXJ_PROM1 (A2C3H1)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001015296.1
- ProteinModelPortal:   A2C3H1
- SMR:   A2C3H1
- STRING:   A2C3H1
- GeneID:   4780531
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_14741
- eggNOG:   COG0854
- HOGENOM:   HBG299314
- OMA:   AGHGLNY
- ProtClustDB:   PRK05265
- BioCyc:   PMAR167555:NATL1_14741-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00279
- InterPro:   IPR013785
- InterPro:   IPR004569
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00559

Pfam domain/function: PF03740 PdxJ; SSF63892 PyrdxlP_synth_PdxJ

EC number: =2.6.99.2

Molecular weight: Translated: 27209; Mature: 27078

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: ACT_SITE 43-43 ACT_SITE 70-70 ACT_SITE 190-190 BINDING 7-7 BINDING 18-18 BINDING 45-45 BINDING 50-50 BINDING 100-100 BINDING 191-191

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLGVNIDHIANVREARKTFEPDPVKMVLLAELGGADGITVHLREDRRHIQDRDLNLLK
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHH
ETVHTRLNLEMAATEEMTSIALNLKPDMVTLVPEKREEVTTEGGLDVIKNKNKLKEIIQR
HHHHHHHCEEHHHHHHHHHEEEECCCCEEEECCCHHHHHCCCCCHHHHCCHHHHHHHHHH
LSGEDIPVSLFVDPVQAQLENCAEVKAAWIELHTGKYAITKNKARDLELSILKENTAKAK
HCCCCCEEEEEECHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCCEEEEEECCCCHHHH
SYGLRVNAGHGLTYQNVEPIAAIEGIEELNIGHTIISRALSVGLSQAVKEMKSLIINPRK
HCCEEEECCCCCEECCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNFLL
CCCCC
>Mature Secondary Structure 
ASLGVNIDHIANVREARKTFEPDPVKMVLLAELGGADGITVHLREDRRHIQDRDLNLLK
CCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHH
ETVHTRLNLEMAATEEMTSIALNLKPDMVTLVPEKREEVTTEGGLDVIKNKNKLKEIIQR
HHHHHHHCEEHHHHHHHHHEEEECCCCEEEECCCHHHHHCCCCCHHHHCCHHHHHHHHHH
LSGEDIPVSLFVDPVQAQLENCAEVKAAWIELHTGKYAITKNKARDLELSILKENTAKAK
HCCCCCEEEEEECHHHHHHHHHHHHHHHHEEEECCCEEEECCCCCCEEEEEECCCCHHHH
SYGLRVNAGHGLTYQNVEPIAAIEGIEELNIGHTIISRALSVGLSQAVKEMKSLIINPRK
HCCEEEECCCCCEECCCCCHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNFLL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA