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The map label for this gene is nblS [H]

Identifier: 123966735

GI number: 123966735

Start: 1337128

End: 1339197

Strand: Direct

Name: nblS [H]

Synonym: P9515_15021

Alternate gene names: 123966735

Gene position: 1337128-1339197 (Clockwise)

Preceding gene: 123966734

Following gene: 123966738

Centisome position: 78.46

GC content: 33.53

Gene sequence:

>2070_bases
ATGATAAATAGCAATGAAACTAAAAAAATAGAAGTAAGTTCCTCAAACCAAACTATTGAGGATGATAGTTACGAATCTCT
TTCAAATAGAGTTTTAACATGGTGGAGTGGTTTCAGCTTAAGAACAAAATTATTAGCAATAGCAACCCTTGTTGTAAGTC
TATTAATGACTGGTATTACTTTTTTTGCTCTTAATAGTATTCAAAGAGATGCAGGTATGAATGACACAAGATACGCAAGA
GATTTGGGTCTATTACTTTCAGGGAACGTTACAGAACTAGTTGCGAATAATCAAAAGCAAGAAATATCAAATGTTGCAGA
AAAGTTTTGGAGATCCAGTAGAAATTTGCGTTATATTTTTTTTACCAATGCTGATGATATTGTTCAACTTGGTATTCCAA
TTAGTGCTACTCCCACAAGTTCAGATAATCAATTTCAATTAACTAGAAAATTAAAGTTACCAAAGGAATTAAAGAAAAGG
CCTCAATTTCCATTAGTGAGACAACATACCACTCCCCAAGGCCAAGTTACTGATGTATTTGTGCCTATGTTATGGAAAGG
CAAGTATCTAGGAACATTAGCTTTAGGAGTTACACCTAACAAAAAAGCTTTAGCCAGTGCTGCTCTAACTAGGGAAGTAA
CAATAGCAGTTTTCATTTCTATTTGGGTTTTAGTGATACTTGGAGCAGTATTTAATGCTTTAACTATTACGAGACCAGTA
AGAGAATTAGTAAGAGGTGTTAGAGAAATATCAAAAGGTAATTTCAAATCGAGGATCTCTTTACCGATGACCGGAGATCT
AGGCGAATTACTTACTGGCTTTAACAGAATGGCTTCTCAATTAGAGAATTATGATGAAGCAAATATTGAAGAGCTTAAAG
CCGCCCAAGTAAAACAACAGTCACTTATAGCCACAATGGCTGATGGAGCAATATTGCTGGACTCAAAAGGCAAAATTGTT
CTCACTAATCCAACTGCAAAAAGACTATTTCGATGGGAAGGAAGATTTTTAGAAGGTAAATATCTTTTAAATGAAATCCC
TGAAATCCTATCTAATGACTTACACACAAATATTGAATCAATCTTAAATAGAGAAAAAGAAAGTGATGATTTAAGGTGTA
GCTTAGGGGAACCTGCAAGAACTTTAAGAATTGTTTTACAATCTGTTTTAGATACAAATAAAATCGAATTAAAAGGAATA
GCAGTAACTATCCAAGATTTAACAAGAGAGGTTGAGCTTAATGCGGCACAAAATAGATTTATTAGCAATGTTTCTCATGA
ATTAAGAACTCCACTTTTTAATATTAAAAGTTATGTAGAGACTTTATACGATTTAAAAGATCAACTTTCTAATGAGGAGC
AACTAGAATTTCTGGGAATTGCCAATTCAGAGACTGACAGATTGACAAGACTAGTTAATGATGTACTTGATTTATCAAGA
TTAGAGTCAGGTAAAATTATTCAATTAGAACCAATGGAAATAAAGCCAGCGATAGAACAAACTCTTAGAAATTATAGACT
TAATGCTTCTGAAAAAAATGTTGCCTTAGCTCATGACATAGAGGAAAACATCCCATTAATTCTGGGAAATTTTGACTTGC
TTTTACAAGTGTTTGATAATTTATTGGGTAACGGTTTGAAATTCAGTCCGAAAAATAGCACTCTTAAAATTAGGGCTTAT
ACTTGGCCTGATTCTTGCCCAGCCTTTCCTCCTAACGACAATAATGAAGCGCCTCAATGTGAATTGGTCTCACCTTTACC
TAAGGTAAGAATTGAGATTGCTGATACAGGTTCCGGTATATCTCAGCCCGATCAAGAGAAAATATTTGATCGTTTTTATA
GAGTTGAAAATGCTGTTCATACAGAACAAGGTACAGGATTAGGTCTATCAATTGTCAGAGGGATAATTGAGAAACATGGT
GGTGAAATTAGAATGGCTAGTGAGCTGGGTATTGGTACAACATTTTGGTTTGATTTACCTCTAGAACAATCAGATAAAGA
TGAACTTATTACTCAAACAATTAATACTACAGAAAATTTTTCTGATTCTCAAGTAAGTGAAATTATCTAA

Upstream 100 bases:

>100_bases
ATACAAAAATTTGAAAGAGATAAGTTTTGAAGGGATTTTTTATAGAAAAGATATTGGTCATCAAGTCAGAACAAAAACTT
TAGATGACGAGATTAATTAA

Downstream 100 bases:

>100_bases
ATTTTATCAATTCCTTTAAATACGTTCTGTATATTTTGATCAGAAATAACTCTATGAGGGGCACCGCTAAATATTTGTTC
AAAATTTGAAAATGAATCTT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 689; Mature: 689

Protein sequence:

>689_residues
MINSNETKKIEVSSSNQTIEDDSYESLSNRVLTWWSGFSLRTKLLAIATLVVSLLMTGITFFALNSIQRDAGMNDTRYAR
DLGLLLSGNVTELVANNQKQEISNVAEKFWRSSRNLRYIFFTNADDIVQLGIPISATPTSSDNQFQLTRKLKLPKELKKR
PQFPLVRQHTTPQGQVTDVFVPMLWKGKYLGTLALGVTPNKKALASAALTREVTIAVFISIWVLVILGAVFNALTITRPV
RELVRGVREISKGNFKSRISLPMTGDLGELLTGFNRMASQLENYDEANIEELKAAQVKQQSLIATMADGAILLDSKGKIV
LTNPTAKRLFRWEGRFLEGKYLLNEIPEILSNDLHTNIESILNREKESDDLRCSLGEPARTLRIVLQSVLDTNKIELKGI
AVTIQDLTREVELNAAQNRFISNVSHELRTPLFNIKSYVETLYDLKDQLSNEEQLEFLGIANSETDRLTRLVNDVLDLSR
LESGKIIQLEPMEIKPAIEQTLRNYRLNASEKNVALAHDIEENIPLILGNFDLLLQVFDNLLGNGLKFSPKNSTLKIRAY
TWPDSCPAFPPNDNNEAPQCELVSPLPKVRIEIADTGSGISQPDQEKIFDRFYRVENAVHTEQGTGLGLSIVRGIIEKHG
GEIRMASELGIGTTFWFDLPLEQSDKDELITQTINTTENFSDSQVSEII

Sequences:

>Translated_689_residues
MINSNETKKIEVSSSNQTIEDDSYESLSNRVLTWWSGFSLRTKLLAIATLVVSLLMTGITFFALNSIQRDAGMNDTRYAR
DLGLLLSGNVTELVANNQKQEISNVAEKFWRSSRNLRYIFFTNADDIVQLGIPISATPTSSDNQFQLTRKLKLPKELKKR
PQFPLVRQHTTPQGQVTDVFVPMLWKGKYLGTLALGVTPNKKALASAALTREVTIAVFISIWVLVILGAVFNALTITRPV
RELVRGVREISKGNFKSRISLPMTGDLGELLTGFNRMASQLENYDEANIEELKAAQVKQQSLIATMADGAILLDSKGKIV
LTNPTAKRLFRWEGRFLEGKYLLNEIPEILSNDLHTNIESILNREKESDDLRCSLGEPARTLRIVLQSVLDTNKIELKGI
AVTIQDLTREVELNAAQNRFISNVSHELRTPLFNIKSYVETLYDLKDQLSNEEQLEFLGIANSETDRLTRLVNDVLDLSR
LESGKIIQLEPMEIKPAIEQTLRNYRLNASEKNVALAHDIEENIPLILGNFDLLLQVFDNLLGNGLKFSPKNSTLKIRAY
TWPDSCPAFPPNDNNEAPQCELVSPLPKVRIEIADTGSGISQPDQEKIFDRFYRVENAVHTEQGTGLGLSIVRGIIEKHG
GEIRMASELGIGTTFWFDLPLEQSDKDELITQTINTTENFSDSQVSEII
>Mature_689_residues
MINSNETKKIEVSSSNQTIEDDSYESLSNRVLTWWSGFSLRTKLLAIATLVVSLLMTGITFFALNSIQRDAGMNDTRYAR
DLGLLLSGNVTELVANNQKQEISNVAEKFWRSSRNLRYIFFTNADDIVQLGIPISATPTSSDNQFQLTRKLKLPKELKKR
PQFPLVRQHTTPQGQVTDVFVPMLWKGKYLGTLALGVTPNKKALASAALTREVTIAVFISIWVLVILGAVFNALTITRPV
RELVRGVREISKGNFKSRISLPMTGDLGELLTGFNRMASQLENYDEANIEELKAAQVKQQSLIATMADGAILLDSKGKIV
LTNPTAKRLFRWEGRFLEGKYLLNEIPEILSNDLHTNIESILNREKESDDLRCSLGEPARTLRIVLQSVLDTNKIELKGI
AVTIQDLTREVELNAAQNRFISNVSHELRTPLFNIKSYVETLYDLKDQLSNEEQLEFLGIANSETDRLTRLVNDVLDLSR
LESGKIIQLEPMEIKPAIEQTLRNYRLNASEKNVALAHDIEENIPLILGNFDLLLQVFDNLLGNGLKFSPKNSTLKIRAY
TWPDSCPAFPPNDNNEAPQCELVSPLPKVRIEIADTGSGISQPDQEKIFDRFYRVENAVHTEQGTGLGLSIVRGIIEKHG
GEIRMASELGIGTTFWFDLPLEQSDKDELITQTINTTENFSDSQVSEII

Specific function: Member Of The Two-Component Regulatory System Atos/Atoc; May Activate Atoc By Phosphorylation. [C]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=411, Percent_Identity=25.7907542579075, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788713, Length=275, Percent_Identity=29.4545454545455, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1788393, Length=284, Percent_Identity=28.5211267605634, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=30.8270676691729, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI145693157, Length=266, Percent_Identity=30.4511278195489, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI87082128, Length=312, Percent_Identity=25.9615384615385, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786600, Length=412, Percent_Identity=24.7572815533981, Blast_Score=93, Evalue=7e-20,
Organism=Escherichia coli, GI1790436, Length=264, Percent_Identity=25.7575757575758, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI87081816, Length=250, Percent_Identity=28.8, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=28.2786885245902, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786783, Length=273, Percent_Identity=24.9084249084249, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1788279, Length=224, Percent_Identity=25.8928571428571, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1786912, Length=253, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 77306; Mature: 77306

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINSNETKKIEVSSSNQTIEDDSYESLSNRVLTWWSGFSLRTKLLAIATLVVSLLMTGIT
CCCCCCCCEEEECCCCCCCCCCCHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
FFALNSIQRDAGMNDTRYARDLGLLLSGNVTELVANNQKQEISNVAEKFWRSSRNLRYIF
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEE
FTNADDIVQLGIPISATPTSSDNQFQLTRKLKLPKELKKRPQFPLVRQHTTPQGQVTDVF
EECCCCEEEECCCCCCCCCCCCCCEEEHHHHCCCHHHHHCCCCCCEECCCCCCCCCHHEE
VPMLWKGKYLGTLALGVTPNKKALASAALTREVTIAVFISIWVLVILGAVFNALTITRPV
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELVRGVREISKGNFKSRISLPMTGDLGELLTGFNRMASQLENYDEANIEELKAAQVKQQ
HHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
SLIATMADGAILLDSKGKIVLTNPTAKRLFRWEGRFLEGKYLLNEIPEILSNDLHTNIES
HHHHHHCCCEEEEECCCCEEEECCHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHH
ILNREKESDDLRCSLGEPARTLRIVLQSVLDTNKIELKGIAVTIQDLTREVELNAAQNRF
HHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHCCHHHHHH
ISNVSHELRTPLFNIKSYVETLYDLKDQLSNEEQLEFLGIANSETDRLTRLVNDVLDLSR
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
LESGKIIQLEPMEIKPAIEQTLRNYRLNASEKNVALAHDIEENIPLILGNFDLLLQVFDN
CCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEECCHHHHHHHHHH
LLGNGLKFSPKNSTLKIRAYTWPDSCPAFPPNDNNEAPQCELVSPLPKVRIEIADTGSGI
HHCCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCCC
SQPDQEKIFDRFYRVENAVHTEQGTGLGLSIVRGIIEKHGGEIRMASELGIGTTFWFDLP
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEHHCCCCEEEEEECC
LEQSDKDELITQTINTTENFSDSQVSEII
CCCCCHHHHHHHHHCCCCCCCCHHHHHCC
>Mature Secondary Structure
MINSNETKKIEVSSSNQTIEDDSYESLSNRVLTWWSGFSLRTKLLAIATLVVSLLMTGIT
CCCCCCCCEEEECCCCCCCCCCCHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
FFALNSIQRDAGMNDTRYARDLGLLLSGNVTELVANNQKQEISNVAEKFWRSSRNLRYIF
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEE
FTNADDIVQLGIPISATPTSSDNQFQLTRKLKLPKELKKRPQFPLVRQHTTPQGQVTDVF
EECCCCEEEECCCCCCCCCCCCCCEEEHHHHCCCHHHHHCCCCCCEECCCCCCCCCHHEE
VPMLWKGKYLGTLALGVTPNKKALASAALTREVTIAVFISIWVLVILGAVFNALTITRPV
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RELVRGVREISKGNFKSRISLPMTGDLGELLTGFNRMASQLENYDEANIEELKAAQVKQQ
HHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
SLIATMADGAILLDSKGKIVLTNPTAKRLFRWEGRFLEGKYLLNEIPEILSNDLHTNIES
HHHHHHCCCEEEEECCCCEEEECCHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHH
ILNREKESDDLRCSLGEPARTLRIVLQSVLDTNKIELKGIAVTIQDLTREVELNAAQNRF
HHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEEHHHHHHHHHCCHHHHHH
ISNVSHELRTPLFNIKSYVETLYDLKDQLSNEEQLEFLGIANSETDRLTRLVNDVLDLSR
HHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
LESGKIIQLEPMEIKPAIEQTLRNYRLNASEKNVALAHDIEENIPLILGNFDLLLQVFDN
CCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEECCHHHHHHHHHH
LLGNGLKFSPKNSTLKIRAYTWPDSCPAFPPNDNNEAPQCELVSPLPKVRIEIADTGSGI
HHCCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEECCCCCEEEEEEEECCCCC
SQPDQEKIFDRFYRVENAVHTEQGTGLGLSIVRGIIEKHGGEIRMASELGIGTTFWFDLP
CCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEHHCCCCEEEEEECC
LEQSDKDELITQTINTTENFSDSQVSEII
CCCCCHHHHHHHHHCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8535519; 8905231; 3141423 [H]