Click here to switch to the map view.

The map label for this gene is thsB [H]

Identifier: 124027368

GI number: 124027368

Start: 457800

End: 459506

Strand: Reverse

Name: thsB [H]

Synonym: Hbut_0481

Alternate gene names: 124027368

Gene position: 459506-457800 (Counterclockwise)

Preceding gene: 124027378

Following gene: 124027367

Centisome position: 27.56

GC content: 52.37

Gene sequence:

>1707_bases
ATGTCTGCACGCCAGGTTGCTGCCCTTGAGCCTACTGGTGTACCAGTACTAATACTCAAGGAGGGCACCCAGAGGACCTA
CGGCCGTGAAGCACTAAGAACAAACATAATGATCGTACGCGCTATCGCCGAGACGCTAAGGACAACCTACGGTCCCAAGG
GCATGGACAAGATGCTAGTGGACAGCCTTGGCGACATAACGATAACCAACGACGGTGCAACAATCCTAGACAAGATGGAC
GTACAGCACCCAACAGCGAAGCTCGTAGTGCAGATTGCCAAGGGTCAGGACGAGGAGGTAGGTGACGGTACAAAGACAGC
AGTAATATTCGCTGGTGAGCTACTACGTTACGCCGAGGAGCTACTAGACAAGAACGTACACCCAACAATCATTGTGAGTG
GCTACAAGAAGGCAGCCGAGGAGGCGGTAAAGAAGCTCCACGAGATAGCTGAACCCATAGACATAAACGACGAGGAGACC
CTCAAGAAGATAGCAATGACAAGCCTCACAAGCAAGGCAGTCCACGGTGCACGCGAGCATCTAGCAGAGATAGTCGTCAA
GGCTGTAAGGCAGGTTGCTGAGAAGAGGGGCGACAAATGGTACATAGACCTAGATGCGATACAGATAATCAAGAAGCATG
GTGGTAGCCTACGCGACACCAAGCTAATCTACGGCATCGTCCTGGACAAGGAGGTTGTACACCCAGGCATGCCCAAGAAG
GTCGAGAACGCCTACATTGTACTCCTCGATGCTCCACTAGAGGTCGAGAAGCCAGAAATCGATGCAGAGATAAGGATCAA
CGATCCAGCATTCCTCAAGAAGTTCCTAGAAGAGGAGGAGAAGATACTAGAAGAGATGGTAAACAAGATCTATAACGTTG
CCATGGAGAGGATACGCAAGGACGGTATGGAGGGTAAGGCTGGTATCGTAGTTATAACCCAGAAGGGTATTGACGAGGTT
GCCCAGCACTTCCTAGCAAAGAAGGGCATCATGGCAGTAAGAAGGGTAAAGAGGAGCGACATAGAGAAGATTGCAAGGGC
GACCGGCGCCAAGATCGTGAGCAACATTGATGACTTAACACCCGAGGACCTAGGCTTCGCCAAGCTCGTCGAGGAGAGGA
AGGTCGGCGAGGACAAGATGGTATTCATCGAGGGCTGTCCGAACCCAAGAGCAGTAACCATACTCATCCGCGGTGGTCTC
GAGAGGCTTGTAGACGAGGCTGAAAGGAGCATCAACGACGCTCTACATGCTGTAGCTGATGCGATTAGGGATGGCAAGAT
TGTTGCTGGTGGTGGCGCGGTTGAGGTAGAGGTTGCTAAGTACCTGCGCGAGATAGCACCAAAGATTGGTGGTAAGGAGC
AGCTAGCAGTAGAAGCCTTCGCGAGGGCTCTCGAGGGCCTACCAATGGCTCTAGCAGAGAACGCTGGCCTAGAACCTGTA
GAGATAATCATGAAGCTACGTGCTGCCCATGCAAAGGCTGAGGGCAAGTGGGTAGGTGTAAACGTCTTCAAGGGCGATGT
TGATGACATGAAGAAGCTCGGTGTCATTGAGCCGGTAAGCGTGAAGGCTAACGCGATCAAGGCCGGTACCGAGGCTGCAA
CAATGGTGCTAAGGATTGACGACATCATAGCGGCTGCACGCCGCGAGGAGAAGGAGGAAGAGAAGAAGAAGGGCGAGGAA
GAGGAGAAGGAGGAGAAGGAGGAGTAA

Upstream 100 bases:

>100_bases
CTGACCCTCCAAGCAAGCCTTGACAGTAACACTTATATAGAAGCACCCCGAAGGCAATCTATCCCGGACATAGGATAGTG
AGCGCATAGGGGTGTAAGCT

Downstream 100 bases:

>100_bases
CCACCCAGCCTTTTTAACCAGGTGTAAGGTCAGCTCTAGCCCCTCATTCTCATTAGCTTCTACATACCTTGTCTTTCCTT
GGCGAGGCTCTGCTTTTCTG

Product: thermosome beta subunit

Products: NA

Alternate protein names: Chaperonin subunit beta; Thermophilic factor 55 beta; TF55-beta; Thermosome subunit 2 [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSARQVAALEPTGVPVLILKEGTQRTYGREALRTNIMIVRAIAETLRTTYGPKGMDKMLVDSLGDITITNDGATILDKMD
VQHPTAKLVVQIAKGQDEEVGDGTKTAVIFAGELLRYAEELLDKNVHPTIIVSGYKKAAEEAVKKLHEIAEPIDINDEET
LKKIAMTSLTSKAVHGAREHLAEIVVKAVRQVAEKRGDKWYIDLDAIQIIKKHGGSLRDTKLIYGIVLDKEVVHPGMPKK
VENAYIVLLDAPLEVEKPEIDAEIRINDPAFLKKFLEEEEKILEEMVNKIYNVAMERIRKDGMEGKAGIVVITQKGIDEV
AQHFLAKKGIMAVRRVKRSDIEKIARATGAKIVSNIDDLTPEDLGFAKLVEERKVGEDKMVFIEGCPNPRAVTILIRGGL
ERLVDEAERSINDALHAVADAIRDGKIVAGGGAVEVEVAKYLREIAPKIGGKEQLAVEAFARALEGLPMALAENAGLEPV
EIIMKLRAAHAKAEGKWVGVNVFKGDVDDMKKLGVIEPVSVKANAIKAGTEAATMVLRIDDIIAAARREEKEEEKKKGEE
EEKEEKEE

Sequences:

>Translated_568_residues
MSARQVAALEPTGVPVLILKEGTQRTYGREALRTNIMIVRAIAETLRTTYGPKGMDKMLVDSLGDITITNDGATILDKMD
VQHPTAKLVVQIAKGQDEEVGDGTKTAVIFAGELLRYAEELLDKNVHPTIIVSGYKKAAEEAVKKLHEIAEPIDINDEET
LKKIAMTSLTSKAVHGAREHLAEIVVKAVRQVAEKRGDKWYIDLDAIQIIKKHGGSLRDTKLIYGIVLDKEVVHPGMPKK
VENAYIVLLDAPLEVEKPEIDAEIRINDPAFLKKFLEEEEKILEEMVNKIYNVAMERIRKDGMEGKAGIVVITQKGIDEV
AQHFLAKKGIMAVRRVKRSDIEKIARATGAKIVSNIDDLTPEDLGFAKLVEERKVGEDKMVFIEGCPNPRAVTILIRGGL
ERLVDEAERSINDALHAVADAIRDGKIVAGGGAVEVEVAKYLREIAPKIGGKEQLAVEAFARALEGLPMALAENAGLEPV
EIIMKLRAAHAKAEGKWVGVNVFKGDVDDMKKLGVIEPVSVKANAIKAGTEAATMVLRIDDIIAAARREEKEEEKKKGEE
EEKEEKEE
>Mature_567_residues
SARQVAALEPTGVPVLILKEGTQRTYGREALRTNIMIVRAIAETLRTTYGPKGMDKMLVDSLGDITITNDGATILDKMDV
QHPTAKLVVQIAKGQDEEVGDGTKTAVIFAGELLRYAEELLDKNVHPTIIVSGYKKAAEEAVKKLHEIAEPIDINDEETL
KKIAMTSLTSKAVHGAREHLAEIVVKAVRQVAEKRGDKWYIDLDAIQIIKKHGGSLRDTKLIYGIVLDKEVVHPGMPKKV
ENAYIVLLDAPLEVEKPEIDAEIRINDPAFLKKFLEEEEKILEEMVNKIYNVAMERIRKDGMEGKAGIVVITQKGIDEVA
QHFLAKKGIMAVRRVKRSDIEKIARATGAKIVSNIDDLTPEDLGFAKLVEERKVGEDKMVFIEGCPNPRAVTILIRGGLE
RLVDEAERSINDALHAVADAIRDGKIVAGGGAVEVEVAKYLREIAPKIGGKEQLAVEAFARALEGLPMALAENAGLEPVE
IIMKLRAAHAKAEGKWVGVNVFKGDVDDMKKLGVIEPVSVKANAIKAGTEAATMVLRIDDIIAAARREEKEEEKKKGEEE
EKEEKEE

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI24307939, Length=557, Percent_Identity=42.1903052064632, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI63162572, Length=553, Percent_Identity=37.0705244122966, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI5453607, Length=546, Percent_Identity=37.3626373626374, Blast_Score=361, Evalue=1e-99,
Organism=Homo sapiens, GI38455427, Length=517, Percent_Identity=39.6518375241779, Blast_Score=357, Evalue=2e-98,
Organism=Homo sapiens, GI57863257, Length=557, Percent_Identity=36.4452423698384, Blast_Score=342, Evalue=6e-94,
Organism=Homo sapiens, GI4502643, Length=517, Percent_Identity=40.0386847195358, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI58761484, Length=490, Percent_Identity=35.7142857142857, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI261399877, Length=500, Percent_Identity=36.4, Blast_Score=322, Evalue=7e-88,
Organism=Homo sapiens, GI58331173, Length=511, Percent_Identity=37.9647749510763, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI5453603, Length=543, Percent_Identity=34.8066298342541, Blast_Score=304, Evalue=2e-82,
Organism=Homo sapiens, GI58331171, Length=517, Percent_Identity=36.3636363636364, Blast_Score=275, Evalue=6e-74,
Organism=Homo sapiens, GI261399875, Length=455, Percent_Identity=33.8461538461538, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI302058290, Length=517, Percent_Identity=34.4294003868472, Blast_Score=264, Evalue=2e-70,
Organism=Homo sapiens, GI302058292, Length=511, Percent_Identity=34.2465753424658, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI48762932, Length=538, Percent_Identity=32.1561338289963, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI57863259, Length=390, Percent_Identity=34.1025641025641, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI58331185, Length=334, Percent_Identity=34.1317365269461, Blast_Score=210, Evalue=2e-54,
Organism=Homo sapiens, GI7657253, Length=530, Percent_Identity=25.4716981132075, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI41399285, Length=579, Percent_Identity=20.7253886010363, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI31542947, Length=579, Percent_Identity=20.7253886010363, Blast_Score=73, Evalue=9e-13,
Organism=Homo sapiens, GI121583483, Length=224, Percent_Identity=27.2321428571429, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1790586, Length=565, Percent_Identity=22.4778761061947, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25144674, Length=538, Percent_Identity=39.5910780669145, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17532603, Length=525, Percent_Identity=40.3809523809524, Blast_Score=358, Evalue=4e-99,
Organism=Caenorhabditis elegans, GI17532601, Length=547, Percent_Identity=37.2943327239488, Blast_Score=346, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI25148561, Length=538, Percent_Identity=33.271375464684, Blast_Score=331, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI17564182, Length=540, Percent_Identity=34.8148148148148, Blast_Score=330, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI25147750, Length=555, Percent_Identity=37.1171171171171, Blast_Score=324, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI25144678, Length=531, Percent_Identity=34.4632768361582, Blast_Score=296, Evalue=2e-80,
Organism=Caenorhabditis elegans, GI32566944, Length=458, Percent_Identity=33.4061135371179, Blast_Score=271, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI25144680, Length=396, Percent_Identity=36.6161616161616, Blast_Score=252, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71998178, Length=550, Percent_Identity=30.9090909090909, Blast_Score=234, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI71981457, Length=333, Percent_Identity=37.8378378378378, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17555558, Length=573, Percent_Identity=23.3856893542757, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322446, Length=545, Percent_Identity=35.9633027522936, Blast_Score=365, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6322524, Length=561, Percent_Identity=35.650623885918, Blast_Score=342, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6322350, Length=536, Percent_Identity=36.3805970149254, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6320418, Length=554, Percent_Identity=34.8375451263538, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6320393, Length=531, Percent_Identity=35.5932203389831, Blast_Score=315, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6320058, Length=523, Percent_Identity=35.5640535372849, Blast_Score=308, Evalue=1e-84,
Organism=Saccharomyces cerevisiae, GI6322049, Length=516, Percent_Identity=35.077519379845, Blast_Score=280, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6322452, Length=533, Percent_Identity=30.5816135084428, Blast_Score=241, Evalue=3e-64,
Organism=Drosophila melanogaster, GI17647245, Length=541, Percent_Identity=39.3715341959335, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652903, Length=513, Percent_Identity=39.766081871345, Blast_Score=359, Evalue=3e-99,
Organism=Drosophila melanogaster, GI24649027, Length=535, Percent_Identity=37.5700934579439, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24649029, Length=535, Percent_Identity=37.5700934579439, Blast_Score=357, Evalue=1e-98,
Organism=Drosophila melanogaster, GI24645179, Length=542, Percent_Identity=36.7158671586716, Blast_Score=350, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24583944, Length=516, Percent_Identity=37.5968992248062, Blast_Score=334, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24647512, Length=540, Percent_Identity=34.8148148148148, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI24647510, Length=540, Percent_Identity=34.8148148148148, Blast_Score=333, Evalue=1e-91,
Organism=Drosophila melanogaster, GI18858175, Length=543, Percent_Identity=35.5432780847145, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI28571140, Length=543, Percent_Identity=35.5432780847145, Blast_Score=312, Evalue=4e-85,
Organism=Drosophila melanogaster, GI18859933, Length=516, Percent_Identity=35.4651162790698, Blast_Score=293, Evalue=2e-79,
Organism=Drosophila melanogaster, GI19921848, Length=555, Percent_Identity=32.0720720720721, Blast_Score=257, Evalue=2e-68,
Organism=Drosophila melanogaster, GI20130093, Length=190, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45552711, Length=190, Percent_Identity=30, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 62425; Mature: 62294

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00750 TCP1_1 ; PS00751 TCP1_2 ; PS00995 TCP1_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARQVAALEPTGVPVLILKEGTQRTYGREALRTNIMIVRAIAETLRTTYGPKGMDKMLV
CCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DSLGDITITNDGATILDKMDVQHPTAKLVVQIAKGQDEEVGDGTKTAVIFAGELLRYAEE
HCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLDKNVHPTIIVSGYKKAAEEAVKKLHEIAEPIDINDEETLKKIAMTSLTSKAVHGAREH
HHCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEIVVKAVRQVAEKRGDKWYIDLDAIQIIKKHGGSLRDTKLIYGIVLDKEVVHPGMPKK
HHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCCEEEEEEECHHHHCCCCCCC
VENAYIVLLDAPLEVEKPEIDAEIRINDPAFLKKFLEEEEKILEEMVNKIYNVAMERIRK
CCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGMEGKAGIVVITQKGIDEVAQHFLAKKGIMAVRRVKRSDIEKIARATGAKIVSNIDDLT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PEDLGFAKLVEERKVGEDKMVFIEGCPNPRAVTILIRGGLERLVDEAERSINDALHAVAD
CCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AIRDGKIVAGGGAVEVEVAKYLREIAPKIGGKEQLAVEAFARALEGLPMALAENAGLEPV
HHCCCCEEECCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHH
EIIMKLRAAHAKAEGKWVGVNVFKGDVDDMKKLGVIEPVSVKANAIKAGTEAATMVLRID
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCHHHHCCCHHHHEEHHHH
DIIAAARREEKEEEKKKGEEEEKEEKEE
HHHHHHHHHHHHHHHHCCCHHHHHHCCC
>Mature Secondary Structure 
SARQVAALEPTGVPVLILKEGTQRTYGREALRTNIMIVRAIAETLRTTYGPKGMDKMLV
CCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
DSLGDITITNDGATILDKMDVQHPTAKLVVQIAKGQDEEVGDGTKTAVIFAGELLRYAEE
HCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LLDKNVHPTIIVSGYKKAAEEAVKKLHEIAEPIDINDEETLKKIAMTSLTSKAVHGAREH
HHCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LAEIVVKAVRQVAEKRGDKWYIDLDAIQIIKKHGGSLRDTKLIYGIVLDKEVVHPGMPKK
HHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCCCCCCCCEEEEEEECHHHHCCCCCCC
VENAYIVLLDAPLEVEKPEIDAEIRINDPAFLKKFLEEEEKILEEMVNKIYNVAMERIRK
CCCCEEEEEECCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGMEGKAGIVVITQKGIDEVAQHFLAKKGIMAVRRVKRSDIEKIARATGAKIVSNIDDLT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PEDLGFAKLVEERKVGEDKMVFIEGCPNPRAVTILIRGGLERLVDEAERSINDALHAVAD
CCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHH
AIRDGKIVAGGGAVEVEVAKYLREIAPKIGGKEQLAVEAFARALEGLPMALAENAGLEPV
HHCCCCEEECCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCCCCHH
EIIMKLRAAHAKAEGKWVGVNVFKGDVDDMKKLGVIEPVSVKANAIKAGTEAATMVLRID
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCHHHHCCCHHHHEEHHHH
DIIAAARREEKEEEKKKGEEEEKEEKEE
HHHHHHHHHHHHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10508614 [H]