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The map label for this gene is pccB [H]

Identifier: 124028017

GI number: 124028017

Start: 1165685

End: 1167232

Strand: Direct

Name: pccB [H]

Synonym: Hbut_1155

Alternate gene names: 124028017

Gene position: 1165685-1167232 (Clockwise)

Preceding gene: 124028016

Following gene: 124028020

Centisome position: 69.92

GC content: 57.56

Gene sequence:

>1548_bases
GTGAGCCTCGAGGAGAAGCTTAGAGAGCTGGAGGAGCTTAGGCGTAGATCGCTCGAGGGTGGCGGCCCCGAGAAGATTAA
GAGGCAGCGTGAGCGCGGCAAGCTCCTCGCGAGGGAGAGGCTTGACCTTCTCCTGGATCCTGGCAGCTTCCAGGAGCTAG
ACTGGCTCGTCACCACCCGCGGTGCACCACTCGGCGAGGTTCCAAGAATCCCTGGCGACGGCGTGGTAGCGGGGTTCGGC
AGGATAAACGGTAGGCCCGTCTTTGTCTTCTCCCAGGACTTCACAGTAGCTGGTGGCAGTATAGGCGAGATGCACGCCGA
GAAGATAGTGCGAACCATAAAGTACGCGTTGAAGAGCGGGGTCCCAGTCATAGGCATCTGGGACTCTGGGGGTGCCAGGA
TACAGGAGGGTGTCGCAGCCCTCCACGGTGTTGGAAGAATATTCAACGCGATAATCCAGGCCAGCGGTGTAATCCCACAG
ATATCCCTCGTCCTGGGCTCCTCGGCTGGTGGTGCAGCCTACGCCCCAGCTCTCATGGACTTCACGATCGTCGTTGACAA
GATAACATACATGTTCGTCACCGGCCCAGACGTCGTAAGAGAGGTCACCGGCGAGGAGGTGACCTTCGAGCAGCTTGGAG
GAGCACGGGTTCACAGCCAGTTAAGCGGCGTAGCCCACTTCCGCGCAGCAAACGAGGAGGAAGCCTTCAGGATTACTAGG
AGGCTACTCAGCTACCTCCCAGACAATAATGAAGCCCCGCTACCAATCATCGACACGGGAGACCCGGTAGATCGACGCGA
TCCCGATCTAGACTCTATGGTGCCCGATGACCCCCATAAACCCTATGATATGAAGCAAGTGCTTGAGAGGATATTCGACC
ACGGCAGCCTCCTCGAGGTACAGCCGGAGTGGGGTACAAGCATCATAACAGCCTTTGCTAGGCTCGGCGGTATACCCGTC
TGCGTGGTTGCCAGCCAGCCACTAGTGCTGAGTGGCGCGATAGACATTAACGCCTCGTGTAAAGCAGCGCGATTCGTTAG
GTTCTGCGACGCGTTCAACCTCCCAGTCATAACCTTCGTAGACGTGCCAGGCTACATGCCCGGCCTAGACCAGGAGCACG
GCGGCATAATCAGGCACGGTGCTAAGATGCTCTACGCTTACGCTGAGGCTACGGTTCCAAAGCTAACAGTCGTGGTTAGG
AAGGCCTACGGCGGAGCATATATCTCGATGGGCAGCAAGTCGCTGGGAGCGGACATAGTCTATGCATGGCCCACGGCAGA
GATAGCCGTGCTCGGTGCTGAGGCAGCTGTACGCATACTTTACCGGAAACGCCTCCGCGCGGCGGAGAACCCAGAGGAGG
AGAGGAAACGACTCATAGACGAGTATCGCAGGACATTCCTAAACCCGTTCCGAGCCGCAGAGTTAGGCCTCGTAGACGAC
GTGGTTAAACCCAGTGAGACCCGCTACAAGCTCTACACAGCACTCGAGGTACTACTAAAGAAGAGGGAACCCAGGCTACC
CAAGAAGCACGGAAACATACCACTCTAA

Upstream 100 bases:

>100_bases
GAAGATAAAGTAGCTTGTAACCCCAACTTTTAACCCTGCCACACCACAATCCTTCCGGACAACCTTATTCACGTAGCTCA
GCGTCCTTTGGTGGCGTGCT

Downstream 100 bases:

>100_bases
CCCCACGAAACCAAGGCCATGCTCTAGAGCAAGATCGCACTGATGACGATAGAAGCGGCATCCAGACCTGAATTCCACAT
CGTAACCCTCCCCTTGCCCA

Product: propionyl-CoA carboxylase beta chain

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 515; Mature: 514

Protein sequence:

>515_residues
MSLEEKLRELEELRRRSLEGGGPEKIKRQRERGKLLARERLDLLLDPGSFQELDWLVTTRGAPLGEVPRIPGDGVVAGFG
RINGRPVFVFSQDFTVAGGSIGEMHAEKIVRTIKYALKSGVPVIGIWDSGGARIQEGVAALHGVGRIFNAIIQASGVIPQ
ISLVLGSSAGGAAYAPALMDFTIVVDKITYMFVTGPDVVREVTGEEVTFEQLGGARVHSQLSGVAHFRAANEEEAFRITR
RLLSYLPDNNEAPLPIIDTGDPVDRRDPDLDSMVPDDPHKPYDMKQVLERIFDHGSLLEVQPEWGTSIITAFARLGGIPV
CVVASQPLVLSGAIDINASCKAARFVRFCDAFNLPVITFVDVPGYMPGLDQEHGGIIRHGAKMLYAYAEATVPKLTVVVR
KAYGGAYISMGSKSLGADIVYAWPTAEIAVLGAEAAVRILYRKRLRAAENPEEERKRLIDEYRRTFLNPFRAAELGLVDD
VVKPSETRYKLYTALEVLLKKREPRLPKKHGNIPL

Sequences:

>Translated_515_residues
MSLEEKLRELEELRRRSLEGGGPEKIKRQRERGKLLARERLDLLLDPGSFQELDWLVTTRGAPLGEVPRIPGDGVVAGFG
RINGRPVFVFSQDFTVAGGSIGEMHAEKIVRTIKYALKSGVPVIGIWDSGGARIQEGVAALHGVGRIFNAIIQASGVIPQ
ISLVLGSSAGGAAYAPALMDFTIVVDKITYMFVTGPDVVREVTGEEVTFEQLGGARVHSQLSGVAHFRAANEEEAFRITR
RLLSYLPDNNEAPLPIIDTGDPVDRRDPDLDSMVPDDPHKPYDMKQVLERIFDHGSLLEVQPEWGTSIITAFARLGGIPV
CVVASQPLVLSGAIDINASCKAARFVRFCDAFNLPVITFVDVPGYMPGLDQEHGGIIRHGAKMLYAYAEATVPKLTVVVR
KAYGGAYISMGSKSLGADIVYAWPTAEIAVLGAEAAVRILYRKRLRAAENPEEERKRLIDEYRRTFLNPFRAAELGLVDD
VVKPSETRYKLYTALEVLLKKREPRLPKKHGNIPL
>Mature_514_residues
SLEEKLRELEELRRRSLEGGGPEKIKRQRERGKLLARERLDLLLDPGSFQELDWLVTTRGAPLGEVPRIPGDGVVAGFGR
INGRPVFVFSQDFTVAGGSIGEMHAEKIVRTIKYALKSGVPVIGIWDSGGARIQEGVAALHGVGRIFNAIIQASGVIPQI
SLVLGSSAGGAAYAPALMDFTIVVDKITYMFVTGPDVVREVTGEEVTFEQLGGARVHSQLSGVAHFRAANEEEAFRITRR
LLSYLPDNNEAPLPIIDTGDPVDRRDPDLDSMVPDDPHKPYDMKQVLERIFDHGSLLEVQPEWGTSIITAFARLGGIPVC
VVASQPLVLSGAIDINASCKAARFVRFCDAFNLPVITFVDVPGYMPGLDQEHGGIIRHGAKMLYAYAEATVPKLTVVVRK
AYGGAYISMGSKSLGADIVYAWPTAEIAVLGAEAAVRILYRKRLRAAENPEEERKRLIDEYRRTFLNPFRAAELGLVDDV
VKPSETRYKLYTALEVLLKKREPRLPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=509, Percent_Identity=53.2416502946955, Blast_Score=535, Evalue=1e-152,
Organism=Homo sapiens, GI295821216, Length=529, Percent_Identity=51.2287334593573, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI11545863, Length=494, Percent_Identity=32.1862348178138, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI134142062, Length=341, Percent_Identity=28.4457478005865, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38679971, Length=345, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI38679960, Length=345, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI38679974, Length=345, Percent_Identity=27.536231884058, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI38679977, Length=345, Percent_Identity=27.536231884058, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI38679967, Length=345, Percent_Identity=27.536231884058, Blast_Score=99, Evalue=7e-21,
Organism=Escherichia coli, GI1788655, Length=190, Percent_Identity=28.9473684210526, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=509, Percent_Identity=51.8664047151277, Blast_Score=524, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI25147359, Length=509, Percent_Identity=51.8664047151277, Blast_Score=523, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17552936, Length=499, Percent_Identity=31.6633266533066, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71997163, Length=310, Percent_Identity=26.4516129032258, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324343, Length=365, Percent_Identity=24.9315068493151, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323863, Length=347, Percent_Identity=25.3602305475504, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586065, Length=523, Percent_Identity=33.2695984703633, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI161076407, Length=341, Percent_Identity=25.8064516129032, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586460, Length=341, Percent_Identity=25.8064516129032, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24586458, Length=341, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161076409, Length=341, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56540; Mature: 56409

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLEEKLRELEELRRRSLEGGGPEKIKRQRERGKLLARERLDLLLDPGSFQELDWLVTTR
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHEEEEEEC
GAPLGEVPRIPGDGVVAGFGRINGRPVFVFSQDFTVAGGSIGEMHAEKIVRTIKYALKSG
CCCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHCC
VPVIGIWDSGGARIQEGVAALHGVGRIFNAIIQASGVIPQISLVLGSSAGGAAYAPALMD
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
FTIVVDKITYMFVTGPDVVREVTGEEVTFEQLGGARVHSQLSGVAHFRAANEEEAFRITR
HHHHEECEEEEEEECHHHHHHHCCCCEEHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
RLLSYLPDNNEAPLPIIDTGDPVDRRDPDLDSMVPDDPHKPYDMKQVLERIFDHGSLLEV
HHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
QPEWGTSIITAFARLGGIPVCVVASQPLVLSGAIDINASCKAARFVRFCDAFNLPVITFV
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
DVPGYMPGLDQEHGGIIRHGAKMLYAYAEATVPKLTVVVRKAYGGAYISMGSKSLGADIV
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEHHHHCCCEEEECCCCCCCCCEE
YAWPTAEIAVLGAEAAVRILYRKRLRAAENPEEERKRLIDEYRRTFLNPFRAAELGLVDD
EECCCCEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
VVKPSETRYKLYTALEVLLKKREPRLPKKHGNIPL
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SLEEKLRELEELRRRSLEGGGPEKIKRQRERGKLLARERLDLLLDPGSFQELDWLVTTR
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHEEEEEEC
GAPLGEVPRIPGDGVVAGFGRINGRPVFVFSQDFTVAGGSIGEMHAEKIVRTIKYALKSG
CCCCCCCCCCCCCCEEEECCCCCCEEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHCC
VPVIGIWDSGGARIQEGVAALHGVGRIFNAIIQASGVIPQISLVLGSSAGGAAYAPALMD
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHH
FTIVVDKITYMFVTGPDVVREVTGEEVTFEQLGGARVHSQLSGVAHFRAANEEEAFRITR
HHHHEECEEEEEEECHHHHHHHCCCCEEHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
RLLSYLPDNNEAPLPIIDTGDPVDRRDPDLDSMVPDDPHKPYDMKQVLERIFDHGSLLEV
HHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
QPEWGTSIITAFARLGGIPVCVVASQPLVLSGAIDINASCKAARFVRFCDAFNLPVITFV
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEEEEEECCCCHHHHHHHHHHHCCCCCEEEEE
DVPGYMPGLDQEHGGIIRHGAKMLYAYAEATVPKLTVVVRKAYGGAYISMGSKSLGADIV
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHEEHHHHCCCEEEECCCCCCCCCEE
YAWPTAEIAVLGAEAAVRILYRKRLRAAENPEEERKRLIDEYRRTFLNPFRAAELGLVDD
EECCCCEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHH
VVKPSETRYKLYTALEVLLKKREPRLPKKHGNIPL
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]