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The map label for this gene is gcvT

Identifier: 123967111

GI number: 123967111

Start: 1666334

End: 1667446

Strand: Direct

Name: gcvT

Synonym: P9515_18781

Alternate gene names: 123967111

Gene position: 1666334-1667446 (Clockwise)

Preceding gene: 123967110

Following gene: 123967112

Centisome position: 97.78

GC content: 33.15

Gene sequence:

>1113_bases
ATGGATTTACTTAAAAGTCCACTTTATTCAAAATATATTGAGTCAAATGCAAAGTTAATCAATTTTGCAGGATGGGAGAT
GCCCATATCCTTTTCGGGATTAATAAACGAACATGAATCAGTAAGAACATCAGCAGGATTCTTTGATATTTCCCATATGG
GTGTAATTTCTCTCAGAGGTATTAATCCTAAAGAATATATTCAGAAATTTTTTCCTACTAATTTATACTCCTTTTCAGAA
GGTCAAGGGCTTTATACACTAATACTTAATGAGAAGGGAGGAATAATAGATGACTTAATCATTTATGACCTTGGTCGACA
AGAAGGTGATATCTCAGAAATCTTTTTAATAGTAAATGCCAGCAGATACCAAGATGATTTTTTATGGATTAAAAATAATT
TAAATACCAACCAAGTTTCTGTATCAAACGCAAAAACAGACAAGGTTCTCTTATCAATACAAGGCAGAAATTCCTTTACG
TTATTTGAAGAATGGATTGGCTCATCGATCTCACATATTCCCTACTTTGGATGTGAATATAAAAATTTTGATCATATTTC
GACTGAAGGAAAATTTTTCTTTTCAAAAACAGGTTACACGGGGGAAAACGGTTTAGAGATACTTTTACCCGCACAATCTG
CCATTAATCTGTGGGATTTCTTAGTTTCAAGGAATATTCAGCCTTGTGGATTGGGTGCTAGAGACACCTTAAGACTTGAG
GCTGGAATGCATTTATATGGCCAAGATTTAGATGAAAAAACTACCCCATATGAGGCAGGTTTGGGCTGGCTAGTAAATTT
AGAGAATAATCATGAATTTTTTGGAAGAGATTTTCTTGAAAAACAATCAAAATTAGGTATTAAAAAAAAATTAGTTGGTC
TAACTATTGAAGGCAGAGCTATTGGAAGAAAAGGGTGCGAAGTATTTAAAGATGAAAAATACATTGGAATTATAACCAGC
GGTACTTGGTCCCCTACTACAGAAAAGGCAATCGCTTTTGCTTATATTCAAAATTCTTACGCTGCTTTGAATAATGTTGT
TGAAGTTTTAATCCGAGGCAAAAAATTCAAGGCGACCATAACGAAAAGAGCTTTTTACAAAAAAGATATTTAA

Upstream 100 bases:

>100_bases
CCGCAAAAGTACTAAGGAGCTTAATTATGTCATTAAAAAATATGCAATAAAAAAATTCTAAACTAAAGTATAGGAAACTA
AAAAAATCGTTTAATATTTC

Downstream 100 bases:

>100_bases
CTAAATTTACCCTTTAAGAATTATTATTATAAGTTATTGCTCAATAAGTCATTTCTAGATGCGAAACAAAATTTGTGAAG
AACTCAATAAGTCTGATATT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MDLLKSPLYSKYIESNAKLINFAGWEMPISFSGLINEHESVRTSAGFFDISHMGVISLRGINPKEYIQKFFPTNLYSFSE
GQGLYTLILNEKGGIIDDLIIYDLGRQEGDISEIFLIVNASRYQDDFLWIKNNLNTNQVSVSNAKTDKVLLSIQGRNSFT
LFEEWIGSSISHIPYFGCEYKNFDHISTEGKFFFSKTGYTGENGLEILLPAQSAINLWDFLVSRNIQPCGLGARDTLRLE
AGMHLYGQDLDEKTTPYEAGLGWLVNLENNHEFFGRDFLEKQSKLGIKKKLVGLTIEGRAIGRKGCEVFKDEKYIGIITS
GTWSPTTEKAIAFAYIQNSYAALNNVVEVLIRGKKFKATITKRAFYKKDI

Sequences:

>Translated_370_residues
MDLLKSPLYSKYIESNAKLINFAGWEMPISFSGLINEHESVRTSAGFFDISHMGVISLRGINPKEYIQKFFPTNLYSFSE
GQGLYTLILNEKGGIIDDLIIYDLGRQEGDISEIFLIVNASRYQDDFLWIKNNLNTNQVSVSNAKTDKVLLSIQGRNSFT
LFEEWIGSSISHIPYFGCEYKNFDHISTEGKFFFSKTGYTGENGLEILLPAQSAINLWDFLVSRNIQPCGLGARDTLRLE
AGMHLYGQDLDEKTTPYEAGLGWLVNLENNHEFFGRDFLEKQSKLGIKKKLVGLTIEGRAIGRKGCEVFKDEKYIGIITS
GTWSPTTEKAIAFAYIQNSYAALNNVVEVLIRGKKFKATITKRAFYKKDI
>Mature_370_residues
MDLLKSPLYSKYIESNAKLINFAGWEMPISFSGLINEHESVRTSAGFFDISHMGVISLRGINPKEYIQKFFPTNLYSFSE
GQGLYTLILNEKGGIIDDLIIYDLGRQEGDISEIFLIVNASRYQDDFLWIKNNLNTNQVSVSNAKTDKVLLSIQGRNSFT
LFEEWIGSSISHIPYFGCEYKNFDHISTEGKFFFSKTGYTGENGLEILLPAQSAINLWDFLVSRNIQPCGLGARDTLRLE
AGMHLYGQDLDEKTTPYEAGLGWLVNLENNHEFFGRDFLEKQSKLGIKKKLVGLTIEGRAIGRKGCEVFKDEKYIGIITS
GTWSPTTEKAIAFAYIQNSYAALNNVVEVLIRGKKFKATITKRAFYKKDI

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=28.3783783783784, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI257796258, Length=346, Percent_Identity=28.6127167630058, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI257796254, Length=368, Percent_Identity=26.6304347826087, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI257796256, Length=302, Percent_Identity=28.8079470198675, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI197927446, Length=327, Percent_Identity=23.5474006116208, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI21361378, Length=327, Percent_Identity=23.5474006116208, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI24797151, Length=386, Percent_Identity=22.7979274611399, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI194306651, Length=372, Percent_Identity=23.1182795698925, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1789272, Length=376, Percent_Identity=36.1702127659575, Blast_Score=241, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=29.1338582677165, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI32563613, Length=352, Percent_Identity=24.1477272727273, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994052, Length=380, Percent_Identity=25, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71994045, Length=380, Percent_Identity=25, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320222, Length=382, Percent_Identity=29.0575916230367, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129441, Length=380, Percent_Identity=30, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI28571104, Length=360, Percent_Identity=24.1666666666667, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20130091, Length=355, Percent_Identity=23.6619718309859, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_PROM5 (A2BZ74)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001012192.1
- ProteinModelPortal:   A2BZ74
- SMR:   A2BZ74
- STRING:   A2BZ74
- GeneID:   4720528
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_18781
- eggNOG:   COG0404
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- BioCyc:   PMAR167542:P9515ORF_1961-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 41847; Mature: 41847

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLKSPLYSKYIESNAKLINFAGWEMPISFSGLINEHESVRTSAGFFDISHMGVISLRG
CCCHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHCCHHHHHHCCCEEEECCCCEEEEEC
INPKEYIQKFFPTNLYSFSEGQGLYTLILNEKGGIIDDLIIYDLGRQEGDISEIFLIVNA
CCHHHHHHHHCCCCCEECCCCCCEEEEEEECCCCCCHHEEEEECCCCCCCCEEEEEEEEC
SRYQDDFLWIKNNLNTNQVSVSNAKTDKVLLSIQGRNSFTLFEEWIGSSISHIPYFGCEY
CCCCCCEEEEECCCCCCEEEECCCCCCEEEEEEECCCCEEHHHHHHCCCCCCCCCCCCCC
KNFDHISTEGKFFFSKTGYTGENGLEILLPAQSAINLWDFLVSRNIQPCGLGARDTLRLE
CCCCCCCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
AGMHLYGQDLDEKTTPYEAGLGWLVNLENNHEFFGRDFLEKQSKLGIKKKLVGLTIEGRA
CCCEEECCCCCCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCC
IGRKGCEVFKDEKYIGIITSGTWSPTTEKAIAFAYIQNSYAALNNVVEVLIRGKKFKATI
CCCCCCHHCCCCCEEEEEECCCCCCCHHHEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEH
TKRAFYKKDI
HHHHHHHCCC
>Mature Secondary Structure
MDLLKSPLYSKYIESNAKLINFAGWEMPISFSGLINEHESVRTSAGFFDISHMGVISLRG
CCCHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHCCHHHHHHCCCEEEECCCCEEEEEC
INPKEYIQKFFPTNLYSFSEGQGLYTLILNEKGGIIDDLIIYDLGRQEGDISEIFLIVNA
CCHHHHHHHHCCCCCEECCCCCCEEEEEEECCCCCCHHEEEEECCCCCCCCEEEEEEEEC
SRYQDDFLWIKNNLNTNQVSVSNAKTDKVLLSIQGRNSFTLFEEWIGSSISHIPYFGCEY
CCCCCCEEEEECCCCCCEEEECCCCCCEEEEEEECCCCEEHHHHHHCCCCCCCCCCCCCC
KNFDHISTEGKFFFSKTGYTGENGLEILLPAQSAINLWDFLVSRNIQPCGLGARDTLRLE
CCCCCCCCCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCEEEEE
AGMHLYGQDLDEKTTPYEAGLGWLVNLENNHEFFGRDFLEKQSKLGIKKKLVGLTIEGRA
CCCEEECCCCCCCCCCHHCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCC
IGRKGCEVFKDEKYIGIITSGTWSPTTEKAIAFAYIQNSYAALNNVVEVLIRGKKFKATI
CCCCCCHHCCCCCEEEEEECCCCCCCHHHEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEH
TKRAFYKKDI
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA