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The map label for this gene is pyrC [H]

Identifier: 124025335

GI number: 124025335

Start: 568193

End: 569257

Strand: Direct

Name: pyrC [H]

Synonym: NATL1_06241

Alternate gene names: 124025335

Gene position: 568193-569257 (Clockwise)

Preceding gene: 124025333

Following gene: 124025336

Centisome position: 30.47

GC content: 36.71

Gene sequence:

>1065_bases
GTGATTGCTTCTGTTAATCAAATCTCATTATTAAAGCCGGATGATTGGCATCTGCATTTGAGAGATGGAAAGATTCTTAA
AGGTGTTTTAAGTCATACAGCAGATGTGTTTTGCCGTGCAATCATCATGCCTAATCTTGATCCGCCAATAACTACTTTAA
GCCAAGCACAAGAGTATAAAAAAAGAATTATCCAGTCTATCCCTGAAGGTGTTTCTTTTACCCCATTAATGACAGCATAT
CTTACAGATGATATGCCTGCGAATGTTTTAGAGAGAGGCTTTAGAGAAGGTGTCTTTCATGGGGCAAAGCTCTATCCAGC
TAATGTGACAACTAATTCTTCTTATGGGGTTACAGATATAAGTAAAGTCGGCAATTTATTTGAGACGATGGAAAGAATTG
GTATGCCATTATTGATTCATGGAGAAGTGACCGATTTCAATGTTGATGTATTTGATAGAGAAGCTGTTTTTATTGAGCGT
CACCTTGAACCACTATTACGAACATTTTCATCACTTAAAGTGGTTTTAGAACACATCACGACCATAGATGCAATTGACTT
TGTAGAAAACAGTGAGTTTGATATAGCCGCTACAATCACACCTCATCATCTACATATCAATCGAAACGCAATGTTCAATG
GTGGTTTAAGGAGTGATTTTTATTGCTTACCCACAGCTAAACGTGAAATCCATCGTATTGCTCTAAGACAAGCGGCTACT
AGCGGTAAAACTTGCTTTTTCCTTGGAACTGATTCAGCACCTCATACCCGTAGATTTAAGGAAAGTTCATGTGGATGTGC
AGGAATCTTTAATGCCCCTTTCGCTTTGGAAAGCTATTTAAAAGTTTTCGAAGAAGAAAATGCCCTAGATAGGTTTGAAG
CTTTTTCAAGTATTAATGGAGCAACTTTTTATGGATTACCTTTAAACACAGAGAGAATAACTTTAATTAGAAAAGATATT
TCCGTACCTCAAATGATTGATGTTGGATTAGATGGTAATCCCAATGATTTTGTAAAACCATTTCATTCAGGAGAAACTCT
TAGCTGGGCAATAAAGGATGTTTAG

Upstream 100 bases:

>100_bases
TTTCCATTTGGTATTATCTTAATATCTTAGCCCTTTATGGATACTTGAAGACTTATAGATCAAGATTGCATAAGATATAT
ATTGAAAAAGCTTTAATCCT

Downstream 100 bases:

>100_bases
TGAGATTGCTGATCCTTATGTAAAACAATTTGATTTAATGACTTTTGGTGGATGGAAAACTTTATAAGCTGTGCAAGTTT
ATTTACATACGAATATCCAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MIASVNQISLLKPDDWHLHLRDGKILKGVLSHTADVFCRAIIMPNLDPPITTLSQAQEYKKRIIQSIPEGVSFTPLMTAY
LTDDMPANVLERGFREGVFHGAKLYPANVTTNSSYGVTDISKVGNLFETMERIGMPLLIHGEVTDFNVDVFDREAVFIER
HLEPLLRTFSSLKVVLEHITTIDAIDFVENSEFDIAATITPHHLHINRNAMFNGGLRSDFYCLPTAKREIHRIALRQAAT
SGKTCFFLGTDSAPHTRRFKESSCGCAGIFNAPFALESYLKVFEEENALDRFEAFSSINGATFYGLPLNTERITLIRKDI
SVPQMIDVGLDGNPNDFVKPFHSGETLSWAIKDV

Sequences:

>Translated_354_residues
MIASVNQISLLKPDDWHLHLRDGKILKGVLSHTADVFCRAIIMPNLDPPITTLSQAQEYKKRIIQSIPEGVSFTPLMTAY
LTDDMPANVLERGFREGVFHGAKLYPANVTTNSSYGVTDISKVGNLFETMERIGMPLLIHGEVTDFNVDVFDREAVFIER
HLEPLLRTFSSLKVVLEHITTIDAIDFVENSEFDIAATITPHHLHINRNAMFNGGLRSDFYCLPTAKREIHRIALRQAAT
SGKTCFFLGTDSAPHTRRFKESSCGCAGIFNAPFALESYLKVFEEENALDRFEAFSSINGATFYGLPLNTERITLIRKDI
SVPQMIDVGLDGNPNDFVKPFHSGETLSWAIKDV
>Mature_354_residues
MIASVNQISLLKPDDWHLHLRDGKILKGVLSHTADVFCRAIIMPNLDPPITTLSQAQEYKKRIIQSIPEGVSFTPLMTAY
LTDDMPANVLERGFREGVFHGAKLYPANVTTNSSYGVTDISKVGNLFETMERIGMPLLIHGEVTDFNVDVFDREAVFIER
HLEPLLRTFSSLKVVLEHITTIDAIDFVENSEFDIAATITPHHLHINRNAMFNGGLRSDFYCLPTAKREIHRIALRQAAT
SGKTCFFLGTDSAPHTRRFKESSCGCAGIFNAPFALESYLKVFEEENALDRFEAFSSINGATFYGLPLNTERITLIRKDI
SVPQMIDVGLDGNPNDFVKPFHSGETLSWAIKDV

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=353, Percent_Identity=55.8073654390935, Blast_Score=406, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6323452, Length=370, Percent_Identity=34.0540540540541, Blast_Score=188, Evalue=1e-48,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 39623; Mature: 39623

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIASVNQISLLKPDDWHLHLRDGKILKGVLSHTADVFCRAIIMPNLDPPITTLSQAQEYK
CCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KRIIQSIPEGVSFTPLMTAYLTDDMPANVLERGFREGVFHGAKLYPANVTTNSSYGVTDI
HHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECEEECCCCCCCCHH
SKVGNLFETMERIGMPLLIHGEVTDFNVDVFDREAVFIERHLEPLLRTFSSLKVVLEHIT
HHHHHHHHHHHHHCCCEEEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIDAIDFVENSEFDIAATITPHHLHINRNAMFNGGLRSDFYCLPTAKREIHRIALRQAAT
HHHHHHHCCCCCCEEEEEECCEEEEECCCCEECCCCCCCEEECCCHHHHHHHHHHHHHCC
SGKTCFFLGTDSAPHTRRFKESSCGCAGIFNAPFALESYLKVFEEENALDRFEAFSSING
CCCEEEEEECCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCC
ATFYGLPLNTERITLIRKDISVPQMIDVGLDGNPNDFVKPFHSGETLSWAIKDV
CEEEECCCCCCEEEEEECCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MIASVNQISLLKPDDWHLHLRDGKILKGVLSHTADVFCRAIIMPNLDPPITTLSQAQEYK
CCCCCCCEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KRIIQSIPEGVSFTPLMTAYLTDDMPANVLERGFREGVFHGAKLYPANVTTNSSYGVTDI
HHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEECEEECCCCCCCCHH
SKVGNLFETMERIGMPLLIHGEVTDFNVDVFDREAVFIERHLEPLLRTFSSLKVVLEHIT
HHHHHHHHHHHHHCCCEEEECCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIDAIDFVENSEFDIAATITPHHLHINRNAMFNGGLRSDFYCLPTAKREIHRIALRQAAT
HHHHHHHCCCCCCEEEEEECCEEEEECCCCEECCCCCCCEEECCCHHHHHHHHHHHHHCC
SGKTCFFLGTDSAPHTRRFKESSCGCAGIFNAPFALESYLKVFEEENALDRFEAFSSING
CCCEEEEEECCCCCCHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHCCCC
ATFYGLPLNTERITLIRKDISVPQMIDVGLDGNPNDFVKPFHSGETLSWAIKDV
CEEEECCCCCCEEEEEECCCCCCCEEEECCCCCCHHHCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA