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The map label for this gene is argE [C]

Identifier: 124028318

GI number: 124028318

Start: 1477356

End: 1478603

Strand: Direct

Name: argE [C]

Synonym: Hbut_1469

Alternate gene names: 124028318

Gene position: 1477356-1478603 (Clockwise)

Preceding gene: 124028316

Following gene: 124028320

Centisome position: 88.61

GC content: 57.93

Gene sequence:

>1248_bases
ATGTCCTCTAGTGGTGGTAGCGAGGAGCTCTATGTTGTTAGGTTATTGGAGAAGTTGATCTCCGTGCCAACTGTCAATCC
TCCTGGCGAGAACTACCAGGAGATGGCTACGCTGCTGAGAGAGGAGCTTGAGGCTCTAGGCCTGGAGGTTAGTATTGTGA
GGGTTCCCGACGATGTTGTCGAGAAGTATTATCCCTGGGCTCAGGGCTATCCTCGCTTCATAGTCGTTGCCCGTCTCTAC
TCGGGTGCTGAAGAGCAGCCTGTGCTGCACTTCAACGGGCACTACGATGTTGTGCCGCCGGGGCAGGGGTGGAGCCTCGA
CCCGTTCAAGCCGGTGGTACGCGACGGGAAGGTCTACGGCCGTGGCGCGAGCGACATGAAGGGCGGCATAGCTGCCATCA
TTGCTGCTGTCCGGAGCCTTGTGGAGCAGGGCTGGAGGCCTCGGAAGGGTGTGCTAGAGCTGAGCTTTACGCCCGACGAG
GAGACGGGTGGCGAGACCGGCGTAGGCTACATGCTCGAGGAGGGCATAGCGCTTCCAGACTATGCTGTGGTGGCTGAGCC
CAGCACCACTGAGCGGATATGGATTGGTAGCAGGGGTAACCTCTGGCTAAACGTTCACATCTACGGTAAGCAAGCGCACG
GCTCAACACCTTGGAGTGGGCTTAACGCGTTCGAGGGAATGGTCGAGATAGCCTATCGACTCATACACGAGTATAAACCG
CTTCTCGAGGAGAGGAAGACAGACCTGCCAATGGATGATCCCAGAGCCGCCAAGCCAACTGTAACGCTTGGCGGCGAGGT
GCAAGGCGGGGCGAAGACGAACATCGTGCCAGGCTACTACCGGTTTAGCATTGATCGCCGCATAATACCCGGCGAAAACC
CCGACGAGGTGGAGAAAGAGCTGCGAGAATTCATAGACCGTGTCTCTGCGCCTTTGCGCGCCCGGGGCTACCGTGTCGAG
GTAGAGGTTACCGCTAAGGCGCCCGCGACATGGATACCGCCTGACCACAACTTTGTGGAGCTCGTAGCCTCAACCATACG
CGACATGCTAGGCATAGAACCCCTCCGCACCATCTGCGTAGGGGGCCTCGATACTAGGTACTTCCAGCTCCGCGGCATAC
CAGCTGTAACCTATGGCCCAGGTGCACTCGACGCTGCCCATAAGCCCGACGAGTACGTACCCATAGAGGAGCTTGTTAGG
GCTAAGAAGGTCTACATGGAGCTTGCAAAGAGAGTACTTGGAGCCTAG

Upstream 100 bases:

>100_bases
CTGCGGCTAGTATGCGGTGTTACATGGGTCCTCGTGGGGTGCCGGGTGTTCCTTTTTATCGCTGCCCGGGGGCTTGTTCC
ACGTAGGTGTGTTGGCCCCC

Downstream 100 bases:

>100_bases
ACCCTTACAACGATGTATATCACTTTTTTCTCGGGATCCACACAAAACTCTTGTATAGCTCTCCACAGCGCCTCCGTGCC
TAGGTATTCTCCACCACCGC

Product: succinyl-diaminopimelate desuccinylase

Products: succinate; LL-2,6-diaminoheptanedioate

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MSSSGGSEELYVVRLLEKLISVPTVNPPGENYQEMATLLREELEALGLEVSIVRVPDDVVEKYYPWAQGYPRFIVVARLY
SGAEEQPVLHFNGHYDVVPPGQGWSLDPFKPVVRDGKVYGRGASDMKGGIAAIIAAVRSLVEQGWRPRKGVLELSFTPDE
ETGGETGVGYMLEEGIALPDYAVVAEPSTTERIWIGSRGNLWLNVHIYGKQAHGSTPWSGLNAFEGMVEIAYRLIHEYKP
LLEERKTDLPMDDPRAAKPTVTLGGEVQGGAKTNIVPGYYRFSIDRRIIPGENPDEVEKELREFIDRVSAPLRARGYRVE
VEVTAKAPATWIPPDHNFVELVASTIRDMLGIEPLRTICVGGLDTRYFQLRGIPAVTYGPGALDAAHKPDEYVPIEELVR
AKKVYMELAKRVLGA

Sequences:

>Translated_415_residues
MSSSGGSEELYVVRLLEKLISVPTVNPPGENYQEMATLLREELEALGLEVSIVRVPDDVVEKYYPWAQGYPRFIVVARLY
SGAEEQPVLHFNGHYDVVPPGQGWSLDPFKPVVRDGKVYGRGASDMKGGIAAIIAAVRSLVEQGWRPRKGVLELSFTPDE
ETGGETGVGYMLEEGIALPDYAVVAEPSTTERIWIGSRGNLWLNVHIYGKQAHGSTPWSGLNAFEGMVEIAYRLIHEYKP
LLEERKTDLPMDDPRAAKPTVTLGGEVQGGAKTNIVPGYYRFSIDRRIIPGENPDEVEKELREFIDRVSAPLRARGYRVE
VEVTAKAPATWIPPDHNFVELVASTIRDMLGIEPLRTICVGGLDTRYFQLRGIPAVTYGPGALDAAHKPDEYVPIEELVR
AKKVYMELAKRVLGA
>Mature_414_residues
SSSGGSEELYVVRLLEKLISVPTVNPPGENYQEMATLLREELEALGLEVSIVRVPDDVVEKYYPWAQGYPRFIVVARLYS
GAEEQPVLHFNGHYDVVPPGQGWSLDPFKPVVRDGKVYGRGASDMKGGIAAIIAAVRSLVEQGWRPRKGVLELSFTPDEE
TGGETGVGYMLEEGIALPDYAVVAEPSTTERIWIGSRGNLWLNVHIYGKQAHGSTPWSGLNAFEGMVEIAYRLIHEYKPL
LEERKTDLPMDDPRAAKPTVTLGGEVQGGAKTNIVPGYYRFSIDRRIIPGENPDEVEKELREFIDRVSAPLRARGYRVEV
EVTAKAPATWIPPDHNFVELVASTIRDMLGIEPLRTICVGGLDTRYFQLRGIPAVTYGPGALDAAHKPDEYVPIEELVRA
KKVYMELAKRVLGA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI4501901, Length=437, Percent_Identity=25.629290617849, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1790395, Length=399, Percent_Identity=29.3233082706767, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788816, Length=417, Percent_Identity=27.5779376498801, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789236, Length=407, Percent_Identity=22.8501228501229, Blast_Score=82, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71982710, Length=437, Percent_Identity=23.1121281464531, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17538642, Length=430, Percent_Identity=22.7906976744186, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17538640, Length=351, Percent_Identity=24.2165242165242, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71982082, Length=429, Percent_Identity=23.5431235431235, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71982085, Length=442, Percent_Identity=23.5294117647059, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24649206, Length=416, Percent_Identity=26.6826923076923, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24649210, Length=417, Percent_Identity=23.7410071942446, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24649202, Length=425, Percent_Identity=24.2352941176471, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24649204, Length=425, Percent_Identity=24.2352941176471, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24649208, Length=429, Percent_Identity=23.5431235431235, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24649212, Length=409, Percent_Identity=22.2493887530562, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21356353, Length=429, Percent_Identity=24.009324009324, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.18

Molecular weight: Translated: 45984; Mature: 45853

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSGGSEELYVVRLLEKLISVPTVNPPGENYQEMATLLREELEALGLEVSIVRVPDDVV
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHH
EKYYPWAQGYPRFIVVARLYSGAEEQPVLHFNGHYDVVPPGQGWSLDPFKPVVRDGKVYG
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCHHHHHCCCEEC
RGASDMKGGIAAIIAAVRSLVEQGWRPRKGVLELSFTPDEETGGETGVGYMLEEGIALPD
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCC
YAVVAEPSTTERIWIGSRGNLWLNVHIYGKQAHGSTPWSGLNAFEGMVEIAYRLIHEYKP
EEEEECCCCCCEEEEECCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLEERKTDLPMDDPRAAKPTVTLGGEVQGGAKTNIVPGYYRFSIDRRIIPGENPDEVEKE
HHHHHHCCCCCCCCCCCCCEEEECCEECCCCCCCCCCCEEEEEECCEECCCCCHHHHHHH
LREFIDRVSAPLRARGYRVEVEVTAKAPATWIPPDHNFVELVASTIRDMLGIEPLRTICV
HHHHHHHHCCCHHHCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHC
GGLDTRYFQLRGIPAVTYGPGALDAAHKPDEYVPIEELVRAKKVYMELAKRVLGA
CCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSSGGSEELYVVRLLEKLISVPTVNPPGENYQEMATLLREELEALGLEVSIVRVPDDVV
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCHHHH
EKYYPWAQGYPRFIVVARLYSGAEEQPVLHFNGHYDVVPPGQGWSLDPFKPVVRDGKVYG
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEECCEEEECCCCCCCCCCCCHHHHHCCCEEC
RGASDMKGGIAAIIAAVRSLVEQGWRPRKGVLELSFTPDEETGGETGVGYMLEEGIALPD
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCCCC
YAVVAEPSTTERIWIGSRGNLWLNVHIYGKQAHGSTPWSGLNAFEGMVEIAYRLIHEYKP
EEEEECCCCCCEEEEECCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLEERKTDLPMDDPRAAKPTVTLGGEVQGGAKTNIVPGYYRFSIDRRIIPGENPDEVEKE
HHHHHHCCCCCCCCCCCCCEEEECCEECCCCCCCCCCCEEEEEECCEECCCCCHHHHHHH
LREFIDRVSAPLRARGYRVEVEVTAKAPATWIPPDHNFVELVASTIRDMLGIEPLRTICV
HHHHHHHHCCCHHHCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHC
GGLDTRYFQLRGIPAVTYGPGALDAAHKPDEYVPIEELVRAKKVYMELAKRVLGA
CCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-LL-2,6-diaminoheptanedioate; H2O

Specific reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]