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The map label for this gene is ilvA [H]

Identifier: 124025678

GI number: 124025678

Start: 890875

End: 892410

Strand: Reverse

Name: ilvA [H]

Synonym: NATL1_09711

Alternate gene names: 124025678

Gene position: 892410-890875 (Counterclockwise)

Preceding gene: 124025680

Following gene: 124025677

Centisome position: 47.86

GC content: 37.37

Gene sequence:

>1536_bases
ATGGAGGACTATTTACAGAAAATACTAAGAGCTCGCGTTTATGACGTTGCTGAAGAAACCCCACTAGAAAAGGCGAAAAA
CTTAAGCAAAAAATTCGAAAATAACATTTGGTTTAAGAGAGAAGACCTTCAACCTGTCTTTTCATTCAAGTTAAGAGGTG
CATTTAACCGCATGTCTCAGCTGAGCAAGGAAGAGCTAGATAAAGGAGTAATTGCATCAAGCGCTGGAAACCATGCACAG
GGAGTTGCGTTAAGTGCATCATTCCTGAAATGCAGAGCAGTAATTGTTATGCCACTGACAACTCCCGTTATGAAAGTAAG
GGCAGTTGAATCACACAAGGCAGAAGTTATTCTTTTCGGTGAAACTTATGATGAGTGCTATGAAAAGGCACTAGATATAT
CTAAGAAAGAAAATCTAACTTTCATACATCCATTTGATGATCCTGAAGTCATAGCAGGACAAGGAACAATAGGTCTTGAA
ATACTTAGACAAAGTCAAACTCCGCCTGATGCGATTTACATAGCTGTTGGAGGCGGGGGACTTATTGCTGGAGTAAGTGC
GTACGTAAAAGCAATATGGCCAGATACAAAGATTATTGGTGTTGAACCAGAAGATGCCTGCGCAATGACACTTTCATTAA
AGGCAAATGAACCTATTGAGCTTGAGAGTATTGGCCTTTTTGCAGACGGAGTTGCGGTAAGAAAGGTAGGAGAAAAGACT
TTCTCGATTTGCAAAAAAAATGTTGATGAAATGGTTACTGTAAGTACAGACGAAATTTGTGCCGCGATAAAAGATGTTTT
CGAGGATACAAGATCAATTCTTGAACCAGCAGGTGCATTATCTATAGCTGGCTTAAAAAAACATGTTGTAAATAATCAGT
TAAAAAACAACAACCTTGTTGCAATAGCTTGTGGTGCAAATATGAATTTTGAACGACTAAGATTTGTAGCAGAAAGAGCC
GAATTAGGTGAAGAAAAAGAAGCTATGATTGCAGTAGGAATTCCTGAAAAAGCGGGCAGTTTAAAACTTTTATGCAAAAC
ACTTGGTTCACGGAGTCTAACTGAATTTAGTTACAGGATTTCAGAAGGTAAAACAGCTCAAATATTTATGGGTGTAGAAG
TTTCGAATAACAATGATAGGGAATTATTAACAGCTGAGATCAAAAGGGGAGGTTTTGATTGTCATGATTTAAGTAATGAT
GAATTATCAAAAGTTCATCTCAGGCATATGGTTGGTGGCAGGCTACCAAGATCAATAAGTCAAATATCTAAAGGAGAATA
CATAGAATTACTATATAGATTTGAGTTTCCTGAAAGGCCTGGTGCCTTAATGAGATTTGTTAACTCAATGAGACCAGAGT
GGACAATAAGCATCTTCCATTATCGAAACCATGGCGCTGATACTGGAAGAATAGTAATAGGTGTACTAGTAAACGATTCC
GAGATTCAAGCTTGGAATGAGTTTGTCAAAAAAATAGGTTATAAAAATTGGGATGAGACAGATAATCCAGCATATAAATT
ATTTTTAGGTGCATAG

Upstream 100 bases:

>100_bases
CCTCCAATCTACGAGGTCTACCGTACATTTTGATAAAACTTGCACAAGAACAAATGGAATGTAGAAAACACAAGAATCAA
AAATCGGTGAAAAACTAGAT

Downstream 100 bases:

