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The map label for this gene is hisC [H]

Identifier: 124027375

GI number: 124027375

Start: 467389

End: 468486

Strand: Direct

Name: hisC [H]

Synonym: Hbut_0488

Alternate gene names: 124027375

Gene position: 467389-468486 (Clockwise)

Preceding gene: 124027374

Following gene: 124027376

Centisome position: 28.03

GC content: 49.18

Gene sequence:

>1098_bases
GTGACCGTTAGGATTAAACAGTGGCTTGAAAATGTTGGCGGTGGAGGGAAAAGCTACCGAGACTATAGTGGTGTTATAGC
TAGGCTTGATCTCAACGAGCCCCCATTCCCGCCTTCGACACGAGTAATAGAAGCTGTAAAGGCTGAAGTTTTTAATGTCA
ATCGCTACCCGGAGCCAGGACTCATACGTAGGCTTGTAGAGCGCCTTGCTGAGTATAGCGATGTAGACGTTGACAACTTG
GTCATTGGGACGGGTGCAGATTTGATTCTTCAGCAAACGTTTAATACTGTTGTTGAGCCTGGTTCCCTCGTGGTATATCC
ATATCCAGCATTCTTTGTCTATGACAAGATTATAGGTTTGCTTGGCGGTAAACCAGCTCGTATAGACCTCGTAGATGATG
GTGATGTCTGGAAGCTCCCGCTAGAAAAGCTTGTCTCAGCGCTAGAGAGTAATGATGTACGTCTAGTCGTCATAGATAAT
CCGAATAATCCAACAGGCTCCCTACTCCTAGCCGATACTGCTGCGGCAAGGAGGATTCTTGATGCGGCCTCGGCTATTGG
CGCCCTTGTAGTCATAGACGAGGCTTACTATGAGTTCTCCGGGGTTACATTTGCAAAGCTTGTGGATAGCTATGATAACC
TCGTCGTAGTACGGACTATGAGCAAGGCCTTTGCCTTAGCTGGTATGAGGATAGGCTATGCGATAGCATCCCGTAAGATA
GCTGGGATTCTCAGAAAACTGCTTCCGCCATTCCCTCCGAGACTTAGCATAGTAGCAGCACTAGCAGCCCTCGATGACAT
AGGGTATAGTAGGAAGCTAGTCGAGTGGGTTAAGCATGAGAGGGAATGGTTAAGGATCGAGCTAGCATCTATACCAGGTG
TAAAGGTGTATCGTAGCACTACAAATTTCCTACTAGTACAGACTCCCGTGGAGAATGTTGTGGCAAAGCTGTCGGAGAAG
GGTGTGGCTGTGCGCTCGGTACCGCTAGGCTCCGAGTGGATGAGGATCTCCGTCGGCTTACATGAGGAGAACCAGGCGGC
GCTAGAGGCTCTCCGTGGTCTTGTTGTAGGAGATACAAGGCAAGCCAGTCAAGCTTGA

Upstream 100 bases:

>100_bases
TTTATCATCCGTACTAGGTGTTAGCTAGTGATGCTATAGTGTTGTCAGCTATATAAACATAAAATTGATGCAACTCTATG
CATAATAGCTGGTGTAACTT

Downstream 100 bases:

>100_bases
AGTTTTTATTGTGGGTTCAATACGGACTCACACTGCTAACCACAACATTCGTAGTTATTAGCTTTCCAGAAAACGTTTTT
GTAGTACAGTTTGCATCGAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MTVRIKQWLENVGGGGKSYRDYSGVIARLDLNEPPFPPSTRVIEAVKAEVFNVNRYPEPGLIRRLVERLAEYSDVDVDNL
VIGTGADLILQQTFNTVVEPGSLVVYPYPAFFVYDKIIGLLGGKPARIDLVDDGDVWKLPLEKLVSALESNDVRLVVIDN
PNNPTGSLLLADTAAARRILDAASAIGALVVIDEAYYEFSGVTFAKLVDSYDNLVVVRTMSKAFALAGMRIGYAIASRKI
AGILRKLLPPFPPRLSIVAALAALDDIGYSRKLVEWVKHEREWLRIELASIPGVKVYRSTTNFLLVQTPVENVVAKLSEK
GVAVRSVPLGSEWMRISVGLHEENQAALEALRGLVVGDTRQASQA

Sequences:

>Translated_365_residues
MTVRIKQWLENVGGGGKSYRDYSGVIARLDLNEPPFPPSTRVIEAVKAEVFNVNRYPEPGLIRRLVERLAEYSDVDVDNL
VIGTGADLILQQTFNTVVEPGSLVVYPYPAFFVYDKIIGLLGGKPARIDLVDDGDVWKLPLEKLVSALESNDVRLVVIDN
PNNPTGSLLLADTAAARRILDAASAIGALVVIDEAYYEFSGVTFAKLVDSYDNLVVVRTMSKAFALAGMRIGYAIASRKI
AGILRKLLPPFPPRLSIVAALAALDDIGYSRKLVEWVKHEREWLRIELASIPGVKVYRSTTNFLLVQTPVENVVAKLSEK
GVAVRSVPLGSEWMRISVGLHEENQAALEALRGLVVGDTRQASQA
>Mature_364_residues
TVRIKQWLENVGGGGKSYRDYSGVIARLDLNEPPFPPSTRVIEAVKAEVFNVNRYPEPGLIRRLVERLAEYSDVDVDNLV
IGTGADLILQQTFNTVVEPGSLVVYPYPAFFVYDKIIGLLGGKPARIDLVDDGDVWKLPLEKLVSALESNDVRLVVIDNP
NNPTGSLLLADTAAARRILDAASAIGALVVIDEAYYEFSGVTFAKLVDSYDNLVVVRTMSKAFALAGMRIGYAIASRKIA
GILRKLLPPFPPRLSIVAALAALDDIGYSRKLVEWVKHEREWLRIELASIPGVKVYRSTTNFLLVQTPVENVVAKLSEKG
VAVRSVPLGSEWMRISVGLHEENQAALEALRGLVVGDTRQASQA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=312, Percent_Identity=32.0512820512821, Blast_Score=136, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322075, Length=356, Percent_Identity=28.6516853932584, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39981; Mature: 39849

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVRIKQWLENVGGGGKSYRDYSGVIARLDLNEPPFPPSTRVIEAVKAEVFNVNRYPEPG
CEEEHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCH
LIRRLVERLAEYSDVDVDNLVIGTGADLILQQTFNTVVEPGSLVVYPYPAFFVYDKIIGL
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
LGGKPARIDLVDDGDVWKLPLEKLVSALESNDVRLVVIDNPNNPTGSLLLADTAAARRIL
HCCCCCEEEEECCCCEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECHHHHHHHH
DAASAIGALVVIDEAYYEFSGVTFAKLVDSYDNLVVVRTMSKAFALAGMRIGYAIASRKI
HHHHHHCEEEEEEHHHHHHCCCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
AGILRKLLPPFPPRLSIVAALAALDDIGYSRKLVEWVKHEREWLRIELASIPGVKVYRST
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCEEEEECC
TNFLLVQTPVENVVAKLSEKGVAVRSVPLGSEWMRISVGLHEENQAALEALRGLVVGDTR
CCEEEEECCHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHCEEECCCC
QASQA
CCCCC
>Mature Secondary Structure 
TVRIKQWLENVGGGGKSYRDYSGVIARLDLNEPPFPPSTRVIEAVKAEVFNVNRYPEPG
EEEHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCH
LIRRLVERLAEYSDVDVDNLVIGTGADLILQQTFNTVVEPGSLVVYPYPAFFVYDKIIGL
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHH
LGGKPARIDLVDDGDVWKLPLEKLVSALESNDVRLVVIDNPNNPTGSLLLADTAAARRIL
HCCCCCEEEEECCCCEEECCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEECHHHHHHHH
DAASAIGALVVIDEAYYEFSGVTFAKLVDSYDNLVVVRTMSKAFALAGMRIGYAIASRKI
HHHHHHCEEEEEEHHHHHHCCCHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
AGILRKLLPPFPPRLSIVAALAALDDIGYSRKLVEWVKHEREWLRIELASIPGVKVYRST
HHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEEEEECCCCEEEEECC
TNFLLVQTPVENVVAKLSEKGVAVRSVPLGSEWMRISVGLHEENQAALEALRGLVVGDTR
CCEEEEECCHHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHCEEECCCC
QASQA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA