Click here to switch to the map view.

The map label for this gene is gpt [C]

Identifier: 124026981

GI number: 124026981

Start: 71771

End: 72457

Strand: Reverse

Name: gpt [C]

Synonym: Hbut_0080

Alternate gene names: 124026981

Gene position: 72457-71771 (Counterclockwise)

Preceding gene: 124026982

Following gene: 124026976

Centisome position: 4.35

GC content: 56.62

Gene sequence:

>687_bases
TTGCCGCGCGTTCCCGTCAAGCTTGTTACCTGGCAGGAGATTGTTGAGTGGAGCCGCGGTCTTGCGAGGAAGATAAAGGA
GTCGGGCTACAAGCCCACAGTCATTATAGCCGTGGCGCGTGGCGGCTACGTGCCCGCTAGGCTTCTCTGTGATTTTCTCG
GCGTAGAGAATCTTCTCAGTGTGCAGAGCCAGCACTGGACGGAGGCTGCCAAAGCTGCTGAGCGTGCCGTGCTCAAGTTC
CCATATCGGGTTGACCTTCGTGGCCACCGCGCGCTACTGGTAGACGACATCGTGGATACTGGCGAGACTGTAATGCTTGC
GCGAGACTACGTATTGAGGGAGTGGAGACCCGACGAGCTCCGCGTAGCTACGCTCCAGTGGATAAGCACGGTTGCCAAGT
TTAAGCCCGACTACTACTACCTAGAGGTTAAGGAGTGGGTGTGGTTCCAGTACCCGTGGACGCGGCTTGAGGACGTGACA
CAGTTCGTCAAGAGGATGATGCAGGAGGTCTACAGGGAGGAGGGTAAAGAGGAGTGGAGCCTAGACGAGATCAAGGCTAA
GTTCAAGGAGTGGTACGGTATAGACGTCGAAGACTTCTACTACAGCGATGCCCTCGAAATGCTTGTGGAGCAGGGCGTTG
TTGAGCCCCTGGACGGCGGCCGCTACAGGCTTAAGGCGAAAAGCTAA

Upstream 100 bases:

>100_bases
GACGAGAACTATGATCCCTGCAGCCAGGCATAGCTGGGAAGACCGGGGATAGCCGTTATTTATCCCTCTTTTTACGTCCC
CGTTAGGGTGAAGTATCGGG

Downstream 100 bases:

>100_bases
CACTACCCGGCAAACGGGGTTATGATGTAACCAGCTATCGCTGACCATGTGACGAGTTTGGCCTTTGCTGAACCCCCTCA
TTCTCACGGGGAGACCCTTC

Product: phosphoribosyltransferase

Products: Diphosphate; Xanthosine 5'-phosphate [C]

Alternate protein names: Purine Phosphoribosyltransferase; Xanthine-Guanine Phosphoribosyltransferase; Hypoxanthine/Guanine Phosphoribosyltransferase; Phosphoribosyl Transferase Domain Protein; Phosphoribosyl Transferase; Hypoxanthine-Guanine Phosphoribosyltransferase; Xanthine-Guanine Phosphoribosyltransferase Conjectural; Phosphoribosyltransferase-Like Protein; Xanthine/Guanine Phosphoribosyltransferase; Nucleotide Phosphoribosyltransferase; Phosphoribosyl Transferase Domain-Containing Protein; Purine Phosphoribosyltransferase Related Protein

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MPRVPVKLVTWQEIVEWSRGLARKIKESGYKPTVIIAVARGGYVPARLLCDFLGVENLLSVQSQHWTEAAKAAERAVLKF
PYRVDLRGHRALLVDDIVDTGETVMLARDYVLREWRPDELRVATLQWISTVAKFKPDYYYLEVKEWVWFQYPWTRLEDVT
QFVKRMMQEVYREEGKEEWSLDEIKAKFKEWYGIDVEDFYYSDALEMLVEQGVVEPLDGGRYRLKAKS

Sequences:

>Translated_228_residues
MPRVPVKLVTWQEIVEWSRGLARKIKESGYKPTVIIAVARGGYVPARLLCDFLGVENLLSVQSQHWTEAAKAAERAVLKF
PYRVDLRGHRALLVDDIVDTGETVMLARDYVLREWRPDELRVATLQWISTVAKFKPDYYYLEVKEWVWFQYPWTRLEDVT
QFVKRMMQEVYREEGKEEWSLDEIKAKFKEWYGIDVEDFYYSDALEMLVEQGVVEPLDGGRYRLKAKS
>Mature_227_residues
PRVPVKLVTWQEIVEWSRGLARKIKESGYKPTVIIAVARGGYVPARLLCDFLGVENLLSVQSQHWTEAAKAAERAVLKFP
YRVDLRGHRALLVDDIVDTGETVMLARDYVLREWRPDELRVATLQWISTVAKFKPDYYYLEVKEWVWFQYPWTRLEDVTQ
FVKRMMQEVYREEGKEEWSLDEIKAKFKEWYGIDVEDFYYSDALEMLVEQGVVEPLDGGRYRLKAKS

Specific function: Acts On Guanine, Xanthine And To A Lesser Extent Hypoxanthine. [C]

COG id: COG2236

COG function: function code R; Predicted phosphoribosyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.4.2.22 [C]

Molecular weight: Translated: 26922; Mature: 26791

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRVPVKLVTWQEIVEWSRGLARKIKESGYKPTVIIAVARGGYVPARLLCDFLGVENLLS
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
VQSQHWTEAAKAAERAVLKFPYRVDLRGHRALLVDDIVDTGETVMLARDYVLREWRPDEL
HHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHCCCCEEEHHHHHHHHCCCCCHH
RVATLQWISTVAKFKPDYYYLEVKEWVWFQYPWTRLEDVTQFVKRMMQEVYREEGKEEWS
HHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LDEIKAKFKEWYGIDVEDFYYSDALEMLVEQGVVEPLDGGRYRLKAKS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
PRVPVKLVTWQEIVEWSRGLARKIKESGYKPTVIIAVARGGYVPARLLCDFLGVENLLS
CCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHH
VQSQHWTEAAKAAERAVLKFPYRVDLRGHRALLVDDIVDTGETVMLARDYVLREWRPDEL
HHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHCCCCEEEHHHHHHHHCCCCCHH
RVATLQWISTVAKFKPDYYYLEVKEWVWFQYPWTRLEDVTQFVKRMMQEVYREEGKEEWS
HHHHHHHHHHHHHCCCCEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LDEIKAKFKEWYGIDVEDFYYSDALEMLVEQGVVEPLDGGRYRLKAKS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.02 {xanthine}} 0.053 {5-phospho-alpha-D-ribose} [C]

Substrates: 5-Phospho-alpha-D-ribose 1-diphosphate; Xanthine [C]

Specific reaction: 5-Phospho-alpha-D-ribose 1-diphosphate + Xanthine --> Diphosphate + Xanthosine 5'-phosphate [C]

General reaction: Glycosyl and Pentosyl group transfer [C]

Inhibitor: 2-Thioxanthine; 6-Thioxanthine; 8-Mercaptoxanthine; ATP; CDP; CTP; GDP; GMP; GTP; TDP; TTP; UDP; UTP; Xanthine; XDP; XMP; XTP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA