Click here to switch to the map view.

The map label for this gene is hemA

Identifier: 124027103

GI number: 124027103

Start: 187788

End: 189023

Strand: Reverse

Name: hemA

Synonym: Hbut_0206

Alternate gene names: 124027103

Gene position: 189023-187788 (Counterclockwise)

Preceding gene: 124027106

Following gene: 124027101

Centisome position: 11.34

GC content: 61.73

Gene sequence:

>1236_bases
ATGCCGCGGCTCCTCGAGGAGCTCACAGCAGTCATACTGACACATCGTGATGCTCCGCTAGATGTTGTGGGCTCTTTCGA
GTCTAGGGTTGGGGAGGCCTACCAGATCCTTCGGGGCGTCGTCGACGAGGCCGTTGTGCTAGCGACGTGCAACCGGTTTG
AGGTCTATGCTCTCCCTCGCCGGGGCTTCGTGGAGACCGTGATAGGCTTCCTCGGCGAAGCCTCCCGGTATGCCCGTATA
CTCCACGGGATGGATGTTGTGCGGCACCTTTTCCGCGTCGCTGCCGGCCTGGAATCAGCTATTATAGGCGAAAACGAGAT
CCTCGGCCAGGTTGCTAGGGCCTACGAGGAGGCCCGCAGGAGGGGGGTTGCGGGCAAGTACCTAGGGCTCCTTTTCAGCC
AGGCTGTCCGCACCGGCAAGCTGGTGCGTAGCCGCACCAGGATATCCTACGGCAACGTGGGCGCGCCTGGCGCGGCCGTG
AAGCTGGCTAGGGAGGCTGCCGGAGGCTTCGATGGCAAGCACGTCGTCGTAGTGGGAGCCGGCGAGGCAGGCTCAATAAT
GGCCAGCCTTGTCCGGGAGGAGGCGCCCACCGCAAGGATCAGCATCGTCAACCGCAGCGTGGACAGGGCTAGGGAGCTAG
CAGGCAAGGTTAGGGGAGAGGCTTACGGGCTCGACATGCTTCCCAAGCTCCTAGCGGCTGCTGACGTGGTCCTGGTAGCT
GTAACCGTCAACGAGCCCGTTATCAAGAGGAGCATGCTTGAGGATGTTGGCCGGCACCTGGTAGTGGTGGACATCTCCAA
CCCGCCAGCCGTGGAGCAGCCCATACCCAGTAACGTCTACTACGCAGGGCTCCGTGACGTCGAGAAGGTTATCAAAGAGG
TTCTCGCCGTGAGGATACGCGAGGTGCCAAAGGCGGAAGCTATTGTGGAGGAGCAGGTGGCGCTTCTCCGCAAGCTCTGG
CTAAAGAGGGGCGCCGACGAGGCCATAGCGGAGATCATGAGGTACGCAAACCGCGTTATGGAGGAGGAGGTCGAGGAGCT
TGTCTCAAGGCTCCGCGGCTTAGGCGTTGACGGTGCCGCACTACTCGTAGCACGCAGCTTCGCCTACAGCCTCACCAAGA
AGCTTCTAAGGCCACTAATCCTATACGCCCATGAAGCCGCCCTCGAGGGCAGCCTCTCGAAGCTCGAGGAGATCGCCCAG
AAGTATCGGGACGAGCTCGCCAGGAGGCAGCACTAG

Upstream 100 bases:

>100_bases
GCATATTTAAAAGATGTAGTACCGTTATAATCTGGGCACAATACCACCATTACACGGTGCCTACGCGGCCTGCGCCAGCT
GAATGAGGGGCTGTAGGGGG

Downstream 100 bases:

>100_bases
CACAGTACTACGATACTCTAGTAGTGTAAGTCCCCTAAGCCTCCAGTGTAAAGAACGTGTGAGGAGTCTGTTACTGCCTT
GAGAGGAGAGCGGCTATAAC

Product: glutamyl-tRNAglu reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MPRLLEELTAVILTHRDAPLDVVGSFESRVGEAYQILRGVVDEAVVLATCNRFEVYALPRRGFVETVIGFLGEASRYARI
LHGMDVVRHLFRVAAGLESAIIGENEILGQVARAYEEARRRGVAGKYLGLLFSQAVRTGKLVRSRTRISYGNVGAPGAAV
KLAREAAGGFDGKHVVVVGAGEAGSIMASLVREEAPTARISIVNRSVDRARELAGKVRGEAYGLDMLPKLLAAADVVLVA
VTVNEPVIKRSMLEDVGRHLVVVDISNPPAVEQPIPSNVYYAGLRDVEKVIKEVLAVRIREVPKAEAIVEEQVALLRKLW
LKRGADEAIAEIMRYANRVMEEEVEELVSRLRGLGVDGAALLVARSFAYSLTKKLLRPLILYAHEAALEGSLSKLEEIAQ
KYRDELARRQH

Sequences:

>Translated_411_residues
MPRLLEELTAVILTHRDAPLDVVGSFESRVGEAYQILRGVVDEAVVLATCNRFEVYALPRRGFVETVIGFLGEASRYARI
LHGMDVVRHLFRVAAGLESAIIGENEILGQVARAYEEARRRGVAGKYLGLLFSQAVRTGKLVRSRTRISYGNVGAPGAAV
KLAREAAGGFDGKHVVVVGAGEAGSIMASLVREEAPTARISIVNRSVDRARELAGKVRGEAYGLDMLPKLLAAADVVLVA
VTVNEPVIKRSMLEDVGRHLVVVDISNPPAVEQPIPSNVYYAGLRDVEKVIKEVLAVRIREVPKAEAIVEEQVALLRKLW
LKRGADEAIAEIMRYANRVMEEEVEELVSRLRGLGVDGAALLVARSFAYSLTKKLLRPLILYAHEAALEGSLSKLEEIAQ
KYRDELARRQH
>Mature_410_residues
PRLLEELTAVILTHRDAPLDVVGSFESRVGEAYQILRGVVDEAVVLATCNRFEVYALPRRGFVETVIGFLGEASRYARIL
HGMDVVRHLFRVAAGLESAIIGENEILGQVARAYEEARRRGVAGKYLGLLFSQAVRTGKLVRSRTRISYGNVGAPGAAVK
LAREAAGGFDGKHVVVVGAGEAGSIMASLVREEAPTARISIVNRSVDRARELAGKVRGEAYGLDMLPKLLAAADVVLVAV
TVNEPVIKRSMLEDVGRHLVVVDISNPPAVEQPIPSNVYYAGLRDVEKVIKEVLAVRIREVPKAEAIVEEQVALLRKLWL
KRGADEAIAEIMRYANRVMEEEVEELVSRLRGLGVDGAALLVARSFAYSLTKKLLRPLILYAHEAALEGSLSKLEEIAQK
YRDELARRQH

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=412, Percent_Identity=29.126213592233, Blast_Score=125, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_HYPBU (A2BJB7)

Other databases:

- EMBL:   CP000493
- RefSeq:   YP_001012423.1
- ProteinModelPortal:   A2BJB7
- SMR:   A2BJB7
- STRING:   A2BJB7
- GeneID:   4782332
- GenomeReviews:   CP000493_GR
- KEGG:   hbu:Hbut_0206
- eggNOG:   arNOG04783
- OMA:   GEDQIIG
- PhylomeDB:   A2BJB7
- BioCyc:   HBUT415426:HBUT_0206-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45008; Mature: 44877

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 99-99 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLLEELTAVILTHRDAPLDVVGSFESRVGEAYQILRGVVDEAVVLATCNRFEVYALPR
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
RGFVETVIGFLGEASRYARILHGMDVVRHLFRVAAGLESAIIGENEILGQVARAYEEARR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHH
RGVAGKYLGLLFSQAVRTGKLVRSRTRISYGNVGAPGAAVKLAREAAGGFDGKHVVVVGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GEAGSIMASLVREEAPTARISIVNRSVDRARELAGKVRGEAYGLDMLPKLLAAADVVLVA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEE
VTVNEPVIKRSMLEDVGRHLVVVDISNPPAVEQPIPSNVYYAGLRDVEKVIKEVLAVRIR
EECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVPKAEAIVEEQVALLRKLWLKRGADEAIAEIMRYANRVMEEEVEELVSRLRGLGVDGAA
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LLVARSFAYSLTKKLLRPLILYAHEAALEGSLSKLEEIAQKYRDELARRQH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PRLLEELTAVILTHRDAPLDVVGSFESRVGEAYQILRGVVDEAVVLATCNRFEVYALPR
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
RGFVETVIGFLGEASRYARILHGMDVVRHLFRVAAGLESAIIGENEILGQVARAYEEARR
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHH
RGVAGKYLGLLFSQAVRTGKLVRSRTRISYGNVGAPGAAVKLAREAAGGFDGKHVVVVGA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
GEAGSIMASLVREEAPTARISIVNRSVDRARELAGKVRGEAYGLDMLPKLLAAADVVLVA
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEE
VTVNEPVIKRSMLEDVGRHLVVVDISNPPAVEQPIPSNVYYAGLRDVEKVIKEVLAVRIR
EECCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVPKAEAIVEEQVALLRKLWLKRGADEAIAEIMRYANRVMEEEVEELVSRLRGLGVDGAA
HCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LLVARSFAYSLTKKLLRPLILYAHEAALEGSLSKLEEIAQKYRDELARRQH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA