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The map label for this gene is ribB [H]

Identifier: 124025697

GI number: 124025697

Start: 908462

End: 910147

Strand: Reverse

Name: ribB [H]

Synonym: NATL1_09901

Alternate gene names: 124025697

Gene position: 910147-908462 (Counterclockwise)

Preceding gene: 124025699

Following gene: 124025691

Centisome position: 48.81

GC content: 35.11

Gene sequence:

>1686_bases
TTGAAATCAGAAGATTGTTATGAAATTGAATTTGATGATATTGCAGATGCACTAGCTGCTATCAGAAATGGTGAATGTGT
TGTTGTGGTTGATGATGAAAAGAGAGAAAACGAAGGCGATTTAATATGTGCTGCTCAATTTGCGACTCCCCAGCAAATAA
ATTTCATGGCAACAGAGGCTAGAGGTTTGATATGTCTAGCAATGCAAGGGGAAAGATTAGACGAATTAGATCTTCCTTTA
ATGGTTGACAGAAATACCGATTCAAACCAAACAGCATTCACTGTAAGTATCGATGCAGGTCCTGAATTTGGAGTATCTAC
GGGCATTTCAGCTGAAGATAGAGCTAAAACAATTCAAGTTGCTCTTAATAGTCAAACAAAACCAATTGATTTAAGAAGAC
CCGGTCATATTTTCCCTTTAAGAGCAAAAATTGGAGGAGTATTAAAAAGGGCTGGACATACGGAAGCGGCAGTAGACCTA
TCTTTGTTAGCAGGCTTATCTCCTGCGGGCGTTATCTGTGAAATTCAAAATCTGGATGGCTCAATGGCAAGATTGCCTGA
GTTAAAAAAATATGCGCAAGAAAGAAAATTAAAGTTGATCAGTATTGCAGATTTAATTCACTACAGACTTGAAAATGAGA
GATTTGTCTACAGACAAGCAGTAGCAAAGTTGCCTAGCCTATTTGGAGATTTCAAGGCAATCGGTTACAAGAATGAATTG
GATGGATCAGAACATGTCGCGATAATAAAAGGAAATCCAGAAAATTTAAAAGAGCCGGTATTGGTAAGAATGCACTCAGA
GTGTCTAACAGGAGACGCATTTGGATCATTAAGGTGTGATTGTCGGCCTCAATTAGAAGCTGCCTTGTCAAGAATTTCAG
AAGAAGGAGAAGGAGTTGTTGTCTATCTAAGGCAGGAAGGTAGAGGTATAGGTTTAGTTAACAAATTAAAAGCCTATAAT
CTTCAAGATGGAGGATTAGATACTGTTGAAGCCAATGAGAAATTAGGTTTTCCTGCAGATTTGAGAAACTATGGAGTGGG
GGCGCAAATATTGACAGATTTAGGAATAAATAGACTTAAATTACTAACAAATAATCCTAGAAAAATAGCTGGTCTTGGTG
GATATGGTCTTCAAGTTGAATCTAGAGTTCCATTAGTTATTTGCCCCGGAGATCATAATGCGGCTTATCTTGAGGTAAAA
AGAGAAAAACTTGGACACTTAATTGATAATAATATTCAGACAAATTTAACCAATGAAAGACAAAATATTGTTGTCTATTG
GGATGGAAAAGTTAACGACAGTGAATTAAAACATTTTGAAAATAAAGCATGTAAGTGGTCAGAAAACCATTTTTTAAATA
TTTCTATTCAAACAGCTCCAAGGTTAATAGCTCTATGTGAAAACCCATTATTCATTTGGAATGTTAGACATAGAGATATC
AAAACACATTTGGAAGGTAACTTTATAGATAAAAGATTGCTTGAGTCACTACTTAAGGAGCTTAGCAATTGGAAAAATAC
AGAAAGAGTTGGAATAATTAAAACTGACAATTATGAAAGGCTTTTACATCCATCTTCAAATATAACTATAGAGTCAAAAA
AAATAAGCGAACTTTCAAATTTTGAAAATTCGCCATTATTTGATTGGAATTTAAAAGATAAGACCAGTACTTTCGAATGG
AGTTAA

Upstream 100 bases:

>100_bases
TACTTTTTGCCATAACATCAATGTTATTTCGTAGAATGAGGAGATATTCATTTGAGAATAATTAGCAAAGAACCATTTCA
CCACAAACACGAGGAATAAG

Downstream 100 bases:

>100_bases
TTATAAGATAAGATAATAAATTTAAGTCTATTAAACAATACTTACACTATTAATCTTTGTACCATTAGTGATAGATAGAA
GAATTTTCATATCATTAGTT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MKSEDCYEIEFDDIADALAAIRNGECVVVVDDEKRENEGDLICAAQFATPQQINFMATEARGLICLAMQGERLDELDLPL
MVDRNTDSNQTAFTVSIDAGPEFGVSTGISAEDRAKTIQVALNSQTKPIDLRRPGHIFPLRAKIGGVLKRAGHTEAAVDL
SLLAGLSPAGVICEIQNLDGSMARLPELKKYAQERKLKLISIADLIHYRLENERFVYRQAVAKLPSLFGDFKAIGYKNEL
DGSEHVAIIKGNPENLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRISEEGEGVVVYLRQEGRGIGLVNKLKAYN
LQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGINRLKLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLEVK
REKLGHLIDNNIQTNLTNERQNIVVYWDGKVNDSELKHFENKACKWSENHFLNISIQTAPRLIALCENPLFIWNVRHRDI
KTHLEGNFIDKRLLESLLKELSNWKNTERVGIIKTDNYERLLHPSSNITIESKKISELSNFENSPLFDWNLKDKTSTFEW
S

Sequences:

>Translated_561_residues
MKSEDCYEIEFDDIADALAAIRNGECVVVVDDEKRENEGDLICAAQFATPQQINFMATEARGLICLAMQGERLDELDLPL
MVDRNTDSNQTAFTVSIDAGPEFGVSTGISAEDRAKTIQVALNSQTKPIDLRRPGHIFPLRAKIGGVLKRAGHTEAAVDL
SLLAGLSPAGVICEIQNLDGSMARLPELKKYAQERKLKLISIADLIHYRLENERFVYRQAVAKLPSLFGDFKAIGYKNEL
DGSEHVAIIKGNPENLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRISEEGEGVVVYLRQEGRGIGLVNKLKAYN
LQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGINRLKLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLEVK
REKLGHLIDNNIQTNLTNERQNIVVYWDGKVNDSELKHFENKACKWSENHFLNISIQTAPRLIALCENPLFIWNVRHRDI
KTHLEGNFIDKRLLESLLKELSNWKNTERVGIIKTDNYERLLHPSSNITIESKKISELSNFENSPLFDWNLKDKTSTFEW
S
>Mature_561_residues
MKSEDCYEIEFDDIADALAAIRNGECVVVVDDEKRENEGDLICAAQFATPQQINFMATEARGLICLAMQGERLDELDLPL
MVDRNTDSNQTAFTVSIDAGPEFGVSTGISAEDRAKTIQVALNSQTKPIDLRRPGHIFPLRAKIGGVLKRAGHTEAAVDL
SLLAGLSPAGVICEIQNLDGSMARLPELKKYAQERKLKLISIADLIHYRLENERFVYRQAVAKLPSLFGDFKAIGYKNEL
DGSEHVAIIKGNPENLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRISEEGEGVVVYLRQEGRGIGLVNKLKAYN
LQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGINRLKLLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLEVK
REKLGHLIDNNIQTNLTNERQNIVVYWDGKVNDSELKHFENKACKWSENHFLNISIQTAPRLIALCENPLFIWNVRHRDI
KTHLEGNFIDKRLLESLLKELSNWKNTERVGIIKTDNYERLLHPSSNITIESKKISELSNFENSPLFDWNLKDKTSTFEW
S

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=208, Percent_Identity=48.5576923076923, Blast_Score=212, Evalue=6e-56,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=52.0833333333333, Blast_Score=202, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=41.747572815534, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6319438, Length=190, Percent_Identity=44.2105263157895, Blast_Score=131, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 62731; Mature: 62731

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSEDCYEIEFDDIADALAAIRNGECVVVVDDEKRENEGDLICAAQFATPQQINFMATEA
CCCCCEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECC
RGLICLAMQGERLDELDLPLMVDRNTDSNQTAFTVSIDAGPEFGVSTGISAEDRAKTIQV
CCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
ALNSQTKPIDLRRPGHIFPLRAKIGGVLKRAGHTEAAVDLSLLAGLSPAGVICEIQNLDG
EECCCCCCEECCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCC
SMARLPELKKYAQERKLKLISIADLIHYRLENERFVYRQAVAKLPSLFGDFKAIGYKNEL
HHHHHHHHHHHHHHHCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
DGSEHVAIIKGNPENLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRISEEGEGVV
CCCCEEEEEECCCCCCCCCEEEEEHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEE
VYLRQEGRGIGLVNKLKAYNLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGINRLK
EEEEECCCCCCCHHHHEECCCCCCCCCEEECCCCCCCCHHHHHCCCCHHHHHHCCCCEEE
LLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLEVKREKLGHLIDNNIQTNLTNER
EEECCCCEEEECCCCCEEECCCCCEEEECCCCCEEEEEEEHHHHHHHHCCCCEECCCCCC
QNIVVYWDGKVNDSELKHFENKACKWSENHFLNISIQTAPRLIALCENPLFIWNVRHRDI
CEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCC
KTHLEGNFIDKRLLESLLKELSNWKNTERVGIIKTDNYERLLHPSSNITIESKKISELSN
HHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHEECCCCCEEEEHHHHHHHHC
FENSPLFDWNLKDKTSTFEWS
CCCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKSEDCYEIEFDDIADALAAIRNGECVVVVDDEKRENEGDLICAAQFATPQQINFMATEA
CCCCCEEEEEHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCEEEEEECC
RGLICLAMQGERLDELDLPLMVDRNTDSNQTAFTVSIDAGPEFGVSTGISAEDRAKTIQV
CCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEE
ALNSQTKPIDLRRPGHIFPLRAKIGGVLKRAGHTEAAVDLSLLAGLSPAGVICEIQNLDG
EECCCCCCEECCCCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEECCCC
SMARLPELKKYAQERKLKLISIADLIHYRLENERFVYRQAVAKLPSLFGDFKAIGYKNEL
HHHHHHHHHHHHHHHCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
DGSEHVAIIKGNPENLKEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRISEEGEGVV
CCCCEEEEEECCCCCCCCCEEEEEHHHHCCCCCCCCEEECCCHHHHHHHHHHHCCCCEEE
VYLRQEGRGIGLVNKLKAYNLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGINRLK
EEEEECCCCCCCHHHHEECCCCCCCCCEEECCCCCCCCHHHHHCCCCHHHHHHCCCCEEE
LLTNNPRKIAGLGGYGLQVESRVPLVICPGDHNAAYLEVKREKLGHLIDNNIQTNLTNER
EEECCCCEEEECCCCCEEECCCCCEEEECCCCCEEEEEEEHHHHHHHHCCCCEECCCCCC
QNIVVYWDGKVNDSELKHFENKACKWSENHFLNISIQTAPRLIALCENPLFIWNVRHRDI
CEEEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCC
KTHLEGNFIDKRLLESLLKELSNWKNTERVGIIKTDNYERLLHPSSNITIESKKISELSN
HHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHEECCCCCEEEEHHHHHHHHC
FENSPLFDWNLKDKTSTFEWS
CCCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]