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The map label for this gene is msrA [H]

Identifier: 124025630

GI number: 124025630

Start: 851655

End: 852401

Strand: Reverse

Name: msrA [H]

Synonym: NATL1_09231

Alternate gene names: 124025630

Gene position: 852401-851655 (Counterclockwise)

Preceding gene: 124025631

Following gene: 124025629

Centisome position: 45.71

GC content: 34.81

Gene sequence:

>747_bases
ATGATTAAAAAGATAATTAAATATTTAACCCTAATAATTGATAAGCTGTATTCTGATAAAAGTATAGAAAAAACAAATAA
GAAATTGCAACATACAATATTAAAAAATGATCTTACAGCAAAACTAAAAGATAATGAGCAAGAAATACTTTTTGGATGTG
GCTGCTTTTGGGGGGCAGAGAAAGGCTTCTGGAGGCTTCCAGGAGTCATAACAACTGCAGTAGGCTATGCAGGAGGCGAG
AAGGAAAAACCAAACTACAGGGAGGTATGTTCTGGTCTAACAGGTCATACCGAAGTCGTGAGAGTTGTTTGGAATAACAA
TGAAATTGATCTAAGCGATCTACTAAAATTATTTTGGGAATGCCATGACCCAACACAAGGCAATCGTCAGGGAAACGATA
GTGGAAGCCAATATAGATCAGCGATTTACACGACAAGCAAAGAGCAGCTAAGTAAAGCGATAGAAAGCAAAAATAGCTAT
CAAATAGAACTACAAAATAATGGCTTTGGCATAATTACTACAGAAATAGAGAATGATATTAAATTTTATTTTGCGGAGGA
CTATCACCAACAATATTTAGCAAAGCCTGGTAGCAGACCATATTGCTCTGCGATGCCGACAAAGGTAAAATTTAAAAATT
TTAGTGGGGCAAACTTTAAACTAAATGAAAAAATTTGGTCCAACTATAATTGGGATATAACGCATTGTATTCTTAGAGGA
GAGAACACACCTATTGAATCTAATTAA

Upstream 100 bases:

>100_bases
GGTGTTGGTTTAATACTTGTATTAAGCCTCCCTTTCTTATTATTTGCATTTGTTACTACACTAATAAATCATATAAGAAT
AGAAACTATAAATTAAAGTT

Downstream 100 bases:

>100_bases
TAATGAATGATCAATTACCAGATAGAACTGTATTGCTATTAATATTAGCTACTTTGTTGTTAGTATTCTTTTTAGTGTTT
AGTTTTAAATCTGATAAAAT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIKKIIKYLTLIIDKLYSDKSIEKTNKKLQHTILKNDLTAKLKDNEQEILFGCGCFWGAEKGFWRLPGVITTAVGYAGGE
KEKPNYREVCSGLTGHTEVVRVVWNNNEIDLSDLLKLFWECHDPTQGNRQGNDSGSQYRSAIYTTSKEQLSKAIESKNSY
QIELQNNGFGIITTEIENDIKFYFAEDYHQQYLAKPGSRPYCSAMPTKVKFKNFSGANFKLNEKIWSNYNWDITHCILRG
ENTPIESN

Sequences:

>Translated_248_residues
MIKKIIKYLTLIIDKLYSDKSIEKTNKKLQHTILKNDLTAKLKDNEQEILFGCGCFWGAEKGFWRLPGVITTAVGYAGGE
KEKPNYREVCSGLTGHTEVVRVVWNNNEIDLSDLLKLFWECHDPTQGNRQGNDSGSQYRSAIYTTSKEQLSKAIESKNSY
QIELQNNGFGIITTEIENDIKFYFAEDYHQQYLAKPGSRPYCSAMPTKVKFKNFSGANFKLNEKIWSNYNWDITHCILRG
ENTPIESN
>Mature_248_residues
MIKKIIKYLTLIIDKLYSDKSIEKTNKKLQHTILKNDLTAKLKDNEQEILFGCGCFWGAEKGFWRLPGVITTAVGYAGGE
KEKPNYREVCSGLTGHTEVVRVVWNNNEIDLSDLLKLFWECHDPTQGNRQGNDSGSQYRSAIYTTSKEQLSKAIESKNSY
QIELQNNGFGIITTEIENDIKFYFAEDYHQQYLAKPGSRPYCSAMPTKVKFKNFSGANFKLNEKIWSNYNWDITHCILRG
ENTPIESN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=173, Percent_Identity=53.757225433526, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI208609995, Length=166, Percent_Identity=54.8192771084337, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI208609993, Length=102, Percent_Identity=60.7843137254902, Blast_Score=135, Evalue=2e-32,
Organism=Escherichia coli, GI1790665, Length=166, Percent_Identity=50.6024096385542, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17533973, Length=142, Percent_Identity=36.6197183098592, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=167, Percent_Identity=38.3233532934132, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24664627, Length=175, Percent_Identity=37.1428571428571, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45553131, Length=172, Percent_Identity=36.6279069767442, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24664631, Length=176, Percent_Identity=36.9318181818182, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 28460; Mature: 28460

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIIKYLTLIIDKLYSDKSIEKTNKKLQHTILKNDLTAKLKDNEQEILFGCGCFWGAE
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEHCCCC
KGFWRLPGVITTAVGYAGGEKEKPNYREVCSGLTGHTEVVRVVWNNNEIDLSDLLKLFWE
CCCEECCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
CHDPTQGNRQGNDSGSQYRSAIYTTSKEQLSKAIESKNSYQIELQNNGFGIITTEIENDI
CCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCE
KFYFAEDYHQQYLAKPGSRPYCSAMPTKVKFKNFSGANFKLNEKIWSNYNWDITHCILRG
EEEEHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEECHHHHCCCCCCEEEEEEEC
ENTPIESN
CCCCCCCC
>Mature Secondary Structure
MIKKIIKYLTLIIDKLYSDKSIEKTNKKLQHTILKNDLTAKLKDNEQEILFGCGCFWGAE
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEEEEHCCCC
KGFWRLPGVITTAVGYAGGEKEKPNYREVCSGLTGHTEVVRVVWNNNEIDLSDLLKLFWE
CCCEECCHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHH
CHDPTQGNRQGNDSGSQYRSAIYTTSKEQLSKAIESKNSYQIELQNNGFGIITTEIENDI
CCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEEEEEECCCE
KFYFAEDYHQQYLAKPGSRPYCSAMPTKVKFKNFSGANFKLNEKIWSNYNWDITHCILRG
EEEEHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCEEECHHHHCCCCCCEEEEEEEC
ENTPIESN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA