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The map label for this gene is pth

Identifier: 124025041

GI number: 124025041

Start: 303458

End: 304066

Strand: Reverse

Name: pth

Synonym: NATL1_03281

Alternate gene names: 124025041

Gene position: 304066-303458 (Counterclockwise)

Preceding gene: 124025042

Following gene: 124025040

Centisome position: 16.31

GC content: 32.84

Gene sequence:

>609_bases
ATGTTGTCTGATGAATTAAAATTATTAGTTGGCTTAGGCAATCCTGGGACTGAGTACGAAAAAACTCGTCATAATGTTGG
ATTTATGGTGCTAGAAGAAATCGCAAGAAAAAATAATTGTAGCTTTCGTGAAAGCAAAAAAATTTTTGGTAGAACTTGTG
AATACGGGTCAGGTATCGAAAAAACAAGGCTTTTAATGCCCAACACATACATGAATGAAAGTGGAAAATCAGTAAGATTA
GCAAAGGATTGGTTTAATTTTCAAAATAATCAATTAATAGTCCTAGTAGATGACATGGATCTCCCACTAGGGAAAATAAG
AGTCCGCTCTAAAGGGAGTTCAGGAGGTCATAATGGATTAAAAAGCATTATCAATCATCTTGGTACTGCTGAGTTTAAGC
GATTAAAGATTGGGATAGGAGCACCAAGCAACGATCAACAAGAGAGAAAATCTAAAACTGTTTCTCACGTTTTAGGTAGA
TTTTCAAAAGAAGAATTCATAATATTAAATTTCATCATTCAGGAAATAATTAGTTGTATTGAATCAATCACATCTAATAA
TTGGGAAAAGATATCTACTCGACTAAATTCTTACAAACCTGACAATTAA

Upstream 100 bases:

>100_bases
GAGTCTGCAAATGAAAACATTGTGGACAAAGAAAATTAATTTCCCCAAAACTAATTAAATATTTAACTATTAAAATCAAC
AACAATTGTGTTTGATTGAT

Downstream 100 bases:

>100_bases
TAATTTTAGGAAAATGTATAACAAGCCATCAACTACTGCATATCTTCAAATTCATAAGCAATGCTTTAATCAAAAAAAAG
TAGAAGGAATTGTCCGTGCA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MLSDELKLLVGLGNPGTEYEKTRHNVGFMVLEEIARKNNCSFRESKKIFGRTCEYGSGIEKTRLLMPNTYMNESGKSVRL
AKDWFNFQNNQLIVLVDDMDLPLGKIRVRSKGSSGGHNGLKSIINHLGTAEFKRLKIGIGAPSNDQQERKSKTVSHVLGR
FSKEEFIILNFIIQEIISCIESITSNNWEKISTRLNSYKPDN

Sequences:

>Translated_202_residues
MLSDELKLLVGLGNPGTEYEKTRHNVGFMVLEEIARKNNCSFRESKKIFGRTCEYGSGIEKTRLLMPNTYMNESGKSVRL
AKDWFNFQNNQLIVLVDDMDLPLGKIRVRSKGSSGGHNGLKSIINHLGTAEFKRLKIGIGAPSNDQQERKSKTVSHVLGR
FSKEEFIILNFIIQEIISCIESITSNNWEKISTRLNSYKPDN
>Mature_202_residues
MLSDELKLLVGLGNPGTEYEKTRHNVGFMVLEEIARKNNCSFRESKKIFGRTCEYGSGIEKTRLLMPNTYMNESGKSVRL
AKDWFNFQNNQLIVLVDDMDLPLGKIRVRSKGSSGGHNGLKSIINHLGTAEFKRLKIGIGAPSNDQQERKSKTVSHVLGR
FSKEEFIILNFIIQEIISCIESITSNNWEKISTRLNSYKPDN

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=175, Percent_Identity=32, Blast_Score=95, Evalue=5e-20,
Organism=Escherichia coli, GI1787455, Length=195, Percent_Identity=39.4871794871795, Blast_Score=124, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321983, Length=168, Percent_Identity=30.952380952381, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_PROM1 (A2C082)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001014157.1
- ProteinModelPortal:   A2C082
- SMR:   A2C082
- STRING:   A2C082
- GeneID:   4780618
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_03281
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   PMAR167555:NATL1_03281-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 22899; Mature: 22899

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSDELKLLVGLGNPGTEYEKTRHNVGFMVLEEIARKNNCSFRESKKIFGRTCEYGSGIE
CCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCC
KTRLLMPNTYMNESGKSVRLAKDWFNFQNNQLIVLVDDMDLPLGKIRVRSKGSSGGHNGL
HHEEECCCCCCCCCCCEEEEHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHH
KSIINHLGTAEFKRLKIGIGAPSNDQQERKSKTVSHVLGRFSKEEFIILNFIIQEIISCI
HHHHHHHCCHHEHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ESITSNNWEKISTRLNSYKPDN
HHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLSDELKLLVGLGNPGTEYEKTRHNVGFMVLEEIARKNNCSFRESKKIFGRTCEYGSGIE
CCCCCEEEEEECCCCCCHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCC
KTRLLMPNTYMNESGKSVRLAKDWFNFQNNQLIVLVDDMDLPLGKIRVRSKGSSGGHNGL
HHEEECCCCCCCCCCCEEEEHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCCCCCHHHH
KSIINHLGTAEFKRLKIGIGAPSNDQQERKSKTVSHVLGRFSKEEFIILNFIIQEIISCI
HHHHHHHCCHHEHEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ESITSNNWEKISTRLNSYKPDN
HHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA