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The map label for this gene is strD [H]

Identifier: 124024937

GI number: 124024937

Start: 209881

End: 211059

Strand: Direct

Name: strD [H]

Synonym: NATL1_02241

Alternate gene names: 124024937

Gene position: 209881-211059 (Clockwise)

Preceding gene: 124024936

Following gene: 124024939

Centisome position: 11.26

GC content: 37.4

Gene sequence:

>1179_bases
ATGAAGGCGATGATCCTAGCTGCTGGGAAAGGAACCCGAGTTCAGCCGATCACGCATGTGATTCCAAAGCCAATGATTCC
TATCCTTCAGAAACCTGTAATGGAGTTTCTGTTGGAACTCCTTAAGGAGCATGGTTTTACTGAGGTTATGGTCAATGTTT
CCCATTTAGCAGAAGAAATAGAAAATTATTTTCGAGATGGACAAAGATTTGGAGTTGAAATTGCATACAGCTTTGAAGGT
CGTATTGAAGACGGAGAATTAATTGGGGATGCACTTGGATCAGCGGGCGGTCTGAAAAAAATTCAAGATTTTCAAAAGTT
TTTTGATGATACTTTTGTCGTCCTCTGTGGAGATGCACTCATTGATTTGGATTTATCTGAAGCAGTAAAACGACATAAAG
AAAAAGGTGCTTTGGCTAGTTTGATTACTAAACGTGTCTCAAAAGATCAAGTAAGTAGTTATGGCGTTGTTGTAACTGAT
GAAGAAGATCGAGTTAAAGCTTTTCAAGAAAAACCTTCTATAGATAATGCGCTAGGCGATACGATTAATACTGGAATTTA
TTTATTTGAGCCAGAGATTTTTAATTATATTCCATCTGGAAAACCCTTTGATATTGGCTCAGATTTGTTTCCAAAACTAG
TAGAGGAAGGAGCACCTTTCTATGCCTTACCGATGGATTTTGAGTGGGTTGATATTGGTAAAGTACCAGATTATTGGAGA
GCAATCAGGAATGTACTTAAAGGTGATGTTAGACAGGTTGAAATTCCAGGAAAGCAAGTAAGACCAGGAATCTATACAGG
TTTAAATGTTGCAGCTAATTGGGATAAAATAAATGTTAAAGGACCTATATATGTTGGTGGAATGACAAGGATTGAAGATG
GTGTAACTATCGTTGGTCCTTCTATGATTGGTCCGAGTTGTTGTATTTGTGAAGGTGCAACAATTGATAATTCAATAATC
TTTGATTATTCATTAATTGGGCCAGGAGTTCAACTTGTGGAGAAGTTAGTCTTTGGTAGATATTGTGTTGGTAAAGAAGG
GGATCACTTTGATTTACAGGAAGCTGCTTTGGATTGGTTAATAACTGATGCTAGAAGACAGGACTTAGGTGAACCGTCAC
CTCAACAAAAAGCAATGGCTGAATTATTAGGTACAGATCTGATTGGTTCTTCTAATTAA

Upstream 100 bases:

>100_bases
TCGCTTCTTTAGACGTGACAGATGTCTCGCCGGCTGCTGCTTAGCTCTTTGTGGAGGCAGCATTCTATGTTGGCCTTGTT
GAGATTAGGTTAAACCGCCT

Downstream 100 bases:

>100_bases
TATTTGCTCTATCTAAAATTATCGGTATTTGTTGTTCTGCTTTAACGGCCATAAGATGAACTCCCTGAGCAATCCCTAGA
AAACTTTTTACTTGGTCAGC

Product: putative sugar-phosphate nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFTEVMVNVSHLAEEIENYFRDGQRFGVEIAYSFEG
RIEDGELIGDALGSAGGLKKIQDFQKFFDDTFVVLCGDALIDLDLSEAVKRHKEKGALASLITKRVSKDQVSSYGVVVTD
EEDRVKAFQEKPSIDNALGDTINTGIYLFEPEIFNYIPSGKPFDIGSDLFPKLVEEGAPFYALPMDFEWVDIGKVPDYWR
AIRNVLKGDVRQVEIPGKQVRPGIYTGLNVAANWDKINVKGPIYVGGMTRIEDGVTIVGPSMIGPSCCICEGATIDNSII
FDYSLIGPGVQLVEKLVFGRYCVGKEGDHFDLQEAALDWLITDARRQDLGEPSPQQKAMAELLGTDLIGSSN

Sequences:

>Translated_392_residues
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFTEVMVNVSHLAEEIENYFRDGQRFGVEIAYSFEG
RIEDGELIGDALGSAGGLKKIQDFQKFFDDTFVVLCGDALIDLDLSEAVKRHKEKGALASLITKRVSKDQVSSYGVVVTD
EEDRVKAFQEKPSIDNALGDTINTGIYLFEPEIFNYIPSGKPFDIGSDLFPKLVEEGAPFYALPMDFEWVDIGKVPDYWR
AIRNVLKGDVRQVEIPGKQVRPGIYTGLNVAANWDKINVKGPIYVGGMTRIEDGVTIVGPSMIGPSCCICEGATIDNSII
FDYSLIGPGVQLVEKLVFGRYCVGKEGDHFDLQEAALDWLITDARRQDLGEPSPQQKAMAELLGTDLIGSSN
>Mature_392_residues
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFTEVMVNVSHLAEEIENYFRDGQRFGVEIAYSFEG
RIEDGELIGDALGSAGGLKKIQDFQKFFDDTFVVLCGDALIDLDLSEAVKRHKEKGALASLITKRVSKDQVSSYGVVVTD
EEDRVKAFQEKPSIDNALGDTINTGIYLFEPEIFNYIPSGKPFDIGSDLFPKLVEEGAPFYALPMDFEWVDIGKVPDYWR
AIRNVLKGDVRQVEIPGKQVRPGIYTGLNVAANWDKINVKGPIYVGGMTRIEDGVTIVGPSMIGPSCCICEGATIDNSII
FDYSLIGPGVQLVEKLVFGRYCVGKEGDHFDLQEAALDWLITDARRQDLGEPSPQQKAMAELLGTDLIGSSN

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=332, Percent_Identity=28.9156626506024, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI11761621, Length=332, Percent_Identity=28.9156626506024, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789837, Length=266, Percent_Identity=26.3157894736842, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=359, Percent_Identity=29.8050139275766, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17509979, Length=357, Percent_Identity=25.2100840336134, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17509981, Length=346, Percent_Identity=24.5664739884393, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=329, Percent_Identity=28.8753799392097, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI21355443, Length=346, Percent_Identity=29.7687861271676, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24644084, Length=346, Percent_Identity=29.7687861271676, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24653912, Length=208, Percent_Identity=27.4038461538462, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 43237; Mature: 43237

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFTEVMVNVSHLAEEI
CCEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ENYFRDGQRFGVEIAYSFEGRIEDGELIGDALGSAGGLKKIQDFQKFFDDTFVVLCGDAL
HHHHHCCHHCCEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCHH
IDLDLSEAVKRHKEKGALASLITKRVSKDQVSSYGVVVTDEEDRVKAFQEKPSIDNALGD
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCHHHHCH
TINTGIYLFEPEIFNYIPSGKPFDIGSDLFPKLVEEGAPFYALPMDFEWVDIGKVPDYWR
HHHCCEEEECHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEEECCCCCHHHH
AIRNVLKGDVRQVEIPGKQVRPGIYTGLNVAANWDKINVKGPIYVGGMTRIEDGVTIVGP
HHHHHHCCCCEEEECCCCCCCCCCEECCCEEECCCEEECCCCEEECCCEECCCCEEEECC
SMIGPSCCICEGATIDNSIIFDYSLIGPGVQLVEKLVFGRYCVGKEGDHFDLQEAALDWL
CCCCCCEEEECCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
ITDARRQDLGEPSPQQKAMAELLGTDLIGSSN
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKAMILAAGKGTRVQPITHVIPKPMIPILQKPVMEFLLELLKEHGFTEVMVNVSHLAEEI
CCEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
ENYFRDGQRFGVEIAYSFEGRIEDGELIGDALGSAGGLKKIQDFQKFFDDTFVVLCGDAL
HHHHHCCHHCCEEEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCHH
IDLDLSEAVKRHKEKGALASLITKRVSKDQVSSYGVVVTDEEDRVKAFQEKPSIDNALGD
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHCCCCHHHHCH
TINTGIYLFEPEIFNYIPSGKPFDIGSDLFPKLVEEGAPFYALPMDFEWVDIGKVPDYWR
HHHCCEEEECHHHHHHCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEEECCCCCHHHH
AIRNVLKGDVRQVEIPGKQVRPGIYTGLNVAANWDKINVKGPIYVGGMTRIEDGVTIVGP
HHHHHHCCCCEEEECCCCCCCCCCEECCCEEECCCEEECCCCEEECCCEECCCCEEEECC
SMIGPSCCICEGATIDNSIIFDYSLIGPGVQLVEKLVFGRYCVGKEGDHFDLQEAALDWL
CCCCCCEEEECCCCCCCCEEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
ITDARRQDLGEPSPQQKAMAELLGTDLIGSSN
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]