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The map label for this gene is gdhII [H]

Identifier: 124028225

GI number: 124028225

Start: 1367542

End: 1368351

Strand: Reverse

Name: gdhII [H]

Synonym: Hbut_1375

Alternate gene names: 124028225

Gene position: 1368351-1367542 (Counterclockwise)

Preceding gene: 124028228

Following gene: 124028221

Centisome position: 82.08

GC content: 59.01

Gene sequence:

>810_bases
TTGCCTGGCAGGGCAAGCTTCGATCTACGTGGCGTGAATGTTCTTGTTACTGCTTCAAGTCGTGGTATCGGGTTCTATGC
CGCCAGGGGGCTTGCCAGGCTTGGCGCTAGCGTGGCTATATCGTCTAGGAGCCGGGAGGCATTGGAGAGGGCTGCCAAGG
AGATAAAGGAGGAGACAGGAGTCGAGCCTATCGCTATCCAGGCTGACCTTACCAGAAGGGATGATCTTGTGAGGCTTGTA
GAGGAGGCATGGGATGGCCTGGGGGGTCTTGACGCTCTAGTATTTAATGCCGGGAACGTCTCCTGCGAGCCCTGCCACCT
CGAGGATGCAGGCTATAGCGACTGGCTTGAAGCAGCAAGGCTCCACCTTGTCGCGCCAGGGTTCCTTACAAGCCTCCTCC
TGCCAAGGTTCCTCAGGCGGGGAAGCGGCGTCTTCGTATACCTTTCATCGGTCAGTGTGAAGGCGCCTATGACCCCGTTC
GCTCTTGCGGATGTGTCGAGGGCGGGACTGGTACAGCTTGCAAAACTGGTTGCACGGAGCTACGGCGGCCGGGGCATAAG
GGCCTACACCGTGCTGCTCGGAAGCTTCGACACGCCGGGAGCCAGGAGAAACGTAGCCAGGATAGGCGAGTCTATGGGTC
TAAGCCCGGAGGAGGCGTGGAGAAAGCTCGTACTGGAGGCAACCCCCCTGGGCAGAGTCGCGCGACCCGAAGAGCTAGCG
AACCTGCTAGCCTTCCTCTTGTCGCCAAGCGCCGAGTACATGAACGGTGCAACAATAGTAATGGATGGTGCGATGACACC
CTGCACATAG

Upstream 100 bases:

>100_bases
ACTTCATGCCTAGCTAAGCACATTATTGCTGCTCCGGAGTCTTGAGCTGCTGGAGCTGCCACGCCCAGACCAAGGGTGCA
GTGAAGGGGTGGGCTCTAAT

Downstream 100 bases:

>100_bases
TCGCGAACTAGCCACAAAGACTATATTGTATTTCAAACTCCATAATTAAGGCTAGTCGCGAGTTAAAAGGTAGCTAGGAT
TTGAGTATTTGCCGTGTGCT

Product: glucose-1-dehydrogenase

Products: NA

Alternate protein names: GLCDH-II [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MPGRASFDLRGVNVLVTASSRGIGFYAARGLARLGASVAISSRSREALERAAKEIKEETGVEPIAIQADLTRRDDLVRLV
EEAWDGLGGLDALVFNAGNVSCEPCHLEDAGYSDWLEAARLHLVAPGFLTSLLLPRFLRRGSGVFVYLSSVSVKAPMTPF
ALADVSRAGLVQLAKLVARSYGGRGIRAYTVLLGSFDTPGARRNVARIGESMGLSPEEAWRKLVLEATPLGRVARPEELA
NLLAFLLSPSAEYMNGATIVMDGAMTPCT

Sequences:

>Translated_269_residues
MPGRASFDLRGVNVLVTASSRGIGFYAARGLARLGASVAISSRSREALERAAKEIKEETGVEPIAIQADLTRRDDLVRLV
EEAWDGLGGLDALVFNAGNVSCEPCHLEDAGYSDWLEAARLHLVAPGFLTSLLLPRFLRRGSGVFVYLSSVSVKAPMTPF
ALADVSRAGLVQLAKLVARSYGGRGIRAYTVLLGSFDTPGARRNVARIGESMGLSPEEAWRKLVLEATPLGRVARPEELA
NLLAFLLSPSAEYMNGATIVMDGAMTPCT
>Mature_268_residues
PGRASFDLRGVNVLVTASSRGIGFYAARGLARLGASVAISSRSREALERAAKEIKEETGVEPIAIQADLTRRDDLVRLVE
EAWDGLGGLDALVFNAGNVSCEPCHLEDAGYSDWLEAARLHLVAPGFLTSLLLPRFLRRGSGVFVYLSSVSVKAPMTPFA
LADVSRAGLVQLAKLVARSYGGRGIRAYTVLLGSFDTPGARRNVARIGESMGLSPEEAWRKLVLEATPLGRVARPEELAN
LLAFLLSPSAEYMNGATIVMDGAMTPCT

Specific function: Catalyzes A Reversible Reduction Of 5-Ketoglutanate To Form D-Gluconate. Dependent On Nadp, Almost Inactive With NAD. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=254, Percent_Identity=31.1023622047244, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI32483357, Length=253, Percent_Identity=31.6205533596838, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI19923817, Length=260, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI33667109, Length=203, Percent_Identity=32.512315270936, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4503301, Length=235, Percent_Identity=28.936170212766, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI126723191, Length=179, Percent_Identity=32.4022346368715, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI66933014, Length=237, Percent_Identity=26.5822784810127, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI126723750, Length=255, Percent_Identity=27.843137254902, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790717, Length=262, Percent_Identity=24.8091603053435, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1787905, Length=255, Percent_Identity=27.4509803921569, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=31.2977099236641, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI2367365, Length=256, Percent_Identity=29.6875, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787335, Length=260, Percent_Identity=27.3076923076923, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082160, Length=266, Percent_Identity=27.0676691729323, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=27.2, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789208, Length=264, Percent_Identity=25.3787878787879, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1786812, Length=270, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=29.8804780876494, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17561402, Length=252, Percent_Identity=24.6031746031746, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17536025, Length=260, Percent_Identity=31.9230769230769, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=263, Percent_Identity=28.8973384030418, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=264, Percent_Identity=29.5454545454545, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560150, Length=269, Percent_Identity=29.368029739777, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=28.4615384615385, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=249, Percent_Identity=29.3172690763052, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=30.6513409961686, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=283, Percent_Identity=27.208480565371, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=28.9473684210526, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI193204405, Length=262, Percent_Identity=29.0076335877863, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=278, Percent_Identity=28.4172661870504, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=286, Percent_Identity=28.6713286713287, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=264, Percent_Identity=25, Blast_Score=65, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=29.0697674418605, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24639444, Length=260, Percent_Identity=28.4615384615385, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI23397609, Length=262, Percent_Identity=32.0610687022901, Blast_Score=84, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24644339, Length=267, Percent_Identity=27.3408239700375, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28571526, Length=260, Percent_Identity=28.4615384615385, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357041, Length=260, Percent_Identity=28.0769230769231, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640442, Length=207, Percent_Identity=28.9855072463768, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 28733; Mature: 28602

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGRASFDLRGVNVLVTASSRGIGFYAARGLARLGASVAISSRSREALERAAKEIKEETG
CCCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHHC
VEPIAIQADLTRRDDLVRLVEEAWDGLGGLDALVFNAGNVSCEPCHLEDAGYSDWLEAAR
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCCCHHHHHHHHH
LHLVAPGFLTSLLLPRFLRRGSGVFVYLSSVSVKAPMTPFALADVSRAGLVQLAKLVARS
HHHCCHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
YGGRGIRAYTVLLGSFDTPGARRNVARIGESMGLSPEEAWRKLVLEATPLGRVARPEELA
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
NLLAFLLSPSAEYMNGATIVMDGAMTPCT
HHHHHHHCCCHHHHCCCEEEECCCCCCCC
>Mature Secondary Structure 
PGRASFDLRGVNVLVTASSRGIGFYAARGLARLGASVAISSRSREALERAAKEIKEETG
CCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHCCHHEECHHHHHHHHHHHHHHHHHHC
VEPIAIQADLTRRDDLVRLVEEAWDGLGGLDALVFNAGNVSCEPCHLEDAGYSDWLEAAR
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCCCCCCCCCCCCHHHHHHHHH
LHLVAPGFLTSLLLPRFLRRGSGVFVYLSSVSVKAPMTPFALADVSRAGLVQLAKLVARS
HHHCCHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCCHHHHHHHHHHHHHHHHHHHHH
YGGRGIRAYTVLLGSFDTPGARRNVARIGESMGLSPEEAWRKLVLEATPLGRVARPEELA
CCCCCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHH
NLLAFLLSPSAEYMNGATIVMDGAMTPCT
HHHHHHHCCCHHHHCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA