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The map label for this gene is aspS

Identifier: 123967112

GI number: 123967112

Start: 1667505

End: 1669313

Strand: Direct

Name: aspS

Synonym: P9515_18791

Alternate gene names: 123967112

Gene position: 1667505-1669313 (Clockwise)

Preceding gene: 123967111

Following gene: 123967113

Centisome position: 97.85

GC content: 31.51

Gene sequence:

>1809_bases
ATGCGAAACAAAATTTGTGAAGAACTCAATAAGTCTGATATTGGGAAAGAAGTTAATTTATGTGGATGGGTAGACCGAAG
AAGAGATCATGGTGGAGTGATTTTTATCGATTTGCGTGATCACAGTGGATTTATGCAAATCACTATTAATCCTGAAGATG
GTGAGACTCTTTTTAAACAAGCTGAAATTCTAAGAAATGAAACTGTGATAATGGTTAATGGAATTGTTAATGAAAGACCA
AAGGATTCAATCAATAAAAATATAATCACTGGGGAGTTAGAACTAAAAGTTCAAGATTTACAAATTCTTAATCAAATTAA
AAATAATTTACCATTTCCTGTCTCAGTGCATGATTATGAGAATACGAAAGAAGAACTTAGATTAAAATATCGATATTTAG
ATATAAGAAGAGGAAAATTACTCGAAAATTTAAAAACAAGACATAAGATTATTAAAGCAATAAGAAATTATCTTGATAAT
TCTGGATTTACAGAGGTTGAAACACCATTACTTACAAAATCGACTCCGGAAGGGGCTAGAGATTTTTTAGTTCCAGCTAG
GCTTTCAAATGGTGATTTTTTTGCTTTACCACAATCTCCTCAATTATTTAAACAACTTTTAATGGTAGGAGGATTAGACA
AGTACTATCAAATCGCAAAATGTTTCCGTGATGAAGACCTAAGAGCAGATAGACAACCAGAATTTACTCAGCTTGATATT
GAAATGAGTTTTGTAAGTGAAGAAGAAATCATTGCTTTTAATGAAAAACTAATAAAACATATATGGAAAAATGTACTCAA
TATAAACTTAAATGAGGATTTCCCAAGAATGTCTTGGCAAGAAGCAATGGACAACTATGGAACAGACAGACCAGATACGA
GATATGGAATGTTACTTAAAAATTTAGGCGAGATACTTGGCAATATTGGTTTTAACATTTTCACCAAAGCAATACAGATG
GGGGGAGCAATAAAATCTATAACTATTAAAAATGGCAATTCAAGTATTAGTAACGTACGTATCAAACCTGGAGGGGATAT
TTTTAAAGTTGCCCAAGAAGCAGGTGCTGGAGGTTTAGCCTTCATAAGGGTTAAAGGAGATGAACTTGAAACAATTGGAG
CAATAAAAAATAATTTAAACAAAGATCATATTTCTAATATTTTAAAAATTACCGAAGCAGAAGATGGAGATTTAATTCTT
TTAGGAGCAGGAAGCACAAAAATTGTAAATCAATCACTAGATAGAGTAAGACAATATATTGCAAAAGATTTAAATCTTTT
AGAAAATCAAAAAGCGCAATCGCAATGGAATTTTTTATGGATCACTGACTTTCCTATGTTTGAAATGAATGAAGAAGAAA
AAAGGTTTGAAGCTTTACACCATCCTTTTTGTTCTCCTAAAAATGTAAAGTTTGAAGATAAAAAAGAATTAACAAAAAAA
ATAGAAACCTCAACTGCATATGCTTATGACTTAGTACTAAATGGATTAGAGTTAGGAGGAGGTTCATTGCGTATACATCA
AGCTGAAATGCAAAAAGAAGTTCTCAGAACAGTTGGATTAACAGATCATCAAATTGATGAGAAATTTGGGTTTTTAATTG
AAGCTCTTGAAATGGGTGCTCCGCCTCATGGAGGCATCGCCTTTGGATTAGATCGCATAACAATGCTGATTTTGGGAGTA
GATTCAATAAGAGAAACAATTGCTTTTCCAAAAAATCAACAAGCCAAATGTCTATTAACTAATGCACCTTCAAATGTCTC
CAAATCACAATTAAAAGAATTAGATATTGAAATAACAATTGATGAATAA

Upstream 100 bases:

>100_bases
GCGACCATAACGAAAAGAGCTTTTTACAAAAAAGATATTTAACTAAATTTACCCTTTAAGAATTATTATTATAAGTTATT
GCTCAATAAGTCATTTCTAG

Downstream 100 bases:

>100_bases
ACTATTTATGGATGATCAATAATTTTTTTGTTTAAATAAAATATAAGGAGGTTGTGCTTAATTAAAAATATTTAATGTCA
AAATTTGTTTTTGTTACTGG

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS

Number of amino acids: Translated: 602; Mature: 602

Protein sequence:

>602_residues
MRNKICEELNKSDIGKEVNLCGWVDRRRDHGGVIFIDLRDHSGFMQITINPEDGETLFKQAEILRNETVIMVNGIVNERP
KDSINKNIITGELELKVQDLQILNQIKNNLPFPVSVHDYENTKEELRLKYRYLDIRRGKLLENLKTRHKIIKAIRNYLDN
SGFTEVETPLLTKSTPEGARDFLVPARLSNGDFFALPQSPQLFKQLLMVGGLDKYYQIAKCFRDEDLRADRQPEFTQLDI
EMSFVSEEEIIAFNEKLIKHIWKNVLNINLNEDFPRMSWQEAMDNYGTDRPDTRYGMLLKNLGEILGNIGFNIFTKAIQM
GGAIKSITIKNGNSSISNVRIKPGGDIFKVAQEAGAGGLAFIRVKGDELETIGAIKNNLNKDHISNILKITEAEDGDLIL
LGAGSTKIVNQSLDRVRQYIAKDLNLLENQKAQSQWNFLWITDFPMFEMNEEEKRFEALHHPFCSPKNVKFEDKKELTKK
IETSTAYAYDLVLNGLELGGGSLRIHQAEMQKEVLRTVGLTDHQIDEKFGFLIEALEMGAPPHGGIAFGLDRITMLILGV
DSIRETIAFPKNQQAKCLLTNAPSNVSKSQLKELDIEITIDE

Sequences:

>Translated_602_residues
MRNKICEELNKSDIGKEVNLCGWVDRRRDHGGVIFIDLRDHSGFMQITINPEDGETLFKQAEILRNETVIMVNGIVNERP
KDSINKNIITGELELKVQDLQILNQIKNNLPFPVSVHDYENTKEELRLKYRYLDIRRGKLLENLKTRHKIIKAIRNYLDN
SGFTEVETPLLTKSTPEGARDFLVPARLSNGDFFALPQSPQLFKQLLMVGGLDKYYQIAKCFRDEDLRADRQPEFTQLDI
EMSFVSEEEIIAFNEKLIKHIWKNVLNINLNEDFPRMSWQEAMDNYGTDRPDTRYGMLLKNLGEILGNIGFNIFTKAIQM
GGAIKSITIKNGNSSISNVRIKPGGDIFKVAQEAGAGGLAFIRVKGDELETIGAIKNNLNKDHISNILKITEAEDGDLIL
LGAGSTKIVNQSLDRVRQYIAKDLNLLENQKAQSQWNFLWITDFPMFEMNEEEKRFEALHHPFCSPKNVKFEDKKELTKK
IETSTAYAYDLVLNGLELGGGSLRIHQAEMQKEVLRTVGLTDHQIDEKFGFLIEALEMGAPPHGGIAFGLDRITMLILGV
DSIRETIAFPKNQQAKCLLTNAPSNVSKSQLKELDIEITIDE
>Mature_602_residues
MRNKICEELNKSDIGKEVNLCGWVDRRRDHGGVIFIDLRDHSGFMQITINPEDGETLFKQAEILRNETVIMVNGIVNERP
KDSINKNIITGELELKVQDLQILNQIKNNLPFPVSVHDYENTKEELRLKYRYLDIRRGKLLENLKTRHKIIKAIRNYLDN
SGFTEVETPLLTKSTPEGARDFLVPARLSNGDFFALPQSPQLFKQLLMVGGLDKYYQIAKCFRDEDLRADRQPEFTQLDI
EMSFVSEEEIIAFNEKLIKHIWKNVLNINLNEDFPRMSWQEAMDNYGTDRPDTRYGMLLKNLGEILGNIGFNIFTKAIQM
GGAIKSITIKNGNSSISNVRIKPGGDIFKVAQEAGAGGLAFIRVKGDELETIGAIKNNLNKDHISNILKITEAEDGDLIL
LGAGSTKIVNQSLDRVRQYIAKDLNLLENQKAQSQWNFLWITDFPMFEMNEEEKRFEALHHPFCSPKNVKFEDKKELTKK
IETSTAYAYDLVLNGLELGGGSLRIHQAEMQKEVLRTVGLTDHQIDEKFGFLIEALEMGAPPHGGIAFGLDRITMLILGV
DSIRETIAFPKNQQAKCLLTNAPSNVSKSQLKELDIEITIDE

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI40789249, Length=609, Percent_Identity=38.2594417077176, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI5031815, Length=256, Percent_Identity=27.34375, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI194272210, Length=256, Percent_Identity=27.34375, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI45439306, Length=242, Percent_Identity=26.0330578512397, Blast_Score=80, Evalue=6e-15,
Organism=Escherichia coli, GI1788173, Length=603, Percent_Identity=46.1028192371476, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1789256, Length=310, Percent_Identity=27.0967741935484, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI1790571, Length=320, Percent_Identity=26.25, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI32566633, Length=610, Percent_Identity=34.0983606557377, Blast_Score=322, Evalue=3e-88,
Organism=Caenorhabditis elegans, GI71994340, Length=266, Percent_Identity=27.8195488721804, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535925, Length=266, Percent_Identity=27.8195488721804, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535927, Length=266, Percent_Identity=27.8195488721804, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17551876, Length=258, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6325153, Length=645, Percent_Identity=33.4883720930233, Blast_Score=298, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6321807, Length=263, Percent_Identity=25.8555133079848, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6323011, Length=250, Percent_Identity=28, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320242, Length=216, Percent_Identity=27.7777777777778, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6324256, Length=171, Percent_Identity=30.9941520467836, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584738, Length=608, Percent_Identity=37.5, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24640849, Length=256, Percent_Identity=28.515625, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24640851, Length=256, Percent_Identity=28.515625, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136276, Length=239, Percent_Identity=27.6150627615063, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19921528, Length=283, Percent_Identity=25.0883392226148, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYD_PROM5 (A2BZ75)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001012193.1
- STRING:   A2BZ75
- GeneID:   4720529
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_18791
- eggNOG:   COG0173
- HOGENOM:   HBG396032
- OMA:   AFPKTQQ
- ProtClustDB:   PRK00476
- BioCyc:   PMAR167542:P9515ORF_1962-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00044_B
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:3.30.1360.30
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF5
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00459

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.12

Molecular weight: Translated: 68411; Mature: 68411

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKICEELNKSDIGKEVNLCGWVDRRRDHGGVIFIDLRDHSGFMQITINPEDGETLFKQ
CCCHHHHHHCHHHCCCCCCHHCCHHCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHH
AEILRNETVIMVNGIVNERPKDSINKNIITGELELKVQDLQILNQIKNNLPFPVSVHDYE
HHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCEEECCCC
NTKEELRLKYRYLDIRRGKLLENLKTRHKIIKAIRNYLDNSGFTEVETPLLTKSTPEGAR
CCHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
DFLVPARLSNGDFFALPQSPQLFKQLLMVGGLDKYYQIAKCFRDEDLRADRQPEFTQLDI
HCEEEEEECCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEE
EMSFVSEEEIIAFNEKLIKHIWKNVLNINLNEDFPRMSWQEAMDNYGTDRPDTRYGMLLK
EEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
NLGEILGNIGFNIFTKAIQMGGAIKSITIKNGNSSISNVRIKPGGDIFKVAQEAGAGGLA
HHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHCCCCCEE
FIRVKGDELETIGAIKNNLNKDHISNILKITEAEDGDLILLGAGSTKIVNQSLDRVRQYI
EEEEECCCHHHHHHHHHCCCHHHHHHHHEEEECCCCCEEEEECCCHHHHHHHHHHHHHHH
AKDLNLLENQKAQSQWNFLWITDFPMFEMNEEEKRFEALHHPFCSPKNVKFEDKKELTKK
HHHHHHHHCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IETSTAYAYDLVLNGLELGGGSLRIHQAEMQKEVLRTVGLTDHQIDEKFGFLIEALEMGA
HHHHHHHHHHHHHCCCEECCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
PPHGGIAFGLDRITMLILGVDSIRETIAFPKNQQAKCLLTNAPSNVSKSQLKELDIEITI
CCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHCCEEEEE
DE
CC
>Mature Secondary Structure
MRNKICEELNKSDIGKEVNLCGWVDRRRDHGGVIFIDLRDHSGFMQITINPEDGETLFKQ
CCCHHHHHHCHHHCCCCCCHHCCHHCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHH
AEILRNETVIMVNGIVNERPKDSINKNIITGELELKVQDLQILNQIKNNLPFPVSVHDYE
HHHHCCCCEEEEECCCCCCCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCCCCEEECCCC
NTKEELRLKYRYLDIRRGKLLENLKTRHKIIKAIRNYLDNSGFTEVETPLLTKSTPEGAR
CCHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCH
DFLVPARLSNGDFFALPQSPQLFKQLLMVGGLDKYYQIAKCFRDEDLRADRQPEFTQLDI
HCEEEEEECCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEE
EMSFVSEEEIIAFNEKLIKHIWKNVLNINLNEDFPRMSWQEAMDNYGTDRPDTRYGMLLK
EEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHH
NLGEILGNIGFNIFTKAIQMGGAIKSITIKNGNSSISNVRIKPGGDIFKVAQEAGAGGLA
HHHHHHHHCCHHHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCCHHHHHHHHCCCCCEE
FIRVKGDELETIGAIKNNLNKDHISNILKITEAEDGDLILLGAGSTKIVNQSLDRVRQYI
EEEEECCCHHHHHHHHHCCCHHHHHHHHEEEECCCCCEEEEECCCHHHHHHHHHHHHHHH
AKDLNLLENQKAQSQWNFLWITDFPMFEMNEEEKRFEALHHPFCSPKNVKFEDKKELTKK
HHHHHHHHCCCHHCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IETSTAYAYDLVLNGLELGGGSLRIHQAEMQKEVLRTVGLTDHQIDEKFGFLIEALEMGA
HHHHHHHHHHHHHCCCEECCCEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
PPHGGIAFGLDRITMLILGVDSIRETIAFPKNQQAKCLLTNAPSNVSKSQLKELDIEITI
CCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHCCEEEEE
DE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA