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The map label for this gene is lysC [H]

Identifier: 123967071

GI number: 123967071

Start: 1622404

End: 1624164

Strand: Direct

Name: lysC [H]

Synonym: P9515_18381

Alternate gene names: 123967071

Gene position: 1622404-1624164 (Clockwise)

Preceding gene: 123967070

Following gene: 123967074

Centisome position: 95.2

GC content: 34.81

Gene sequence:

>1761_bases
ATGGCTTTATTAATCAAAAAATTTGGCGGCACTTCGGTTGGTGACATTACAAAAATTAAGGCTATTGCGCAAAGTATTGC
TCAAAGTAAAGAAGCTGGGAATGATATCGTCGTAGTTGTATCTGCAATGGGCAACTCTACAGATAAATTAAATAAATTAG
CAGAATCAATCAGCAAAAATCCAAATAGGCGGGAATTAGACATGCTCCTCTCTACAGGTGAGCAAGTATCTATGGCACTT
CTATCAATGTCATTAAACGAATATGGGATCCCTGCAATATCTATGACCGGTAGCCAAGTTGGCATTATTACTGAATCTAT
TCATGGGAAAGCAAGAATTCTAGATATCAAAACAGAACGTATAAAAAATTATATTAATCAAGGTTATGTTGTGGTTATTG
CTGGTTTTCAAGGTTCAACTCTTAGTCATACAGGAACAACGGAAATCACAACTTTGGGCAGGGGCGGTTCAGATACTTCA
GCAGTAGCCCTTTCCACAGCATTAGGTGCAGAAACTTGCGAGATATATACAGATGTTCCTGGAGTTCTTACAACTGACCC
AAGGATAGTATCTGATGCGAAATTATTAGATGTTATAAGTTGTGAAGAGATGCTAGAACTCGCAAGTGTTGGTGCATCAG
TACTCCATCCAAGAGCTGTAGAAATTGCTCGCAATTATGGAATAAAATTATATGTTAAATCTAGTCAAACCCTCTCAAAG
GGCACTCTTCTACATAGCAACATTAAGCCTTTGGCTCTCAAAAGAGGAGGGTTAGAATTAACAAAAACCGTTAATAGTCT
TGAAGTATTAGAAAAACAAATCGTTTTTAGTATTTCCAAACTACCTGATAGGCCTGGAATTGCAGCTCAAATATTTGAAA
CCTTGTCTGAAGCAAGCATCAATGTTGATTTAATAATCCAAGCTACACATGATGGAAATAGTAATGACATCGCATTTACC
GTTAATCAATTTGATTTAACCAAAACGATTGAGCAATGTAAATTAATAACAAATCAATTAGGTGGGGAATATAATTTCAA
AACAAATATGACAAAGTTAAGTATTCAAGGCGCTGGGATAATGGGAAGACCAAGTGTCTCGGCTGATTTATTTGATACTC
TATCCCAAGCAAACATAAATGTAAGATTAATAGCAACAAGCGAAATCAAAGTCAGCTGCGTAATCGACATAGATAATATT
CCAAAAGCTATAAGATTTGTAGGTGAAAAATTTAAATTATCTGATAAACAAATATTTATTAATCCACTTTTTGAAAGAGA
GGATCAACCCGAAGTCAGAGGAATTGCATTAGATAAAAATCAAGTTCAAGTTAGCTTTCGAAACCTACCGGATAAACCTG
GTGTTGCAGCTTCGATATGTTTAGCTCTAGCAGAGAGTAATTTAATTTTTGATACTATTGTTCAATCTGAAAGCTTAACA
TCTTTCAAAACTAAAGATATAAGTTTTACTATGAATAAACAAGACAGAGCAAGAGCTAATAAAATTTTTTACTCTTTAAC
AAAAAAATTATCAGGAGCATTCGTTGAAGATGGACCTGCGATTGCCAAAGTAAGCACAGTTGGAGCTGGAATGGCATCTA
AGGTCGGAACAGCAGGGAAAATATTTAGAGCACTTGCTAATAAAAACATTAATATTGAAATGATTGCCACAAGTGAAATC
AGAACTTCTTGTATTGTCTTAGAAAAGGATTGTGACCAAGCAGTAAATGCTATTCATTCTTATTTCGAATTAGATAAATA
A

Upstream 100 bases:

>100_bases
ACTAAAAAAAGGTAATAATCCCTTTAATGTTTTTACAGAACATCTCGTTAACTTAAGTTAACCAAATATTAAGTTAGAAA
ATTTATATTATGATTAAAAT

Downstream 100 bases:

>100_bases
AAAAAATTAATTAATTATTCCTAGATAATTTTTGCCTAAGTTTCTTAATTCTATCTCTAAGATTTGCTGCCTCTTCGAAA
TTTAGTTCTTTTGCTGCTTC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase 2; Aspartokinase II [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MALLIKKFGGTSVGDITKIKAIAQSIAQSKEAGNDIVVVVSAMGNSTDKLNKLAESISKNPNRRELDMLLSTGEQVSMAL
LSMSLNEYGIPAISMTGSQVGIITESIHGKARILDIKTERIKNYINQGYVVVIAGFQGSTLSHTGTTEITTLGRGGSDTS
AVALSTALGAETCEIYTDVPGVLTTDPRIVSDAKLLDVISCEEMLELASVGASVLHPRAVEIARNYGIKLYVKSSQTLSK
GTLLHSNIKPLALKRGGLELTKTVNSLEVLEKQIVFSISKLPDRPGIAAQIFETLSEASINVDLIIQATHDGNSNDIAFT
VNQFDLTKTIEQCKLITNQLGGEYNFKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIDIDNI
PKAIRFVGEKFKLSDKQIFINPLFEREDQPEVRGIALDKNQVQVSFRNLPDKPGVAASICLALAESNLIFDTIVQSESLT
SFKTKDISFTMNKQDRARANKIFYSLTKKLSGAFVEDGPAIAKVSTVGAGMASKVGTAGKIFRALANKNINIEMIATSEI
RTSCIVLEKDCDQAVNAIHSYFELDK

Sequences:

>Translated_586_residues
MALLIKKFGGTSVGDITKIKAIAQSIAQSKEAGNDIVVVVSAMGNSTDKLNKLAESISKNPNRRELDMLLSTGEQVSMAL
LSMSLNEYGIPAISMTGSQVGIITESIHGKARILDIKTERIKNYINQGYVVVIAGFQGSTLSHTGTTEITTLGRGGSDTS
AVALSTALGAETCEIYTDVPGVLTTDPRIVSDAKLLDVISCEEMLELASVGASVLHPRAVEIARNYGIKLYVKSSQTLSK
GTLLHSNIKPLALKRGGLELTKTVNSLEVLEKQIVFSISKLPDRPGIAAQIFETLSEASINVDLIIQATHDGNSNDIAFT
VNQFDLTKTIEQCKLITNQLGGEYNFKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIDIDNI
PKAIRFVGEKFKLSDKQIFINPLFEREDQPEVRGIALDKNQVQVSFRNLPDKPGVAASICLALAESNLIFDTIVQSESLT
SFKTKDISFTMNKQDRARANKIFYSLTKKLSGAFVEDGPAIAKVSTVGAGMASKVGTAGKIFRALANKNINIEMIATSEI
RTSCIVLEKDCDQAVNAIHSYFELDK
>Mature_585_residues
ALLIKKFGGTSVGDITKIKAIAQSIAQSKEAGNDIVVVVSAMGNSTDKLNKLAESISKNPNRRELDMLLSTGEQVSMALL
SMSLNEYGIPAISMTGSQVGIITESIHGKARILDIKTERIKNYINQGYVVVIAGFQGSTLSHTGTTEITTLGRGGSDTSA
VALSTALGAETCEIYTDVPGVLTTDPRIVSDAKLLDVISCEEMLELASVGASVLHPRAVEIARNYGIKLYVKSSQTLSKG
TLLHSNIKPLALKRGGLELTKTVNSLEVLEKQIVFSISKLPDRPGIAAQIFETLSEASINVDLIIQATHDGNSNDIAFTV
NQFDLTKTIEQCKLITNQLGGEYNFKTNMTKLSIQGAGIMGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIDIDNIP
KAIRFVGEKFKLSDKQIFINPLFEREDQPEVRGIALDKNQVQVSFRNLPDKPGVAASICLALAESNLIFDTIVQSESLTS
FKTKDISFTMNKQDRARANKIFYSLTKKLSGAFVEDGPAIAKVSTVGAGMASKVGTAGKIFRALANKNINIEMIATSEIR
TSCIVLEKDCDQAVNAIHSYFELDK

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=367, Percent_Identity=31.0626702997275, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790455, Length=363, Percent_Identity=31.404958677686, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1790376, Length=289, Percent_Identity=25.9515570934256, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320893, Length=403, Percent_Identity=25.5583126550869, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 63177; Mature: 63046

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALLIKKFGGTSVGDITKIKAIAQSIAQSKEAGNDIVVVVSAMGNSTDKLNKLAESISKN
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PNRRELDMLLSTGEQVSMALLSMSLNEYGIPAISMTGSQVGIITESIHGKARILDIKTER
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCEEEEEEEHHH
IKNYINQGYVVVIAGFQGSTLSHTGTTEITTLGRGGSDTSAVALSTALGAETCEIYTDVP
HHHHHCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHEEEHHHCCCCEEEEEECCC
GVLTTDPRIVSDAKLLDVISCEEMLELASVGASVLHPRAVEIARNYGIKLYVKSSQTLSK
CCEECCCCEECCHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCCEEEEEECCCCCCC
GTLLHSNIKPLALKRGGLELTKTVNSLEVLEKQIVFSISKLPDRPGIAAQIFETLSEASI
CCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
NVDLIIQATHDGNSNDIAFTVNQFDLTKTIEQCKLITNQLGGEYNFKTNMTKLSIQGAGI
CEEEEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCC
MGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIDIDNIPKAIRFVGEKFKLSDKQIFI
CCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCHHHHHHCCHHEECCCCEEEE
NPLFEREDQPEVRGIALDKNQVQVSFRNLPDKPGVAASICLALAESNLIFDTIVQSESLT
EHHHCCCCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEHHHCCCCCC
SFKTKDISFTMNKQDRARANKIFYSLTKKLSGAFVEDGPAIAKVSTVGAGMASKVGTAGK
CEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEHHCCCHHHHCCCHHH
IFRALANKNINIEMIATSEIRTSCIVLEKDCDQAVNAIHSYFELDK
HHHHHHCCCCEEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ALLIKKFGGTSVGDITKIKAIAQSIAQSKEAGNDIVVVVSAMGNSTDKLNKLAESISKN
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCC
PNRRELDMLLSTGEQVSMALLSMSLNEYGIPAISMTGSQVGIITESIHGKARILDIKTER
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCEEEEEEEHHH
IKNYINQGYVVVIAGFQGSTLSHTGTTEITTLGRGGSDTSAVALSTALGAETCEIYTDVP
HHHHHCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCHHEEEHHHCCCCEEEEEECCC
GVLTTDPRIVSDAKLLDVISCEEMLELASVGASVLHPRAVEIARNYGIKLYVKSSQTLSK
CCEECCCCEECCHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHCCCEEEEEECCCCCCC
GTLLHSNIKPLALKRGGLELTKTVNSLEVLEKQIVFSISKLPDRPGIAAQIFETLSEASI
CCEEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCC
NVDLIIQATHDGNSNDIAFTVNQFDLTKTIEQCKLITNQLGGEYNFKTNMTKLSIQGAGI
CEEEEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCC
MGRPSVSADLFDTLSQANINVRLIATSEIKVSCVIDIDNIPKAIRFVGEKFKLSDKQIFI
CCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEEEECCCCHHHHHHCCHHEECCCCEEEE
NPLFEREDQPEVRGIALDKNQVQVSFRNLPDKPGVAASICLALAESNLIFDTIVQSESLT
EHHHCCCCCCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEEHHHCCCCCC
SFKTKDISFTMNKQDRARANKIFYSLTKKLSGAFVEDGPAIAKVSTVGAGMASKVGTAGK
CEEECCEEEEECCHHHHHHHHHHHHHHHHHCCCEECCCCCEEEEEHHCCCHHHHCCCHHH
IFRALANKNINIEMIATSEIRTSCIVLEKDCDQAVNAIHSYFELDK
HHHHHHCCCCEEEEEEECCCCEEEEEEECHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1444390 [H]