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The map label for this gene is pyrD [H]

Identifier: 124027158

GI number: 124027158

Start: 248277

End: 249185

Strand: Direct

Name: pyrD [H]

Synonym: Hbut_0261

Alternate gene names: 124027158

Gene position: 248277-249185 (Clockwise)

Preceding gene: 124027156

Following gene: 124027159

Centisome position: 14.89

GC content: 59.08

Gene sequence:

>909_bases
GTGGCTGGGCTTGCTGTGAGGGTTGCGGGGCTGACACTGAGGCACCCTGTTATGAATGCTAGCGGCATCCTGGGCTCTCA
CCCAGAGGGCGTTAAGCTCCTAGTGGATGCTGGTGTATCGGCTGTCGTGACGAAGTCGTTTACCGTGGAACCACGGGAGG
GCTACCCTACTCCAATAGCTGTCCCGCTACCCTATGGGCTCCTCAATGCTGTTGGCCTTTCAAACCCCGGCATAGACGGT
ATATCGGTTGTTGTGGAGGAGGCTAGGCGGGCTGGGCTCCCCGTGGTGGTGAGCATTGCCGGGTCGTCAGAGGACGAGTT
CTCCCGTCTAGCATCTGCAGCCGAAGAGGCTGGCGCCGATGCCATCGAGGTCAACCTCAGCTGCCCCCATGCCAAGGGCA
TGGGGAGAGAGATAGGCATTGAGCCGAGGCTGGTCTACTCCGTCGTCTCTGCAACTGCCTCAGTGACGCGTATACCGGTC
ATAGCTAAGCTGGGCTACGTTGACCGACTCGTGGAGGCAGTGGGGAAGGCGCTTGAGGCTGGGGCGAGAGCTGTCACACT
GATAAACACATTGCCTGCAATGATGATAGACGTGTATGCTATGAAGCCGGTCCTGGGCAACCTTGTCGGAGGCCTCTCAG
GCCCAGCAATACATCCAGTTGCTGTTAGAGCAATCTACGAGGTCTACAGAGAGTACCGGATAGACATCATAGGCGCTGGA
GGCGTAGAGGACTGGAGGACAGCAGCCGAGCTGGTGCTTGCTGGAGCCCGCGCTGTACAGGTGGGCACAGCACTAGTAAC
CCGCGGGCTGAGAGTCATCGGAGAGATAGTCCAAGGACTAGAGAGGTACATGGAGGAGGTGGGCGTAGAGTCTATAGAGG
AGCTAGTGGGGGCCGCCCACCGGGACTAG

Upstream 100 bases:

>100_bases
ACGCTATGTAGAGGGGTTTTACAGGCTAGGCTCTGGGGCTAAGTACGTCCACAACACTCCCTGGGTATGTGGCGCACAGG
AGCGTGGAGGGGCTCCCCCT

Downstream 100 bases:

>100_bases
AGTCTTGGCCCGAGAATTCGAGGAAAAGATAGTTCTGGGCAGCTGCGAGGAGCTAGCAGCTGTTGAAGAGAGGCTCCGCG
AGCTAGGGGCAACGCTCGAG

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MAGLAVRVAGLTLRHPVMNASGILGSHPEGVKLLVDAGVSAVVTKSFTVEPREGYPTPIAVPLPYGLLNAVGLSNPGIDG
ISVVVEEARRAGLPVVVSIAGSSEDEFSRLASAAEEAGADAIEVNLSCPHAKGMGREIGIEPRLVYSVVSATASVTRIPV
IAKLGYVDRLVEAVGKALEAGARAVTLINTLPAMMIDVYAMKPVLGNLVGGLSGPAIHPVAVRAIYEVYREYRIDIIGAG
GVEDWRTAAELVLAGARAVQVGTALVTRGLRVIGEIVQGLERYMEEVGVESIEELVGAAHRD

Sequences:

>Translated_302_residues
MAGLAVRVAGLTLRHPVMNASGILGSHPEGVKLLVDAGVSAVVTKSFTVEPREGYPTPIAVPLPYGLLNAVGLSNPGIDG
ISVVVEEARRAGLPVVVSIAGSSEDEFSRLASAAEEAGADAIEVNLSCPHAKGMGREIGIEPRLVYSVVSATASVTRIPV
IAKLGYVDRLVEAVGKALEAGARAVTLINTLPAMMIDVYAMKPVLGNLVGGLSGPAIHPVAVRAIYEVYREYRIDIIGAG
GVEDWRTAAELVLAGARAVQVGTALVTRGLRVIGEIVQGLERYMEEVGVESIEELVGAAHRD
>Mature_301_residues
AGLAVRVAGLTLRHPVMNASGILGSHPEGVKLLVDAGVSAVVTKSFTVEPREGYPTPIAVPLPYGLLNAVGLSNPGIDGI
SVVVEEARRAGLPVVVSIAGSSEDEFSRLASAAEEAGADAIEVNLSCPHAKGMGREIGIEPRLVYSVVSATASVTRIPVI
AKLGYVDRLVEAVGKALEAGARAVTLINTLPAMMIDVYAMKPVLGNLVGGLSGPAIHPVAVRAIYEVYREYRIDIIGAGG
VEDWRTAAELVLAGARAVQVGTALVTRGLRVIGEIVQGLERYMEEVGVESIEELVGAAHRD

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=325, Percent_Identity=29.8461538461538, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI45006951, Length=328, Percent_Identity=30.1829268292683, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI87082059, Length=219, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71984108, Length=205, Percent_Identity=32.1951219512195, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322633, Length=316, Percent_Identity=31.3291139240506, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24640763, Length=200, Percent_Identity=32, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI18858217, Length=200, Percent_Identity=32, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 31396; Mature: 31265

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLAVRVAGLTLRHPVMNASGILGSHPEGVKLLVDAGVSAVVTKSFTVEPREGYPTPIA
CCCCEEEEECEEHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECEEECCCCCCCCCEE
VPLPYGLLNAVGLSNPGIDGISVVVEEARRAGLPVVVSIAGSSEDEFSRLASAAEEAGAD
EECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
AIEVNLSCPHAKGMGREIGIEPRLVYSVVSATASVTRIPVIAKLGYVDRLVEAVGKALEA
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARAVTLINTLPAMMIDVYAMKPVLGNLVGGLSGPAIHPVAVRAIYEVYREYRIDIIGAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEECC
GVEDWRTAAELVLAGARAVQVGTALVTRGLRVIGEIVQGLERYMEEVGVESIEELVGAAH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
RD
CC
>Mature Secondary Structure 
AGLAVRVAGLTLRHPVMNASGILGSHPEGVKLLVDAGVSAVVTKSFTVEPREGYPTPIA
CCCEEEEECEEHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEECEEECCCCCCCCCEE
VPLPYGLLNAVGLSNPGIDGISVVVEEARRAGLPVVVSIAGSSEDEFSRLASAAEEAGAD
EECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHCCCC
AIEVNLSCPHAKGMGREIGIEPRLVYSVVSATASVTRIPVIAKLGYVDRLVEAVGKALEA
EEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GARAVTLINTLPAMMIDVYAMKPVLGNLVGGLSGPAIHPVAVRAIYEVYREYRIDIIGAG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCEEEEECC
GVEDWRTAAELVLAGARAVQVGTALVTRGLRVIGEIVQGLERYMEEVGVESIEELVGAAH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
RD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]