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The map label for this gene is adk [H]

Identifier: 123966954

GI number: 123966954

Start: 1518604

End: 1519152

Strand: Reverse

Name: adk [H]

Synonym: P9515_17211

Alternate gene names: 123966954

Gene position: 1519152-1518604 (Counterclockwise)

Preceding gene: 123966955

Following gene: 123966953

Centisome position: 89.14

GC content: 28.96

Gene sequence:

>549_bases
ATGAAAAAACATTTACTCTTCTTAGGACCTCCTGGAGCAGGTAAAGGCACTCAGGCTGCATACTTGAGTGAAGCTAATTC
TTATTTGCATTTATCAACTGGAGAATTATTAAGAAAAGAAATTGATCTGGATACTTATTTGGGGAAACAAGTAAAAGATA
TTATGAACAAGGGCGAACTTGTAAGCGACCAATTAGTTTTAGAAATTGTCAATAAAAATCTGTCTAAGGATAATAAAGGT
TGGATTTTAGATGGCTATCCTAGAAATTTGTCACAAGTTAATTCTTTAAATGAGGTTTTGATGAATATAAATCAACCTTT
AGAGATAGTCTTTTATTTAGATGTACCAGACGAAGTTTTAATAAAGCGTTTACTTCTGAGAGGTAGAAAAGATGATAATG
AAGAAACTATAAAAACAAGATTAAAAATATATAAGGAAACTACTGAACCATTAATTGAATATTATAAAAATCTCTCTTTA
CTAGAATATATAAATGCAGATGGGGATTTAAAAACAATTTCTAATGATATAAAACAAAAAATGGCTTGA

Upstream 100 bases:

>100_bases
CAACTTCTTTATTAATTCTTGTGGGAGTTGCGATCGATACAGCCAAACAAATTCAAACTTATGTTATTTCTCAGAGATAT
GAGGGACTAGTTAATAATTA

Downstream 100 bases:

>100_bases
TCATGATGTAGAATAAAAAATTAATGTTTTAATGAGAAAACCTTATGAAGGTTAGAGCCTCAGTAAAAAAAATGTGTGAC
AAATGTCGCGTTATTCGTAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 182; Mature: 182

Protein sequence:

>182_residues
MKKHLLFLGPPGAGKGTQAAYLSEANSYLHLSTGELLRKEIDLDTYLGKQVKDIMNKGELVSDQLVLEIVNKNLSKDNKG
WILDGYPRNLSQVNSLNEVLMNINQPLEIVFYLDVPDEVLIKRLLLRGRKDDNEETIKTRLKIYKETTEPLIEYYKNLSL
LEYINADGDLKTISNDIKQKMA

Sequences:

>Translated_182_residues
MKKHLLFLGPPGAGKGTQAAYLSEANSYLHLSTGELLRKEIDLDTYLGKQVKDIMNKGELVSDQLVLEIVNKNLSKDNKG
WILDGYPRNLSQVNSLNEVLMNINQPLEIVFYLDVPDEVLIKRLLLRGRKDDNEETIKTRLKIYKETTEPLIEYYKNLSL
LEYINADGDLKTISNDIKQKMA
>Mature_182_residues
MKKHLLFLGPPGAGKGTQAAYLSEANSYLHLSTGELLRKEIDLDTYLGKQVKDIMNKGELVSDQLVLEIVNKNLSKDNKG
WILDGYPRNLSQVNSLNEVLMNINQPLEIVFYLDVPDEVLIKRLLLRGRKDDNEETIKTRLKIYKETTEPLIEYYKNLSL
LEYINADGDLKTISNDIKQKMA

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=182, Percent_Identity=37.3626373626374, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI7524346, Length=194, Percent_Identity=35.5670103092784, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI4502013, Length=194, Percent_Identity=35.5670103092784, Blast_Score=127, Evalue=7e-30,
Organism=Homo sapiens, GI28144897, Length=173, Percent_Identity=36.9942196531792, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI28144899, Length=173, Percent_Identity=36.9942196531792, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI7706497, Length=192, Percent_Identity=31.25, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI310110345, Length=193, Percent_Identity=29.0155440414508, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI53832003, Length=193, Percent_Identity=29.0155440414508, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI8051579, Length=193, Percent_Identity=29.0155440414508, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI53832001, Length=193, Percent_Identity=29.0155440414508, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI19923437, Length=190, Percent_Identity=30, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI22749187, Length=126, Percent_Identity=34.1269841269841, Blast_Score=81, Evalue=6e-16,
Organism=Escherichia coli, GI1786680, Length=185, Percent_Identity=35.6756756756757, Blast_Score=124, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17552384, Length=210, Percent_Identity=32.8571428571429, Blast_Score=128, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17567503, Length=177, Percent_Identity=37.8531073446328, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=184, Percent_Identity=30.9782608695652, Blast_Score=106, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=184, Percent_Identity=30.9782608695652, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=187, Percent_Identity=28.3422459893048, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147457, Length=182, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=212, Percent_Identity=33.0188679245283, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322828, Length=183, Percent_Identity=31.6939890710383, Blast_Score=111, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=30.1020408163265, Blast_Score=96, Evalue=5e-21,
Organism=Drosophila melanogaster, GI22026816, Length=183, Percent_Identity=35.5191256830601, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24663208, Length=186, Percent_Identity=34.4086021505376, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17647141, Length=186, Percent_Identity=34.4086021505376, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=27.7173913043478, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=27.7173913043478, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17737899, Length=188, Percent_Identity=28.7234042553192, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24645822, Length=188, Percent_Identity=28.7234042553192, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24582962, Length=181, Percent_Identity=26.5193370165746, Blast_Score=64, Evalue=5e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20796; Mature: 20796

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHLLFLGPPGAGKGTQAAYLSEANSYLHLSTGELLRKEIDLDTYLGKQVKDIMNKGEL
CCCCEEEECCCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHCHHHHHHHHHHHHHHCCCH
VSDQLVLEIVNKNLSKDNKGWILDGYPRNLSQVNSLNEVLMNINQPLEIVFYLDVPDEVL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHH
IKRLLLRGRKDDNEETIKTRLKIYKETTEPLIEYYKNLSLLEYINADGDLKTISNDIKQK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHH
MA
CC
>Mature Secondary Structure
MKKHLLFLGPPGAGKGTQAAYLSEANSYLHLSTGELLRKEIDLDTYLGKQVKDIMNKGEL
CCCCEEEECCCCCCCCCHHHHHHCCCCEEEECHHHHHHHHHCHHHHHHHHHHHHHHCCCH
VSDQLVLEIVNKNLSKDNKGWILDGYPRNLSQVNSLNEVLMNINQPLEIVFYLDVPDEVL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHH
IKRLLLRGRKDDNEETIKTRLKIYKETTEPLIEYYKNLSLLEYINADGDLKTISNDIKQK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHH
MA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]