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The map label for this gene is eriC [H]

Identifier: 123967125

GI number: 123967125

Start: 1684311

End: 1685669

Strand: Direct

Name: eriC [H]

Synonym: P9515_18921

Alternate gene names: 123967125

Gene position: 1684311-1685669 (Clockwise)

Preceding gene: 123967124

Following gene: 123967127

Centisome position: 98.83

GC content: 33.55

Gene sequence:

>1359_bases
ATGAAAAAGCTAATAAAAGAAAATATTCAAAAAACCAGTAGTAACTCTTCTCAAAGCATAAAAAAATTACTTAAACAGAG
ATCTTTTGTTGTTGTCATATCAATTCTATTAACAGGATTAGGAGCATCAATAACTAGTATTTCTTTTAAAACTGGTATTT
ATTTTATAAATAATTGGAGATTAGAACTTTTAGAGAATTTTCCATCCATTGCAGTATTACCAGCATTTGGGGCTATTGGT
GGAGCCATAGCAGGCTTTTTAATTAAAAACTTAGCTCCAGCAGCAAAAGGTTCTGGTGTAAGTCAAATTATGGGATTCTT
GAGGCATAAAAAAGTACCCATGAATCTAAAAGTTGGCTTAGTTAAATTATTATCTGGAATAATTGCAATTGGAAGTGGGT
TTCCTTTAGGTCCTGAAGGACCATCAGTTCAAATGGGAGGTTCAGTTGCTTGGCAAATGGCAAGATGGCTGAAAGCTCCA
TTAGCTTTTAGAAGAGTAATTGTTGCAGCAGGAGGAGGTGCTGGAATAGCTGCAGTATTTAGCGCTCCATTAGGTGGATT
CATCTACGCGATTGAAGAATTATTAAATTCTGCAAGACCAATAATTTTATTATTAGTTGTAATAACAACTTTTATAGCAG
ATTCATCTGCGGATATTATTCAAGCCCTGGGTCTTGACCCCAAAGCAGGAGGTTTTGATTTCAACTTAGGATTTTTAATC
CAAAAAGAATATGATCCATCTGTCTTTTTCTTACCTATAGATTTTATTTATCTTATTTTACTAGGAGTTATTATTGGACT
ATTTGCAGAACTTTACAGCAAATATGTTCTTGTAATGCAGGATCTTGGGAAAAAATGGTATAAAAAAAAATTTGTTTTAA
AAATGAGTATTTGTGGACTCTTACTTGGTAGTATTTATTCATTTTTACCTAGCTCTTTTCATAATTTAGATGAATTACAA
AAAATAATAGCTGAAAAAAACACCAGTATCGAAATAGCTCTTTTAGCTGTGTTGATACTCTTCATTACAACTGGATTAGC
TGCAGCTTCTGGAGCGCCTGGAGGATTGTTCTACCCAATGCTTACCTTGGGTGGGGCCATAGGATTAATAATGGGAAGCT
GGGTAGAAATTGCCACAGGCCATGCTCCAAGTACATATATCTTTGCTGGCATGGGGGCATTTGTAGCAGGATGTTCTAGA
ACACCTATAACAGCTATGTTCTTGGCTTTTGCCTTAACAAAAAATTTATTAATAATGAAACCTGTTCTTATTAGTTGTAT
TACAAGTTTTTTAGTGGCAAGAGCTTTTAATGAAAAATCTATTTATGAAAGACAAATACAGATTGAATTAGAAGAATAA

Upstream 100 bases:

>100_bases
TATTACTAAAAACAAAATAAATCCATACTCAGACGAACTTTATCGTTATCTTCAATTTGATGAAATAGAAAATTTCAGTT
TGACAAAATAATAAAGGACT

Downstream 100 bases:

>100_bases
AATTGATTTCTAATCAAAAACAGCTGTTTTGCTATCGTATACGAAAATCTGATGATTCAAATGTAATCTAACTGCCCTTG
CAAGCGCAATCCTCTCAGTA

Product: putative chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MKKLIKENIQKTSSNSSQSIKKLLKQRSFVVVISILLTGLGASITSISFKTGIYFINNWRLELLENFPSIAVLPAFGAIG
GAIAGFLIKNLAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLLSGIIAIGSGFPLGPEGPSVQMGGSVAWQMARWLKAP
LAFRRVIVAAGGGAGIAAVFSAPLGGFIYAIEELLNSARPIILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
QKEYDPSVFFLPIDFIYLILLGVIIGLFAELYSKYVLVMQDLGKKWYKKKFVLKMSICGLLLGSIYSFLPSSFHNLDELQ
KIIAEKNTSIEIALLAVLILFITTGLAAASGAPGGLFYPMLTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSR
TPITAMFLAFALTKNLLIMKPVLISCITSFLVARAFNEKSIYERQIQIELEE

Sequences:

>Translated_452_residues
MKKLIKENIQKTSSNSSQSIKKLLKQRSFVVVISILLTGLGASITSISFKTGIYFINNWRLELLENFPSIAVLPAFGAIG
GAIAGFLIKNLAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLLSGIIAIGSGFPLGPEGPSVQMGGSVAWQMARWLKAP
LAFRRVIVAAGGGAGIAAVFSAPLGGFIYAIEELLNSARPIILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
QKEYDPSVFFLPIDFIYLILLGVIIGLFAELYSKYVLVMQDLGKKWYKKKFVLKMSICGLLLGSIYSFLPSSFHNLDELQ
KIIAEKNTSIEIALLAVLILFITTGLAAASGAPGGLFYPMLTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSR
TPITAMFLAFALTKNLLIMKPVLISCITSFLVARAFNEKSIYERQIQIELEE
>Mature_452_residues
MKKLIKENIQKTSSNSSQSIKKLLKQRSFVVVISILLTGLGASITSISFKTGIYFINNWRLELLENFPSIAVLPAFGAIG
GAIAGFLIKNLAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLLSGIIAIGSGFPLGPEGPSVQMGGSVAWQMARWLKAP
LAFRRVIVAAGGGAGIAAVFSAPLGGFIYAIEELLNSARPIILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
QKEYDPSVFFLPIDFIYLILLGVIIGLFAELYSKYVLVMQDLGKKWYKKKFVLKMSICGLLLGSIYSFLPSSFHNLDELQ
KIIAEKNTSIEIALLAVLILFITTGLAAASGAPGGLFYPMLTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSR
TPITAMFLAFALTKNLLIMKPVLISCITSFLVARAFNEKSIYERQIQIELEE

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=422, Percent_Identity=30.3317535545024, Blast_Score=111, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI71985148, Length=522, Percent_Identity=24.5210727969349, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71985141, Length=523, Percent_Identity=24.4741873804971, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322500, Length=400, Percent_Identity=25.75, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48500; Mature: 48500

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLIKENIQKTSSNSSQSIKKLLKQRSFVVVISILLTGLGASITSISFKTGIYFINNWR
CHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCHHHEEEHCCCEEEEECCH
LELLENFPSIAVLPAFGAIGGAIAGFLIKNLAPAAKGSGVSQIMGFLRHKKVPMNLKVGL
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VKLLSGIIAIGSGFPLGPEGPSVQMGGSVAWQMARWLKAPLAFRRVIVAAGGGAGIAAVF
HHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SAPLGGFIYAIEELLNSARPIILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEE
QKEYDPSVFFLPIDFIYLILLGVIIGLFAELYSKYVLVMQDLGKKWYKKKFVLKMSICGL
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGSIYSFLPSSFHNLDELQKIIAEKNTSIEIALLAVLILFITTGLAAASGAPGGLFYPM
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRTPITAMFLAFALTKNLLIMK
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
PVLISCITSFLVARAFNEKSIYERQIQIELEE
HHHHHHHHHHHHHHHCCHHHHHHEEEEEEECC
>Mature Secondary Structure
MKKLIKENIQKTSSNSSQSIKKLLKQRSFVVVISILLTGLGASITSISFKTGIYFINNWR
CHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHCCCHHHEEEHCCCEEEEECCH
LELLENFPSIAVLPAFGAIGGAIAGFLIKNLAPAAKGSGVSQIMGFLRHKKVPMNLKVGL
HHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VKLLSGIIAIGSGFPLGPEGPSVQMGGSVAWQMARWLKAPLAFRRVIVAAGGGAGIAAVF
HHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
SAPLGGFIYAIEELLNSARPIILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEEEE
QKEYDPSVFFLPIDFIYLILLGVIIGLFAELYSKYVLVMQDLGKKWYKKKFVLKMSICGL
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGSIYSFLPSSFHNLDELQKIIAEKNTSIEIALLAVLILFITTGLAAASGAPGGLFYPM
HHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTLGGAIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRTPITAMFLAFALTKNLLIMK
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
PVLISCITSFLVARAFNEKSIYERQIQIELEE
HHHHHHHHHHHHHHHCCHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA