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The map label for this gene is pncB [H]

Identifier: 124027989

GI number: 124027989

Start: 1138141

End: 1139322

Strand: Direct

Name: pncB [H]

Synonym: Hbut_1124

Alternate gene names: 124027989

Gene position: 1138141-1139322 (Clockwise)

Preceding gene: 124027988

Following gene: 124027993

Centisome position: 68.27

GC content: 47.97

Gene sequence:

>1182_bases
TTGAAGGAGCCTCAGCTGTATATTGCTGATGCGGACTCTATTCGGAGTGGTGCTGTTACAGATATTTACTTTGTTAGGAC
TAGGCAGGTACTTGCTGCTAAGGGGCTCTGTGATACATACGTTCGTGCGGAATTACATGCTTATAGTCTGCCAAGAGGAT
ATGAATGGGCAGTTTTTGCAGGGCTAGAGGAGGCTCTCGCAATTCTTAGGGGGAGACGCGTCAACGTCTATGCAATGCCC
GAGGGAACACTCTTTAAACCTATGGAACCTCTCATGGTTATTGAGGGGCCTTACTGTGAGTTTGCTGAGCTTGAAACAGC
TATCCTCGGTGTTTTAAGGCACGAAACGAGTATCGCCACTAAGGCTGCAAGAATACGACTTGCAGCCGGCGATAGGACGG
TATTGTTCTTCGGCCTTAGAGCGCTCCATCCCGCAATAGCACCAATGGCTGATAGAGCCGCGTATATAGGTGGCTGTGAC
GGTGTTTCGGGCATTATGTCCGAGCGGTTCCTTGGAGTAAAGCCTACAGGCACTATGCCTCATGCATTGATAATAGTGTT
CGGTGACCAGGTTAAAGCATGGAAAGCCTTTGACGAAGTTGTTGATGAAACTGTGCCGCGGATAGCGCTTACAGATACTT
TCTACGATGAACGCGTAGAGGCGTTAATGGCTGCTAAGGCTCTAGGCTCCAGACTGTATGGGGTTAGGCTTGATACGCCA
AGTAGTAGAAGGGGCAATATGAGAAAGATAGTTCAAGAGGTTAGATGGACACTAGACATTAACGGATTTAGGCATGTCAA
GATATTTGTTAGCGGCGGCCTAGACGAGGATGAGGTGAGAGAGCTAAGGGATATCGTTGATGGGTTTGGTGTCGGAACCT
CAATAGCGTTTCCACCGAGCATAGACATAAGTATGGATATTGTTGAGGTACGGCGTGGAGATAAATGGGAACCCATAGCT
AAGCGTGGCAAGCTGCCAGGATTTAAGCAAGTGTATAGGTGTAGACTACTCGAAGACTACATTGTACCATGGGATGCCAA
GCCACCAAGCTGTCCTGACGGCAGTAAGCCTAAACCTCTGCTAGAAAAGGTTATGGAGAACGGAGAAATCATCAAGGAGC
TTCCAACAGTCCATGATATAAGGTCATACGTGCTTGAGCAGCTTAGAGCTTTTAGCCAGTAG

Upstream 100 bases:

>100_bases
GGTAGGCTTGTGAGGGGTACATGGCAGAGTATTTTACTGCTTGAGCTTGACGGACCTCGGAGTAGAAGGATTATTGTTGA
GGTTATGGGTGAGTAGCAAG

Downstream 100 bases:

>100_bases
ACTTGCCGAGCGCACCGCTAGGCGAAGTATAGCCTCCACTATCTCTGCTGCACTGTAGGTTTTTCTTCCACGCGAAGTAT
ATGTCACAACATTACAGTAC

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKEPQLYIADADSIRSGAVTDIYFVRTRQVLAAKGLCDTYVRAELHAYSLPRGYEWAVFAGLEEALAILRGRRVNVYAMP
EGTLFKPMEPLMVIEGPYCEFAELETAILGVLRHETSIATKAARIRLAAGDRTVLFFGLRALHPAIAPMADRAAYIGGCD
GVSGIMSERFLGVKPTGTMPHALIIVFGDQVKAWKAFDEVVDETVPRIALTDTFYDERVEALMAAKALGSRLYGVRLDTP
SSRRGNMRKIVQEVRWTLDINGFRHVKIFVSGGLDEDEVRELRDIVDGFGVGTSIAFPPSIDISMDIVEVRRGDKWEPIA
KRGKLPGFKQVYRCRLLEDYIVPWDAKPPSCPDGSKPKPLLEKVMENGEIIKELPTVHDIRSYVLEQLRAFSQ

Sequences:

>Translated_393_residues
MKEPQLYIADADSIRSGAVTDIYFVRTRQVLAAKGLCDTYVRAELHAYSLPRGYEWAVFAGLEEALAILRGRRVNVYAMP
EGTLFKPMEPLMVIEGPYCEFAELETAILGVLRHETSIATKAARIRLAAGDRTVLFFGLRALHPAIAPMADRAAYIGGCD
GVSGIMSERFLGVKPTGTMPHALIIVFGDQVKAWKAFDEVVDETVPRIALTDTFYDERVEALMAAKALGSRLYGVRLDTP
SSRRGNMRKIVQEVRWTLDINGFRHVKIFVSGGLDEDEVRELRDIVDGFGVGTSIAFPPSIDISMDIVEVRRGDKWEPIA
KRGKLPGFKQVYRCRLLEDYIVPWDAKPPSCPDGSKPKPLLEKVMENGEIIKELPTVHDIRSYVLEQLRAFSQ
>Mature_393_residues
MKEPQLYIADADSIRSGAVTDIYFVRTRQVLAAKGLCDTYVRAELHAYSLPRGYEWAVFAGLEEALAILRGRRVNVYAMP
EGTLFKPMEPLMVIEGPYCEFAELETAILGVLRHETSIATKAARIRLAAGDRTVLFFGLRALHPAIAPMADRAAYIGGCD
GVSGIMSERFLGVKPTGTMPHALIIVFGDQVKAWKAFDEVVDETVPRIALTDTFYDERVEALMAAKALGSRLYGVRLDTP
SSRRGNMRKIVQEVRWTLDINGFRHVKIFVSGGLDEDEVRELRDIVDGFGVGTSIAFPPSIDISMDIVEVRRGDKWEPIA
KRGKLPGFKQVYRCRLLEDYIVPWDAKPPSCPDGSKPKPLLEKVMENGEIIKELPTVHDIRSYVLEQLRAFSQ

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=402, Percent_Identity=26.1194029850746, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997947, Length=457, Percent_Identity=24.72647702407, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71997952, Length=457, Percent_Identity=24.72647702407, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71997955, Length=128, Percent_Identity=35.15625, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24581587, Length=431, Percent_Identity=24.1299303944316, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI161076680, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581595, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574709, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581593, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581591, Length=141, Percent_Identity=37.5886524822695, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 43890; Mature: 43890

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEPQLYIADADSIRSGAVTDIYFVRTRQVLAAKGLCDTYVRAELHAYSLPRGYEWAVFA
CCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHH
GLEEALAILRGRRVNVYAMPEGTLFKPMEPLMVIEGPYCEFAELETAILGVLRHETSIAT
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
KAARIRLAAGDRTVLFFGLRALHPAIAPMADRAAYIGGCDGVSGIMSERFLGVKPTGTMP
HHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
HALIIVFGDQVKAWKAFDEVVDETVPRIALTDTFYDERVEALMAAKALGSRLYGVRLDTP
EEEEEEECCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCC
SSRRGNMRKIVQEVRWTLDINGFRHVKIFVSGGLDEDEVRELRDIVDGFGVGTSIAFPPS
CCCCCCHHHHHHHHHHEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCC
IDISMDIVEVRRGDKWEPIAKRGKLPGFKQVYRCRLLEDYIVPWDAKPPSCPDGSKPKPL
CCCEEEHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
LEKVMENGEIIKELPTVHDIRSYVLEQLRAFSQ
HHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKEPQLYIADADSIRSGAVTDIYFVRTRQVLAAKGLCDTYVRAELHAYSLPRGYEWAVFA
CCCCCEEEECCCCCCCCCCEEEEEEHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHH
GLEEALAILRGRRVNVYAMPEGTLFKPMEPLMVIEGPYCEFAELETAILGVLRHETSIAT
CHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
KAARIRLAAGDRTVLFFGLRALHPAIAPMADRAAYIGGCDGVSGIMSERFLGVKPTGTMP
HHHEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
HALIIVFGDQVKAWKAFDEVVDETVPRIALTDTFYDERVEALMAAKALGSRLYGVRLDTP
EEEEEEECCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHCCEEEEEECCC
SSRRGNMRKIVQEVRWTLDINGFRHVKIFVSGGLDEDEVRELRDIVDGFGVGTSIAFPPS
CCCCCCHHHHHHHHHHEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCC
IDISMDIVEVRRGDKWEPIAKRGKLPGFKQVYRCRLLEDYIVPWDAKPPSCPDGSKPKPL
CCCEEEHHHHCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
LEKVMENGEIIKELPTVHDIRSYVLEQLRAFSQ
HHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]