>100_bases
TTTAATTAGACGCGTTAATTTTGGATATACAGAAAAATAATTTTGGTTTTAATGTTATGAGTGAGAGCATACAAATTTCA
TTACCAGCGAAGATTGAGGC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MEDYLQKILRARVYDVAEETPLEKAKNLSKKFENNIWFKREDLQPVFSFKLRGAFNRMSQLSKEELDKGVIASSAGNHAQ
GVALSASFLKCRAVIVMPLTTPVMKVRAVESHKAEVILFGETYDECYEKALDISKKENLTFIHPFDDPEVIAGQGTIGLE
ILRQSQTPPDAIYIAVGGGGLIAGVSAYVKAIWPDTKIIGVEPEDACAMTLSLKANEPIELESIGLFADGVAVRKVGEKT
FSICKKNVDEMVTVSTDEICAAIKDVFEDTRSILEPAGALSIAGLKKHVVNNQLKNNNLVAIACGANMNFERLRFVAERA
ELGEEKEAMIAVGIPEKAGSLKLLCKTLGSRSLTEFSYRISEGKTAQIFMGVEVSNNNDRELLTAEIKRGGFDCHDLSND
ELSKVHLRHMVGGRLPRSISQISKGEYIELLYRFEFPERPGALMRFVNSMRPEWTISIFHYRNHGADTGRIVIGVLVNDS
EIQAWNEFVKKIGYKNWDETDNPAYKLFLGA

Sequences:

>Translated_511_residues
MEDYLQKILRARVYDVAEETPLEKAKNLSKKFENNIWFKREDLQPVFSFKLRGAFNRMSQLSKEELDKGVIASSAGNHAQ
GVALSASFLKCRAVIVMPLTTPVMKVRAVESHKAEVILFGETYDECYEKALDISKKENLTFIHPFDDPEVIAGQGTIGLE
ILRQSQTPPDAIYIAVGGGGLIAGVSAYVKAIWPDTKIIGVEPEDACAMTLSLKANEPIELESIGLFADGVAVRKVGEKT
FSICKKNVDEMVTVSTDEICAAIKDVFEDTRSILEPAGALSIAGLKKHVVNNQLKNNNLVAIACGANMNFERLRFVAERA
ELGEEKEAMIAVGIPEKAGSLKLLCKTLGSRSLTEFSYRISEGKTAQIFMGVEVSNNNDRELLTAEIKRGGFDCHDLSND
ELSKVHLRHMVGGRLPRSISQISKGEYIELLYRFEFPERPGALMRFVNSMRPEWTISIFHYRNHGADTGRIVIGVLVNDS
EIQAWNEFVKKIGYKNWDETDNPAYKLFLGA
>Mature_511_residues
MEDYLQKILRARVYDVAEETPLEKAKNLSKKFENNIWFKREDLQPVFSFKLRGAFNRMSQLSKEELDKGVIASSAGNHAQ
GVALSASFLKCRAVIVMPLTTPVMKVRAVESHKAEVILFGETYDECYEKALDISKKENLTFIHPFDDPEVIAGQGTIGLE
ILRQSQTPPDAIYIAVGGGGLIAGVSAYVKAIWPDTKIIGVEPEDACAMTLSLKANEPIELESIGLFADGVAVRKVGEKT
FSICKKNVDEMVTVSTDEICAAIKDVFEDTRSILEPAGALSIAGLKKHVVNNQLKNNNLVAIACGANMNFERLRFVAERA
ELGEEKEAMIAVGIPEKAGSLKLLCKTLGSRSLTEFSYRISEGKTAQIFMGVEVSNNNDRELLTAEIKRGGFDCHDLSND
ELSKVHLRHMVGGRLPRSISQISKGEYIELLYRFEFPERPGALMRFVNSMRPEWTISIFHYRNHGADTGRIVIGVLVNDS
EIQAWNEFVKKIGYKNWDETDNPAYKLFLGA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=305, Percent_Identity=33.4426229508197, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=30.2250803858521, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI19923959, Length=316, Percent_Identity=28.1645569620253, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790207, Length=508, Percent_Identity=46.6535433070866, Blast_Score=472, Evalue=1e-134,
Organism=Escherichia coli, GI1789505, Length=305, Percent_Identity=38.3606557377049, Blast_Score=178, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17537387, Length=341, Percent_Identity=36.0703812316716, Blast_Score=159, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI71991565, Length=332, Percent_Identity=34.6385542168675, Blast_Score=158, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17508781, Length=288, Percent_Identity=29.1666666666667, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320930, Length=527, Percent_Identity=46.1100569259962, Blast_Score=445, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6322631, Length=303, Percent_Identity=34.983498349835, Blast_Score=170, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6319788, Length=326, Percent_Identity=25.4601226993865, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355833, Length=332, Percent_Identity=35.5421686746988, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24645328, Length=253, Percent_Identity=35.9683794466403, Blast_Score=119, Evalue=7e-27,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 56806; Mature: 56806

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDYLQKILRARVYDVAEETPLEKAKNLSKKFENNIWFKREDLQPVFSFKLRGAFNRMSQ
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
LSKEELDKGVIASSAGNHAQGVALSASFLKCRAVIVMPLTTPVMKVRAVESHKAEVILFG
HHHHHHCCCCEECCCCCCCCCEEEHHHHHEEEEEEEEECCCHHHHHEECCCCCCEEEEEE
ETYDECYEKALDISKKENLTFIHPFDDPEVIAGQGTIGLEILRQSQTPPDAIYIAVGGGG
CCHHHHHHHHHCCCCCCCEEEECCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEECCCH
LIAGVSAYVKAIWPDTKIIGVEPEDACAMTLSLKANEPIELESIGLFADGVAVRKVGEKT
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCEEEEECCEEECCHHHHHHHHHH
FSICKKNVDEMVTVSTDEICAAIKDVFEDTRSILEPAGALSIAGLKKHVVNNQLKNNNLV
HHHHHHCHHHEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCEE
AIACGANMNFERLRFVAERAELGEEKEAMIAVGIPEKAGSLKLLCKTLGSRSLTEFSYRI
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHEEE
SEGKTAQIFMGVEVSNNNDRELLTAEIKRGGFDCHDLSNDELSKVHLRHMVGGRLPRSIS
CCCCEEEEEEEEEECCCCCCHHEEHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
QISKGEYIELLYRFEFPERPGALMRFVNSMRPEWTISIFHYRNHGADTGRIVIGVLVNDS
HHCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCCEEEEEEEECCC
EIQAWNEFVKKIGYKNWDETDNPAYKLFLGA
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MEDYLQKILRARVYDVAEETPLEKAKNLSKKFENNIWFKREDLQPVFSFKLRGAFNRMSQ
CHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHH
LSKEELDKGVIASSAGNHAQGVALSASFLKCRAVIVMPLTTPVMKVRAVESHKAEVILFG
HHHHHHCCCCEECCCCCCCCCEEEHHHHHEEEEEEEEECCCHHHHHEECCCCCCEEEEEE
ETYDECYEKALDISKKENLTFIHPFDDPEVIAGQGTIGLEILRQSQTPPDAIYIAVGGGG
CCHHHHHHHHHCCCCCCCEEEECCCCCCCEEECCCCHHHHHHHCCCCCCCEEEEEECCCH
LIAGVSAYVKAIWPDTKIIGVEPEDACAMTLSLKANEPIELESIGLFADGVAVRKVGEKT
HHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCEEEEECCEEECCHHHHHHHHHH
FSICKKNVDEMVTVSTDEICAAIKDVFEDTRSILEPAGALSIAGLKKHVVNNQLKNNNLV
HHHHHHCHHHEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCEE
AIACGANMNFERLRFVAERAELGEEKEAMIAVGIPEKAGSLKLLCKTLGSRSLTEFSYRI
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCHHHHHEEE
SEGKTAQIFMGVEVSNNNDRELLTAEIKRGGFDCHDLSNDELSKVHLRHMVGGRLPRSIS
CCCCEEEEEEEEEECCCCCCHHEEHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHH
QISKGEYIELLYRFEFPERPGALMRFVNSMRPEWTISIFHYRNHGADTGRIVIGVLVNDS
HHCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCEEEEEEEEECCCCCCCEEEEEEEECCC
EIQAWNEFVKKIGYKNWDETDNPAYKLFLGA
HHHHHHHHHHHCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA