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The map label for this gene is eif6

Identifier: 124028443

GI number: 124028443

Start: 1603479

End: 1604156

Strand: Direct

Name: eif6

Synonym: Hbut_1599

Alternate gene names: 124028443

Gene position: 1603479-1604156 (Clockwise)

Preceding gene: 124028442

Following gene: 124028444

Centisome position: 96.18

GC content: 47.35

Gene sequence:

>678_bases
TTGATAGAGTACCTTAATGTGCATGGAAACCCCAACATAGGTGTATACATATACGCTAACAACAAGATAGCGCTAGTACC
ACCAACACTGACAGAGAAGGATAAGAAGAAAATAGAGGAGACCCTAGGCGTCGAAGTTATTGAGACCAAAATAGCTGACA
TGATAATTAACGGGGTAATGATTGCTGGAAACGATAATGGACTACTCCTTCCACGCATCGTGAAGCCCGAAGAGCTAGAC
TACCTACGCGAACACATCGGCGACAAGGTTAGGCTCGAAATACTTGAGGTTAGGCAGACTGCCCTGGGGAACCTAATCGC
AGCCAATAACCGTGGCGCTCTAGTATCACCGCTTATAGACAAGGCTATACTTGATAAGATAAAGTCCGTATTGGGTGTAG
AGACTATATATCAGCGCCACCTAGCCAACATACCCACCGTGGGCTCAATGATCGTTGTTACTAACCGGGGCGGTGTTGTA
CACCCCGGTGTAAGCGATGACGAGATAAGGATACTGAATAGCGTGTTCGGAGTAGAATTCACGACCGCCACCGTAAACTT
TGGCCTCTACTTCGTAAAGGCAGGCCTAGTAGCTAATGATCACGGTGCACTCGTTGGGGATGAAACTACTGGCCCGGAAC
TTATGCGTATCCAGCAAGCCTTAAGATTAAGAGGCTAG

Upstream 100 bases:

>100_bases
TTTTCTTCACATTTCGCGGTATGGAGAATTGCCGTGTGCTGGCCCTCCCACTTAACCTCCTTTACCCTCTAGGCTATCCC
GCTTATACTGGGGGTTACAG

Downstream 100 bases:

>100_bases
CCTGCCACTGCAGGCTCGGGGGAGGGGTATGGGAGAGGTAAAGTTCTACCTGGTTGAGGGCAGGATGCTGATAAGACACG
ACCGGATGCCGGAATGGTGG

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MIEYLNVHGNPNIGVYIYANNKIALVPPTLTEKDKKKIEETLGVEVIETKIADMIINGVMIAGNDNGLLLPRIVKPEELD
YLREHIGDKVRLEILEVRQTALGNLIAANNRGALVSPLIDKAILDKIKSVLGVETIYQRHLANIPTVGSMIVVTNRGGVV
HPGVSDDEIRILNSVFGVEFTTATVNFGLYFVKAGLVANDHGALVGDETTGPELMRIQQALRLRG

Sequences:

>Translated_225_residues
MIEYLNVHGNPNIGVYIYANNKIALVPPTLTEKDKKKIEETLGVEVIETKIADMIINGVMIAGNDNGLLLPRIVKPEELD
YLREHIGDKVRLEILEVRQTALGNLIAANNRGALVSPLIDKAILDKIKSVLGVETIYQRHLANIPTVGSMIVVTNRGGVV
HPGVSDDEIRILNSVFGVEFTTATVNFGLYFVKAGLVANDHGALVGDETTGPELMRIQQALRLRG
>Mature_225_residues
MIEYLNVHGNPNIGVYIYANNKIALVPPTLTEKDKKKIEETLGVEVIETKIADMIINGVMIAGNDNGLLLPRIVKPEELD
YLREHIGDKVRLEILEVRQTALGNLIAANNRGALVSPLIDKAILDKIKSVLGVETIYQRHLANIPTVGSMIVVTNRGGVV
HPGVSDDEIRILNSVFGVEFTTATVNFGLYFVKAGLVANDHGALVGDETTGPELMRIQQALRLRG

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=216, Percent_Identity=33.7962962962963, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI31563378, Length=216, Percent_Identity=33.7962962962963, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17506075, Length=221, Percent_Identity=28.9592760180996, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325273, Length=214, Percent_Identity=39.7196261682243, Blast_Score=129, Evalue=3e-31,
Organism=Drosophila melanogaster, GI21492634, Length=216, Percent_Identity=36.5740740740741, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_HYPBU (A2BN57)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001013763.1
- ProteinModelPortal:   A2BN57
- SMR:   A2BN57
- STRING:   A2BN57
- GeneID:   4782004
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_1599
- eggNOG:   arNOG10240
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- PhylomeDB:   A2BN57
- ProtClustDB:   PRK04046
- BioCyc:   HBUT415426:HBUT_1599-MONOMER
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 24553; Mature: 24553

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEYLNVHGNPNIGVYIYANNKIALVPPTLTEKDKKKIEETLGVEVIETKIADMIINGVM
CCEEEEECCCCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCEE
IAGNDNGLLLPRIVKPEELDYLREHIGDKVRLEILEVRQTALGNLIAANNRGALVSPLID
EEECCCCEEECEECCCHHHHHHHHHCCCCEEHHHHHHHHHHHCCEEEECCCCCCHHHHHH
KAILDKIKSVLGVETIYQRHLANIPTVGSMIVVTNRGGVVHPGVSDDEIRILNSVFGVEF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCCCCCHHHHHHHHHCCEE
TTATVNFGLYFVKAGLVANDHGALVGDETTGPELMRIQQALRLRG
EEEEEECCEEEEEECEEECCCCCEECCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIEYLNVHGNPNIGVYIYANNKIALVPPTLTEKDKKKIEETLGVEVIETKIADMIINGVM
CCEEEEECCCCCEEEEEEECCEEEEECCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCEE
IAGNDNGLLLPRIVKPEELDYLREHIGDKVRLEILEVRQTALGNLIAANNRGALVSPLID
EEECCCCEEECEECCCHHHHHHHHHCCCCEEHHHHHHHHHHHCCEEEECCCCCCHHHHHH
KAILDKIKSVLGVETIYQRHLANIPTVGSMIVVTNRGGVVHPGVSDDEIRILNSVFGVEF
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEECCCCCCCHHHHHHHHHCCEE
TTATVNFGLYFVKAGLVANDHGALVGDETTGPELMRIQQALRLRG
EEEEEECCEEEEEECEEECCCCCEECCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA