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The map label for this gene is top6B [H]

Identifier: 124027833

GI number: 124027833

Start: 969305

End: 970912

Strand: Direct

Name: top6B [H]

Synonym: Hbut_0960

Alternate gene names: 124027833

Gene position: 969305-970912 (Clockwise)

Preceding gene: 124027829

Following gene: 124027834

Centisome position: 58.14

GC content: 48.01

Gene sequence:

>1608_bases
GTGCCGCCGAAAAGGCAGCGGGCAGCTGTACAGGAAAGCTTCCGTAGCATGACACCTTCGCAGTTCTTCTATGAATACAA
GGAGGTAGCTGGATTTGGCAGCCCTGCACGTGCACTCTACCAGACAGTACGCGAGCTAGTAGAGAACGCACTCGATGCAA
CAGACGTTCATGGAATACTGCCAGACATAACAATTGTCATTGAACGTGTCAATGAAAATTCCAACTACTATCGTATAACG
GTTGAGGATAATGGTATAGGTATACAGCCCCAGTATGTCCCATATGCGTTTGGCCAAGTACTCTATAGCTCGAAGTATAA
GCTACGCCAGGCTAGGGGCCGTTTCGGCCTCGGCGCAAAAATGGCTATACTATACGGGCAGATAAGGACTGGCAGACCCG
TCGAAGTCTATACAGCTCCAATAGGCTCTAGAAAGATCTACTACTTCAAGCTAAAGATAGACATTGAGCATAATAGGCCA
ATAGTACTCACCAAAGCCGAATACCCGAACCCGAAGGGCTGGCACGGCACAAGGGTAAGCCTAGTAATTGAGGGGGACTG
GTGGCACTCAAAGCACCGAGTCTACGAATACATTAAGCGTACAGCTATAGCAGCACCATACGCTAACATAGTGTTCATAG
ACCCCAATGGCAATGTGGTTATCTACAAGAGGAGTATATCTAAGCTGCCGAAACAACCTAAAGAGGTAAAGCCTCATCCA
CATGGCGTCGACATAGAGTTGCTAAAGCAGCTTATAAGCGGGTCTCAAGCAAAAACTATGGTAGAATTCCTCGCCGAGGC
ATTCCGGGGCGTAGGAAGAAAAACTGCTGAGGCGTTTCTCGAATGGGCAGGTATAGCTAAGAATCTTGATCCTCATAGCC
TTGATGACAGACAGCTAGAACTACTAGCCAGAAAGCTCCGGGAATACCAGAAGTTTAGAGCACCAAGCGCAGATGCCCTA
TCTCCGTTCGGGCCCGAAATAATCGAGGCGGGACTACGCTCCATACTAAAGCCAGAGTTTGTTGCGGCGGTCACGAGGAG
GCCTAGGGCGTACGAGGGTCATCCATTCATAGTAGAGGTAGGGATAGCCTATGGCGGAGAAATACCTCCAACCAATGAGC
CCATACTGCTGCGGTATGCTAACAAGATACCACTCCTATACGACGAGAAGTCTGATGTAGCATGGAAGGTTGTTGATCCA
CACAATTTTGACTGGAGGAACTATCTAGTAACATTTCCCGCCCCTGTGGCAGTACTAACACATATAGCAAGCACTAAAGT
CCCCTACAAGAGCGTTGGCAAGGAGAGTGTAGCAGATGTACCAGAGATAGAGCAAGAACTCCGCAATGCGCTAAGAGAAG
CTGCGAGAAGGCTCAGAGGATATCTGCTACAAAAGCGCAAGGAAGAAGAGGCAAAACGCAGAATCATAACATTCATGAAG
TATACGCCCGAGATAGCTAAGAGCCTAGCAGTAATACTAAAGGACTACAATGTGAGCGAGCACACAGTAAGGGAGATGCT
ACTATCAGCCATGAAGAGGAGGCTGCGCATAGAGGATGACAAGTTTGCAAAACTAGTAGAGGGTCTAGAGGTAGATATTG
AAGAATAA

Upstream 100 bases:

>100_bases
TTAGTTAGTGGAAAGGCATTTATTCAGCGAAGCTGTTTCGGCGGCTTATTCTTGAAATCCTATAAGGGAAGCTTAGCCTA
ACGAGGATTGAGGGGTTAAA

Downstream 100 bases:

>100_bases
AGAGGGGGTAGGGCGTGGCTGAGGAGTATGTAGACGTAGTCGATATTGAGGCTAGGAAGAAAGCACTAGCGGTGTTCAGG
GAGAAGTTTAAGGAGATACT

Product: DNA topoisomerase VI subunit B

Products: NA

Alternate protein names: Type II DNA topoisomerase VI subunit B; TopoVI-B [H]

Number of amino acids: Translated: 535; Mature: 534

Protein sequence:

>535_residues
MPPKRQRAAVQESFRSMTPSQFFYEYKEVAGFGSPARALYQTVRELVENALDATDVHGILPDITIVIERVNENSNYYRIT
VEDNGIGIQPQYVPYAFGQVLYSSKYKLRQARGRFGLGAKMAILYGQIRTGRPVEVYTAPIGSRKIYYFKLKIDIEHNRP
IVLTKAEYPNPKGWHGTRVSLVIEGDWWHSKHRVYEYIKRTAIAAPYANIVFIDPNGNVVIYKRSISKLPKQPKEVKPHP
HGVDIELLKQLISGSQAKTMVEFLAEAFRGVGRKTAEAFLEWAGIAKNLDPHSLDDRQLELLARKLREYQKFRAPSADAL
SPFGPEIIEAGLRSILKPEFVAAVTRRPRAYEGHPFIVEVGIAYGGEIPPTNEPILLRYANKIPLLYDEKSDVAWKVVDP
HNFDWRNYLVTFPAPVAVLTHIASTKVPYKSVGKESVADVPEIEQELRNALREAARRLRGYLLQKRKEEEAKRRIITFMK
YTPEIAKSLAVILKDYNVSEHTVREMLLSAMKRRLRIEDDKFAKLVEGLEVDIEE

Sequences:

>Translated_535_residues
MPPKRQRAAVQESFRSMTPSQFFYEYKEVAGFGSPARALYQTVRELVENALDATDVHGILPDITIVIERVNENSNYYRIT
VEDNGIGIQPQYVPYAFGQVLYSSKYKLRQARGRFGLGAKMAILYGQIRTGRPVEVYTAPIGSRKIYYFKLKIDIEHNRP
IVLTKAEYPNPKGWHGTRVSLVIEGDWWHSKHRVYEYIKRTAIAAPYANIVFIDPNGNVVIYKRSISKLPKQPKEVKPHP
HGVDIELLKQLISGSQAKTMVEFLAEAFRGVGRKTAEAFLEWAGIAKNLDPHSLDDRQLELLARKLREYQKFRAPSADAL
SPFGPEIIEAGLRSILKPEFVAAVTRRPRAYEGHPFIVEVGIAYGGEIPPTNEPILLRYANKIPLLYDEKSDVAWKVVDP
HNFDWRNYLVTFPAPVAVLTHIASTKVPYKSVGKESVADVPEIEQELRNALREAARRLRGYLLQKRKEEEAKRRIITFMK
YTPEIAKSLAVILKDYNVSEHTVREMLLSAMKRRLRIEDDKFAKLVEGLEVDIEE
>Mature_534_residues
PPKRQRAAVQESFRSMTPSQFFYEYKEVAGFGSPARALYQTVRELVENALDATDVHGILPDITIVIERVNENSNYYRITV
EDNGIGIQPQYVPYAFGQVLYSSKYKLRQARGRFGLGAKMAILYGQIRTGRPVEVYTAPIGSRKIYYFKLKIDIEHNRPI
VLTKAEYPNPKGWHGTRVSLVIEGDWWHSKHRVYEYIKRTAIAAPYANIVFIDPNGNVVIYKRSISKLPKQPKEVKPHPH
GVDIELLKQLISGSQAKTMVEFLAEAFRGVGRKTAEAFLEWAGIAKNLDPHSLDDRQLELLARKLREYQKFRAPSADALS
PFGPEIIEAGLRSILKPEFVAAVTRRPRAYEGHPFIVEVGIAYGGEIPPTNEPILLRYANKIPLLYDEKSDVAWKVVDPH
NFDWRNYLVTFPAPVAVLTHIASTKVPYKSVGKESVADVPEIEQELRNALREAARRLRGYLLQKRKEEEAKRRIITFMKY
TPEIAKSLAVILKDYNVSEHTVREMLLSAMKRRLRIEDDKFAKLVEGLEVDIEE

Specific function: Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP [H]

COG id: COG1389

COG function: function code L; DNA topoisomerase VI, subunit B

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TOP6B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008616
- InterPro:   IPR010979
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005734
- InterPro:   IPR015320
- ProDom:   PD013790 [H]

Pfam domain/function: PF05833 FbpA; PF02518 HATPase_c; PF09239 Topo-VIb_trans [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 61160; Mature: 61029

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPKRQRAAVQESFRSMTPSQFFYEYKEVAGFGSPARALYQTVRELVENALDATDVHGIL
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHCC
PDITIVIERVNENSNYYRITVEDNGIGIQPQYVPYAFGQVLYSSKYKLRQARGRFGLGAK
CCHHHHHEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
MAILYGQIRTGRPVEVYTAPIGSRKIYYFKLKIDIEHNRPIVLTKAEYPNPKGWHGTRVS
EEEEEEECCCCCCEEEEECCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCEEE
LVIEGDWWHSKHRVYEYIKRTAIAAPYANIVFIDPNGNVVIYKRSISKLPKQPKEVKPHP
EEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHCCCCCCCCCCCC
HGVDIELLKQLISGSQAKTMVEFLAEAFRGVGRKTAEAFLEWAGIAKNLDPHSLDDRQLE
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LLARKLREYQKFRAPSADALSPFGPEIIEAGLRSILKPEFVAAVTRRPRAYEGHPFIVEV
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCEEEEE
GIAYGGEIPPTNEPILLRYANKIPLLYDEKSDVAWKVVDPHNFDWRNYLVTFPAPVAVLT
EECCCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCEEEECCHHHHHHH
HIASTKVPYKSVGKESVADVPEIEQELRNALREAARRLRGYLLQKRKEEEAKRRIITFMK
HHHHCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTPEIAKSLAVILKDYNVSEHTVREMLLSAMKRRLRIEDDKFAKLVEGLEVDIEE
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PPKRQRAAVQESFRSMTPSQFFYEYKEVAGFGSPARALYQTVRELVENALDATDVHGIL
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHCC
PDITIVIERVNENSNYYRITVEDNGIGIQPQYVPYAFGQVLYSSKYKLRQARGRFGLGAK
CCHHHHHEEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCE
MAILYGQIRTGRPVEVYTAPIGSRKIYYFKLKIDIEHNRPIVLTKAEYPNPKGWHGTRVS
EEEEEEECCCCCCEEEEECCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCCCCEEE
LVIEGDWWHSKHRVYEYIKRTAIAAPYANIVFIDPNGNVVIYKRSISKLPKQPKEVKPHP
EEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHCCCCCCCCCCCC
HGVDIELLKQLISGSQAKTMVEFLAEAFRGVGRKTAEAFLEWAGIAKNLDPHSLDDRQLE
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LLARKLREYQKFRAPSADALSPFGPEIIEAGLRSILKPEFVAAVTRRPRAYEGHPFIVEV
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCEEEEE
GIAYGGEIPPTNEPILLRYANKIPLLYDEKSDVAWKVVDPHNFDWRNYLVTFPAPVAVLT
EECCCCCCCCCCCCEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCEEEECCHHHHHHH
HIASTKVPYKSVGKESVADVPEIEQELRNALREAARRLRGYLLQKRKEEEAKRRIITFMK
HHHHCCCCHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTPEIAKSLAVILKDYNVSEHTVREMLLSAMKRRLRIEDDKFAKLVEGLEVDIEE
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA