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The map label for this gene is hisC [H]

Identifier: 124024974

GI number: 124024974

Start: 238509

End: 239624

Strand: Reverse

Name: hisC [H]

Synonym: NATL1_02611

Alternate gene names: 124024974

Gene position: 239624-238509 (Counterclockwise)

Preceding gene: 124024975

Following gene: 124024967

Centisome position: 12.85

GC content: 35.93

Gene sequence:

>1116_bases
ATGGAAAACATAGAAAATTCATTTGTTGATCTACCAAACCCCAGGAAAGATATCGAGGATTTACAGCCATATTCAGCACC
ACTGGAAGGAAGACGAAATTTACTAAGACTAGACTTTAATGAAAACACTATTGGACCAAGCCCACTAGTACTTAAATCTC
TCAGAGAAATAAGCAGAGATGAAATCTCTGTTTATCCTGAATACTCAGGTTTAAAAGAAAAAGTAGTAGAGAGTCTCATC
AAAAAAAATTCAAATGTGAATATCAACTCATCTGAAGTTGGTATTTTTAATGGAGTAGATGCAGCAATAAATGCTATTTT
TCACGCATATGGCAACTTTGATGATCTAATGCTAACAACATCGCCTACTTTTGGATATTATACTCCTTGCGCACAAATGC
GAGGAATGCAAATCAAAGCAATACCTTATGAGGGAGGGGGATTTCAATATCCATTTGATAGTATTTGCGAATTCCTCACG
CAAAATAATCCGAAAATTTTACTCATCTGCAACCCCAATAACCCCACTGGAACAAGATTAAGCCCAGAAAGAATTATAGA
AATCAGCAAACTTTCATCTAAAACACTCGTTGTTGTGGATGAACTTTACGAGGCGTTTACAGGTGATAGTGTTCTGCCAT
TTGTAAATTTCCAAACAACACCTAATCTTGTTGTATTAAGATCGCTTTCTAAAACAGCTGGTTTAGCAAGTCTAAGAATT
GGATTTGCTATTGGTCATTCTAAAGTAATTAATATAGTTAATAGAGTTACTGGTCCTTATGACGTCAACAGCTTTGCCGT
GATCGCTGCTTTTGCAGCACTTAAAGATCAATCTTATATTGACTCATATGTACAGGAAGTGCTTGAGGCTCGTAATTGGA
TCAAGGATCAATTCGAGAAGCACCACGTCAAGCATCATATTGACGGAGGAAACTATTTTCTACTTTGGCCAAAATCAAAA
CCACAACAAGTTGAGCAAAAGCTAAAATCATCTGGAATTCTAATTAGAAATATGGATAAGAAAAAAAATTTAAAAGGCTC
TATCAGAGTGAGCATAGGAACCATTGACCAAATGAAAAGATTCTGGTCAGCTTTCAGAATTGTCGACGAAGTATAG

Upstream 100 bases:

>100_bases
AACCTTCAAGAGCCAGTAGACTTGTTTTATGCTCTATCACTGCAGATACACTTAAACTGGGGATGAGTTTGCTAGGCATC
CCCACTCTGGAGAGAATGTA

Downstream 100 bases:

>100_bases
CTCAAATAATTTGATAACGTCTACAAAGCATAAGACAATCTAGGTAGCTTTTGCTATATCTAGGAAATTAGAAAGTAGCT
TATGACCAGCTTCAGTTAAT

Product: aminotransferases class-I

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MENIENSFVDLPNPRKDIEDLQPYSAPLEGRRNLLRLDFNENTIGPSPLVLKSLREISRDEISVYPEYSGLKEKVVESLI
KKNSNVNINSSEVGIFNGVDAAINAIFHAYGNFDDLMLTTSPTFGYYTPCAQMRGMQIKAIPYEGGGFQYPFDSICEFLT
QNNPKILLICNPNNPTGTRLSPERIIEISKLSSKTLVVVDELYEAFTGDSVLPFVNFQTTPNLVVLRSLSKTAGLASLRI
GFAIGHSKVINIVNRVTGPYDVNSFAVIAAFAALKDQSYIDSYVQEVLEARNWIKDQFEKHHVKHHIDGGNYFLLWPKSK
PQQVEQKLKSSGILIRNMDKKKNLKGSIRVSIGTIDQMKRFWSAFRIVDEV

Sequences:

>Translated_371_residues
MENIENSFVDLPNPRKDIEDLQPYSAPLEGRRNLLRLDFNENTIGPSPLVLKSLREISRDEISVYPEYSGLKEKVVESLI
KKNSNVNINSSEVGIFNGVDAAINAIFHAYGNFDDLMLTTSPTFGYYTPCAQMRGMQIKAIPYEGGGFQYPFDSICEFLT
QNNPKILLICNPNNPTGTRLSPERIIEISKLSSKTLVVVDELYEAFTGDSVLPFVNFQTTPNLVVLRSLSKTAGLASLRI
GFAIGHSKVINIVNRVTGPYDVNSFAVIAAFAALKDQSYIDSYVQEVLEARNWIKDQFEKHHVKHHIDGGNYFLLWPKSK
PQQVEQKLKSSGILIRNMDKKKNLKGSIRVSIGTIDQMKRFWSAFRIVDEV
>Mature_371_residues
MENIENSFVDLPNPRKDIEDLQPYSAPLEGRRNLLRLDFNENTIGPSPLVLKSLREISRDEISVYPEYSGLKEKVVESLI
KKNSNVNINSSEVGIFNGVDAAINAIFHAYGNFDDLMLTTSPTFGYYTPCAQMRGMQIKAIPYEGGGFQYPFDSICEFLT
QNNPKILLICNPNNPTGTRLSPERIIEISKLSSKTLVVVDELYEAFTGDSVLPFVNFQTTPNLVVLRSLSKTAGLASLRI
GFAIGHSKVINIVNRVTGPYDVNSFAVIAAFAALKDQSYIDSYVQEVLEARNWIKDQFEKHHVKHHIDGGNYFLLWPKSK
PQQVEQKLKSSGILIRNMDKKKNLKGSIRVSIGTIDQMKRFWSAFRIVDEV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=358, Percent_Identity=26.536312849162, Blast_Score=117, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=25.7894736842105, Blast_Score=122, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41772; Mature: 41772

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENIENSFVDLPNPRKDIEDLQPYSAPLEGRRNLLRLDFNENTIGPSPLVLKSLREISRD
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCC
EISVYPEYSGLKEKVVESLIKKNSNVNINSSEVGIFNGVDAAINAIFHAYGNFDDLMLTT
CEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEE
SPTFGYYTPCAQMRGMQIKAIPYEGGGFQYPFDSICEFLTQNNPKILLICNPNNPTGTRL
CCCCCCCCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCC
SPERIIEISKLSSKTLVVVDELYEAFTGDSVLPFVNFQTTPNLVVLRSLSKTAGLASLRI
CHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHHHHCCHHHEEE
GFAIGHSKVINIVNRVTGPYDVNSFAVIAAFAALKDQSYIDSYVQEVLEARNWIKDQFEK
EHEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
HHVKHHIDGGNYFLLWPKSKPQQVEQKLKSSGILIRNMDKKKNLKGSIRVSIGTIDQMKR
HHHHEEECCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCHHHHHH
FWSAFRIVDEV
HHHHHHHHHCC
>Mature Secondary Structure
MENIENSFVDLPNPRKDIEDLQPYSAPLEGRRNLLRLDFNENTIGPSPLVLKSLREISRD
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHCCC
EISVYPEYSGLKEKVVESLIKKNSNVNINSSEVGIFNGVDAAINAIFHAYGNFDDLMLTT
CEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEE
SPTFGYYTPCAQMRGMQIKAIPYEGGGFQYPFDSICEFLTQNNPKILLICNPNNPTGTRL
CCCCCCCCCHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCC
SPERIIEISKLSSKTLVVVDELYEAFTGDSVLPFVNFQTTPNLVVLRSLSKTAGLASLRI
CHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHHHHCCHHHEEE
GFAIGHSKVINIVNRVTGPYDVNSFAVIAAFAALKDQSYIDSYVQEVLEARNWIKDQFEK
EHEECHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
HHVKHHIDGGNYFLLWPKSKPQQVEQKLKSSGILIRNMDKKKNLKGSIRVSIGTIDQMKR
HHHHEEECCCCEEEECCCCCHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCHHHHHH
FWSAFRIVDEV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA