Click here to switch to the map view.

The map label for this gene is ahcY [H]

Identifier: 124027994

GI number: 124027994

Start: 1144756

End: 1146009

Strand: Direct

Name: ahcY [H]

Synonym: Hbut_1132

Alternate gene names: 124027994

Gene position: 1144756-1146009 (Clockwise)

Preceding gene: 124027993

Following gene: 124027996

Centisome position: 68.66

GC content: 50.72

Gene sequence:

>1254_bases
GTGGCTAGCAAGATAAAGCATCCCGAACTTGCTGATAGGGGCAGGCTTCAGATCGAATGGGCAGAAAAGCATATGCCTGT
AGTTGCCAAGTTTATCCGTGAAAGATTTGCTGCCGAGAAGCCACTTAACGGTATCAGGGTTGGAGCCGTACTACACGTCA
CCAAGGAGACTGCTGCATTAGTACGCACACTTGTTGCTGGCGGCGCTGTAGTAAGACTTGCAGCTAGCAATCCTTTAAGC
ACACAGGACGATGTAGCTGCTGCACTAGCAAGCGAGGAAGGTATCGAGGTCTGTGCTTGGCGCGGCATGAGTGAGGACGA
GTATTTTGACTGCATACGCTGGATTGCATCCTGGGAGCCAAACATAGTCATAGACGATGGAGGAGACCTACACGCTACAC
TACATAAGGAATACCTTGACATCGCTGCAAGGGTTTGGGGCGGCACGGAGGAGACAACAACAGGCGTCATAAGACTTAGA
GCTATGGAGAGGGAGGGTGTGCTAAAGTACCCCGCGATAGCGGTCAATGATGCAAAAACCAAAATGATGTTCGACAACCG
CTACGGTACCGGCCAGAGCGCAATAGACGGGATACTGAGAGCTACAAACATACTGCTTGCAGGCAAGAGGGTCGTCGTTG
CAGGTTATGGCTGGGTTGGACGGGGTATAGCTATACGTGCACGTGGCATGGGTGCACGTGTCATAGTCACAGAGGTTGAC
CCCATAAAGGCGCTCGAAGCAGTAATGGATGGCTTCGAAGTCATGCCAATGAAGGAGGCGGCAAAGATAGGCGATGTATT
CATAACTGCCACTGGTAACAAGAAGGTTATCCGTCGCGAACACTTCGAGGTAATGAAGGATGGCGCGATACTAGCCAATG
CTGGCCACTTCAACGTGGAGATATGGGTGCCGGACCTGGAGGAGCTAGCAGTTTCGAAGAGGCAGGTTAGACCCTACGTA
ACCGAGTACACGCTAGCCGATGGAAGAAAGATATACCTACTAGCTGAGGGAAGGCTCGTAAACCTCGTGGCTGCCGAGGG
ACACCCAAGCGAAGTCATGGATATGAGCTTTGCAAACCAAGCACTCTCCGTGGAATATCTCGTCAAGAGCCGTGGAAAGC
TAGAACCCAAAGTATACAATGTACCGAGAGAGATCGACGAAGAGGTAGCAAGACTAAAGCTCAAAGCTATGGGCATAGAG
ATTGACAAGCTGACAGAAGAACAGAAACAATACCTTGAGAGCTGGAAACTATAA

Upstream 100 bases:

>100_bases
TCCCTCTGTATTGTTTACAATTGCTTACTGCTTTTAGAGCGTCGGAGAAGAGGCTTCAAGTACCGCGGTTTCCTCTTCGG
TGTCTGCTGGGTGGCTAGGC

Downstream 100 bases:

>100_bases
GGCTGTTGTCAATGCTCTCTAACCAACCACTTGGGGGCTGTGACGCCTTACAGCCGAGCCGAGAGACTATAACTCTATGA
GGAGTTTCGCCCCTCGGGAG

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MASKIKHPELADRGRLQIEWAEKHMPVVAKFIRERFAAEKPLNGIRVGAVLHVTKETAALVRTLVAGGAVVRLAASNPLS
TQDDVAAALASEEGIEVCAWRGMSEDEYFDCIRWIASWEPNIVIDDGGDLHATLHKEYLDIAARVWGGTEETTTGVIRLR
AMEREGVLKYPAIAVNDAKTKMMFDNRYGTGQSAIDGILRATNILLAGKRVVVAGYGWVGRGIAIRARGMGARVIVTEVD
PIKALEAVMDGFEVMPMKEAAKIGDVFITATGNKKVIRREHFEVMKDGAILANAGHFNVEIWVPDLEELAVSKRQVRPYV
TEYTLADGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQALSVEYLVKSRGKLEPKVYNVPREIDEEVARLKLKAMGIE
IDKLTEEQKQYLESWKL

Sequences:

>Translated_417_residues
MASKIKHPELADRGRLQIEWAEKHMPVVAKFIRERFAAEKPLNGIRVGAVLHVTKETAALVRTLVAGGAVVRLAASNPLS
TQDDVAAALASEEGIEVCAWRGMSEDEYFDCIRWIASWEPNIVIDDGGDLHATLHKEYLDIAARVWGGTEETTTGVIRLR
AMEREGVLKYPAIAVNDAKTKMMFDNRYGTGQSAIDGILRATNILLAGKRVVVAGYGWVGRGIAIRARGMGARVIVTEVD
PIKALEAVMDGFEVMPMKEAAKIGDVFITATGNKKVIRREHFEVMKDGAILANAGHFNVEIWVPDLEELAVSKRQVRPYV
TEYTLADGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQALSVEYLVKSRGKLEPKVYNVPREIDEEVARLKLKAMGIE
IDKLTEEQKQYLESWKL
>Mature_416_residues
ASKIKHPELADRGRLQIEWAEKHMPVVAKFIRERFAAEKPLNGIRVGAVLHVTKETAALVRTLVAGGAVVRLAASNPLST
QDDVAAALASEEGIEVCAWRGMSEDEYFDCIRWIASWEPNIVIDDGGDLHATLHKEYLDIAARVWGGTEETTTGVIRLRA
MEREGVLKYPAIAVNDAKTKMMFDNRYGTGQSAIDGILRATNILLAGKRVVVAGYGWVGRGIAIRARGMGARVIVTEVDP
IKALEAVMDGFEVMPMKEAAKIGDVFITATGNKKVIRREHFEVMKDGAILANAGHFNVEIWVPDLEELAVSKRQVRPYVT
EYTLADGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQALSVEYLVKSRGKLEPKVYNVPREIDEEVARLKLKAMGIEI
DKLTEEQKQYLESWKL

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=406, Percent_Identity=48.7684729064039, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI239937451, Length=391, Percent_Identity=49.1048593350384, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI298286489, Length=412, Percent_Identity=42.2330097087379, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI195539349, Length=412, Percent_Identity=42.2330097087379, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI195539337, Length=412, Percent_Identity=42.2330097087379, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI24308043, Length=412, Percent_Identity=42.2330097087379, Blast_Score=315, Evalue=4e-86,
Organism=Homo sapiens, GI21361647, Length=412, Percent_Identity=40.7766990291262, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI17506425, Length=418, Percent_Identity=46.4114832535885, Blast_Score=344, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6320882, Length=428, Percent_Identity=45.0934579439252, Blast_Score=336, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24642172, Length=413, Percent_Identity=46.2469733656174, Blast_Score=336, Evalue=1e-92,
Organism=Drosophila melanogaster, GI24656245, Length=403, Percent_Identity=42.4317617866005, Blast_Score=305, Evalue=5e-83,
Organism=Drosophila melanogaster, GI45553387, Length=402, Percent_Identity=43.5323383084577, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI45553385, Length=402, Percent_Identity=43.5323383084577, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46208; Mature: 46077

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKIKHPELADRGRLQIEWAEKHMPVVAKFIRERFAAEKPLNGIRVGAVLHVTKETAAL
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHH
VRTLVAGGAVVRLAASNPLSTQDDVAAALASEEGIEVCAWRGMSEDEYFDCIRWIASWEP
HHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
NIVIDDGGDLHATLHKEYLDIAARVWGGTEETTTGVIRLRAMEREGVLKYPAIAVNDAKT
CEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCEECCEEEECCCCE
KMMFDNRYGTGQSAIDGILRATNILLAGKRVVVAGYGWVGRGIAIRARGMGARVIVTEVD
EEEEECCCCCCHHHHHHHHHHHHEEEECCEEEEEECCCCCCCEEEEEECCCCEEEEEECC
PIKALEAVMDGFEVMPMKEAAKIGDVFITATGNKKVIRREHFEVMKDGAILANAGHFNVE
HHHHHHHHHCCCEECCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCEEEEE
IWVPDLEELAVSKRQVRPYVTEYTLADGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQ
EECCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHH
ALSVEYLVKSRGKLEPKVYNVPREIDEEVARLKLKAMGIEIDKLTEEQKQYLESWKL
HHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASKIKHPELADRGRLQIEWAEKHMPVVAKFIRERFAAEKPLNGIRVGAVLHVTKETAAL
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHHHH
VRTLVAGGAVVRLAASNPLSTQDDVAAALASEEGIEVCAWRGMSEDEYFDCIRWIASWEP
HHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCC
NIVIDDGGDLHATLHKEYLDIAARVWGGTEETTTGVIRLRAMEREGVLKYPAIAVNDAKT
CEEEECCCCEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCEECCEEEECCCCE
KMMFDNRYGTGQSAIDGILRATNILLAGKRVVVAGYGWVGRGIAIRARGMGARVIVTEVD
EEEEECCCCCCHHHHHHHHHHHHEEEECCEEEEEECCCCCCCEEEEEECCCCEEEEEECC
PIKALEAVMDGFEVMPMKEAAKIGDVFITATGNKKVIRREHFEVMKDGAILANAGHFNVE
HHHHHHHHHCCCEECCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHCCEEEEECCEEEEE
IWVPDLEELAVSKRQVRPYVTEYTLADGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQ
EECCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCEEEEEECCCCCHHHHHHHHHHH
ALSVEYLVKSRGKLEPKVYNVPREIDEEVARLKLKAMGIEIDKLTEEQKQYLESWKL
HHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHCEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8921839; 10701121; 11427726 [H]