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The map label for this gene is lpxC [H]

Identifier: 123966731

GI number: 123966731

Start: 1331904

End: 1332740

Strand: Reverse

Name: lpxC [H]

Synonym: P9515_14981

Alternate gene names: 123966731

Gene position: 1332740-1331904 (Counterclockwise)

Preceding gene: 123966732

Following gene: 123966730

Centisome position: 78.2

GC content: 32.14

Gene sequence:

>837_bases
GTGTTTTCATGGCCTCCTAATTATGATTTCTGTTATACGCTCTCTGGTGTTATCACTAAAGAGGGAATAGGACTGCATAG
TGGAGAAAAGACAAGAGTTAAAATTTCCCCTTATGAAAAAGAGGGATTTTATGTTTCCTTTGCAGATAATCCTGATGAGA
TTTTTAAGCTAGATCAAAATTTAATTGGAAGTACTATGTTATGTACTGCAGTCAAATTAGCAGGTAGAAATTTATATACT
ATTGAGCACTTATTAGCCTCACTTGCAGGCTGTGGATTGAGCTATATACATATTGAAGTTGATGGAAGAGAAATACCACT
ACTAGATGGATCAGCAATTCAATGGGTCAAGGCCTTTGAAGAAGTTGGCATTAAAAAAGTTCCTAAACCAGCAAACTTTA
TAAGAGAAATAAATAAATCGATCATTTTTAATAAAAACAATTCAGTTATTGCTTTAACTCCATCTAATAAAATTACAATT
ATTTCAACAATAAGTTTTTCGTATAAAGCAATTGGAAATCAAACTTATGTAATAGATTTGAGTCCGAAATGTTTTGTTGA
AAATATAGCTCCCGCTAGGACATTTGGTTTTAAGGACCAATTTCAAGAGTTAAGTGAACTTGGATTAATTAAAGGAGGGA
GTTTAGAAAATGCTCTTGTCTGTGATGGTGATAAATGGGTTAATCCTCCATTAAGATTTAGTAATGAACCTATAAGACAT
AAAATTTTAGACCTTATTGGGGACTTGGCTTTGGTAGGCTTACCAAAGGCACAAATTTTAGTATATAAGGGATCACATTC
TTTAAATGCTTTATTGGCCTCATCATTAAAAAATTAA

Upstream 100 bases:

>100_bases
GGGTGTTAAGACCCCAGTTGGACCATTAAGATTAGATGTAGCTAGTAAAGAATTAAGTGGTGATTGGAGATATACTCTCG
GAGTTGGATGGAAATTTTAA

Downstream 100 bases:

>100_bases
TTTTATCTTTTTTAAGTTTTGGACAAGCAATTACTAAGTGAAAATAATCAACTATCTTCTGAGGAAATACTTGGTCTTTT
GCCACATAGATTCCCTTTCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MFSWPPNYDFCYTLSGVITKEGIGLHSGEKTRVKISPYEKEGFYVSFADNPDEIFKLDQNLIGSTMLCTAVKLAGRNLYT
IEHLLASLAGCGLSYIHIEVDGREIPLLDGSAIQWVKAFEEVGIKKVPKPANFIREINKSIIFNKNNSVIALTPSNKITI
ISTISFSYKAIGNQTYVIDLSPKCFVENIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDKWVNPPLRFSNEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN

Sequences:

>Translated_278_residues
MFSWPPNYDFCYTLSGVITKEGIGLHSGEKTRVKISPYEKEGFYVSFADNPDEIFKLDQNLIGSTMLCTAVKLAGRNLYT
IEHLLASLAGCGLSYIHIEVDGREIPLLDGSAIQWVKAFEEVGIKKVPKPANFIREINKSIIFNKNNSVIALTPSNKITI
ISTISFSYKAIGNQTYVIDLSPKCFVENIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDKWVNPPLRFSNEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN
>Mature_278_residues
MFSWPPNYDFCYTLSGVITKEGIGLHSGEKTRVKISPYEKEGFYVSFADNPDEIFKLDQNLIGSTMLCTAVKLAGRNLYT
IEHLLASLAGCGLSYIHIEVDGREIPLLDGSAIQWVKAFEEVGIKKVPKPANFIREINKSIIFNKNNSVIALTPSNKITI
ISTISFSYKAIGNQTYVIDLSPKCFVENIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDKWVNPPLRFSNEPIRH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=264, Percent_Identity=35.9848484848485, Blast_Score=145, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30683; Mature: 30683

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSWPPNYDFCYTLSGVITKEGIGLHSGEKTRVKISPYEKEGFYVSFADNPDEIFKLDQN
CCCCCCCCCEEEEECCEEEECCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHH
LIGSTMLCTAVKLAGRNLYTIEHLLASLAGCGLSYIHIEVDGREIPLLDGSAIQWVKAFE
HHCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCCHHHHHHHHH
EVGIKKVPKPANFIREINKSIIFNKNNSVIALTPSNKITIISTISFSYKAIGNQTYVIDL
HCCCCCCCCHHHHHHHHHHHEEEECCCCEEEECCCCCEEEEEEECEEEEECCCEEEEEEC
SPKCFVENIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDKWVNPPLRFSNEPIRH
CCHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MFSWPPNYDFCYTLSGVITKEGIGLHSGEKTRVKISPYEKEGFYVSFADNPDEIFKLDQN
CCCCCCCCCEEEEECCEEEECCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHHHH
LIGSTMLCTAVKLAGRNLYTIEHLLASLAGCGLSYIHIEVDGREIPLLDGSAIQWVKAFE
HHCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCCHHHHHHHHH
EVGIKKVPKPANFIREINKSIIFNKNNSVIALTPSNKITIISTISFSYKAIGNQTYVIDL
HCCCCCCCCHHHHHHHHHHHEEEECCCCEEEECCCCCEEEEEEECEEEEECCCEEEEEEC
SPKCFVENIAPARTFGFKDQFQELSELGLIKGGSLENALVCDGDKWVNPPLRFSNEPIRH
CCHHHHHCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHH
KILDLIGDLALVGLPKAQILVYKGSHSLNALLASSLKN
HHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA