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The map label for this gene is cyoE

Identifier: 124025213

GI number: 124025213

Start: 457511

End: 458506

Strand: Direct

Name: cyoE

Synonym: NATL1_05021

Alternate gene names: 124025213

Gene position: 457511-458506 (Clockwise)

Preceding gene: 124025212

Following gene: 124025214

Centisome position: 24.53

GC content: 41.06

Gene sequence:

>996_bases
ATGGTTAGCTCTACATCAGAATTAATTACACAGCCTGTTAATCGTGAGGAAGTAGTTCCTTCTAGAAAGCGTATTAAACT
GCCAGCCTGGCTAGAAGTCGTCAAACCAAGATTAATTCCTCTTTTACTCGCAACAACTGTTGGAGGAATGGCTCTCTCGG
AGGAATGGCCTTTACCCTCTCCAAGATTGGCATGCACTTTAGGAGGAGGAGCCCTTGCTGCTGCGGCTGCAGGAGCTCTT
AATTGCTTATGGGAACAAGATCTTGATAAGCGAATGAAACGAACCAGTAATAGAGCATTACCTTCTGGTCGCCTTTCTCA
GTCTTCTGTTTTTATTGGAGCAGTTGCTTGTACACTTGTTTCTTCAGCCCTTTTAGTAAGTGGAGTTAACTGTTTAGCAG
CGGGACTTACTCTTTTAGGACTTTGTAGTTACGTACTTCTCTATACAGCGTTCTTAAAACCTAGAACATCTCAAAATATA
GTTTTTGGAGGTGTCGCTGGAGCAATTCCCCCTCTTGTAGGAGCTTCAGCAGCGGCAGGACATATTGGGTTAGGTGGTTG
GTGGCTATTCTCTTTGGTTATGGTGTGGACCCCAGCACATTTTTGGGCTTTGGCCATCTTGTTGAAAGAGGACTATCGAT
CTGTTGGCATTCCTATGCTTCCTACAGTAAGTGGACCTTTTGTTACAGCTAAGGCTATCTCTGTGTATGGCTATCTAACT
GTATTTTTAAGCTTTTTAGGGTGCTTCGTTTTACCTGAAGGAGGTTTGTTATACGGAATTTTGTTGCTACCTTATAATTC
AAGACTTCTTCAATTGGTTTCCAGATTAAGAGATAATCCCGAAGATTTAGATCGTGCGAAGGGTTTATTTCGATGGTCTA
TTCTTTACATGTTTGGGGTTTGTTTTTTGCTGGTTATTAGTAGATTACAAGTGTCAATTGTTTTTAATGATCAGTTGATA
GCTTTAATTAAAGACTTCTCTATCGGATTTTCGTAA

Upstream 100 bases:

>100_bases
TTGTTAGTTGCCGTAATAGCAGCCTTGAATTTTAAAGGTCGAGGAAATGATGACTCTTCCCAATCACTTTATATAAATCA
ATCAACATTGGAGACATGTC

Downstream 100 bases:

>100_bases
ATCTATAAAATAAAAATAAAAACTTTATGAACTTGCTCTCCAAAATTAATTAGAATTTGTTAGAAGATATCAGCTTATCT
TTTTAGGCAATTTATTCCTA

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MVSSTSELITQPVNREEVVPSRKRIKLPAWLEVVKPRLIPLLLATTVGGMALSEEWPLPSPRLACTLGGGALAAAAAGAL
NCLWEQDLDKRMKRTSNRALPSGRLSQSSVFIGAVACTLVSSALLVSGVNCLAAGLTLLGLCSYVLLYTAFLKPRTSQNI
VFGGVAGAIPPLVGASAAAGHIGLGGWWLFSLVMVWTPAHFWALAILLKEDYRSVGIPMLPTVSGPFVTAKAISVYGYLT
VFLSFLGCFVLPEGGLLYGILLLPYNSRLLQLVSRLRDNPEDLDRAKGLFRWSILYMFGVCFLLVISRLQVSIVFNDQLI
ALIKDFSIGFS

Sequences:

>Translated_331_residues
MVSSTSELITQPVNREEVVPSRKRIKLPAWLEVVKPRLIPLLLATTVGGMALSEEWPLPSPRLACTLGGGALAAAAAGAL
NCLWEQDLDKRMKRTSNRALPSGRLSQSSVFIGAVACTLVSSALLVSGVNCLAAGLTLLGLCSYVLLYTAFLKPRTSQNI
VFGGVAGAIPPLVGASAAAGHIGLGGWWLFSLVMVWTPAHFWALAILLKEDYRSVGIPMLPTVSGPFVTAKAISVYGYLT
VFLSFLGCFVLPEGGLLYGILLLPYNSRLLQLVSRLRDNPEDLDRAKGLFRWSILYMFGVCFLLVISRLQVSIVFNDQLI
ALIKDFSIGFS
>Mature_331_residues
MVSSTSELITQPVNREEVVPSRKRIKLPAWLEVVKPRLIPLLLATTVGGMALSEEWPLPSPRLACTLGGGALAAAAAGAL
NCLWEQDLDKRMKRTSNRALPSGRLSQSSVFIGAVACTLVSSALLVSGVNCLAAGLTLLGLCSYVLLYTAFLKPRTSQNI
VFGGVAGAIPPLVGASAAAGHIGLGGWWLFSLVMVWTPAHFWALAILLKEDYRSVGIPMLPTVSGPFVTAKAISVYGYLT
VFLSFLGCFVLPEGGLLYGILLLPYNSRLLQLVSRLRDNPEDLDRAKGLFRWSILYMFGVCFLLVISRLQVSIVFNDQLI
ALIKDFSIGFS

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=192, Percent_Identity=35.9375, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1786631, Length=207, Percent_Identity=31.4009661835749, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71998235, Length=269, Percent_Identity=29.368029739777, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6325085, Length=240, Percent_Identity=27.9166666666667, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19921064, Length=284, Percent_Identity=29.5774647887324, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_PROM1 (A2C0Q4)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014329.1
- STRING:   A2C0Q4
- GeneID:   4780948
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_05021
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   MALTEEW
- ProtClustDB:   PRK04375
- BioCyc:   PMAR167555:NATL1_05021-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 35656; Mature: 35656

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1f943e34)-; HASH(0x1feed694)-; HASH(0x1feed580)-; HASH(0x1fcf6f94)-; HASH(0x1feea7d4)-; HASH(0x1fee73c0)-; HASH(0x1fee73d8)-; HASH(0x1f4feea4)-;

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSSTSELITQPVNREEVVPSRKRIKLPAWLEVVKPRLIPLLLATTVGGMALSEEWPLPS
CCCCCHHHHHCCCCHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
PRLACTLGGGALAAAAAGALNCLWEQDLDKRMKRTSNRALPSGRLSQSSVFIGAVACTLV
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SSALLVSGVNCLAAGLTLLGLCSYVLLYTAFLKPRTSQNIVFGGVAGAIPPLVGASAAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHCCCCCCC
HIGLGGWWLFSLVMVWTPAHFWALAILLKEDYRSVGIPMLPTVSGPFVTAKAISVYGYLT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
VFLSFLGCFVLPEGGLLYGILLLPYNSRLLQLVSRLRDNPEDLDRAKGLFRWSILYMFGV
HHHHHHHHHHCCCCCCEEEHEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
CFLLVISRLQVSIVFNDQLIALIKDFSIGFS
HHHHHHHHHHEEEEECCHHHHHHHHHCCCCH
>Mature Secondary Structure
MVSSTSELITQPVNREEVVPSRKRIKLPAWLEVVKPRLIPLLLATTVGGMALSEEWPLPS
CCCCCHHHHHCCCCHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCC
PRLACTLGGGALAAAAAGALNCLWEQDLDKRMKRTSNRALPSGRLSQSSVFIGAVACTLV
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
SSALLVSGVNCLAAGLTLLGLCSYVLLYTAFLKPRTSQNIVFGGVAGAIPPLVGASAAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHCCCCCCC
HIGLGGWWLFSLVMVWTPAHFWALAILLKEDYRSVGIPMLPTVSGPFVTAKAISVYGYLT
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
VFLSFLGCFVLPEGGLLYGILLLPYNSRLLQLVSRLRDNPEDLDRAKGLFRWSILYMFGV
HHHHHHHHHHCCCCCCEEEHEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
CFLLVISRLQVSIVFNDQLIALIKDFSIGFS
HHHHHHHHHHEEEEECCHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA