Click here to switch to the map view.

The map label for this gene is purC [H]

Identifier: 123966733

GI number: 123966733

Start: 1334928

End: 1335656

Strand: Reverse

Name: purC [H]

Synonym: P9515_15001

Alternate gene names: 123966733

Gene position: 1335656-1334928 (Counterclockwise)

Preceding gene: 123966736

Following gene: 123966732

Centisome position: 78.38

GC content: 26.89

Gene sequence:

>729_bases
ATGAATAGTAAATTTGGGTTGATTTATGAAGGGAAAGCAAAGAAAATATTTGCTCATAAAGATTCAGATAAAGTAATTAT
TGAATTCAAGGATGATGCCACGGCTTTTAATGCATTAAAGAAAGCTAAATTTGAAGGTAAAGGAGAATTAAACTGCCTTA
TTAGTTCAAAAATATTTGAGTTCCTTATCAAAAATAATATACCAACACATTTTCTTGAGTTAAAAAATAATAATTCAATG
ATTGCTCAGAAAATAAAAATTATCCCCCTTGAAGTTGTTTTAAGAAATATTGCATATGGTTCTCTTTGTAAGCAGACCAC
GATTAAACCCGGATCAGTTTTGGAAAGACCTTTGATTGATATTTATCTTAAAAATGATAATCTCAACGATCCTCTCCTCA
CAAAAGATAGAATAAATTTATTAAAAATAATCGATAATAAAGAGTTAGAATTTATTAGTGGTATGACTTTAAGAATTAAT
AAACTACTCAAAAAATTTTTCTTTAATATCAACCTAAAGTTAGTAGATTTTAAATTAGAATTTGGTTATAACTCTAAGGG
TGAAATCGTTTTAGGTGATGAAATTAGTCCTGATAATTGTAGATTATGGGACTTAAATCAAAGTAATGGTACAATAGTAA
GCCTAGATAAAGATAGATTTAGAAATGATTTAGGAGGCTTTATTGAAGCTTATGGTGAAATTAATAAACGAATAAACGAT
TTCATTTAG

Upstream 100 bases:

>100_bases
GAAAAATCAGTTAAAATTGTATTAATAAAACTATAAAACGTTTCTAATGCCAGTAAACAGTCTAATTATATTCTATTTTT
AAATTGCAAAGGATTTTTTC

Downstream 100 bases:

>100_bases
TCCCAAACACGATTCTATTTATTTATCTTGATTCACATTACTATGCGAAATAATCTTTCAAAATATACAAAAGTATTTAC
AAGCATAGCTTGCTTCTCTT

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MNSKFGLIYEGKAKKIFAHKDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFEFLIKNNIPTHFLELKNNNSM
IAQKIKIIPLEVVLRNIAYGSLCKQTTIKPGSVLERPLIDIYLKNDNLNDPLLTKDRINLLKIIDNKELEFISGMTLRIN
KLLKKFFFNINLKLVDFKLEFGYNSKGEIVLGDEISPDNCRLWDLNQSNGTIVSLDKDRFRNDLGGFIEAYGEINKRIND
FI

Sequences:

>Translated_242_residues
MNSKFGLIYEGKAKKIFAHKDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFEFLIKNNIPTHFLELKNNNSM
IAQKIKIIPLEVVLRNIAYGSLCKQTTIKPGSVLERPLIDIYLKNDNLNDPLLTKDRINLLKIIDNKELEFISGMTLRIN
KLLKKFFFNINLKLVDFKLEFGYNSKGEIVLGDEISPDNCRLWDLNQSNGTIVSLDKDRFRNDLGGFIEAYGEINKRIND
FI
>Mature_242_residues
MNSKFGLIYEGKAKKIFAHKDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFEFLIKNNIPTHFLELKNNNSM
IAQKIKIIPLEVVLRNIAYGSLCKQTTIKPGSVLERPLIDIYLKNDNLNDPLLTKDRINLLKIIDNKELEFISGMTLRIN
KLLKKFFFNINLKLVDFKLEFGYNSKGEIVLGDEISPDNCRLWDLNQSNGTIVSLDKDRFRNDLGGFIEAYGEINKRIND
FI

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=227, Percent_Identity=34.3612334801762, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI5453539, Length=227, Percent_Identity=34.3612334801762, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI119220559, Length=234, Percent_Identity=33.7606837606838, Blast_Score=109, Evalue=2e-24,
Organism=Escherichia coli, GI1788820, Length=232, Percent_Identity=38.7931034482759, Blast_Score=170, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17531275, Length=224, Percent_Identity=35.2678571428571, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI18860083, Length=224, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24583917, Length=206, Percent_Identity=29.6116504854369, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27755; Mature: 27755

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKFGLIYEGKAKKIFAHKDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFE
CCCCEEEEEECCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEHHHHHH
FLIKNNIPTHFLELKNNNSMIAQKIKIIPLEVVLRNIAYGSLCKQTTIKPGSVLERPLID
HHHHCCCCCEEEEEECCCCEEEHEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEE
IYLKNDNLNDPLLTKDRINLLKIIDNKELEFISGMTLRINKLLKKFFFNINLKLVDFKLE
EEECCCCCCCCCCCCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCEEEEEEEEEE
FGYNSKGEIVLGDEISPDNCRLWDLNQSNGTIVSLDKDRFRNDLGGFIEAYGEINKRIND
ECCCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FI
CC
>Mature Secondary Structure
MNSKFGLIYEGKAKKIFAHKDSDKVIIEFKDDATAFNALKKAKFEGKGELNCLISSKIFE
CCCCEEEEEECCCCEEEEECCCCEEEEEECCCCHHHHHHHHHCCCCCCCEEEEEHHHHHH
FLIKNNIPTHFLELKNNNSMIAQKIKIIPLEVVLRNIAYGSLCKQTTIKPGSVLERPLID
HHHHCCCCCEEEEEECCCCEEEHEEEEEHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEE
IYLKNDNLNDPLLTKDRINLLKIIDNKELEFISGMTLRINKLLKKFFFNINLKLVDFKLE
EEECCCCCCCCCCCCCCCCEEEEECCCCCHHHCCCHHHHHHHHHHHHHCCEEEEEEEEEE
FGYNSKGEIVLGDEISPDNCRLWDLNQSNGTIVSLDKDRFRNDLGGFIEAYGEINKRIND
ECCCCCCCEEECCCCCCCCCEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]