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The map label for this gene is purL

Identifier: 124024715

GI number: 124024715

Start: 2124

End: 4535

Strand: Direct

Name: purL

Synonym: NATL1_00021

Alternate gene names: 124024715

Gene position: 2124-4535 (Clockwise)

Preceding gene: 124024714

Following gene: 124024716

Centisome position: 0.11

GC content: 33.87

Gene sequence:

>2412_bases
ATGACAGTATCCTTTGAAAATAAAGATTTCAACCAATTCATTAATTCATCAAAATTTCTTGTTGAATATGATGTTATGTC
CGCTCTTAAGCAAGAAGGGTTAAAACAATCTGATTATGTAGAAATTTGTAGAAGACTTAATCGGGGTCCAAATAGAAATG
AGTTAGGAATGTTTGGTGTTATGTGGTCTGAACATTGTTGCTATCGAAACTCTCGTCCTTTACTAAAAAACTTGCCTACA
ACAGGTAGTCGAATCCTTGTAGGGCCTGGAGAAAATGCAGGCGTAGTTGATATTGGTTTTGGACAAAGATTAGTTTTTAA
AATTGAAAGTCATAACCATCCATCAGCCGTCGAGCCTTTTCAAGGAGCAGCAACTGGTGTAGGTGGAATTCTTAGAGATA
TTTTTACTATGGGAGCTAGGCCAATAGCCTTATTGAATGCTTTAAGGTTTGGTCCATTAGATGATGAAAAAAATATTAGT
TTATTGGAAGGTGTCGTTGCAGGTATTTCTCACTATGGAAATTGCGTAGGAGTTCCTACTATTGGAGGAGAAGTGGGATT
TGATAGTAGTTATTCAGGTAACCCCTTAGTTAATGTAATGGGGTTGGGTTTGATGGAAACAGAAGAAATAGTTTGTTCAG
GTGCCAGTGGAATAGACTTTCCAGTTCTTTACGTAGGAAATACAACTGGTAGAGATGGTATGGGAGGAGCAAGCTTTGCT
AGTTCTGAACTTTCTAAAACTTCAATAGATGATCGACCAGCCGTTCAAGTTGGTGATCCTTTTCTTGAGAAAGGATTAAT
AGAAGCTTGTTTAGAGGCTTTTAAAACAGGATATGTAATTGCTGCACAGGATATGGGAGCGGCGGGGTTGACTTGTAGTT
GTTCTGAAATGGCTTCAAAAGGTGAGGTAGGAATTGAATTGAATCTTGACCTTGTTCCGGCTAGGGAAAAGGGCATGACT
GCATATGAATTTTTGTTGTCTGAATCACAAGAACGAATGCTGTTTGTTGTGAAGCCTGGTTCAGAAGAAGAATTGAGAGA
ATTATTTATAAGATGGGGATTATATGTTGAAGTTGTTGGAAAAGTTTTAAAAGAAAAAGTTGTTAGAGTGATTCATAAAG
GTGAAGTTGTAGCAAATCTTCCCGCATCTGCGCTTGCTGATGATACGCCTATAGAAGAACATTTATTAATAAATTCAACA
CCTGAATATTTGCAAGAACATTGGAAATGGACTGAAGATTTATTACCTAAAACTTTAGATAATGGAATTATTAATATAAA
GAATAATTTATTTATTAGTTGGAATAATGTTCTATTAGATTTATTAAGTATGCCTTCAATAGCTTCAAAAAATTGGATTT
ATAAACAATATGATTATCAAGTACAATCTAATACAGTTGTTTCTCCTGGAGAAGCTGATGCTGCTGTTATTAGGATTCGA
TCTCAAAATGACTTTTTAACCAAGCCAAAGAAAGATAGAGGAATAGCTTCAGTCGTAGATTGTAATGATAGATGGGTTTA
TTTAGATCCTCTAAGAGGAAGTATGTCTGCTGTCGCAGAAGCAGCTAGGAATTTAAGTTCTGTGGGAGCTGAACCTATAG
CAATTACAAATAATTTAAATTTTTCTTCTCCAGACAAACCAGTTGGTTTTTGGCAATTATCAATGTCATGTGAAGGGATA
ACTAAAGCTTGTTTAGCATTGAGTACTCCTGTTACAGGAGGAAATGTGTCATTATATAATGATACTAAATTGCAAAATAA
TACCGTTTTACCTATACATCCAACTCCAGTAATTGGTATGGTTGGGTTAATAGAAGATATCAATAAAATTTGTAAAAAAT
CTTGGGTTAAAGCTGAAGATCAAATATGGATGATTGGGTTACCTTTAGAAAATAATATAAACCAAGATGAAAGAATTTCA
CTATCTGCTTCTTCTTTTTTAGAGTATATTCATGGATTGAAAACAGGAAGACCTCCTGAAATAGATTTAAATTTAGAAAA
ACAAGTTCATGCATTTCTAAGAGAAGTAATAAAACAAGGTATTGTTAATTCTGCTCATGATTTAGGTGATGGTGGTCTGG
CAGTTGCTATAGCTGAATGTTGTATCTCTTCTGGCTATGGAGCAAATATTATTCTCCCTCCTAGCCAATCAAGGTTAGAT
AGACTTTTATTTGCTGAAGGAGGCGCAAGAGTTTTAGTGAGTTGTTCAACTGATCAAAGCGAAGAATTAAAGAAATATTA
TAAAAATATTTCCTTACAAGGATCTAATCTTTTTTCAATATCTCATTTAGGTAATGTAAATAATCAAAAAAAACTATTAG
TGTCTCAATCGAATAATACAATTATAGATGTTAATATTCTAGACTTGAAAGATACATATAAAGATGCCATCCATAAAAAA
ATAACTAAATAA

Upstream 100 bases:

>100_bases
ATTTAGATATAGATAGTTCTGAAGAATTTAATAGAATGAATGAATCTAAGAAAAATACAAATTCCAGTAATGAAAGAGAT
CTTGATCCTTGGATTTAATA

Downstream 100 bases:

>100_bases
AATCATTTATGATTTATAATCCTAAAACTACATTTATTTTACTTAACCTAGGAATATAATTATGTGTGGAATAGTAGGTG
TTGTTTCAACTGATCAATGT

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MTVSFENKDFNQFINSSKFLVEYDVMSALKQEGLKQSDYVEICRRLNRGPNRNELGMFGVMWSEHCCYRNSRPLLKNLPT
TGSRILVGPGENAGVVDIGFGQRLVFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLDDEKNIS
LLEGVVAGISHYGNCVGVPTIGGEVGFDSSYSGNPLVNVMGLGLMETEEIVCSGASGIDFPVLYVGNTTGRDGMGGASFA
SSELSKTSIDDRPAVQVGDPFLEKGLIEACLEAFKTGYVIAAQDMGAAGLTCSCSEMASKGEVGIELNLDLVPAREKGMT
AYEFLLSESQERMLFVVKPGSEEELRELFIRWGLYVEVVGKVLKEKVVRVIHKGEVVANLPASALADDTPIEEHLLINST
PEYLQEHWKWTEDLLPKTLDNGIINIKNNLFISWNNVLLDLLSMPSIASKNWIYKQYDYQVQSNTVVSPGEADAAVIRIR
SQNDFLTKPKKDRGIASVVDCNDRWVYLDPLRGSMSAVAEAARNLSSVGAEPIAITNNLNFSSPDKPVGFWQLSMSCEGI
TKACLALSTPVTGGNVSLYNDTKLQNNTVLPIHPTPVIGMVGLIEDINKICKKSWVKAEDQIWMIGLPLENNINQDERIS
LSASSFLEYIHGLKTGRPPEIDLNLEKQVHAFLREVIKQGIVNSAHDLGDGGLAVAIAECCISSGYGANIILPPSQSRLD
RLLFAEGGARVLVSCSTDQSEELKKYYKNISLQGSNLFSISHLGNVNNQKKLLVSQSNNTIIDVNILDLKDTYKDAIHKK
ITK

Sequences:

>Translated_803_residues
MTVSFENKDFNQFINSSKFLVEYDVMSALKQEGLKQSDYVEICRRLNRGPNRNELGMFGVMWSEHCCYRNSRPLLKNLPT
TGSRILVGPGENAGVVDIGFGQRLVFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLDDEKNIS
LLEGVVAGISHYGNCVGVPTIGGEVGFDSSYSGNPLVNVMGLGLMETEEIVCSGASGIDFPVLYVGNTTGRDGMGGASFA
SSELSKTSIDDRPAVQVGDPFLEKGLIEACLEAFKTGYVIAAQDMGAAGLTCSCSEMASKGEVGIELNLDLVPAREKGMT
AYEFLLSESQERMLFVVKPGSEEELRELFIRWGLYVEVVGKVLKEKVVRVIHKGEVVANLPASALADDTPIEEHLLINST
PEYLQEHWKWTEDLLPKTLDNGIINIKNNLFISWNNVLLDLLSMPSIASKNWIYKQYDYQVQSNTVVSPGEADAAVIRIR
SQNDFLTKPKKDRGIASVVDCNDRWVYLDPLRGSMSAVAEAARNLSSVGAEPIAITNNLNFSSPDKPVGFWQLSMSCEGI
TKACLALSTPVTGGNVSLYNDTKLQNNTVLPIHPTPVIGMVGLIEDINKICKKSWVKAEDQIWMIGLPLENNINQDERIS
LSASSFLEYIHGLKTGRPPEIDLNLEKQVHAFLREVIKQGIVNSAHDLGDGGLAVAIAECCISSGYGANIILPPSQSRLD
RLLFAEGGARVLVSCSTDQSEELKKYYKNISLQGSNLFSISHLGNVNNQKKLLVSQSNNTIIDVNILDLKDTYKDAIHKK
ITK
>Mature_802_residues
TVSFENKDFNQFINSSKFLVEYDVMSALKQEGLKQSDYVEICRRLNRGPNRNELGMFGVMWSEHCCYRNSRPLLKNLPTT
GSRILVGPGENAGVVDIGFGQRLVFKIESHNHPSAVEPFQGAATGVGGILRDIFTMGARPIALLNALRFGPLDDEKNISL
LEGVVAGISHYGNCVGVPTIGGEVGFDSSYSGNPLVNVMGLGLMETEEIVCSGASGIDFPVLYVGNTTGRDGMGGASFAS
SELSKTSIDDRPAVQVGDPFLEKGLIEACLEAFKTGYVIAAQDMGAAGLTCSCSEMASKGEVGIELNLDLVPAREKGMTA
YEFLLSESQERMLFVVKPGSEEELRELFIRWGLYVEVVGKVLKEKVVRVIHKGEVVANLPASALADDTPIEEHLLINSTP
EYLQEHWKWTEDLLPKTLDNGIINIKNNLFISWNNVLLDLLSMPSIASKNWIYKQYDYQVQSNTVVSPGEADAAVIRIRS
QNDFLTKPKKDRGIASVVDCNDRWVYLDPLRGSMSAVAEAARNLSSVGAEPIAITNNLNFSSPDKPVGFWQLSMSCEGIT
KACLALSTPVTGGNVSLYNDTKLQNNTVLPIHPTPVIGMVGLIEDINKICKKSWVKAEDQIWMIGLPLENNINQDERISL
SASSFLEYIHGLKTGRPPEIDLNLEKQVHAFLREVIKQGIVNSAHDLGDGGLAVAIAECCISSGYGANIILPPSQSRLDR
LLFAEGGARVLVSCSTDQSEELKKYYKNISLQGSNLFSISHLGNVNNQKKLLVSQSNNTIIDVNILDLKDTYKDAIHKKI
TK

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=795, Percent_Identity=23.3962264150943, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17553022, Length=703, Percent_Identity=23.1863442389758, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24582111, Length=664, Percent_Identity=24.2469879518072, Blast_Score=90, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24582109, Length=664, Percent_Identity=24.2469879518072, Blast_Score=90, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17137292, Length=664, Percent_Identity=24.2469879518072, Blast_Score=90, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_PROM1 (A2BZA6)

Other databases:

- EMBL:   CP000553
- RefSeq:   YP_001013831.1
- ProteinModelPortal:   A2BZA6
- SMR:   A2BZA6
- STRING:   A2BZA6
- GeneID:   4780626
- GenomeReviews:   CP000553_GR
- KEGG:   pme:NATL1_00021
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BioCyc:   PMAR167555:NATL1_00021-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 87743; Mature: 87612

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSFENKDFNQFINSSKFLVEYDVMSALKQEGLKQSDYVEICRRLNRGPNRNELGMFGV
CEEECCCCHHHHHHCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEE
MWSEHCCYRNSRPLLKNLPTTGSRILVGPGENAGVVDIGFGQRLVFKIESHNHPSAVEPF
HHHHHHHCCCCCCHHHCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCC
QGAATGVGGILRDIFTMGARPIALLNALRFGPLDDEKNISLLEGVVAGISHYGNCVGVPT
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEECCC
IGGEVGFDSSYSGNPLVNVMGLGLMETEEIVCSGASGIDFPVLYVGNTTGRDGMGGASFA
CCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHH
SSELSKTSIDDRPAVQVGDPFLEKGLIEACLEAFKTGYVIAAQDMGAAGLTCSCSEMASK
HHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEHHHHHCC
GEVGIELNLDLVPAREKGMTAYEFLLSESQERMLFVVKPGSEEELRELFIRWGLYVEVVG
CCCEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KVLKEKVVRVIHKGEVVANLPASALADDTPIEEHLLINSTPEYLQEHWKWTEDLLPKTLD
HHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHC
NGIINIKNNLFISWNNVLLDLLSMPSIASKNWIYKQYDYQVQSNTVVSPGEADAAVIRIR
CCEEEECCCEEEEHHHHHHHHHCCCCCCCCCCEEEEECEEECCCEEECCCCCCEEEEEEE
SQNDFLTKPKKDRGIASVVDCNDRWVYLDPLRGSMSAVAEAARNLSSVGAEPIAITNNLN
CCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
FSSPDKPVGFWQLSMSCEGITKACLALSTPVTGGNVSLYNDTKLQNNTVLPIHPTPVIGM
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHH
VGLIEDINKICKKSWVKAEDQIWMIGLPLENNINQDERISLSASSFLEYIHGLKTGRPPE
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECHHHHHHHHHHHCCCCCCC
IDLNLEKQVHAFLREVIKQGIVNSAHDLGDGGLAVAIAECCISSGYGANIILPPSQSRLD
EECCHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHH
RLLFAEGGARVLVSCSTDQSEELKKYYKNISLQGSNLFSISHLGNVNNQKKLLVSQSNNT
HHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEHHCCCCCCCCEEEEECCCCE
IIDVNILDLKDTYKDAIHKKITK
EEEEEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVSFENKDFNQFINSSKFLVEYDVMSALKQEGLKQSDYVEICRRLNRGPNRNELGMFGV
EEECCCCHHHHHHCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEEE
MWSEHCCYRNSRPLLKNLPTTGSRILVGPGENAGVVDIGFGQRLVFKIESHNHPSAVEPF
HHHHHHHCCCCCCHHHCCCCCCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCC
QGAATGVGGILRDIFTMGARPIALLNALRFGPLDDEKNISLLEGVVAGISHYGNCVGVPT
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEECCC
IGGEVGFDSSYSGNPLVNVMGLGLMETEEIVCSGASGIDFPVLYVGNTTGRDGMGGASFA
CCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCHH
SSELSKTSIDDRPAVQVGDPFLEKGLIEACLEAFKTGYVIAAQDMGAAGLTCSCSEMASK
HHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEEEHHHHHCC
GEVGIELNLDLVPAREKGMTAYEFLLSESQERMLFVVKPGSEEELRELFIRWGLYVEVVG
CCCEEEEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KVLKEKVVRVIHKGEVVANLPASALADDTPIEEHLLINSTPEYLQEHWKWTEDLLPKTLD
HHHHHHHHHHHHCCCEEECCCHHHHCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHC
NGIINIKNNLFISWNNVLLDLLSMPSIASKNWIYKQYDYQVQSNTVVSPGEADAAVIRIR
CCEEEECCCEEEEHHHHHHHHHCCCCCCCCCCEEEEECEEECCCEEECCCCCCEEEEEEE
SQNDFLTKPKKDRGIASVVDCNDRWVYLDPLRGSMSAVAEAARNLSSVGAEPIAITNNLN
CCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
FSSPDKPVGFWQLSMSCEGITKACLALSTPVTGGNVSLYNDTKLQNNTVLPIHPTPVIGM
CCCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEECCCCHHHH
VGLIEDINKICKKSWVKAEDQIWMIGLPLENNINQDERISLSASSFLEYIHGLKTGRPPE
HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCEEEECHHHHHHHHHHHCCCCCCC
IDLNLEKQVHAFLREVIKQGIVNSAHDLGDGGLAVAIAECCISSGYGANIILPPSQSRLD
EECCHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHH
RLLFAEGGARVLVSCSTDQSEELKKYYKNISLQGSNLFSISHLGNVNNQKKLLVSQSNNT
HHHHCCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCEEEEHHCCCCCCCCEEEEECCCCE
IIDVNILDLKDTYKDAIHKKITK
EEEEEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA