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The map label for this gene is rph [C]

Identifier: 124027457

GI number: 124027457

Start: 543736

End: 544722

Strand: Direct

Name: rph [C]

Synonym: Hbut_0572

Alternate gene names: 124027457

Gene position: 543736-544722 (Clockwise)

Preceding gene: 124027456

Following gene: 124027458

Centisome position: 32.61

GC content: 53.39

Gene sequence:

>987_bases
ATGAGTATCACGCCCTCATTCCAACCAGTTATTCCCAAGCTCAAGAAGCATACTATGGAGACGCTGCTCTCGCGCGGCGT
TAGGCTTGACGGTAGGAAGCTGGACGAGACAAGGCCGGTAGAGATAACGCCGGGCTACATTGATAGGGCTGAGGGCTCGG
CACTAGTCAAGCTCGGCCAGACAGTTGTATTAGCGGGAGTTAAGACTGATATCGTTGCCCCGTTCCCCGATACGCCTAAT
GAGGCTGTGCTAGTAGTTCACGCCGAGTTCGTGCCGCTGGCATCGCCAACCTTTGAGCCAGGCCCACCAGACGAGAACGC
TATTGAGCTTGCAAGAGTTATTGATAGAAGTCTACGAGAAATCAAGGCTGTTGCGCTGGATAAGCTTGTATTGGAGCCGG
GTAAGCATGTGTGGAGGCTCTATGTGGATCTCTACATACTAAACCATGACGGCAACCTATTTGATGCCTCTATGCTGGCA
GCAATGGCTGCACTCATGACTACACGGCTGCCAGCAGCAGTTAAGACCGAGGACGGCTACACTGTGGATAGGTCGAAGTT
TACAGGCTTGGTGCCAGTGAACCATAAGGTTGTAACGGTAACGATAGCAAAGCTGAGTAATAGGCTCATAGTTGACCCGA
CCTATGAGGAGGAGCAGGTAGCCGATACAAGGCTCGTAGTAGCGGTTAGCGACGATGGCAGGATTGCGGGTATACAGAAG
ACAGGTATGGGTGACCTCACCTACAAGGAAGTACTCACTGCGGTAGCTATAGCGCTAAACAAGGCTCAAGTCTACCTCAA
AGCTCTTGAGGAGAAGGTTGTTCCCTACCGTGCAGAGCTCGAGAAGAAGCTAGCTGAGCAGGCTGCTGGGGCTACTCCTG
CAGCAGCGGTACCGGCACCTGCTAGGGAGCATGAAGAAGTTGTAGAGCAGGCTGAGTCCGCTGGCGAGGAGACCGTTGAA
CAGAGCTACGAGGAGGAGCGGGACTAG

Upstream 100 bases:

>100_bases
AGAGCTTGCCCGGAAGGGTATACAAGTGATCTACAACCTCCAGAAGGAGGCTCTCCGCAAGAAGTATGTCGAGGTAAGTG
TTGAGGAGGGTGCATAAGCC

Downstream 100 bases:

>100_bases
ACCTTCAAGGCTTATAAGTTGGCTCTCCTAGAGCCGTGGCGGGGGAACAGCGTTGGCCAGGCGGACGCGCGTCGTAGGCA
TTGCTGGCAGGTTCGGGCCG

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSITPSFQPVIPKLKKHTMETLLSRGVRLDGRKLDETRPVEITPGYIDRAEGSALVKLGQTVVLAGVKTDIVAPFPDTPN
EAVLVVHAEFVPLASPTFEPGPPDENAIELARVIDRSLREIKAVALDKLVLEPGKHVWRLYVDLYILNHDGNLFDASMLA
AMAALMTTRLPAAVKTEDGYTVDRSKFTGLVPVNHKVVTVTIAKLSNRLIVDPTYEEEQVADTRLVVAVSDDGRIAGIQK
TGMGDLTYKEVLTAVAIALNKAQVYLKALEEKVVPYRAELEKKLAEQAAGATPAAAVPAPAREHEEVVEQAESAGEETVE
QSYEEERD

Sequences:

>Translated_328_residues
MSITPSFQPVIPKLKKHTMETLLSRGVRLDGRKLDETRPVEITPGYIDRAEGSALVKLGQTVVLAGVKTDIVAPFPDTPN
EAVLVVHAEFVPLASPTFEPGPPDENAIELARVIDRSLREIKAVALDKLVLEPGKHVWRLYVDLYILNHDGNLFDASMLA
AMAALMTTRLPAAVKTEDGYTVDRSKFTGLVPVNHKVVTVTIAKLSNRLIVDPTYEEEQVADTRLVVAVSDDGRIAGIQK
TGMGDLTYKEVLTAVAIALNKAQVYLKALEEKVVPYRAELEKKLAEQAAGATPAAAVPAPAREHEEVVEQAESAGEETVE
QSYEEERD
>Mature_327_residues
SITPSFQPVIPKLKKHTMETLLSRGVRLDGRKLDETRPVEITPGYIDRAEGSALVKLGQTVVLAGVKTDIVAPFPDTPNE
AVLVVHAEFVPLASPTFEPGPPDENAIELARVIDRSLREIKAVALDKLVLEPGKHVWRLYVDLYILNHDGNLFDASMLAA
MAALMTTRLPAAVKTEDGYTVDRSKFTGLVPVNHKVVTVTIAKLSNRLIVDPTYEEEQVADTRLVVAVSDDGRIAGIQKT
GMGDLTYKEVLTAVAIALNKAQVYLKALEEKVVPYRAELEKKLAEQAAGATPAAAVPAPAREHEEVVEQAESAGEETVEQ
SYEEERD

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential) [H]

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family [H]

Homologues:

Organism=Homo sapiens, GI31415882, Length=252, Percent_Identity=34.5238095238095, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI189083688, Length=229, Percent_Identity=34.4978165938865, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI77812672, Length=251, Percent_Identity=34.6613545816733, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI77812670, Length=251, Percent_Identity=34.6613545816733, Blast_Score=120, Evalue=1e-27,
Organism=Escherichia coli, GI157672248, Length=225, Percent_Identity=27.5555555555556, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25144570, Length=262, Percent_Identity=29.7709923664122, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI32566065, Length=226, Percent_Identity=28.7610619469027, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320486, Length=237, Percent_Identity=29.535864978903, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24642649, Length=240, Percent_Identity=30.8333333333333, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28573444, Length=197, Percent_Identity=34.5177664974619, Blast_Score=105, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568 [H]

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C [H]

EC number: 3.1.13.-

Molecular weight: Translated: 35764; Mature: 35633

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITPSFQPVIPKLKKHTMETLLSRGVRLDGRKLDETRPVEITPGYIDRAEGSALVKLGQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEHHCC
TVVLAGVKTDIVAPFPDTPNEAVLVVHAEFVPLASPTFEPGPPDENAIELARVIDRSLRE
EEEEEECCCCEEECCCCCCCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
IKAVALDKLVLEPGKHVWRLYVDLYILNHDGNLFDASMLAAMAALMTTRLPAAVKTEDGY
HHHHHHHHHHHCCCHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
TVDRSKFTGLVPVNHKVVTVTIAKLSNRLIVDPTYEEEQVADTRLVVAVSDDGRIAGIQK
EEEHHHCCEEEECCCEEEEEEEEHHCCEEEECCCCCHHHHCCEEEEEEECCCCCEEEEEE
TGMGDLTYKEVLTAVAIALNKAQVYLKALEEKVVPYRAELEKKLAEQAAGATPAAAVPAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCC
AREHEEVVEQAESAGEETVEQSYEEERD
CHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SITPSFQPVIPKLKKHTMETLLSRGVRLDGRKLDETRPVEITPGYIDRAEGSALVKLGQ
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEEHHCC
TVVLAGVKTDIVAPFPDTPNEAVLVVHAEFVPLASPTFEPGPPDENAIELARVIDRSLRE
EEEEEECCCCEEECCCCCCCCEEEEEEECEEECCCCCCCCCCCCHHHHHHHHHHHHHHHH
IKAVALDKLVLEPGKHVWRLYVDLYILNHDGNLFDASMLAAMAALMTTRLPAAVKTEDGY
HHHHHHHHHHHCCCHHHEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
TVDRSKFTGLVPVNHKVVTVTIAKLSNRLIVDPTYEEEQVADTRLVVAVSDDGRIAGIQK
EEEHHHCCEEEECCCEEEEEEEEHHCCEEEECCCCCHHHHCCEEEEEEECCCCCEEEEEE
TGMGDLTYKEVLTAVAIALNKAQVYLKALEEKVVPYRAELEKKLAEQAAGATPAAAVPAP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCC
AREHEEVVEQAESAGEETVEQSYEEERD
CHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]