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The map label for this gene is parC [H]

Identifier: 124024717

GI number: 124024717

Start: 6051

End: 8534

Strand: Reverse

Name: parC [H]

Synonym: NATL1_00041

Alternate gene names: 124024717

Gene position: 8534-6051 (Counterclockwise)

Preceding gene: 124024718

Following gene: NA

Centisome position: 0.46

GC content: 30.56

Gene sequence:

>2484_bases
ATGGCCAAGGAACGCCTGAAACCTATATCGTTGCATCAGGAAATGCAGCGTTCTTATCTCGAGTACGCAATGAGCGTAAT
CGTTGGGAGAGCATTGCCAGACGCGAGAGATGGATTGAAGCCGGTGCAAAGAAGAATTCTTTTTGCAATGCACGAGTTAG
GACTTACGCCCGAAAGGCCTTACAGAAAATGTGCTCGTGTCGTAGGAGATGTTCTTGGCAAATATCATCCACATGGAGAT
CAAGCTGTCTACGACGCACTTGTAAGACAAGTTCAAATATTTAATTCAAGATACCCAATTCTTGATGGTCACGGAAACTT
TGGATCTATTGATGATGATCCTCCTGCTGCAATGAGATACACAGAGACTAGGCTGGCGCCAATATCTAACGATGCAATTT
TAAGTGAAATAGATAAAGAAACTGTTGATTTTTCACCAAATTTTGATGGATCACAACAAGAACCAGACGTTTTACCAGCT
CAATTACCTTTCCTCATCTTAAATGGAAGTACAGGAATTGCCGTTGGAATGGCAACAAGCATTCCTCCACACAATTTGAA
CGAAGTGGTAGAGGCCTTAATAGCAATAATAAAAAAACCTTCACTAAACGAAGAAAAATTATTAGAAATAATACCTGGAC
CAGACTTTCCAACAGGAGGAGAGATATTAGTTAGTAACGGAATAAAAGAAACTTACACAAAAGGGAGAGGAAGCATAACC
ATGAGAGGAATAGCTCGCATTGAAGAAATTAATCCTGGAAAAGGTAAACACAAAAGAAGTGGGATTATTATTTCAGAACT
ACCTTATCAATTAAACAAAGCTGGCTGGATTGAAAAATTAGCTGACCTTGTAAATAATGGAAAAATTTCGGGGATAGCTG
ATATTAGAGATGAAAGCGATCGAGACGGAATGCGAATTCTTGTTGAAGTTAAAAGAGATTCTGATCCAAAAAAAATTCTG
GATTTTTTATATCAAAAAACTTCTTTACAAAGCAATTTTGGTGCAATTTTACTTGCATTAGTTAATGGCCAGCCAGTACA
ACTTACGTTAAGAAAATTATTAAATAATTTCTTAGAGTTTAGAGAAAATACTATTTTACTAAGAAGTAATTATTTACTAA
AAAATATAAAAAATAGAGAAGAGATAGTTGAGGCTCTAATCCAAGCAACAAATAATGTTAGAAAAGTAATTGAATTAATT
GAAAATTCTAAAGATACACCTGAAGCAAAAAGTAATTTAATTATCAGCTTAAAGATTAATGAAAGGCAAGCAGATGGGAT
TCTAGGTATGCCTTTAAAGAAAATTACAGGTCTTGAAAAAGATTCTCTCAAGAATGAACTTAAAGATTTAAAAACTAAAA
GAGCAGAACTCGAATTAATAATTAACGACAAAGAAAATTTAATGAAAGTTATGGTTAAAGAACTCAAAGATCTTAAAAAA
AGATTTGGTAGTAAAAGAAGAACAAAATTAATAGAAGGTGGAGATGCTCTTATTGCTGAAAAGATGGCAAATCAAAGACC
AAATAAAGAACTTCAAAGAATAAATGCATTAAAAGAATTATCAAAAGATTCTGAAATAATTATTCAATCAAATAATGAAA
TAAAGATAATTCCCTCACTAACAATAAAAAAATTAAAACTGAAAGAAAGTGATCAAGAAAGAAAAGATATTCTACCTGCA
AAGCTAATATGGCCAATTAAAAATGAACCAAAGATATTAGCCGTCAGTCAAGAAGGTAAGATAGGTCTTCTTAAGTGGGA
ATTTGCGGGACAAAAACCTGGGCCTTTAAAACAATTTTTACCAGCAGGTTTAGAGAATGATAAAATAATTAATCTTATTC
CACTAACAGAAATAAGAGATATAAGTATAGGATTAATAAGTACTGATGGAAAGTTTAAAAGAATTTCAATTAATGAGATT
AGCGATATTTCTAATAGATCAACAACGATTTTAAAATTAAAAGACAGTATAAAGCTTAAATCTTGCATTCTTTGTAAAGA
GAATAGCTATTTGTATATAGTGAGTGATATTGGCAGAATTATTAAAATTAAAATAACAGAAAATGATTTCCCTTTTATGG
GCAAGTTAGCTCAAGGAACAAATATAATAAAATTATTCCCTAATGAAAATATAGTGGAAGCTTTAAGTTTTCAAGAAAAG
AAAAATAAAGATTTAATTTTAATAACTAACAAAGGTTCTTTTGTAAAACATTCTACAAAAGAAATAACTATATCCAAAAA
AGGAGCATTAGGAATAATGGGAATACATTTTAAAGATAATAAAACAATTAAAGAAAGAGTAATTGATTGTTTTATAAATA
ATAAACACGTTTTTATTAAAACTGATAAGGATAGATATCAAAGATTAAAAACCGATCAAATTGATAATAGTTCATATAGA
AAAGAGAACAAATTAAATATAGAATTAAACAATGATGAGTTTTTAAAATCTACTTTTTCAATGAAAGTACCAGACAAAAA
TTAA

Upstream 100 bases:

>100_bases
GAGAAAAAACTGAATAACTTAATGTTTAACAAAAAACTGGTTTTTAACAAATTAGTTAGTAACCTAAATAAAGAAATTTA
GGCCTCTTTCATACTCCAAG

Downstream 100 bases:

>100_bases
GACAAAGATGTTTCTTCAACCCAAGTTAAATATTCATCAGTGACTGTTCCTGTAATATATTTTCCTGTAAAGCATGATAA
ATCTAATTCCTTAATTTTAG

Product: DNA gyrase/topoisomerase IV, subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 827; Mature: 826

Protein sequence:

>827_residues
MAKERLKPISLHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPERPYRKCARVVGDVLGKYHPHGD
QAVYDALVRQVQIFNSRYPILDGHGNFGSIDDDPPAAMRYTETRLAPISNDAILSEIDKETVDFSPNFDGSQQEPDVLPA
QLPFLILNGSTGIAVGMATSIPPHNLNEVVEALIAIIKKPSLNEEKLLEIIPGPDFPTGGEILVSNGIKETYTKGRGSIT
MRGIARIEEINPGKGKHKRSGIIISELPYQLNKAGWIEKLADLVNNGKISGIADIRDESDRDGMRILVEVKRDSDPKKIL
DFLYQKTSLQSNFGAILLALVNGQPVQLTLRKLLNNFLEFRENTILLRSNYLLKNIKNREEIVEALIQATNNVRKVIELI
ENSKDTPEAKSNLIISLKINERQADGILGMPLKKITGLEKDSLKNELKDLKTKRAELELIINDKENLMKVMVKELKDLKK
RFGSKRRTKLIEGGDALIAEKMANQRPNKELQRINALKELSKDSEIIIQSNNEIKIIPSLTIKKLKLKESDQERKDILPA
KLIWPIKNEPKILAVSQEGKIGLLKWEFAGQKPGPLKQFLPAGLENDKIINLIPLTEIRDISIGLISTDGKFKRISINEI
SDISNRSTTILKLKDSIKLKSCILCKENSYLYIVSDIGRIIKIKITENDFPFMGKLAQGTNIIKLFPNENIVEALSFQEK
KNKDLILITNKGSFVKHSTKEITISKKGALGIMGIHFKDNKTIKERVIDCFINNKHVFIKTDKDRYQRLKTDQIDNSSYR
KENKLNIELNNDEFLKSTFSMKVPDKN

Sequences:

>Translated_827_residues
MAKERLKPISLHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPERPYRKCARVVGDVLGKYHPHGD
QAVYDALVRQVQIFNSRYPILDGHGNFGSIDDDPPAAMRYTETRLAPISNDAILSEIDKETVDFSPNFDGSQQEPDVLPA
QLPFLILNGSTGIAVGMATSIPPHNLNEVVEALIAIIKKPSLNEEKLLEIIPGPDFPTGGEILVSNGIKETYTKGRGSIT
MRGIARIEEINPGKGKHKRSGIIISELPYQLNKAGWIEKLADLVNNGKISGIADIRDESDRDGMRILVEVKRDSDPKKIL
DFLYQKTSLQSNFGAILLALVNGQPVQLTLRKLLNNFLEFRENTILLRSNYLLKNIKNREEIVEALIQATNNVRKVIELI
ENSKDTPEAKSNLIISLKINERQADGILGMPLKKITGLEKDSLKNELKDLKTKRAELELIINDKENLMKVMVKELKDLKK
RFGSKRRTKLIEGGDALIAEKMANQRPNKELQRINALKELSKDSEIIIQSNNEIKIIPSLTIKKLKLKESDQERKDILPA
KLIWPIKNEPKILAVSQEGKIGLLKWEFAGQKPGPLKQFLPAGLENDKIINLIPLTEIRDISIGLISTDGKFKRISINEI
SDISNRSTTILKLKDSIKLKSCILCKENSYLYIVSDIGRIIKIKITENDFPFMGKLAQGTNIIKLFPNENIVEALSFQEK
KNKDLILITNKGSFVKHSTKEITISKKGALGIMGIHFKDNKTIKERVIDCFINNKHVFIKTDKDRYQRLKTDQIDNSSYR
KENKLNIELNNDEFLKSTFSMKVPDKN
>Mature_826_residues
AKERLKPISLHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPERPYRKCARVVGDVLGKYHPHGDQ
AVYDALVRQVQIFNSRYPILDGHGNFGSIDDDPPAAMRYTETRLAPISNDAILSEIDKETVDFSPNFDGSQQEPDVLPAQ
LPFLILNGSTGIAVGMATSIPPHNLNEVVEALIAIIKKPSLNEEKLLEIIPGPDFPTGGEILVSNGIKETYTKGRGSITM
RGIARIEEINPGKGKHKRSGIIISELPYQLNKAGWIEKLADLVNNGKISGIADIRDESDRDGMRILVEVKRDSDPKKILD
FLYQKTSLQSNFGAILLALVNGQPVQLTLRKLLNNFLEFRENTILLRSNYLLKNIKNREEIVEALIQATNNVRKVIELIE
NSKDTPEAKSNLIISLKINERQADGILGMPLKKITGLEKDSLKNELKDLKTKRAELELIINDKENLMKVMVKELKDLKKR
FGSKRRTKLIEGGDALIAEKMANQRPNKELQRINALKELSKDSEIIIQSNNEIKIIPSLTIKKLKLKESDQERKDILPAK
LIWPIKNEPKILAVSQEGKIGLLKWEFAGQKPGPLKQFLPAGLENDKIINLIPLTEIRDISIGLISTDGKFKRISINEIS
DISNRSTTILKLKDSIKLKSCILCKENSYLYIVSDIGRIIKIKITENDFPFMGKLAQGTNIIKLFPNENIVEALSFQEKK
NKDLILITNKGSFVKHSTKEITISKKGALGIMGIHFKDNKTIKERVIDCFINNKHVFIKTDKDRYQRLKTDQIDNSSYRK
ENKLNIELNNDEFLKSTFSMKVPDKN

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1788562, Length=840, Percent_Identity=35, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI1789396, Length=493, Percent_Identity=41.7849898580122, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI212645845, Length=519, Percent_Identity=23.6994219653179, Blast_Score=78, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=188, Percent_Identity=28.7234042553192, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.3

Molecular weight: Translated: 93440; Mature: 93309

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKERLKPISLHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPERP
CCCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
YRKCARVVGDVLGKYHPHGDQAVYDALVRQVQIFNSRYPILDGHGNFGSIDDDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEE
TETRLAPISNDAILSEIDKETVDFSPNFDGSQQEPDVLPAQLPFLILNGSTGIAVGMATS
CHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLNEVVEALIAIIKKPSLNEEKLLEIIPGPDFPTGGEILVSNGIKETYTKGRGSIT
CCCCCHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCCCCCCEEEECCCHHHHHCCCCCEE
MRGIARIEEINPGKGKHKRSGIIISELPYQLNKAGWIEKLADLVNNGKISGIADIRDESD
EHHHHHHHHCCCCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHCCCCCCEEECCCCCCC
RDGMRILVEVKRDSDPKKILDFLYQKTSLQSNFGAILLALVNGQPVQLTLRKLLNNFLEF
CCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RENTILLRSNYLLKNIKNREEIVEALIQATNNVRKVIELIENSKDTPEAKSNLIISLKIN
CCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEC
ERQADGILGMPLKKITGLEKDSLKNELKDLKTKRAELELIINDKENLMKVMVKELKDLKK
CCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHH
RFGSKRRTKLIEGGDALIAEKMANQRPNKELQRINALKELSKDSEIIIQSNNEIKIIPSL
HHCCHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECC
TIKKLKLKESDQERKDILPAKLIWPIKNEPKILAVSQEGKIGLLKWEFAGQKPGPLKQFL
CEEEEECCCCCHHHHHCCCCEEEECCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHC
PAGLENDKIINLIPLTEIRDISIGLISTDGKFKRISINEISDISNRSTTILKLKDSIKLK
CCCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEHHHHHCCCCCCEEEEEECCCCCEE
SCILCKENSYLYIVSDIGRIIKIKITENDFPFMGKLAQGTNIIKLFPNENIVEALSFQEK
EEEEEECCCEEEEEECCCCEEEEEEECCCCCCHHHHCCCCCEEEECCCCCHHHHHHHHHC
KNKDLILITNKGSFVKHSTKEITISKKGALGIMGIHFKDNKTIKERVIDCFINNKHVFIK
CCCCEEEEECCCCCEECCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHEECCCEEEEE
TDKDRYQRLKTDQIDNSSYRKENKLNIELNNDEFLKSTFSMKVPDKN
ECHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHEEECCCCC
>Mature Secondary Structure 
AKERLKPISLHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPERP
CCHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCCCCHH
YRKCARVVGDVLGKYHPHGDQAVYDALVRQVQIFNSRYPILDGHGNFGSIDDDPPAAMRY
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCEEE
TETRLAPISNDAILSEIDKETVDFSPNFDGSQQEPDVLPAQLPFLILNGSTGIAVGMATS
CHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECC
IPPHNLNEVVEALIAIIKKPSLNEEKLLEIIPGPDFPTGGEILVSNGIKETYTKGRGSIT
CCCCCHHHHHHHHHHHHCCCCCCHHHHHEEECCCCCCCCCCEEEECCCHHHHHCCCCCEE
MRGIARIEEINPGKGKHKRSGIIISELPYQLNKAGWIEKLADLVNNGKISGIADIRDESD
EHHHHHHHHCCCCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHCCCCCCEEECCCCCCC
RDGMRILVEVKRDSDPKKILDFLYQKTSLQSNFGAILLALVNGQPVQLTLRKLLNNFLEF
CCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHH
RENTILLRSNYLLKNIKNREEIVEALIQATNNVRKVIELIENSKDTPEAKSNLIISLKIN
CCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEC
ERQADGILGMPLKKITGLEKDSLKNELKDLKTKRAELELIINDKENLMKVMVKELKDLKK
CCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHH
RFGSKRRTKLIEGGDALIAEKMANQRPNKELQRINALKELSKDSEIIIQSNNEIKIIPSL
HHCCHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEECCCCEEEEECC
TIKKLKLKESDQERKDILPAKLIWPIKNEPKILAVSQEGKIGLLKWEFAGQKPGPLKQFL
CEEEEECCCCCHHHHHCCCCEEEECCCCCCEEEEEECCCCEEEEEEEECCCCCCCHHHHC
PAGLENDKIINLIPLTEIRDISIGLISTDGKFKRISINEISDISNRSTTILKLKDSIKLK
CCCCCCCCEEEEEECCCCCEEEEEEEECCCCEEEEEHHHHHCCCCCCEEEEEECCCCCEE
SCILCKENSYLYIVSDIGRIIKIKITENDFPFMGKLAQGTNIIKLFPNENIVEALSFQEK
EEEEEECCCEEEEEECCCCEEEEEEECCCCCCHHHHCCCCCEEEECCCCCHHHHHHHHHC
KNKDLILITNKGSFVKHSTKEITISKKGALGIMGIHFKDNKTIKERVIDCFINNKHVFIK
CCCCEEEEECCCCCEECCCCEEEEECCCCEEEEEEEECCCCHHHHHHHHHEECCCEEEEE
TDKDRYQRLKTDQIDNSSYRKENKLNIELNNDEFLKSTFSMKVPDKN
ECHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Isomerization [C]

Inhibitor: CJ-12, 371; CJ-12, 372; Coumermycin; Doxorubicin; Sitafloxacin [C]

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]