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The map label for this gene is 124027829

Identifier: 124027829

GI number: 124027829

Start: 964540

End: 965496

Strand: Direct

Name: 124027829

Synonym: Hbut_0956

Alternate gene names: NA

Gene position: 964540-965496 (Clockwise)

Preceding gene: 124027825

Following gene: 124027833

Centisome position: 57.86

GC content: 51.1

Gene sequence:

>957_bases
ATGCTTGGCTTGCTAGGAACTGGTGGCTATGCAGTGGAGGATATTCTTGCTAAGCTTAAGATCAAGCCTCTTGAATGGGT
TGAAGATAAGGAGGGGCCCAAGCTAAGGTGGTTGGATACACGTCTCCTTCCGTGGGAGGAGGTTTACCGGGAGACAAGGG
ACTATAAGAGGGTTGCAAAGGCCATCAAGGATATGGAGATACGTGGCGCTCCAGCTATAGGTGTTGCAGCTGCCTACGGT
CTGGCACTGGCAGCCTACTACTCCAAGGCGCGTGATGTCAACGAGCTACTTGCACAACTAGAAGAGGCTAGGAAGGTTCT
AGCCTCCACAAGGCCCACCGCCTACAACCTCTTCTGGGCCCTAGAAAGGGTGATGAAGGCTGCACGTAACGCGGAACAGC
ATGGAGTTGATGCAGTTGTTAGGCGTGTTATAGAGGAGGCAAGGACTATACACCTTGAGGATGTTAGGGCGAATATAGAG
CTCGGCCGTATCGGGGCTAAGCTAATAGATGATGGCGATACGATACTAACACACTGCAACGCAGGTGCACTGGCAACGTC
GGGGTATGGCACTGCAGAGGGCATTATGAGAGCAGCTGTTGAGGAGGGTAAGAGGATAAGGGTAATTGCTACCGAGACTA
GACCCTTACTGCAAGGTGCCCGGCTTACAGTATGGGAGCTCTTAAAGGAGGGTATTGAGGTTAGGCTCATAACAGATAAC
ATGGTCGGCTACGTCATGTACAAGGGTCTTGTGGACAAGGTTATTGTTGGTGCTGACCGCATCACAGCTGACGGCTACGT
AGCCAACAAGATTGGCACATACATGATAGCAGTATTAGCTAATAGGCATGGTGTGCCATTCTATGTTGCTGCACCTACTT
CACATTTGACCTCAGCATTGAGGGCGACAACATACCTATCGAGGAGCGTAGCCCTAACGAGGTTAGGACGGTTCTAG

Upstream 100 bases:

>100_bases
TCTGTGCAACCTAAGCACTATGGTCTCGTTGGTTTTCCCCCCATGTAGCTGTACCCCCTGTAGTTTACCGTGTTCTAGCT
AGTGAGGTTTAAGATGTTCT

Downstream 100 bases:

>100_bases
GCAAGCTAGCAATAACAGTGCCCGATGTACCAGTGTATAATCCTGCCTTCGATATTACACCCCCAGAGCTTGTTACTGCT
ATAGTTACTGAGAAGGGTAT

Product: methylthioribose-1-phosphate isomerase

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; MTNA-like protein; aMTNA; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MLGLLGTGGYAVEDILAKLKIKPLEWVEDKEGPKLRWLDTRLLPWEEVYRETRDYKRVAKAIKDMEIRGAPAIGVAAAYG
LALAAYYSKARDVNELLAQLEEARKVLASTRPTAYNLFWALERVMKAARNAEQHGVDAVVRRVIEEARTIHLEDVRANIE
LGRIGAKLIDDGDTILTHCNAGALATSGYGTAEGIMRAAVEEGKRIRVIATETRPLLQGARLTVWELLKEGIEVRLITDN
MVGYVMYKGLVDKVIVGADRITADGYVANKIGTYMIAVLANRHGVPFYVAAPTSHLTSALRATTYLSRSVALTRLGRF

Sequences:

>Translated_318_residues
MLGLLGTGGYAVEDILAKLKIKPLEWVEDKEGPKLRWLDTRLLPWEEVYRETRDYKRVAKAIKDMEIRGAPAIGVAAAYG
LALAAYYSKARDVNELLAQLEEARKVLASTRPTAYNLFWALERVMKAARNAEQHGVDAVVRRVIEEARTIHLEDVRANIE
LGRIGAKLIDDGDTILTHCNAGALATSGYGTAEGIMRAAVEEGKRIRVIATETRPLLQGARLTVWELLKEGIEVRLITDN
MVGYVMYKGLVDKVIVGADRITADGYVANKIGTYMIAVLANRHGVPFYVAAPTSHLTSALRATTYLSRSVALTRLGRF
>Mature_318_residues
MLGLLGTGGYAVEDILAKLKIKPLEWVEDKEGPKLRWLDTRLLPWEEVYRETRDYKRVAKAIKDMEIRGAPAIGVAAAYG
LALAAYYSKARDVNELLAQLEEARKVLASTRPTAYNLFWALERVMKAARNAEQHGVDAVVRRVIEEARTIHLEDVRANIE
LGRIGAKLIDDGDTILTHCNAGALATSGYGTAEGIMRAAVEEGKRIRVIATETRPLLQGARLTVWELLKEGIEVRLITDN
MVGYVMYKGLVDKVIVGADRITADGYVANKIGTYMIAVLANRHGVPFYVAAPTSHLTSALRATTYLSRSVALTRLGRF

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=272, Percent_Identity=41.5441176470588, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI23943880, Length=264, Percent_Identity=34.8484848484849, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4503503, Length=126, Percent_Identity=37.3015873015873, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI78000158, Length=217, Percent_Identity=23.963133640553, Blast_Score=65, Evalue=7e-11,
Organism=Homo sapiens, GI187607323, Length=218, Percent_Identity=24.3119266055046, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI78000156, Length=217, Percent_Identity=23.963133640553, Blast_Score=65, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=272, Percent_Identity=34.9264705882353, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17557123, Length=204, Percent_Identity=28.921568627451, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6325375, Length=309, Percent_Identity=32.3624595469256, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6322878, Length=199, Percent_Identity=31.1557788944724, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21357667, Length=283, Percent_Identity=37.8091872791519, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24651647, Length=283, Percent_Identity=37.8091872791519, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 35120; Mature: 35120

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLLGTGGYAVEDILAKLKIKPLEWVEDKEGPKLRWLDTRLLPWEEVYRETRDYKRVAK
CCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AIKDMEIRGAPAIGVAAAYGLALAAYYSKARDVNELLAQLEEARKVLASTRPTAYNLFWA
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LERVMKAARNAEQHGVDAVVRRVIEEARTIHLEDVRANIELGRIGAKLIDDGDTILTHCN
HHHHHHHHHCCHHCCHHHHHHHHHHHHHEEEHHHHHCCCCHHHCCHHHCCCCCEEEEECC
AGALATSGYGTAEGIMRAAVEEGKRIRVIATETRPLLQGARLTVWELLKEGIEVRLITDN
CCCEEECCCCHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCHHHHHHHHCCCEEEEEECH
MVGYVMYKGLVDKVIVGADRITADGYVANKIGTYMIAVLANRHGVPFYVAAPTSHLTSAL
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHH
RATTYLSRSVALTRLGRF
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLGLLGTGGYAVEDILAKLKIKPLEWVEDKEGPKLRWLDTRLLPWEEVYRETRDYKRVAK
CCCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHH
AIKDMEIRGAPAIGVAAAYGLALAAYYSKARDVNELLAQLEEARKVLASTRPTAYNLFWA
HHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHH
LERVMKAARNAEQHGVDAVVRRVIEEARTIHLEDVRANIELGRIGAKLIDDGDTILTHCN
HHHHHHHHHCCHHCCHHHHHHHHHHHHHEEEHHHHHCCCCHHHCCHHHCCCCCEEEEECC
AGALATSGYGTAEGIMRAAVEEGKRIRVIATETRPLLQGARLTVWELLKEGIEVRLITDN
CCCEEECCCCHHHHHHHHHHHCCCEEEEEEECCHHHHCCCCHHHHHHHHCCCEEEEEECH
MVGYVMYKGLVDKVIVGADRITADGYVANKIGTYMIAVLANRHGVPFYVAAPTSHLTSAL
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHH
RATTYLSRSVALTRLGRF
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]