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The map label for this gene is moaA [H]

Identifier: 124028060

GI number: 124028060

Start: 1211534

End: 1212577

Strand: Direct

Name: moaA [H]

Synonym: Hbut_1201

Alternate gene names: 124028060

Gene position: 1211534-1212577 (Clockwise)

Preceding gene: 124028055

Following gene: 124028062

Centisome position: 72.67

GC content: 47.41

Gene sequence:

>1044_bases
ATGGTTACAGGTAGATGCAATTTTGCATGCTTTTTCTGCCACATGGAAGGCTATAAGCAGGGATATCGGGTAGAGGACGA
GGTTAGCCTTGAGGAAATTGAGCTTCTAGCCAAAGCTGCTAAGAGGATTGGCATTGAGGCTTTCAAGATCACTGGCGGCG
AGCCGACAGTAAGGAGTGATCTTGTCGATATTGTTAAGATTCTTCACAGCTACGGGTTCTATGTGTCAATGACGACCAAT
GCTTCACTCCTACACAACCATATGCCAGGCCTTGCAGATGCTGGTATAGGACATGTGAATGTTAGCCTACACTCTCTCTC
CGAGAACGTGTTTGAGAAGATTACTGGACGTAGGATGCTCGGCCAGGTTATCCAGAACATAAGGCTACTACGCGAGTACG
GAATACCAGTTAAGATAAACTTTGTAGTACTGAGAGGGCTCAACGAGGACGATGTCGTAAAGTTGATAGACTTTGCAGCA
TCTGTTGATGCAACAGTGCAGATTATAGAACTCCACCCTGTAGGCAGGGCTGTGAAAAGGTTTAAGGACTATTATCTGCC
GCGCTGGCATATACTTGAGAAGCTTGAGGATAGGGTTGTCGAGATAAAGTACAGGGTTGGACTCCACAATAGACCAATAC
TAGTACTTGATAACGGTGTACGTGTAGAACTCGTAGGTCCCGTAGGCAACTACGCATTCTGCGCCGCTTGCACACGTATG
CGAGTCACTTACGACTTTAAGCTAATACCATGTCTAAACTGGCGCGGTAGCCCAATTGATATTAGGAAGCGGCTTGTCAA
TACACACTCTCCCGAGGAGAAAGTTGAGAAGATTATTGAAGCCTTAAAGGAGGCTAACATGCTCCGCAGACCCTTTGTCC
TATTTCCAAGGAGTGGTAAACCGTTCACAGTTAAGCGTAAGTGGCGTATCGCGAGACTTGGCATACCTCGGCGCGACGGT
AGCTTATCAATAACAGGGCAGCGACGCGAGAAGGTTCTAGCCCTGCTACTCGGAGAGTGGGGTAAGTATCTACAAGCTAG
CTGA

Upstream 100 bases:

>100_bases
GCTTAATATACCGATTTCGCTTCTAAGACTAACCCGGACGAGGTGAAGCATTACGATACTCTTTGACGCTTATGGGAGGC
CGTTAACTAATCTGAGACTT

Downstream 100 bases:

>100_bases
TGATGTATGATACAACCTTTTCAAGCATCATTACGAGGAATACAAGGCCTAGCATCATGTTTGTTTTCTTGAATGCCGTT
CTGCTGTAATTCGGATCTCC

Product: molybdenum cofactor biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MVTGRCNFACFFCHMEGYKQGYRVEDEVSLEEIELLAKAAKRIGIEAFKITGGEPTVRSDLVDIVKILHSYGFYVSMTTN
ASLLHNHMPGLADAGIGHVNVSLHSLSENVFEKITGRRMLGQVIQNIRLLREYGIPVKINFVVLRGLNEDDVVKLIDFAA
SVDATVQIIELHPVGRAVKRFKDYYLPRWHILEKLEDRVVEIKYRVGLHNRPILVLDNGVRVELVGPVGNYAFCAACTRM
RVTYDFKLIPCLNWRGSPIDIRKRLVNTHSPEEKVEKIIEALKEANMLRRPFVLFPRSGKPFTVKRKWRIARLGIPRRDG
SLSITGQRREKVLALLLGEWGKYLQAS

Sequences:

>Translated_347_residues
MVTGRCNFACFFCHMEGYKQGYRVEDEVSLEEIELLAKAAKRIGIEAFKITGGEPTVRSDLVDIVKILHSYGFYVSMTTN
ASLLHNHMPGLADAGIGHVNVSLHSLSENVFEKITGRRMLGQVIQNIRLLREYGIPVKINFVVLRGLNEDDVVKLIDFAA
SVDATVQIIELHPVGRAVKRFKDYYLPRWHILEKLEDRVVEIKYRVGLHNRPILVLDNGVRVELVGPVGNYAFCAACTRM
RVTYDFKLIPCLNWRGSPIDIRKRLVNTHSPEEKVEKIIEALKEANMLRRPFVLFPRSGKPFTVKRKWRIARLGIPRRDG
SLSITGQRREKVLALLLGEWGKYLQAS
>Mature_347_residues
MVTGRCNFACFFCHMEGYKQGYRVEDEVSLEEIELLAKAAKRIGIEAFKITGGEPTVRSDLVDIVKILHSYGFYVSMTTN
ASLLHNHMPGLADAGIGHVNVSLHSLSENVFEKITGRRMLGQVIQNIRLLREYGIPVKINFVVLRGLNEDDVVKLIDFAA
SVDATVQIIELHPVGRAVKRFKDYYLPRWHILEKLEDRVVEIKYRVGLHNRPILVLDNGVRVELVGPVGNYAFCAACTRM
RVTYDFKLIPCLNWRGSPIDIRKRLVNTHSPEEKVEKIIEALKEANMLRRPFVLFPRSGKPFTVKRKWRIARLGIPRRDG
SLSITGQRREKVLALLLGEWGKYLQAS

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=301, Percent_Identity=31.5614617940199, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI116734668, Length=301, Percent_Identity=31.5614617940199, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1786999, Length=289, Percent_Identity=28.0276816608997, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32566329, Length=316, Percent_Identity=30.379746835443, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17561210, Length=292, Percent_Identity=29.7945205479452, Blast_Score=114, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI32566331, Length=293, Percent_Identity=31.3993174061433, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI28574488, Length=322, Percent_Identity=27.9503105590062, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574490, Length=294, Percent_Identity=28.9115646258503, Blast_Score=98, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013485
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39549; Mature: 39549

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTGRCNFACFFCHMEGYKQGYRVEDEVSLEEIELLAKAAKRIGIEAFKITGGEPTVRSD
CCCCCCCEEEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
LVDIVKILHSYGFYVSMTTNASLLHNHMPGLADAGIGHVNVSLHSLSENVFEKITGRRML
HHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
GQVIQNIRLLREYGIPVKINFVVLRGLNEDDVVKLIDFAASVDATVQIIELHPVGRAVKR
HHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
FKDYYLPRWHILEKLEDRVVEIKYRVGLHNRPILVLDNGVRVELVGPVGNYAFCAACTRM
HHHHCCCHHHHHHHHHHHEEEEEEEECCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHE
RVTYDFKLIPCLNWRGSPIDIRKRLVNTHSPEEKVEKIIEALKEANMLRRPFVLFPRSGK
EEEEEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PFTVKRKWRIARLGIPRRDGSLSITGQRREKVLALLLGEWGKYLQAS
CEEEEECEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVTGRCNFACFFCHMEGYKQGYRVEDEVSLEEIELLAKAAKRIGIEAFKITGGEPTVRSD
CCCCCCCEEEEEEEEHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHH
LVDIVKILHSYGFYVSMTTNASLLHNHMPGLADAGIGHVNVSLHSLSENVFEKITGRRML
HHHHHHHHHHCCEEEEEECCHHHHHHCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHH
GQVIQNIRLLREYGIPVKINFVVLRGLNEDDVVKLIDFAASVDATVQIIELHPVGRAVKR
HHHHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
FKDYYLPRWHILEKLEDRVVEIKYRVGLHNRPILVLDNGVRVELVGPVGNYAFCAACTRM
HHHHCCCHHHHHHHHHHHEEEEEEEECCCCCCEEEEECCEEEEEECCCCCHHHHHHHHHE
RVTYDFKLIPCLNWRGSPIDIRKRLVNTHSPEEKVEKIIEALKEANMLRRPFVLFPRSGK
EEEEEEEEEEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PFTVKRKWRIARLGIPRRDGSLSITGQRREKVLALLLGEWGKYLQAS
CEEEEECEEEEECCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]