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The map label for this gene is 124027362

Identifier: 124027362

GI number: 124027362

Start: 452983

End: 454266

Strand: Reverse

Name: 124027362

Synonym: Hbut_0474

Alternate gene names: NA

Gene position: 454266-452983 (Counterclockwise)

Preceding gene: 124027364

Following gene: 124027361

Centisome position: 27.25

GC content: 49.14

Gene sequence:

>1284_bases
GTGGCTAAGATAGCTCTCCGCATATTGGGTGGTGGAGGAGAGGTAGGCAGACTCTCAGTGCTAGTTAGGGTTAGGCCGGA
GGAGCGTGATGGTATACTGCTAGATGCTGGCGTAAACTTTGATGAGGAAGACAGGCCGGTATTTGCGGCAACATACCCAC
CAAAGTATGTTAAGGCGATGATACTTAGTCATGCACATCTGGACCACATAGGCACAGCACCAATGTACTTTATCTCTGGT
AGACCAAGAGTCTATGCTACAAAGCCAACACTCGAAATGGCAAAGCTAATGCTTGAGGACTTCCTAAAGCTCAACGGATA
CTATTCACCATACGAGCACTATGAGGTAAAGCTGTTGCTCGAGGCTGGAGAAAAGATTCACTATGGCCAACGCATAGACA
TAGATGGTGTTGAGGCAACCTTTTACTCGGCAGGACACGTCCCAGGTAGCACATTTACAGTACTAGATATTGACGGTACA
AGGATGGGCTTCACAGGCGACATAAATACGATAGAGACCAAGCTTATGAAGCCAGCAAACCATCACATAATCGGCAGCCT
CGACATACTGGTAACAGAGGCGACCTACGGTAGCAGCCTTCATCCACCAAGAGCCAACGCTGAGAAGAGGCTACTCTCAA
TAATCGAGGAGACGATCGACAGGAAGGGTACAGTGCTAATCCCGGCCTTCAGCATTGCGCGTGGCCAAGAGATAATGATG
ATACTAGCCGAGCACGATCCGGGTGTGCCTGTCTACGTCGATGGTATGATTAGGCAGATAACTGAGATATTCCTCGAAAA
TCCCGAGTACATAAACAACGTTAACCTGCTGAGGAAAGCCTACGAGGAGTTTAACATTGTGCGGGGCTGGCGCGATCGAA
ACAAGGCGTGGCGTGAGCCAGCAGTAATAATAGCCTCGGCAGGCATGCTCAAGGGAGGCCCAAGCCTATACTACCTAAAG
AGGCTTGGGTCAAATCCGCGAAACGCAATCATACTAGTCAGCTTCCAGGCACCAGGCTCCAACGGTAGACGCATTCTCGA
AGAGGGTCTAATGCCAGATACAGAGGAACCCGTAAGAGCTAGAGTTGAATGGCTAGATTTTAGCAGTCATGCCGACCGCA
ACGGTCTCTTAGATGTCGTAAGGACGACAAAGCCACGCTACATAGTAGTAGTCCACAGCGAAGCCGATGTAGCTGTAAAA
TATGCAGAGCTACTACGCAGTACTGGCATTCCAGAAGAAGTTATCGTAGCCGAAAACAATAGGGAGTATACGCTAGAAGT
CTAG

Upstream 100 bases:

>100_bases
TATATAATAGGTTGTTTGGTTTTGGAGTTTAGAGCGGGACAGCCACCATTCATGCAATATGTGCACTACGCGACGTAGGT
TGCAGAGGTGAGTCTATGTC

Downstream 100 bases:

>100_bases
GCAGAAAAACACGGTATTTGTCTGGGATGGGTTGAGTAGTGGTGGGCCCGCCGGGATTTGAACCCGGGACCACGGGGTCC
CGAGTCGGGCACAGCCCCGC

Product: putative exoribonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MAKIALRILGGGGEVGRLSVLVRVRPEERDGILLDAGVNFDEEDRPVFAATYPPKYVKAMILSHAHLDHIGTAPMYFISG
RPRVYATKPTLEMAKLMLEDFLKLNGYYSPYEHYEVKLLLEAGEKIHYGQRIDIDGVEATFYSAGHVPGSTFTVLDIDGT
RMGFTGDINTIETKLMKPANHHIIGSLDILVTEATYGSSLHPPRANAEKRLLSIIEETIDRKGTVLIPAFSIARGQEIMM
ILAEHDPGVPVYVDGMIRQITEIFLENPEYINNVNLLRKAYEEFNIVRGWRDRNKAWREPAVIIASAGMLKGGPSLYYLK
RLGSNPRNAIILVSFQAPGSNGRRILEEGLMPDTEEPVRARVEWLDFSSHADRNGLLDVVRTTKPRYIVVVHSEADVAVK
YAELLRSTGIPEEVIVAENNREYTLEV

Sequences:

>Translated_427_residues
MAKIALRILGGGGEVGRLSVLVRVRPEERDGILLDAGVNFDEEDRPVFAATYPPKYVKAMILSHAHLDHIGTAPMYFISG
RPRVYATKPTLEMAKLMLEDFLKLNGYYSPYEHYEVKLLLEAGEKIHYGQRIDIDGVEATFYSAGHVPGSTFTVLDIDGT
RMGFTGDINTIETKLMKPANHHIIGSLDILVTEATYGSSLHPPRANAEKRLLSIIEETIDRKGTVLIPAFSIARGQEIMM
ILAEHDPGVPVYVDGMIRQITEIFLENPEYINNVNLLRKAYEEFNIVRGWRDRNKAWREPAVIIASAGMLKGGPSLYYLK
RLGSNPRNAIILVSFQAPGSNGRRILEEGLMPDTEEPVRARVEWLDFSSHADRNGLLDVVRTTKPRYIVVVHSEADVAVK
YAELLRSTGIPEEVIVAENNREYTLEV
>Mature_426_residues
AKIALRILGGGGEVGRLSVLVRVRPEERDGILLDAGVNFDEEDRPVFAATYPPKYVKAMILSHAHLDHIGTAPMYFISGR
PRVYATKPTLEMAKLMLEDFLKLNGYYSPYEHYEVKLLLEAGEKIHYGQRIDIDGVEATFYSAGHVPGSTFTVLDIDGTR
MGFTGDINTIETKLMKPANHHIIGSLDILVTEATYGSSLHPPRANAEKRLLSIIEETIDRKGTVLIPAFSIARGQEIMMI
LAEHDPGVPVYVDGMIRQITEIFLENPEYINNVNLLRKAYEEFNIVRGWRDRNKAWREPAVIIASAGMLKGGPSLYYLKR
LGSNPRNAIILVSFQAPGSNGRRILEEGLMPDTEEPVRARVEWLDFSSHADRNGLLDVVRTTKPRYIVVVHSEADVAVKY
AELLRSTGIPEEVIVAENNREYTLEV

Specific function: Unknown

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=453, Percent_Identity=25.3863134657837, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI33300633, Length=428, Percent_Identity=26.8691588785047, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32566029, Length=424, Percent_Identity=27.3584905660377, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI32564696, Length=414, Percent_Identity=27.0531400966184, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17559452, Length=374, Percent_Identity=24.0641711229947, Blast_Score=76, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323307, Length=436, Percent_Identity=27.0642201834862, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24648013, Length=423, Percent_Identity=25.7683215130024, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI21358523, Length=431, Percent_Identity=26.9141531322506, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 47812; Mature: 47680

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIALRILGGGGEVGRLSVLVRVRPEERDGILLDAGVNFDEEDRPVFAATYPPKYVKAM
CCEEEEEEEECCCCEEEEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEECCCHHHHHHH
ILSHAHLDHIGTAPMYFISGRPRVYATKPTLEMAKLMLEDFLKLNGYYSPYEHYEVKLLL
HHHHHHHHHCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
EAGEKIHYGQRIDIDGVEATFYSAGHVPGSTFTVLDIDGTRMGFTGDINTIETKLMKPAN
ECCCEECCCCEECCCCCEEEEEECCCCCCCEEEEEEECCCEECCCCCCHHHHHHHCCCCC
HHIIGSLDILVTEATYGSSLHPPRANAEKRLLSIIEETIDRKGTVLIPAFSIARGQEIMM
CEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCEEEE
ILAEHDPGVPVYVDGMIRQITEIFLENPEYINNVNLLRKAYEEFNIVRGWRDRNKAWREP
EEECCCCCCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCHHHCCC
AVIIASAGMLKGGPSLYYLKRLGSNPRNAIILVSFQAPGSNGRRILEEGLMPDTEEPVRA
EEEEEECCCCCCCCCEEEHHHHCCCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCHHH
RVEWLDFSSHADRNGLLDVVRTTKPRYIVVVHSEADVAVKYAELLRSTGIPEEVIVAENN
EEEEEECCCCCCCCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECC
REYTLEV
CEEEEEC
>Mature Secondary Structure 
AKIALRILGGGGEVGRLSVLVRVRPEERDGILLDAGVNFDEEDRPVFAATYPPKYVKAM
CEEEEEEEECCCCEEEEEEEEEECCCCCCCEEEECCCCCCCCCCCEEEECCCHHHHHHH
ILSHAHLDHIGTAPMYFISGRPRVYATKPTLEMAKLMLEDFLKLNGYYSPYEHYEVKLLL
HHHHHHHHHCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
EAGEKIHYGQRIDIDGVEATFYSAGHVPGSTFTVLDIDGTRMGFTGDINTIETKLMKPAN
ECCCEECCCCEECCCCCEEEEEECCCCCCCEEEEEEECCCEECCCCCCHHHHHHHCCCCC
HHIIGSLDILVTEATYGSSLHPPRANAEKRLLSIIEETIDRKGTVLIPAFSIARGQEIMM
CEEEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCEEEE
ILAEHDPGVPVYVDGMIRQITEIFLENPEYINNVNLLRKAYEEFNIVRGWRDRNKAWREP
EEECCCCCCCEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHCCHHHCCC
AVIIASAGMLKGGPSLYYLKRLGSNPRNAIILVSFQAPGSNGRRILEEGLMPDTEEPVRA
EEEEEECCCCCCCCCEEEHHHHCCCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCHHH
RVEWLDFSSHADRNGLLDVVRTTKPRYIVVVHSEADVAVKYAELLRSTGIPEEVIVAENN
EEEEEECCCCCCCCCCHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECC
REYTLEV
CEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]