Click here to switch to the map view.

The map label for this gene is gds [H]

Identifier: 124027425

GI number: 124027425

Start: 519676

End: 520686

Strand: Direct

Name: gds [H]

Synonym: Hbut_0540

Alternate gene names: 124027425

Gene position: 519676-520686 (Clockwise)

Preceding gene: 124027424

Following gene: 124027426

Centisome position: 31.17

GC content: 54.6

Gene sequence:

>1011_bases
ATGACCGGCCAGCTACCCGAGAGCGTTGTGGCCTACTTGAAGCGAGTTGCCAGCCTAGTAGACGGCTACATATACGCTAA
GGTGAAGGGCGAGCCTAAGGAGGTCTATGATGCCGGCCTACACCTCATAAGGGCGGGCGGGAAGAGACTAAGGCCAGCCA
TAGTTGTTGCCATTGCTGAGGCTCTCGGGGAGCCTGCTGAGCGCGCCCTACCCTTCGCAGCAGCGGTGGAACTCGTACAC
AATTTTACCCTCATACACGACGACATAATGGACCGCGATGAGTTCCGCCGTGGAGTTCCCACCGTGCACAAGGTCTGGGG
CGAACCCCTAGCAATAACGGCGGGCGACCTCCTCTTTGCCAAGGCGTTTGAAACGCTCACTGACGCCCTCGACAAAGGCA
TACCGCCCGACAGAGTTGCAAGAGCCACGAGAGTATTATCCAGGGCATCAGCGGTCATAGCTGAGGGCCAAGCTATGGAC
CTGATGTTCGAGGAGGAGGACGAAGTTAGCATTGATGAATACCTAATAATGATATACAAGAAGACCGGTGCACTCTTCGA
AGCCTCAGCTGTGCTCGGGGGCCTAGTAGCAACGGGTGATGACGCAACCCTGGAGAAGCTTGCAGAGTTCGGCAAGAACC
TTGGCATAGCATTCCAGATACGCGATGACATTCTTGGTATTGTCGGCAAGGAGGAGGAGCTAGGAAAACCCGTCTATAGC
GACATAAGGGAGGGCAAGAAGACTCTCCCAATAATCTATGCCTTGAGGAACCTTGAGGACGAGGATAGGGAGAAGCTAGT
AATGGTTCTCGGAAACAGAGAGGCTTCAAGAGAGGAACTCGAGCAGGCAGCAAAACTCGTGGTAGCATCCGGCGCGATAG
ACTACGCCGAGAGCAAGGCTAGAGAATACATAGACCGTGCCCTAGAAGCCCTCCGGGGTGCGGTACCCGAAAACAACTAC
CGTAGGATACTCGAGGAGCTAGCAAAATTCGTGGCAACTAGAACCTGGTAG

Upstream 100 bases:

>100_bases
CGGGGAGTAAAGCTGGATCTCTACCTTAACGGTGCCAGACTCCTTTTCAAGCCCGGTGAGACATGTAGCAACTGGGCCTA
GCCGGCAGAGGGCATGGGTT

Downstream 100 bases:

>100_bases
CTGAAGGGTTTCCCGGGATGGAGTCCGGAGAGAAATCCTGCCACAGATCCCCCTATCACATCCCCCGGATATACATTGAG
GGTATAGGTAGCGACGAGTA

Product: geranylgeranyl pyrophosphate synthetase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTGQLPESVVAYLKRVASLVDGYIYAKVKGEPKEVYDAGLHLIRAGGKRLRPAIVVAIAEALGEPAERALPFAAAVELVH
NFTLIHDDIMDRDEFRRGVPTVHKVWGEPLAITAGDLLFAKAFETLTDALDKGIPPDRVARATRVLSRASAVIAEGQAMD
LMFEEEDEVSIDEYLIMIYKKTGALFEASAVLGGLVATGDDATLEKLAEFGKNLGIAFQIRDDILGIVGKEEELGKPVYS
DIREGKKTLPIIYALRNLEDEDREKLVMVLGNREASREELEQAAKLVVASGAIDYAESKAREYIDRALEALRGAVPENNY
RRILEELAKFVATRTW

Sequences:

>Translated_336_residues
MTGQLPESVVAYLKRVASLVDGYIYAKVKGEPKEVYDAGLHLIRAGGKRLRPAIVVAIAEALGEPAERALPFAAAVELVH
NFTLIHDDIMDRDEFRRGVPTVHKVWGEPLAITAGDLLFAKAFETLTDALDKGIPPDRVARATRVLSRASAVIAEGQAMD
LMFEEEDEVSIDEYLIMIYKKTGALFEASAVLGGLVATGDDATLEKLAEFGKNLGIAFQIRDDILGIVGKEEELGKPVYS
DIREGKKTLPIIYALRNLEDEDREKLVMVLGNREASREELEQAAKLVVASGAIDYAESKAREYIDRALEALRGAVPENNY
RRILEELAKFVATRTW
>Mature_335_residues
TGQLPESVVAYLKRVASLVDGYIYAKVKGEPKEVYDAGLHLIRAGGKRLRPAIVVAIAEALGEPAERALPFAAAVELVHN
FTLIHDDIMDRDEFRRGVPTVHKVWGEPLAITAGDLLFAKAFETLTDALDKGIPPDRVARATRVLSRASAVIAEGQAMDL
MFEEEDEVSIDEYLIMIYKKTGALFEASAVLGGLVATGDDATLEKLAEFGKNLGIAFQIRDDILGIVGKEEELGKPVYSD
IREGKKTLPIIYALRNLEDEDREKLVMVLGNREASREELEQAAKLVVASGAIDYAESKAREYIDRALEALRGAVPENNYR
RILEELAKFVATRTW

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=299, Percent_Identity=27.7591973244147, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI4758430, Length=280, Percent_Identity=26.4285714285714, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI83700220, Length=280, Percent_Identity=26.4285714285714, Blast_Score=99, Evalue=5e-21,
Organism=Escherichia coli, GI1789578, Length=317, Percent_Identity=31.2302839116719, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1786623, Length=234, Percent_Identity=38.8888888888889, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17505681, Length=312, Percent_Identity=26.9230769230769, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319475, Length=308, Percent_Identity=26.6233766233766, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6325188, Length=219, Percent_Identity=28.310502283105, Blast_Score=90, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322294, Length=270, Percent_Identity=28.5185185185185, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24651612, Length=296, Percent_Identity=27.7027027027027, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI281365769, Length=251, Percent_Identity=28.6852589641434, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24660002, Length=251, Percent_Identity=28.6852589641434, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 37011; Mature: 36880

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQLPESVVAYLKRVASLVDGYIYAKVKGEPKEVYDAGLHLIRAGGKRLRPAIVVAIAE
CCCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALGEPAERALPFAAAVELVHNFTLIHDDIMDRDEFRRGVPTVHKVWGEPLAITAGDLLFA
HHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCCCEEEEHHHHHHH
KAFETLTDALDKGIPPDRVARATRVLSRASAVIAEGQAMDLMFEEEDEVSIDEYLIMIYK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
KTGALFEASAVLGGLVATGDDATLEKLAEFGKNLGIAFQIRDDILGIVGKEEELGKPVYS
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCHHHHCCHHHH
DIREGKKTLPIIYALRNLEDEDREKLVMVLGNREASREELEQAAKLVVASGAIDYAESKA
HHHCCCHHHHHHHHHHCCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
REYIDRALEALRGAVPENNYRRILEELAKFVATRTW
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGQLPESVVAYLKRVASLVDGYIYAKVKGEPKEVYDAGLHLIRAGGKRLRPAIVVAIAE
CCCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
ALGEPAERALPFAAAVELVHNFTLIHDDIMDRDEFRRGVPTVHKVWGEPLAITAGDLLFA
HHCCCHHHHCHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCCCEEEEHHHHHHH
KAFETLTDALDKGIPPDRVARATRVLSRASAVIAEGQAMDLMFEEEDEVSIDEYLIMIYK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
KTGALFEASAVLGGLVATGDDATLEKLAEFGKNLGIAFQIRDDILGIVGKEEELGKPVYS
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEHHHHHHHCCCHHHHCCHHHH
DIREGKKTLPIIYALRNLEDEDREKLVMVLGNREASREELEQAAKLVVASGAIDYAESKA
HHHCCCHHHHHHHHHHCCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHH
REYIDRALEALRGAVPENNYRRILEELAKFVATRTW
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]